Evidence for parent of origin effect in late-onset Alzheimer disease
Abstract
Evidence for a parent of origin effect in Alzheimer disease was obtained from a sample of 148 sibships on which affection status of the parents was sought using family history interviews. The parent study recruited families with two or more affected sibs for late onset AD utilizing rigorous diagnostic criteria. In 74 families, there was evidence of an affected parent, 49 maternal and 25 paternal. Genome scan data were analyzed for the sample as a whole and for the maternal and paternal families separately, using Genehunter-ASM. Seven regions with Z(lr) scores >or=2 were identified, four in maternal families (chr. 10,12,19,20) and three in paternal families (chr. 1,7,13). With the exception of the chromosome 10 finding, analysis by parent of origin greatly increased evidence of linkage in areas showing no linkage in the overall analyses. For example, a chr. 12 region reached a LOD = 2.29 among maternal families whereas the same region showed a LOD = 0.3 when all families were analyzed together. The strongest findings among maternal families (chr. 10 and 12) were followed up with fine mapping that resulted in an increase in maximum LOD scores from 2.7-3.2 on chr. 10, and 2.29-2.42 on chr. 12. These analyses highlight the importance of parent of origin effects in late-onset AD families and identify several genomic regions that may include genes linked to late-onset AD specific to disease transmission from the mother and require further investigation.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Both mothers and fathers contribute to their offspring's AD risk, but mothers contribute more because mtDNA is maternally inherited.
“In this respect, both mothers and fathers contribute to their offspring's AD risk, but because mitochondrial DNA (mtDNA) is maternally inherited mothers contribute more.”
From The Alzheimer’s disease mitochondrial cascade hypothesis: progress and perspectives (2014) · cites this paper as [115]
Cites
Green, D. R., & Reed, J. C. (1998) · Science · doi:10.1126/science.281.5381.1309 · Cited by 8,998 · see citing works
Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1977 · Cited by 4,268 · see citing works
Parametric and nonparametric linkage analysis: a unified multipoint approach.
Kruglyak, L., Daly, M. J., Daly, M. J., & Lander, E. S. (1996) · PubMed Central · Cited by 2,883 · see citing works
Brookmeyer, R., Gray, S. G., & Kawas, C. H. (1998) · American Journal of Public Health · doi:10.2105/ajph.88.9.1337 · Cited by 1,774 · see citing works
Albert Hofman, D., Ott, A., Breteler, M. M. B., Bots, M. L., Slooter, A. J. C., van Harskamp, F., van Duijn, C. M., Broeckhoven, C. V., & Grobbee, D. E. (1997) · The Lancet · doi:10.1016/s0140-6736(96)09328-2 · Cited by 1,365 · see citing works
Oxidative damage to mitochondrial DNA is increased in Alzheimer’s disease
Mecocci, P., MacGarvey, U., & Beal, M. F. (1994) · Annals of Neurology · doi:10.1002/ana.410360510 · Cited by 1,037 · see citing works
Alpha-2 macroglobulin is genetically associated with Alzheimer disease
Blacker, D., Wilcox, M., Laird, N. M., Rodes, L., Horvath, S. M., Go, R. C. P., Perry, R. T., Watson, B., Bassett, S. S., McInnis, M. G., et al. (1998) · Nature Genetics · doi:10.1038/1243 · Cited by 642 · see citing works
Self-citationGenomic imprinting: review and relevance to human diseases.
