Bile acid receptors as targets for drug development

Bile salt biotransformations by human intestinal bacteria

Ridlon, J. M., Kang, D.-J., & Hylemon, P. B. (2006) · Journal of Lipid Research · doi:10.1194/jlr.r500013-jlr200 · Cited by 2,829

Identification of a nuclear receptor for bile acids

Makishima, M., Okamoto, A. Y., Repa, J. J., Tu, H., Learned, R. M., Luk, A., Hull, M. V., Lustig, K. D., Mangelsdorf, D. J., & Shan, B. (1999) · Science · doi:10.1126/science.284.5418.1362 · Cited by 2,714

Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist

Sayin, S. I., Wahlström, A., Felin, J., Jäntti, S., Marschall, H.-U., Bamberg, K., Angelin, B., Hyötyläinen, T., Orešič, M., & Bäckhed, F. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.01.003 · Cited by 2,331

Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

Watanabe, M., Houten, S. M., Mataki, C., Christoffolete, M. A., Kim, B. W., Sato, H., Messaddeq, N., Harney, J. W., Ezaki, O., Kodama, T., et al. (2006) · Nature · doi:10.1038/nature04330 · Cited by 2,220

The Enzymes, Regulation, and Genetics of Bile Acid Synthesis

Russell, D. W. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161712 · Cited by 2,069

A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

Goodwin, B., Jones, S. A., Price, R. R., Watson, M. A., McKee, D. D., Moore, L. B., Galardi, C., Wilson, J. G., Lewis, M. C., Roth, M. E., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00051-4 · Cited by 1,940

TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

Thomas, C., Gioiello, A., Noriega, L., Strehle, A., Oury, J., Rizzo, G., Macchiarulo, A., Yamamoto, H., Mataki, C., Pruzanski, M., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.08.001 · Cited by 1,885

Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

Inagaki, T., Choi, M., Moschetta, A., Peng, L., Cummins, C. L., McDonald, J. G., Luo, G., Jones, S. A., Goodwin, B., Richardson, J. A., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.09.001 · Cited by 1,865

EASL Clinical Practice Guidelines: management of cholestatic liver diseases

European Association for the Study of the Liver (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2009.04.009 · Cited by 1,729

A G Protein-coupled Receptor Responsive to Bile Acids

Kawamata, Y., Fujii, R., Hosoya, M., Harada, M., Yoshida, H., Miwa, M., Fukusumi, S., Habata, Y., Itoh, T., Shintani, Y., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209706200 · Cited by 1,628

Integrative systems analysis identifies genetic and dietary modulators of bile acid homeostasis

Li, H., Perino, A., Huang, Q. D., von Alvensleben, G., Banaei‐Esfahani, A., Velázquez‐Villegas, L. A., Gariani, K., Korbelius, M., Sleiman, M. S. B., Imbach, J., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.08.015 · Cited by 33

Role of bile acids in overweight and obese children and adolescents

Giannini, C., Mastromauro, C., Scapaticci, S., Gentile, C., & Chiarelli, F. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1011994 · Cited by 32

Non-Alcoholic Steatohepatitis: From Pathophysiology to Novel Therapies

Jahn, D., Rau, M., Wohlfahrt, J., Hermanns, H. M., & Geier, A. (2016) · Digestive Diseases · doi:10.1159/000444547 · Cited by 32

Altered systemic bile acid homeostasis contributes to liver disease in pediatric patients with intestinal failure

Xiao, Y., Cao, Y. L., Zhou, K., Lu, L., & Cai, W. (2016) · Scientific Reports · doi:10.1038/srep39264 · Cited by 32

Peroxisomal disorders: Improved laboratory diagnosis, new defects and the complicated route to treatment

Wanders, R. J. A. (2018) · Molecular and Cellular Probes · doi:10.1016/j.mcp.2018.02.001 · Cited by 33

Impact of lipid-lowering therapy on glycemic control and the risk for new-onset diabetes mellitus

Kosmas, C. E., Silverio, D., Sourlas, A., Garcia, F., Montan, P. D., & Guzman, E. (2018) · Drugs in Context · doi:10.7573/dic.212562 · Cited by 31

