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The 5300-year-old Helicobacter pylori genome of the Iceman

Maixner, Frank, Krause-Kyora, Ben, Turaev, Dmitrij, Herbig, Alexander, Hoopmann, Michael R., Hallows, Janice L., Kusebauch, Ulrike, Vigl, Eduard Egarter, Malfertheiner, Peter, Megraud, Francis, O’Sullivan, Niall, Cipollini, Giovanna, Coia, Valentina, Samadelli, Marco, Engstrand, Lars, Linz, Bodo, Moritz, Robert L., Grimm, Rudolf, Krause, Johannes, Nebel, Almut, Moodley, Yoshan, Rattei, Thomas, Zink, Albert·2016·Science
DOI 10.1126/science.aad2545PMC PMC4775254
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Abstract

Stomach ache for a European mummy: Five thousand years ago in the European Alps, a man was shot by an arrow, then clubbed to death. His body was subsequently mummified by ice until glacier retreat exhumed him in 1991. Subsequently, this ancient corpse has provided a trove of intriguing information about copper-age Europeans. Now, Maixner et al. have identified the human pathogen Helicobacter pylori within the mummy's stomach contents. The strain the “Iceman” hosted appears to most closely resemble pathogenic Asian strains found today in Central and Southern Asia. Science , this issue p. 162

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  • aDNA extracts also generally play host to an entire metagenomic diversity of environmental microbes that mainly colonized the subfossil material after death.

    “In addition to containing genomic fragments from the focal species, aDNA extracts also generally play host to an entire metagenomic diversity of environmental microbes that mainly colonized the subfossil material after death 7,231 .”

    From Ancient DNA analysis (2021) · cites this paper as [231]

    The paper’s metagenomic-analysis passage (indexed under Abstract; page unavailable) reports endogenous ancient H. pylori DNA in the Iceman’s gastrointestinal samples. It does not address whether aDNA extracts generally contain diverse environmental microbes or whether those microbes mainly colonized remains after death; searches for postmortem colonization and environmental contamination found no supporting passage. (LLM, conf=0.72)

    Experimental — accuracy not yet measured

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Metadata

Authors
Maixner, F., Krause-Kyora, B., Turaev, D., Herbig, A., Hoopmann, M. R., Hallows, J. L., Kusebauch, U., Vigl, E. E., Malfertheiner, P., Megraud, F., O’Sullivan, N., Cipollini, G., Coia, V., Samadelli, M., Engstrand, L., Linz, B., Moritz, R. L., Grimm, R., Krause, J., Nebel, A., Moodley, Y., Rattei, T., & Zink, A.
Affiliations
  • Institute for Mummies and the Iceman, European Academy of Bozen/Bolzano (EURAC), Viale Druso 1, 39100 Bolzano, Italy.
  • Institute of Clinical Molecular Biology, Kiel University, Schittenhelmstrasse 12, 24105 Kiel, Germany.
  • CUBE–Division of Computational Systems Biology, Department of Microbiology and Ecosystem Science, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria.
  • Institute for Archaeological Sciences, University of Tübingen, Rümelinstrasse 23, 72072 Tübingen, Germany.
  • Institute for Systems Biology, 401 Terry Avenue North, Seattle, WA 98109, USA.
  • Scuola Superiore Sanitaria Provinciale “Claudiana,” Via Lorenz Böhler 13, 39100 Bolzano, Italy.
  • Department of Gastroenterology, Hepatology, and Infectious Diseases, Otto-von-Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany.
  • Université de Bordeaux, Centre National de Référence des Helicobacters et Campylobacters and INSERM U853, 146 rue Léo Saignat, 33076 Bordeaux, France.
  • Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 141 83 Stockholm, Sweden.
  • Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA 16802, USA.
  • Robert Mondavi Institute for Food Science, University of California, Davis, CA 95616, USA.
  • Department of Zoology, University of Venda, Private Bag X5050, Thohoyandou 0950, Republic of South Africa.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2016-01-08
Volume
351
Issue
6269
Pages
162-165
ISSN
  • 0036-8075
  • 1095-9203
DOI
10.1126/science.aad2545
PMC
PMC4775254
Cited by
231
References
13
Language
en
Funders
  • South Tyrolean
  • Ernst Ludwig Ehrlich Studienwerk
  • European Research Council
  • National Institutes of Health
  • National Institute of General Medical Sciences (R01 GM087221, S10 RR027584, 2P50 GM076547)
  • Center for Systems Biology

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