Hall, J. G. (1990) · PubMed · Cited by 628 · see citing works
ApoE-4 and Age at Onset of Alzheimer's Disease: The NIMH Genetics Initiative
Blacker, D., Haines, J. L., Rodes, L., Terwedow, H., Go, R. C. P., Harrell, L. E., Perry, R. T., Bassett, S. S., Chase, G., Meyers, D., et al. (1997) · Neurology · doi:10.1212/wnl.48.1.139 · Cited by 479 · see citing works
Self-citationSusceptibility Locus for Alzheimer's Disease on Chromosome 10
Myers, A., Holmans, P., Marshall, H. N., Kwon, J. M., Meyer, D., Ramic, D., Shears, S., Booth, J., DeVriéze, F. W., Crook, R., et al. (2000) · Science · doi:10.1126/science.290.5500.2304 · Cited by 385 · see citing works
Jarvik, G. P., Wijsman, E. M., Kukull, W. A., Schellenberg, G. D., Yu, C., & Larson, E. B. (1995) · Neurology · doi:10.1212/wnl.45.6.1092 · Cited by 371 · see citing works
Ertekin‐Taner, N., Graff-Radford, N., Younkin, L. H., Eckman, C. B., Baker, M., Adamson, J. L., Ronald, J., Blangero, J., Hutton, M. L., & Younkin, S. G. (2000) · Science · doi:10.1126/science.290.5500.2303 · Cited by 370 · see citing works
A full genome scan for late onset Alzheimer's disease
Kehoe, P. G. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.2.237 · Cited by 356 · see citing works
The Number of Trait Loci in Late-Onset Alzheimer Disease
Daw, E. W., Payami, H., Nemens, E. J., Nochlin, D., Bird, T. D., Schellenberg, G. D., & Wijsman, E. M. (2000) · The American Journal of Human Genetics · doi:10.1086/302710 · Cited by 295 · see citing works
Mitochondria and degenerative disorders
Orth, M., & Schapira, A. H. V. (2001) · American Journal of Medical Genetics · doi:10.1002/ajmg.1425 · Cited by 278 · see citing works
A Validation Study of the Dementia Questionnaire
Kawas, C. H., Segal, J., Stewart, W. F., Corrada, M. M., & Thal, L. J. (1994) · Archives of Neurology · doi:10.1001/archneur.1994.00540210073015 · Cited by 231 · see citing works
Silverman, J. M., Breitner, J. C. S., Mohs, R. C., & Davis, K. L. (1986) · American Journal of Psychiatry · doi:10.1176/ajp.143.10.1279 · Cited by 207 · see citing works
van Duijn, C. M., Clayton, D. G., Chandra, V., Fratiglioni, L., Graves, A. B., Heyman, A., Jorm, A. F., Kokmen, E., Kondo, K., Mortimer, J. A., et al. (1991) · International Journal of Epidemiology · doi:10.1093/ije/20.supplement_2.s13 · Cited by 206 · see citing works
Pericak-Vance, M. A. (1997) · JAMA · doi:10.1001/jama.1997.03550150041033 · Cited by 206 · see citing works
Farlow, M. R., Lahiri, D. K., Poirier, J., Davignon, J., Schneider, L., & Hui, S. L. (1998) · Neurology · doi:10.1212/wnl.50.3.669 · Cited by 199 · see citing works
Familial aggregation in Alzheimer's disease
Breitner, J. C. S., Silverman, J. M., Mohs, R. C., & Davis, K. L. (1988) · Neurology · doi:10.1212/wnl.38.2.207 · Cited by 195 · see citing works
Identification of Novel Genes in Late-Onset Alzheimer's Disease
Pericak‐Vance, M. A., Grubber, J. M., Bailey, L., Hedges, D. J., West, S. G., Santoro, L., Kemmerer, B., Hall, J. L., Saunders, A. M., Roses, A. D., et al. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00196-0 · Cited by 195 · see citing works
Mitochondrial involvement in Alzheimer’s disease
Bonilla, E., Tanji, K., Hirano, M., Vu, T., DiMauro, S., & Schon, E. A. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(98)00165-0 · Cited by 165 · see citing works
Kremer, B. P. H., Almqvist, E. W., Theilmann, J., Spence, N., Telenius, H., Goldberg, Y. P., & Hayden, M. R. (1995) · Europe PMC (PubMed Central) · Cited by 155 · see citing works