Xanthohumol ameliorates Diet-Induced Liver Dysfunction via Farnesoid X Receptor-Dependent and Independent Signaling

Paraiso, I. L., Tran, T. Q., Magaña, A. A., Kundu, P., Choi, J., Maier, C. S., Bobe, G., Raber, J., Kioussi, C., & Stevens, J. F. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.643857 · Cited by 31

Pathophysiology and Clinical Management of Bile Acid Diarrhea

Marasco, G., Cremon, C., Barbaro, M. R., Falangone, F., Montanari, D., Capuani, F., Mastel, G., Stanghellini, V., & Barbara, G. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11113102 · Cited by 33

Mucosal and Plasma Metabolomes in New-onset Paediatric Inflammatory Bowel Disease: Correlations with Disease Characteristics and Plasma Inflammation Protein Markers

Nyström, N., Prast‐Nielsen, S., Correia, M. S. P., Globisch, D., Engstrand, L. G., Schuppe‐Koistinen, I., & Halfvarson, J. (2022) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjac149 · Cited by 31

Bile acid metabolism and signaling: potential therapeutic target for nonalcoholic fatty liver disease

Lin, C.-H., & Kohli, R. (2018) · Clinical and Translational Gastroenterology · doi:10.1038/s41424-018-0034-3 · Cited by 31

Pleiotropic roles of FXR in liver and colorectal cancers

Huang, X., Fan, M., & Huang, W. (2022) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111543 · Cited by 32

Probiotic Pediococcus pentosaceus Li05 Improves Cholestasis through the FXR-SHP and FXR-FGF15 Pathways

Han, S., Wang, K., Shen, J., He, X., Lu, Y., Zhuge, A., Li, S., Qiu, B., Zhang, S., Dong, X., et al. (2023) · Nutrients · doi:10.3390/nu15234864 · Cited by 30

The small bowel microbiota

Moran, C. P., Sheehan, D., & Shanahan, F. (2015) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000157 · Cited by 31

Roles of the inflammasome in the gut‑liver axis (Review)

Wang, J., Dong, R., & Zheng, S. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9679 · Cited by 31

Characterization of LP-Z Lipoprotein Particles and Quantification in Subjects with Liver Disease Using a Newly Developed NMR-Based Assay

Bedi, S., Garcia, E., Jeyarajah, E. J., SHALAUROVA, I. Y., Pérez-Matos, M. C., Jiang, Z. G., Dullaart, R. P. F., Matyus, S. P., Kirk, W., Otvos, J. D., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9092915 · Cited by 30

Effects of supplemented isoenergetic diets varying in cereal fiber and protein content on the bile acid metabolic signature and relation to insulin resistance

Weickert, M. O., Hattersley, J. G., Kyrou, I., Arafat, A. M., Rudovich, N., Roden, M., Nowotny, P., von Loeffelholz, C., Matysik, S., Schmitz, G., et al. (2018) · Nutrition & Diabetes · doi:10.1038/s41387-018-0020-6 · Cited by 29

TGR5 in the Cholangiociliopathies

Masyuk, T. V., Masyuk, A. I., & LaRusso, N. F. (2015) · Digestive Diseases · doi:10.1159/000371696 · Cited by 29

Regulation of Immune Homeostasis, Inflammation, and HIV Persistence by the Microbiome, Short-Chain Fatty Acids, and Bile Acids

Enriquez, A. B., ten-Caten, F., Ghneim, K., Sékaly, R., & Sharma, A. (2023) · Annual Review of Virology · doi:10.1146/annurev-virology-040323-082822 · Cited by 29

Bifidobacterium animalis subsp. lactis F1–7 Alleviates Lipid Accumulation in Atherosclerotic Mice via Modulating Bile Acid Metabolites to Downregulate Intestinal FXR

Liang, X., Zheng, X., Wang, P., Zhang, H., Ma, Y., Liang, H., & Zhang, Z. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c05709 · Cited by 29

Structure-based drug design targeting the cell membrane receptor GPBAR1: exploiting the bile acid scaffold towards selective agonism

Leva, F. S. D., Festa, C., Renga, B., Sepe, V., Novellino, E., Fiorucci, S., Zampella, A., & Limongelli, V. (2015) · Scientific Reports · doi:10.1038/srep16605 · Cited by 30

