Cited by 504Genomics and Chromatin DynamicsGene Regulatory Network AnalysisChromatin Remodeling and Cancer

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Dynamic regulation of transcriptional states by chromatin and transcription factors

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Voss, Ty C., Hager, Gordon L.·2014·Nature Reviews Genetics

Abstract

The interaction of regulatory proteins with the complex nucleoprotein structures that are found in mammalian cells involves chromatin reorganization at multiple levels. Mechanisms that support these transitions are complex on many timescales, which range from milliseconds to minutes or hours. In this Review, we discuss emerging concepts regarding the function of regulatory elements in living cells. We also explore the involvement of these dynamic and stochastic processes in the evolution of fluctuating transcriptional activity states that are now commonly reported in eukaryotic systems.

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Metadata

Authors
Voss, T. C., & Hager, G. L.
Affiliations
National Institutes of Health (US)
Corresponding author
Hager, Gordon L.
Venue
Nature Reviews Genetics
Published
2013-12-17
Volume
15
Issue
2
Pages
69-81
ISSN
  • 1471-0056 (ISSN-L)
  • 1471-0064
OpenAlex
W2163353298
Cited by
504
References
124
Citations by year
2026: 31 · 2025: 23 · 2024: 26 · 2023: 24 · 2022: 41 · 2021: 50 · 2020: 34 · 2019: 44 · 2018: 41 · 2017: 57 · 2016: 53 · 2015: 60 · 2014: 18
FWCI
4.11
Type
journal article
Language
en
Open access
Locations
  • Nature Reviews Genetics (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Cancer Institute (Z01BC005450)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Keywords
chromatin, transcription factors, transcriptional regulation, chromatin reorganization, gene expression, stochastic gene expression, regulatory elements, nucleoprotein structure, chromatin dynamics
MeSH terms
Animals, Chromatin, Gene Expression Regulation, Humans, Models, Genetic, Nucleosomes, Protein Binding, Transcription Factors, Transcription, Genetic, Chromatin Assembly and Disassembly

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