Rogaeva, E. A. (1998) · JAMA · doi:10.1001/jama.280.7.614 · Cited by 150 · see citing works
Edland, S. D., Silverman, J. M., Peskind, E. R., Tsuang, D., Wijsman, E., & Morris, J. C. (1996) · Neurology · doi:10.1212/wnl.47.1.254 · Cited by 145 · see citing works
Lendon, C. L., Talbot, C. J., Craddock, N. J., Han, S. W., Wragg, M. A., Morris, J. C., & Goate, A. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)13381-x · Cited by 138 · see citing works
A comparison of familial and sporadic Alzheimer's disease
Duara, R., Lopez-Alberola, R. F., Barker, W. W., Loewenstein, D. A., Zatinsky, M., Eisdorfer, C. E., & Weinberg, G. B. (1993) · Neurology · doi:10.1212/wnl.43.7.1377 · Cited by 122 · see citing works
Scott, W. K., Grubber, J. M., Conneally, P. M., Small, G. W., Hulette, C. M., Rosenberg, C. K., Saunders, A. M., Roses, A. D., Haines, J. L., & Pericak‐Vance, M. A. (2000) · The American Journal of Human Genetics · doi:10.1086/302828 · Cited by 114 · see citing works
Epidemiology of the dementias: recent developments and new approaches.
van Duijn, C. M. (1996) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.60.5.478 · Cited by 102 · see citing works
Furlong, R. A., Ho, L. W., Rubinsztein, J. S., Walsh, C., Paykel, E. S., & Rubinsztein, D. C. (1999) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19990820)88:4 · Cited by 100 · see citing works
Genetic Studies on Chromosome 12 in Late-Onset Alzheimer Disease
Wu, W. S. (1998) · JAMA · doi:10.1001/jama.280.7.619 · Cited by 100 · see citing works
DNA methylation and epigenetic mechanisms
Holliday, R. (1989) · Cell Biophysics · doi:10.1007/bf02991575 · Cited by 99 · see citing works
Apolipoprotein E Genotype and Gender Influence Response to Tacrine Therapya
Farlow, M. R., Lahiri, D. K., Poirier, J., Davignon, J., & Hui, S. L. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb32603.x · Cited by 92 · see citing works
Apolipoprotein E genotype and association between smoking and early onset Alzheimer's disease
van Duijn, C. M., Havekes, L. M., Broeckhoven, C. V., de Knijff, P., & Albert Hofman, D. (1995) · BMJ · doi:10.1136/bmj.310.6980.627 · Cited by 80 · see citing works
Lambert, J., Goumidi, L., Vrièze, F. W., Frigard, B., Harris, J. M., Cummings, A., Coates, J., Pasquier, F., Cottel, D., Gaillac, M., et al. (2000) · Human Molecular Genetics · doi:10.1093/oxfordjournals.hmg.a018918 · Cited by 77 · see citing works
Jarvik, G. P., Larson, E. B., Goddard, K. A. B., Schellenberg, G. D., & Wijsman, E. M. (1996) · PubMed Central · Cited by 75 · see citing works
The apolipoprotein E ε4 allele and the response to tacrine therapy in Alzheimer’s disease
Rigaud, A., Traykov, L., Caputo, L., Guelfi, M., Latour, F., Couderc, R., Moulin, F., de Rotrou, J., Forette, F., & Boller, F. (2000) · European Journal of Neurology · doi:10.1046/j.1468-1331.2000.00073.x · Cited by 70 · see citing works
Bennett, C., Crawford, F., Osborne, A., Diaz, P., Hoyne, J., Lopez, R., Roques, P., Duara, R., Rossor, M., & Mullan, M. (1995) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320600102 · Cited by 67 · see citing works
A Study of the Reliability of the Family History Method in Genetic Sudies of Alzheimer Disease
Silverman, J. M., Keefe, R. S. E., Mohs, R. C., & Davis, K. L. (1989) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-198900000-00004 · Cited by 62 · see citing works
Devi, G., Ottman, R., Tang, M. ‐., Marder, K. S., Stern, Y., & Mayeux, R. P. (2000) · Archives of Neurology · doi:10.1001/archneur.57.1.72 · Cited by 42 · see citing works