Bile acid effects are mediated by ATP release and purinergic signalling in exocrine pancreatic cells

Kowal, J. M., Haanes, K. A., Christensen, N. M., & Novak, I. (2015) · Cell Communication and Signaling · doi:10.1186/s12964-015-0107-9 · Cited by 29

Multifaceted Aspects of Metabolic Plasticity in Human Cholangiocarcinoma: An Overview of Current Perspectives

Pastore, M., Lori, G., Gentilini, A., Taddei, M. L., Maira, G. D., Campani, C., Recalcati, S., Invernizzi, P., Marra, F., & Raggi, C. (2020) · Cells · doi:10.3390/cells9030596 · Cited by 28

Nonalcoholic Fatty Liver Disease: A Drug Revolution Is Coming

Jeong, S. W. (2020) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2020.0115 · Cited by 29

Isolation of six novel 7-oxo- or urso-type secondary bile acid-producing bacteria from rat cecal contents

Tawthep, S., Fukiya, S., Lee, J.-Y., Hagio, M., Ogura, Y., Hayashi, T., & Yokota, A. (2017) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2017.06.002 · Cited by 28

Update on New Drugs and Those in Development for the Treatment of Primary Biliary Cholangitis.

Bahar, R., Wong, K. A., Liu, C. H., & Bowlus, C. L. (2018) · Europe PMC (PubMed Central) · Cited by 29

Role of gut microbial metabolites in nonalcoholic fatty liver disease

Zhao, Z. H., Lai, J. K., Qiao, L., & Fan, J. (2019) · Journal of Digestive Diseases · doi:10.1111/1751-2980.12709 · Cited by 28

FXR-FGF19 signaling in the gut–liver axis is dysregulated in patients with cirrhosis and correlates with impaired intestinal defence

Simbrunner, B., Hofer, B., Schwabl, P., Zinober, K., Petrenko, O., Fuchs, C. D., Semmler, G., Marculescu, R., Mandorfer, M., Datz, C., et al. (2024) · Hepatology International · doi:10.1007/s12072-023-10636-4 · Cited by 27

Bioactive metabolites: A clue to the link between MASLD and CKD?

Chen, W., Zhang, J.-H., Chen, L., Byrne, C. D., Targher, G., Luo, L., Ni, Y., Zheng, M., & Sun, D. (2024) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2024.0782 · Cited by 27

Gut Microbiota, Peroxisome Proliferator-Activated Receptors, and Hepatocellular Carcinoma

Yu, Q., Wu, L., Ji, J., Feng, J., Dai, W., Li, J., Wu, J., & Guo, C. (2020) · Journal of Hepatocellular Carcinoma · doi:10.2147/jhc.s277870 · Cited by 27

Deoxycholic acid as a molecular scaffold for tyrosyl-DNA phosphodiesterase 1 inhibition: A synthesis, structure–activity relationship and molecular modeling study

Salomatina, O. V., Popadyuk, I. I., Zakharenko, A. L., Zakharova, O. D., Chepanova, A. A., Dyrkheeva, N. S., Комарова, Н. И., Reynisson, J., Anarbaev, R. O., Salakhutdinov, N. F., et al. (2020) · Steroids · doi:10.1016/j.steroids.2020.108771 · Cited by 27

Conjugated C-6 hydroxylated bile acids in serum relate to human metabolic health and gut Clostridia species

Petersen, A. Ø., Julienne, H., Hyötyläinen, T., Sen, P., Fan, Y., Pedersen, H., Jäntti, S. E., Hansen, T. H., Nielsen, T., Jørgensen, T., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-91482-y · Cited by 27

Oral Delivery of Parathyroid Hormone Using a Triple-Padlock Nanocarrier for Osteoporosis via an Enterohepatic Circulation Pathway

An, J. M., Shahriar, S. M. S., Hwang, Y. H., Hwang, S. R., Lee, D. Y., Cho, S., & Lee, Y.-K. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c22170 · Cited by 27

Epiberberine reduces serum cholesterol in diet-induced dyslipidemia Syrian golden hamsters via network pathways involving cholesterol metabolism

Zou, Z., Hu, Y., Ma, H., Feng, M., Li, X., & Ye, X. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.11.017 · Cited by 27

