Bile acid receptors as targets for drug development

Bile salt biotransformations by human intestinal bacteria

Ridlon, J. M., Kang, D.-J., & Hylemon, P. B. (2006) · Journal of Lipid Research · doi:10.1194/jlr.r500013-jlr200 · Cited by 2,829

Identification of a nuclear receptor for bile acids

Makishima, M., Okamoto, A. Y., Repa, J. J., Tu, H., Learned, R. M., Luk, A., Hull, M. V., Lustig, K. D., Mangelsdorf, D. J., & Shan, B. (1999) · Science · doi:10.1126/science.284.5418.1362 · Cited by 2,714

Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist

Sayin, S. I., Wahlström, A., Felin, J., Jäntti, S., Marschall, H.-U., Bamberg, K., Angelin, B., Hyötyläinen, T., Orešič, M., & Bäckhed, F. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.01.003 · Cited by 2,331

Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

Watanabe, M., Houten, S. M., Mataki, C., Christoffolete, M. A., Kim, B. W., Sato, H., Messaddeq, N., Harney, J. W., Ezaki, O., Kodama, T., et al. (2006) · Nature · doi:10.1038/nature04330 · Cited by 2,220

The Enzymes, Regulation, and Genetics of Bile Acid Synthesis

Russell, D. W. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161712 · Cited by 2,069

A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

Goodwin, B., Jones, S. A., Price, R. R., Watson, M. A., McKee, D. D., Moore, L. B., Galardi, C., Wilson, J. G., Lewis, M. C., Roth, M. E., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00051-4 · Cited by 1,940

TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

Thomas, C., Gioiello, A., Noriega, L., Strehle, A., Oury, J., Rizzo, G., Macchiarulo, A., Yamamoto, H., Mataki, C., Pruzanski, M., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.08.001 · Cited by 1,885

Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

Inagaki, T., Choi, M., Moschetta, A., Peng, L., Cummins, C. L., McDonald, J. G., Luo, G., Jones, S. A., Goodwin, B., Richardson, J. A., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.09.001 · Cited by 1,865

EASL Clinical Practice Guidelines: management of cholestatic liver diseases

European Association for the Study of the Liver (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2009.04.009 · Cited by 1,729

A G Protein-coupled Receptor Responsive to Bile Acids

Kawamata, Y., Fujii, R., Hosoya, M., Harada, M., Yoshida, H., Miwa, M., Fukusumi, S., Habata, Y., Itoh, T., Shintani, Y., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209706200 · Cited by 1,628

Obeticholic Acid for the Treatment of Nonalcoholic Steatohepatitis

Ratziu, V. (2021) · Clinical Liver Disease · doi:10.1002/cld.1076 · Cited by 17

New Kids on the Block: Bile Salt Conjugates of Microbial Origin

Ay, Ü., Leníček, M., Claßen, A., Damink, S. W. M. O., Bolm, C., & Schaap, F. G. (2022) · Metabolites · doi:10.3390/metabo12020176 · Cited by 18

Nonalcoholic Steatohepatitis (NASH) and Atherosclerosis: Explaining Their Pathophysiology, Association and the Role of Incretin-Based Drugs

Galatou, E., Mourelatou, E. A., Hatziantoniou, S., & Vizirianakis, I. S. (2022) · Antioxidants · doi:10.3390/antiox11061060 · Cited by 18

Integrative “-Omics” Analysis in Primary Human Hepatocytes Unravels Persistent Mechanisms of Cyclosporine A-Induced Cholestasis

Wolters, J. E. J., van Herwijnen, M. H. M., Theunissen, D. H. J., Jennen, D. G. J., den Hof, W. F. P. M. V., de Kok, T. M. C. M., Schaap, F. G., van Breda, S. G., & Kleinjans, J. C. S. (2016) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.6b00337 · Cited by 17

Discovery of ((1,2,4-oxadiazol-5-yl)pyrrolidin-3-yl)ureidyl derivatives as selective non-steroidal agonists of the G-protein coupled bile acid receptor-1

Leva, F. S. D., Festa, C., Carino, A., Marino, S. D., Marchianò, S., Marino, D. D., Finamore, C., Monti, M. C., Zampella, A., Fiorucci, S., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-38840-z · Cited by 17

Evaluation of acute and subacute toxicity of sodium taurodeoxycholate in rats

Choi, H.-J., Yun, J.-W., Kim, Y.-H., Kwon, E., Hyon, M.-K., Kim, J. Y., Che, J., Kim, W. H., Seong, S., & Kang, B.-C. (2019) · Drug and Chemical Toxicology · doi:10.1080/01480545.2019.1609493 · Cited by 17