“On–Off” Phenomenon in Parkinson’s Disease
Breitner, J. C., & Folstein, M. F. (1984) · New England Journal of Medicine · doi:10.1056/nejm198407193110316 · Cited by 30 · see citing works
Familial and Population‐Based Studies of Apolipoprotein E and Alzheimer's Diseasea
MULLAN, M. J., Scibelli, P., Duara, R., Fallin, D., Gold, M. R., Schinka, J. A., Hoyne, J. B., Osborne, A. R., Sevush, S., & Crawford, F. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb32594.x · Cited by 25 · see citing works
Self-citationDifferential Chromosome Sensitivity to 5-Azacytidine in Alzheimer’s Disease
Payão, S. L. M., Smith, M. D. A. C., & Bertolucci, P. H. F. (1998) · Gerontology · doi:10.1159/000022023 · Cited by 22 · see citing works
A permutation procedure for the haplotype method for identification of disease‐predisposing variants
Li, H. (2001) · Annals of Human Genetics · doi:10.1046/j.1469-1809.2001.6520189.x · Cited by 20 · see citing works
Familial Nature of Alzheimer's Disease
(1984) · New England Journal of Medicine · doi:10.1056/nejm198407193110315 · Cited by 14 · see citing works
Flagged first, then by citations
1 of the 47 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The Alzheimer’s disease mitochondrial cascade hypothesis: progress and perspectives
Swerdlow, R. H., Burns, J. M., & Khan, S. M. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.09.010 · Cited by 786 · see citing works
Epigenetic gene regulation: Linking early developmental environment to adult disease
Dolinoy, D. C., Weidman, J. R., & Jirtle, R. L. (2006) · Reproductive Toxicology · doi:10.1016/j.reprotox.2006.08.012 · Cited by 494 · see citing works
Genomic imprinting and parent-of-origin effects on complex traits
Lawson, H. A., Cheverud, J. M., & Wolf, J. B. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3543 · Cited by 262 · see citing works
The genetic architecture of Alzheimer's disease: beyond APP, PSENs and APOE
Guerreiro, R. J., Gustafson, D. R., & Hardy, J. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.03.025 · Cited by 285 · see citing works
Epigenetic regulation in the pathophysiology of Alzheimer's disease
Chouliaras, L., Rutten, B. P. F., Kenis, G., Peerbooms, O., Visser, P. J., Verhey, F., van Os, J., Steinbusch, H. W. M., & van den Hove, D. L. A. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.01.002 · Cited by 262 · see citing works
Genome-wide prediction of imprinted murine genesPreprint
Luedi, P. P., Hartemink, A. J., & Jirtle, R. L. (2005) · Genome Research · doi:10.1101/gr.3303505 · Cited by 259 · see citing works
Maternal family history of Alzheimer's disease predisposes to reduced brain glucose metabolism
Mosconi, L., Brys, M., Switalski, R., Mistur, R., Glodzik, L., Pirraglia, E., Tsui, W., De Santi, S., & de Leon, M. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705036104 · Cited by 237 · see citing works
Swerdlow, R. H. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4149 · Cited by 203 · see citing works
Mitochondria in Neurodegeneration
Lezi, E., & Swerdlow, R. H. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-2869-1_12 · Cited by 204 · see citing works
Familial risk for Alzheimer's disease alters fMRI activation patterns
Bassett, S. S., Yousem, D. M., Cristinzio, C., Kusevic, I., Yassa, M. A., Caffo, B. S., & Zeger, S. L. (2006) · Brain · doi:10.1093/brain/awl089 · Cited by 171 · see citing works