Bile acid signaling in MASLD: From pathogenesis to therapeutic applications

Simbrunner, B., Paternostro, R., Reiberger, T., & Trauner, M. (2025) · Hepatology · doi:10.1097/hep.0000000000001539 · Cited by 30

Discovery of a tricyclic farnesoid X receptor agonist HEC96719, a clinical candidate for treatment of non-alcoholic steatohepatitis

Cao, S., Yang, X., Zhang, Z., Wu, J., Chi, B., Chen, H., Yu, J., Feng, S., Xu, Y., Li, J., et al. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.114089 · Cited by 26

Tomato Pectin Ameliorated Hepatic Steatosis in High-Fat-Diet Mice by Modulating Gut Microbiota and Bile Acid Metabolism

Wang, P., Sun, J., Zhao, W., Wang, D., Ma, Y., Zhao, Y., Wang, Y., & Zhao, X. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c01598 · Cited by 25

Structural basis of tropifexor as a potent and selective agonist of farnesoid X receptor

Jiang, L., Xiao, D., Li, Y., Dai, S., Qu, L., Chen, X., Guo, M., Wei, H., & Chen, Y. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.10.039 · Cited by 25

Rutin and Quercetin Decrease Cholesterol in HepG2 Cells but Not Plasma Cholesterol in Hamsters by Oral Administration

Liang, N. N., Li, Y. M., He, Z., Hao, W., Zhao, Y., Liu, J., Zhu, H., Kwek, E., Ma, K. Y., He, W., et al. (2021) · Molecules · doi:10.3390/molecules26123766 · Cited by 25

Not all (bile acids) who wander are lost: The first report of a patient with an isolated NTCP defect

Karpen, S. J., & Dawson, P. A. (2014) · Hepatology · doi:10.1002/hep.27294 · Cited by 25

Nutritional Modulation of Innate Immunity: The Fat–Bile–Gut Connection

Chèvre, R., Silvestre-Roig, C., & Soehnlein, O. (2018) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2018.08.002 · Cited by 24

Dietary Intervention With α-Amylase Inhibitor in White Kidney Beans Added Yogurt Modulated Gut Microbiota to Adjust Blood Glucose in Mice

Wang, S., Guo, C., Xing, Z., Li, M., Yang, H., Zhang, Y., Ren, F., Chen, L., & Mi, S. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.664976 · Cited by 24

Hepatotoxicity of the Major Anthraquinones Derived From Polygoni Multiflori Radix Based on Bile Acid Homeostasis

Li, K., Li, D., Jiang, X. L., Zhang, Y., Pan, M., Hu, Y., Si, L., Zhang, Y., & Huang, J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.878817 · Cited by 24

The shaping of gut immunity in cirrhosis

Muñoz, L., Caparrós, E., Albillos, A., & Francés, R. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1139554 · Cited by 24

TGR5 suppresses high glucose-induced upregulation of fibronectin and transforming growth factor-β1 in rat glomerular mesangial cells by inhibiting RhoA/ROCK signaling

Xiong, F., Li, X., Yang, Z., Wang, Y., Gong, W., Huang, J., Chen, C., Liu, P., & Huang, H. (2016) · Endocrine · doi:10.1007/s12020-016-1032-4 · Cited by 24

Prolonged fibroblast growth factor 19 response in patients with primary sclerosing cholangitis after an oral chenodeoxycholic acid challenge

Zweers, S. J. L. B., de Vries, E. M., Leníček, M., Tolenaars, D., de Waart, D. R., Koelfat, K. V. K., Groen, A. K., Damink, S. W. M. O., Beuers, U. H., Ponsioen, C. Y., et al. (2016) · Hepatology International · doi:10.1007/s12072-016-9769-7 · Cited by 24

Antimicrobial promotion of pig growth is associated with tissue-specific remodeling of bile acid signature and signaling

Ipharraguerre, I. R., Pastor, J. J., Gavaldà‐Navarro, A., Villarroya, F., & Mereu, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-32107-9 · Cited by 26

Pioneer factor Foxa2 enables ligand-dependent activation of type II nuclear receptors FXR and LXRα

