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Dynamic regulation of transcriptional states by chromatin and transcription factors
Open accessAbstract
The interaction of regulatory proteins with the complex nucleoprotein structures that are found in mammalian cells involves chromatin reorganization at multiple levels. Mechanisms that support these transitions are complex on many timescales, which range from milliseconds to minutes or hours. In this Review, we discuss emerging concepts regarding the function of regulatory elements in living cells. We also explore the involvement of these dynamic and stochastic processes in the evolution of fluctuating transcriptional activity states that are now commonly reported in eukaryotic systems.
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“As a transcription factor, the GR interacts with and influences the histone landscape, playing a critical role in shaping it.124,125”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [125]
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“In contrast to the long-held view, an accumulating body of work suggests that TFs do not bind DNA for periods of time longer than a few seconds26, 27.”
From Synergistic gene expression during the acute phase response is characterized by transcription factor assisted loading (2017) · cites this paper as [26]
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“While it is clear that enhancers typically favour the more flexible models of sequence organisation, the degree of necessary cooperation between TFs is less obvious, particularly since TF binding to DNA appears to be very transient [113–117].”
From Transcriptional enhancers and their communication with gene promoters (2021) · cites this paper as [114]
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Metadata
- Authors
- Voss, T. C., & Hager, G. L.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Hager, Gordon L.
- Venue
- Nature Reviews Genetics
- Published
- 2013-12-17
- Volume
- 15
- Issue
- 2
- Pages
- 69-81
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- PMC
- PMC6322398
- OpenAlex
- W2163353298
- Cited by
- 504
- References
- 124
- Citations by year
- 2026: 31 · 2025: 23 · 2024: 26 · 2023: 24 · 2022: 41 · 2021: 50 · 2020: 34 · 2019: 44 · 2018: 41 · 2017: 57 · 2016: 53 · 2015: 60 · 2014: 18
- FWCI
- 4.11
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Genetics (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (Z01BC005450)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- chromatin, transcription factors, transcriptional regulation, chromatin reorganization, gene expression, stochastic gene expression, regulatory elements, nucleoprotein structure, chromatin dynamics
- MeSH terms
- Animals, Chromatin, Gene Expression Regulation, Humans, Models, Genetic, Nucleosomes, Protein Binding, Transcription Factors, Transcription, Genetic, Chromatin Assembly and Disassembly
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