Self-citationEpigenetics and Complex Disease: From Etiology to New Therapeutics
Ptak, C., & Petronis, A. (2007) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.48.113006.094731 · Cited by 167 · see citing works
Cadmium and Its Epigenetic Effects
Wang, B., Li, Y., Shao, C., Tan, Y., & Cai, L. (2012) · Current Medicinal Chemistry · doi:10.2174/092986712800492913 · Cited by 160 · see citing works
Epigenetic approaches to psychiatric disorders
Ptak, C., & Petronis, A. (2010) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2010.12.1/cptak · Cited by 118 · see citing works
Mitochondria, Cybrids, Aging, and Alzheimer's Disease
Swerdlow, R. H., Koppel, S., Weidling, I., Hayley, C., Ji, Y., & Wilkins, H. M. (2017) · Progress in Molecular Biology and Translational Science · doi:10.1016/bs.pmbts.2016.12.017 · Cited by 106 · see citing works
Okonkwo, O. C., Xu, G., Oh, J. M., Dowling, N. M., Carlsson, C. M., Gallagher, C. L., Birdsill, A. C., Palotti, M. L., Wharton, W., Hermann, B. P., et al. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs381 · Cited by 99 · see citing works
Qureshi, I., & Mehler, M. F. (2010) · Progress in brain research · doi:10.1016/b978-0-444-53630-3.00006-3 · Cited by 94 · see citing works
Genomewide Linkage Scan for Bipolar-Disorder Susceptibility Loci among Ashkenazi Jewish Families
Fallin, M. D., Lasseter, V. K., Wolyniec, P. S., McGrath, J. A., Nestadt, G., Valle, D. L., Liang, K., & Pulver, A. E. (2004) · The American Journal of Human Genetics · doi:10.1086/422474 · Cited by 91 · see citing works
Maternal transmission of Alzheimer's disease: prodromal metabolic phenotype and the search for genes
Mosconi, L., Berti, V., Swerdlow, R. H., Pupi, A., Duara, R., & de Leon, M. (2010) · Human Genomics · doi:10.1186/1479-7364-4-3-170 · Cited by 85 · see citing works
What Are Imprinted Genes Doing in the Brain?
Davies, W., Isles, A. R., Humby, T., & Wilkinson, L. S. (2008) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-77576-0_5 · Cited by 68 · see citing works
Guilmatre, A., & Sharp, A. (2011) · Clinical Genetics · doi:10.1111/j.1399-0004.2011.01790.x · Cited by 66 · see citing works
Genetic association of CTNNA3 with late-onset Alzheimer's disease in females
Miyashita, A., Arai, H., Asada, T., Imagawa, M., Matsubara, E., Shoji, M., Higuchi, S., Urakami, K., Kakita, A., Takahashi, H., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm244 · Cited by 64 · see citing works
Genome-wide linkage analysis of 723 affected relative pairs with late-onset Alzheimer's disease
Hamshere, M. L., Holmans, P., Avramopoulos, D., Bassett, S. S., Blacker, D., Bertram, L., Wiener, H. W., Rochberg, N., Tanzi, R. E., Myers, A., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm224 · Cited by 53 · see citing works
Self-citationGünther, C., Hadeln, K. V., Müller-Thomsen, T., Alberici, A., Binetti, G., Hock, C., Nitsch, R. M., Stoppe, G., Reiss, J., Gal, A., et al. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.07.070 · Cited by 53 · see citing works
Variability of age at onset in siblings with familial Alzheimer disease
Gómez-Tortosa, E., Barquero, M. S., Barón, M., Sainz, M. J., Manzano, S., Payno, M., Ros, R., Almaraz, C., Gómez-Garré, P., & Jiménez-Escrig, A. (2007) · Archives of Neurology · doi:10.1001/archneur.64.12.1743 · Cited by 47 · see citing works
Increased familial risk and genomewide significant linkage for Alzheimer's disease with psychosis