Kain, J., Wei, X., Reddy, N. A., Price, A. J., Woods, C. E., & Bochkis, I. M. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101291 · Cited by 24

Farnesoid X receptor (FXR) and G protein-coupled bile acid receptor 1 (TGR5) signaling pathways improved the hepatic lipid metabolism in hybrid grouper

Xu, J., He, G., Chen, L., Xie, S., Chi, S., Zhang, S., Cao, J., & Tan, B. (2021) · Aquaculture Reports · doi:10.1016/j.aqrep.2021.100997 · Cited by 23

Discovery of HPG1860, a Structurally Novel Nonbile Acid FXR Agonist Currently in Clinical Development for the Treatment of Nonalcoholic Steatohepatitis

Mo, C., Xu, X., Zhang, P., Peng, Y., Zhao, X., Chen, S., Guo, F., Xiong, Y., Chu, X., & Xu, X. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c00456 · Cited by 23

Microbial transformations of bile acids and their receptors in the regulation of metabolic dysfunction-associated steatotic liver disease

Gao, Y., Lin, J., Ye, C., Guo, S., & Jiang, C. (2023) · Liver Research · doi:10.1016/j.livres.2023.09.002 · Cited by 26

On the Role of Illness Duration and Nutrient Restriction in Cholestatic Alterations that Occur During Critical Illness

Jenniskens, M., Güiza, F., Oorts, M., Perre, S. V., Derde, S., Dufour, T., Thiessen, S., Annaert, P., den Berghe, G. V., & Langouche, L. (2017) · Shock · doi:10.1097/shk.0000000000001001 · Cited by 23

Intestinal Inflammation Alters the Expression of Hepatic Bile Acid Receptors Causing Liver Impairment

Negroni, A., Fiaschini, N., Palone, F., Vitali, R., Colantoni, E., Laudadio, I., Oliva, S., Aloi, M., Cucchiara, S., & Stronati, L. (2020) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000002759 · Cited by 24

Gut Microbiota and Liver Dysfunction in Sepsis: The Role of Inflammatory Mediators and Therapeutic Approaches

Shahid, A., Chambers, S. T., Scott-Thomas, A., & Bhatia, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252413415 · Cited by 23

The Bile Acid-Sensitive Ion Channel (BASIC) Is Activated by Alterations of Its Membrane Environment

Schmidt, A., Lenzig, P., Oslender-Bujotzek, A., Kusch, J., Lucas, S. D., Gründer, S., & Wiemuth, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111549 · Cited by 22

Bile Acids—A Peek Into Their History and Signaling

Nguyen, J. T., Shaw, R. P. H., & Anakk, S. (2022) · Endocrinology · doi:10.1210/endocr/bqac155 · Cited by 22

Roseburia intestinalis relieves intrahepatic cholestasis of pregnancy through bile acid/FXR-FGF15 in rats

Sun, H., Su, X., Liu, Y., Li, G., & Du, Q. (2023) · iScience · doi:10.1016/j.isci.2023.108392 · Cited by 22

Kefir Ameliorates Alcohol‐Induced Liver Injury Through Modulating Gut Microbiota and Fecal Bile Acid Profile in Mice

Cui, Y., Jing, C., Yue, Y., Ning, M., Chen, H., Yuan, Y., & Yue, T. (2023) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202300301 · Cited by 22

Targeting Farnesoid X Receptor in Tumor and the Tumor Microenvironment: Implication for Therapy

Nenkov, M., Shi, Y. H., Ma, Y., Gaßler, N., & Chen, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010006 · Cited by 23

Cross-Talk Between Bile Acids and Gastro-Intestinal and Thermogenic Hormones: Clues from Bariatric Surgery

Garruti, G., Ciaula, A. D., Wang, H. H., Wang, D. Q. ‐., & Portincasa, P. (2017) · Annals of Hepatology · doi:10.5604/01.3001.0010.5499 · Cited by 22

Bile acid signaling and bariatric surgery

Tian, J., Huang, S., Sun, S., Ding, L., Zhang, E., Liu, Y., & Huang, W. (2017) · Liver Research · doi:10.1016/j.livres.2017.12.007 · Cited by 23

Intestinal failure to produce FGF19: A culprit in intestinal failure–associated liver disease?