Mechanisms for Bile Acids CDCA- and DCA-Stimulated Hepatic Spexin Expression

Lai, Q., Ma, Y., Bai, J., Zhuang, M., Pei, S., He, N., Yin, J.-L., Fan, B., Bian, Z., Zeng, G., et al. (2022) · Cells · doi:10.3390/cells11142159 · Cited by 17

Structure-guided design and synthesis of isoflavone analogs of GW4064 with potent lipid accumulation inhibitory activities

Qiu, R., Luo, G., Cai, X., Liu, L., Chen, M., Chen, D., You, Q., & Xiang, H. (2018) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2018.10.021 · Cited by 17

Targeting Bile-Acid Metabolism: Nutritional and Microbial Approaches to Alleviate Ulcerative Colitis

Jiang, X., Ren, J., Yu, G., Wu, W., Chen, M., Zhao, Y., & He, C. (2025) · Nutrients · doi:10.3390/nu17071174 · Cited by 16

Thermodynamic interference with bile acid demicelleization reduces systemic entry and injury during cholestasis

de Oliveira, C., Khatua, B., El-Kurdi, B., Patel, K. S., Mishra, V. K., Navina, S., Grim, B. J., Gupta, S., Bëlohlávek, M., Cherry, B. R., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-65451-w · Cited by 16

GPCRs get fatty: the role of G protein-coupled receptor signaling in the development and progression of nonalcoholic fatty liver disease

Kurtz, R., Anderman, M. F., & Shepard, B. D. (2020) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00275.2020 · Cited by 17

Lithocholic acid promotes rosacea-like skin inflammation via G protein-coupled bile acid receptor 1

Xiao, W., Chen, M., Peng, Q., Sha, K., Liu, T., Xia, J., Xie, H., Li, J., Xu, S., & Deng, Z. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2022.166563 · Cited by 16

The Gut Microbiome, Microbial Metabolites, and Cardiovascular Disease in People Living with HIV

Peters, B. A., Burk, R. D., Kaplan, R. C., & Qi, Q. (2023) · Current HIV/AIDS Reports · doi:10.1007/s11904-023-00648-y · Cited by 16

Artificial Bear Bile: A Novel Approach to Balancing Medical Requirements and Animal Welfare

Li, Y., Huang, Y., Feng, N., Zhang, H., Qu, J., Ma, S., Liu, Y., Li, J., Xu, S., Wang, L., et al. (2023) · Engineering · doi:10.1016/j.eng.2023.09.017 · Cited by 16

Exploring the Effects of Cyanidin-3-O-Glucoside on Type 2 Diabetes Mellitus: Insights into Gut Microbiome Modulation and Potential Antidiabetic Benefits

Ye, X., Chen, W., Yan, F., Zheng, X., Tu, P., & Shan, P. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c03121 · Cited by 16

Heterozygous knockout of Bile salt export pump ameliorates liver steatosis in mice fed a high-fat diet

Okushin, K., Tsutsumi, T., Ikeuchi, K., Kado, A., Enooku, K., Fujinaga, H., Yamauchi, N., Ushiku, T., Moriya, K., Yotsuyanagi, H., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0234750 · Cited by 16

Activity‐Based Protein Profiling of Bile Salt Hydrolysis in the Human Gut Microbiome with Beta‐Lactam or Acrylamide‐Based Probes

Brandvold, K. R., Miller, C. J., Volk, R. F., Killinger, B., Whidbey, C., & Wright, A. (2020) · ChemBioChem · doi:10.1002/cbic.202000748 · Cited by 16

Characterization of EDP-305, a Highly Potent and Selective Farnesoid X Receptor Agonist, for the Treatment of Non-alcoholic Steatohepatitis

Chau, M., Li, Y., Roqueta‐Rivera, M., Garlick, K., Shen, R., Wang, G., Or, Y. S., & Jiang, L. (2019) · International Journal of Gastroenterology · doi:10.11648/j.ijg.20190301.12 · Cited by 16

Cancer immunity thwarted by the microbiome

Hartmann, N., & Kronenberg, M. (2018) · Science · doi:10.1126/science.aat8289 · Cited by 16

Balancing cholesterol metabolism in the liver and gut: perspectives in health and disease

Yamauchi, Y., Sharpe, L. J., & Brown, A. J. (2026) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-025-01168-3 · Cited by 15

Influence of high-fat diet on host animal health via bile acid metabolism and benefits of oral-fed Streptococcus thermophilus MN-ZLW-002