Hollingworth, P., Hamshere, M. L., Holmans, P., O’Donovan, M. C., Sims, R., Powell, J. F., Lovestone, S., Myers, A., DeVriéze, F. W., Hardy, J., et al. (2007) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30515 · Cited by 43 · see citing works
Genome scan on Swedish Alzheimer's disease families
Sillén, A., Forsell, C., Lilius, L., Axelman, K., Björk, B. F., Onkamo, P., Kere, J., Winblad, B. G., & Graff, C. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001772 · Cited by 42 · see citing works
Genetic Variation in Imprinted Genes is Associated with Risk of Late-Onset Alzheimer's Disease
Chaudhry, M., Wang, X., Bamne, M. N., Hasnain, S., Demirci, F. Y., López, O. L., & Kamboh, M. I. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142106 · Cited by 40 · see citing works
Genomic imprinting effects on complex traits in domesticated animal species
O’Doherty, A., MacHugh, D. E., Spillane, C., & Magee, D. A. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00156 · Cited by 37 · see citing works
Altered fMRI activation during mental rotation in those at genetic risk for Alzheimer disease
Yassa, M. A., Verduzco, G., Cristinzio, C., & Bassett, S. S. (2008) · Neurology · doi:10.1212/01.wnl.0000312288.45119.d1 · Cited by 34 · see citing works
Self-citationBassett, S. S., Avramopoulos, D., Perry, R. T., Wiener, H. W., Watson, B., Go, R. C. P., & Fallin, M. D. (2006) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30350 · Cited by 33 · see citing works
Self-citationGenomic Imprinting and Human Psychology: Cognition, Behavior and Pathology
Goos, L. M., & Ragsdale, G. (2008) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-77576-0_6 · Cited by 30 · see citing works
Determinants of Onset of Huntington’s Disease with Behavioral Symptoms: Insight from 92 Patients
Lenka, A., Kamble, N. L., Sowmya, V., Jhunjhunwala, K. R., Yadav, R., Netravathi, M., Kandasamy, M., Moily, N. S., Purushottam, M., Jain, S., et al. (2015) · Journal of Huntington s Disease · doi:10.3233/jhd-150166 · Cited by 29 · see citing works
Linkage to chromosome 14q in Alzheimer's disease (AD) patients without psychotic symptoms
Avramopoulos, D., Fallin, M. D., & Bassett, S. (2005) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30074 · Cited by 27 · see citing works
Self-citationAmyloid-β Alters the DNA Methylation Status of Cell-fate Genes in an Alzheimer's Disease Model
Taher, N., McKenzie, C. E., Garrett, R., Baker, M. S., Fox, N., & Isaacs, G. D. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-131061 · Cited by 27 · see citing works
What Are Imprinted Genes Doing in the Brain?
Davies, W., Isles, A. R., Humby, T., & Wilkinson, L. S. (2007) · Epigenetics · doi:10.4161/epi.2.4.5379 · Cited by 25 · see citing works
Cuéllar-Partida, G., Laurin, C., Ring, S. M., Gaunt, T. R., McRae, A. F., Visscher, P. M., Montgomery, G. W., Martin, N. G., Hemani, G., Suderman, M. J., et al. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy206 · Cited by 21 · see citing works
Fine mapping of the chromosome 10q11-q21 linkage region in Alzheimer's disease cases and controls
Fallin, M. D., Szymanski, M., Wang, R., Gherman, A., Bassett, S. S., & Avramopoulos, D. (2010) · Neurogenetics · doi:10.1007/s10048-010-0234-9 · Cited by 21 · see citing works
Self-citationBrown, A. M., Gordon, D., Lee, H., Caudy, M. A., Hardy, J., Haroutunian, V. H., & Blass, J. P. (2004) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30008 · Cited by 20 · see citing works
Perinatal folate-related exposures and risk of psychotic symptoms in the ALSPAC birth cohort
