The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.
Mechanisms of disease: Helicobacter pylori virulence factors
Open accessAbstract
Helicobacter pylori plays an essential role in the development of various gastroduodenal diseases; however, only a small proportion of people infected with H. pylori develop these diseases. Some populations that have a high prevalence of H. pylori infection also have a high incidence of gastric cancer (for example, in East Asia), whereas others do not (for example, in Africa and South Asia). Even within East Asia, the incidence of gastric cancer varies (decreasing in the south). H. pylori is a highly heterogeneous bacterium and its virulence varies geographically. Geographic differences in the incidence of gastric cancer can be explained, at least in part, by the presence of different types of H. pylori virulence factor, especially CagA, VacA and OipA. However, it is still unclear why the pathogenicity of H. pylori increased as it migrated from Africa to East Asia during the course of evolution. H. pylori infection is also thought to be involved in the development of duodenal ulcer, which is at the opposite end of the disease spectrum to gastric cancer. This discrepancy can be explained in part by the presence of H. pylori virulence factor DupA. Despite advances in our understanding of the development of H. pylori-related diseases, further work is required to clarify the roles of H. pylori virulence factors.
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The 5300-year-old Helicobacter pylori genome of the Iceman
Maixner, F., Krause-Kyora, B., Turaev, D., Herbig, A., Hoopmann, M. R., Hallows, J. L., Kusebauch, U., Vigl, E. E., Malfertheiner, P., Megraud, F., et al. (2016) · Science · doi:10.1126/science.aad2545 · Cited by 231
The emerging roles of bacterial proteases in intestinal diseases
Caminero, A., Guzman, M., Libertucci, J., & Lomax, A. E. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2181922 · Cited by 92
Metadata
- Authors
- Yamaoka, Y.
- Venue
- Nature Reviews Gastroenterology & Hepatology
- Published
- 2010-10-12
- Volume
- 7
- Issue
- 11
- Pages
- 629-641
- ISSN
- 1759-5045 (ISSN-L)
- 1759-5053
- OpenAlex
- W2001751680
- Cited by
- 666
- References
- 110
- FWCI
- 4.54
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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