van Erpecum, K. J., & Schaap, F. G. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.03.012 · Cited by 22

Targeting the FXR Nuclear Receptor to Treat Liver Disease

Neuschwander‐Tetri, B. A. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.02.037 · Cited by 22

Bile acid signaling in skeletal muscle homeostasis: from molecular mechanisms to clinical applications

Feng, J., Liu, X., & Liu, Y. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1551100 · Cited by 22

Deoxycholic acid induces proinflammatory cytokine production by model oesophageal cells via lipid rafts

Quilty, F., Freeley, M., Gargan, S., Gilmer, J. F., & Long, A. (2021) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2021.105987 · Cited by 21

Aromatic Amino Acids Promote Lipid Metabolism Disorders by Increasing Hepatic Bile Acid Synthesis

Chen, J., Qin, Y., Li, Z., Shan, A., & Ma, Q. (2024) · Journal of Nutrition · doi:10.1016/j.tjnut.2023.12.047 · Cited by 21

Activation of TGR5 alleviates inflammation in rheumatoid arthritis peripheral blood mononuclear cells and in mice with collagen II‑induced arthritis

Li, Z., Zhou, J., Luo, C., & Zhang, L. (2019) · Molecular Medicine Reports · doi:10.3892/mmr.2019.10711 · Cited by 21

Evolutionary Analysis of Bile Acid-Conjugating Enzymes Reveals a Complex Duplication and Reciprocal Loss History

Kirilenko, B., Hagey, L. R., Barnes, S., Falany, C. N., & Hiller, M. (2019) · Genome Biology and Evolution · doi:10.1093/gbe/evz238 · Cited by 24

The molecular basis for current targets of NASH therapies

Qureshi, K., & Neuschwander‐Tetri, B. A. (2019) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2020.1703949 · Cited by 23

Vitamin A levels reflect disease severity and portal hypertension in patients with cirrhosis

Simbrunner, B., Semmler, G., Stadlmann, A., Scheiner, B., Schwabl, P., Paternostro, R., Bucsics, T., Bauer, D. J. M., Eigenbauer, E., Pinter, M., et al. (2020) · Hepatology International · doi:10.1007/s12072-020-10112-3 · Cited by 21

Gas-propelled nanomotors alleviate colitis through the regulation of intestinal immunoenvironment-hematopexis-microbiota circuits

Xiao, B., Liang, Y., Liu, G., Wang, L., Zhang, Z., Qiu, L., Xu, H., Carr, S. M., Shi, X., Reis, R. L., et al. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.02.008 · Cited by 20

Tauroursodeoxycholic acid/TGR5 signaling promotes survival and early development of glucose-stressed porcine embryos

Dicks, N., Gutierrez, K., Currin, L., de Macedo, M. P., Glanzner, W. G., Mondadori, R. G., Michalak, M., Agellon, L. B., & Bordignon, V. (2021) · Biology of Reproduction · doi:10.1093/biolre/ioab072 · Cited by 20

Revisited role of the placenta in bile acid homeostasis

Ontsouka, E. C., Schroeder, M., & Albrecht, C. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1213757 · Cited by 20

Ginkgetin exhibits antifibrotic effects by inducing hepatic stellate cell apoptosis via STAT1 activation

Wang, C., Bai, Y., Li, T., Liu, J., Wang, Y., Ju, S., Yao, W., & Xiong, B. (2024) · Phytotherapy Research · doi:10.1002/ptr.8106 · Cited by 21

Metal–Organic Cage Receptors for Encapsulation and Sensing of Bile Acids

Paul, B., & Natarajan, R. (2024) · Inorganic Chemistry · doi:10.1021/acs.inorgchem.4c00934 · Cited by 20

Oleanolic acid improved intestinal immune function by activating and potentiating bile acids receptor signaling in E. coli-challenged piglets

Xue, C., Jia, H., Cao, R., Cai, W., Hong, W., Tu, J., Wang, S., Jiang, Q., Bi, C., Shan, A., et al. (2024) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-024-01037-0 · Cited by 20

Hepatocyte specific expression of an oncogenic variant of β-catenin results in cholestatic liver disease

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High-fat diet overfeeding promotes nondetrimental liver steatosis in female mice

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