Glaser, B., Ades, A. E., Lewis, S. J., Emmet, P. M., Lewis, G., Smith, G. D., & Zammit, S. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.03.006 · Cited by 18 · see citing works
Effect of heterogeneity on the chromosome 10 risk in late-onset Alzheimer disease
Liang, X. S., Martin, E. R., Schnetz‐Boutaud, N. C., Bartlett, J., Anderson, B. C., Zuchner, S. L., Gwirtsman, H. E., Schmechel, D. E., Carney, R. M., Gilbert, J. R., et al. (2007) · Human Mutation · doi:10.1002/humu.20567 · Cited by 16 · see citing works
Maternal dementia age at onset in relation to amyloid burden in non-demented elderly offspring
Maye, J. E., Betensky, R. A., Gidicsin, C. M., Locascio, J. J., Becker, J. A., Pepin, L. C., Carmasin, J. S., Rentz, D. M., Marshall, G. A., Blacker, D., et al. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.12.013 · Cited by 16 · see citing works
Analysis of Group ICA-Based Connectivity Measures from fMRI: Application to Alzheimer's Disease
Li, S., Eloyan, A., Joel, S., Mostofsky, S. H., Pekar, J. J., Bassett, S. S., & Caffo, B. S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049340 · Cited by 16 · see citing works
Self-citationA novel gene derived from a segmental duplication shows perturbed expression in Alzheimer’s disease
Avramopoulos, D., Wang, R., Valle, D. L., Fallin, M. D., & Bassett, S. S. (2007) · Neurogenetics · doi:10.1007/s10048-007-0081-5 · Cited by 12 · see citing works
Self-citationModified test statistics by inter-voxel variance shrinkage with an application to f MRI
Su, S.-C., Caffo, B. S., Garrett-Mayer, E. S., & Bassett, S. S. (2008) · Biostatistics · doi:10.1093/biostatistics/kxn028 · Cited by 12 · see citing works
Self-citationDNA Methylation and Alzheimer’s Disease
van Groen, T. (2009) · Springer eBooks · doi:10.1007/978-1-4419-0639-7_17 · Cited by 9 · see citing works
Brown, A. M., Gordon, D., Lee, H., Caudy, M. A., Haroutunian, V. H., & Blass, J. P. (2004) · Neurochemical Research · doi:10.1023/b:nere.0000014833.54481.1d · Cited by 8 · see citing works
Mitochondria and Alzheimer’s Disease: An Electron Microscopy Study
Balogiannis, S. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.84881 · Cited by 8 · see citing works
Brain activation in offspring of AD cases corresponds to 10q linkage
Bassett, S. S., Kusevic, I., Cristinzio, C., Yassa, M. A., Avramopoulos, D., Yousem, D. M., & Fallin, M. D. (2005) · Annals of Neurology · doi:10.1002/ana.20515 · Cited by 8 · see citing works
Self-citationCuéllar-Partida, G., Laurin, C., Ring, S. M., Gaunt, T. R., Relton, C. L., Smith, G. D., & Evans, D. M. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/161471 · Cited by 5 · see citing works
Gao, C., Amador, C., Walker, R. M., Campbell, A. I., Madden, R. A., Adams, M. J., Bai, X., Liu, Y., Li, M., Hayward, C., et al. (2023) · Genome biology · doi:10.1186/s13059-023-02953-6 · Cited by 4 · see citing works
Genetic Risk Factors for Dementia
Hollingworth, P., & Williams, J. H. (2011) · doi:10.1002/9781444344110.ch6 · Cited by 4 · see citing works
Genetic determinants of neuroglobin transcription
Wang, R., Halper‐Stromberg, E., Szymanski, M., Bassett, S. S., & Avramopoulos, D. (2013) · Neurogenetics · doi:10.1007/s10048-013-0388-3 · Cited by 3 · see citing works
Self-citationA REVIEW ON ALZHIMER’S DISEASE: PATHOLOGY, MOLECULAR CONDITIONS, MANAGEMNT AND CAUSES
Moorthi, V., & Basavaraju, P. (2017) · Asian Journal of Pharmaceutical and Clinical Research · doi:10.22159/ajpcr.2017.v10i5.16942 · Cited by 2 · see citing works
Observer Design for a Class of Exothermal Plug-Flow Tubular Reactors
Barje, N., Achhab, M. E., & Vincent Wertz, B. (2013) · International Journal of Applied Mathematical Research · doi:10.14419/ijamr.v2i4.1214 · Cited by 1 · see citing works
Feng, R., Patel, H., & Howard, G. (2014) · International Journal of Statistics in Medical Research · doi:10.6000/1929-6029.2014.03.01.4
A CANDIDATE GENE STUDY OF LATE-ONSET ALZHEIMER'S DISEASE
Burns, L. C. (2010) · D-Scholarship@Pitt (University of Pittsburgh)
Genetic-epigenetic Interactions: Sequence-dependent and Independent DNA Nethylation
Ptak, C. (2013) · TSpace (University of Toronto)
Alzheimer’s Disease: A Complex Paradigm
Avramopoulos, D. (2007) · CRC Press eBooks · doi:10.3109/9781420019544-4
Self-citationEpistatic Networks Associated with Parent-of-Origin Effects on Metabolic TraitsPreprint
Macias-Velasco, J. F., Pierre, C. L. S., Wayhart, J. P., Li, Y., Spears, L. D., Miranda, M. A., Funai, K., Cheverud, J. M., Semenkovich, C. F., & Lawson, H. A. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/579748 · Cited by 1 · see citing works
Epigenetic Remodeling in an IMR-32 Cell Line and Transgenic Mouse Model of Alzheimer's Disease
Baker, M. S. (2014) · Digital Commons (Liberty University)
Current Awareness in Geriatric Psychiatry
(2002) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.583
Alzheimer's Disease: A Complex Paradigm
Avramopoulos, D. (2007) · Medical psychiatry · doi:10.3109/9781420019544.001
Self-citationEffects of Beta Amyloid on the DNA Methylation Status of an in Vitro Model of Alzheimer’s Disease
Taher, N. (2013) · Digital Commons (Liberty University)
Gao, C., Amador, C., Walker, R. M., Campbell, A., Madden, R. A., Adams, M. J., Xiaomeng, B., Ying, L., Li, M., Hayward, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26589501
Gao, C., Amador, C., Walker, R. M., Campbell, A., Madden, R. A., Adams, M. J., Xiaomeng, B., Liu, Y., Li, M., Hayward, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26589504
Gao, C., Amador, C., Walker, R. M., Campbell, A., Madden, R. A., Adams, M. J., Xiaomeng, B., Ying, L., Li, M., Hayward, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26589498
Khoueiry, R. (2009) · doi:10.70675/6a359dd5zb71dz4e51zaa08z4aa18c4e06b8
- Authors
- Bassett, S. S., Avramopoulos, D., & Fallin, D.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Bassett, Susan Spear
- Venue
- American Journal of Medical Genetics
- Publisher
- Wiley
- Published
- 2002-08-08
- Volume
- 114
- Issue
- 6
- Pages
- 679-686
- ISSN
- 0148-7299 (ISSN-L)
- 1096-8628
- OpenAlex
- W1968087197
- Cited by
- 66
- References
- 47
- Citations by year
- 2024: 2 · 2023: 1 · 2019: 2 · 2018: 1 · 2017: 3 · 2015: 4 · 2014: 2 · 2013: 7 · 2012: 3
- FWCI
- 1.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Medical Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Johns Hopkins University
- National Institute of Mental Health (U01MH046290, MH46290)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- late-onset Alzheimer's disease, parent-of-origin effects, sibships, family history (medicine), genome scan, genetic linkage, maternal family, chromosome 10, chromosome 12, fine mapping
- MeSH terms
- Alzheimer Disease, Chromosome Mapping, Fathers, Female, Genotype, Humans, Genetic Linkage, Lod Score, Male, Mothers, Models, Statistical, Age of Onset, Genomic Imprinting, Microsatellite Repeats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