Luo, Y., Cheng, R., Liang, H., Miao, Z., Wang, J., Zhou, Q., Chen, J., He, F., & Shen, X. P. (2022) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.21-0182 · Cited by 15

Deoxyschizandrin ameliorates obesity and non‐alcoholic fatty liver disease: Involvement of dual Farnesyl X receptor / G protein‐coupled bile acid receptor 1 activation and leptin sensitization

Gu, M., Feng, Y., Chen, Y., Fan, S., & Huang, C. (2023) · Phytotherapy Research · doi:10.1002/ptr.7770 · Cited by 15

Microbiota-Liver-Bile Salts Axis, a Novel Mechanism Involved in the Contrasting Effects of Sodium Selenite and Selenium-Nanoparticle Supplementation on Adipose Tissue Development in Adolescent Rats

Ojeda, M. L., Nogales, F., Carrasco, J. A., Gallego‐López, M. D. C., Carreras, O., Alcudia, A., & Pajuelo, E. (2023) · Antioxidants · doi:10.3390/antiox12051123 · Cited by 17

Effect of Gut Microbiota on the Pharmacokinetics of Nifedipine in Spontaneously Hypertensive Rats

Zhou, R., Yang, H., Zhu, P., Liu, Y., Zhang, Y., Zhang, W., Zhou, H., Li, X., & Li, Q. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15082085 · Cited by 15

Bile acids and coronavirus disease 2019

Huang, X., Liu, X., & Li, Z. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.02.011 · Cited by 15

Design, Synthesis, and Therapeutic Evaluation of Poly(acrylic acid)–tetraDOCA Conjugate as a Bile Acid Transporter Inhibitor

Park, J., Al-Hilal, T. A., Jeong, J., Choi, J. U., & Byun, Y. (2015) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.5b00230 · Cited by 15

Parenteral nutrition dysregulates bile salt homeostasis in a rat model of parenteral nutrition-associated liver disease

Koelfat, K. V. K., Schaap, F. G., Hodin, C. M. I. M., Visschers, R. G. J., Svavarsson, B. I., Leníček, M., Shiri‐Sverdlov, R., Lenaerts, K., & Damink, S. W. M. O. (2016) · Clinical Nutrition · doi:10.1016/j.clnu.2016.09.012 · Cited by 15

Effect of bile acid supplementation on endogenous lipid synthesis in patients with short bowel syndrome: A pilot study

Mouillot, T., Beylot, M., Drai, J., Hillon, P., Gelas, P., Lauverjat, M., Brondel, L., & Chambrier, C. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2019.03.037 · Cited by 15

Bile Acids as a New Type of Steroid Hormones Regulating Nonspecific Energy Expenditure of the Body (Review)

Загоскин, П. П., & Erlykina, E. I. (2020) · Современные технологии в медицине · doi:10.17691/stm2020.12.5.13 · Cited by 16

Hepatokines, bile acids and ketone bodies are novel Hormones regulating energy homeostasis

Garruti, G., Baj, J., Cignarelli, A., Perrini, S., & Giorgino, F. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1154561 · Cited by 15

Emerging pharmacologic therapies for primary sclerosing cholangitis

Cheung, A., Lazaridis, K. N., LaRusso, N. F., & Gores, G. J. (2017) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000352 · Cited by 15

Roux-en-Y Gastric Bypass Improves Metabolic Conditions in Association with Increased Serum Bile Acids Level and Hepatic Farnesoid X Receptor Expression in a T2DM Rat Model

Yan, Y., Sha, Y.-H., Huang, X., Yuan, W., Wu, F., Hong, J., Fang, S., Huang, B., Hu, C., Wang, B., et al. (2019) · Obesity Surgery · doi:10.1007/s11695-019-03918-0 · Cited by 15

Altered ethanol metabolism and increased oxidative stress enhance alcohol‐associated liver injury in farnesoid X receptor‐deficient mice

Morel, C., Chowdhary, V., Nagesh, P. T., Ribeiro, M. D. C., Hawryluk, D., Catalano, D. E., Adorini, L., & Szabó, G. (2022) · Liver International · doi:10.1111/liv.15374 · Cited by 14

Bile acids ameliorates lipopolysaccharide-induced endometritis in mice by inhibiting NLRP3 inflammasome activation

Yang, M., Liu, S., Cai, J., Sun, X., Li, C., Tan, M., & He, B. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.122062 · Cited by 14

Increased hepatic ABCA1 transporter is associated with hypercholesterolemia in a cholestatic rat model and primary biliary cholangitis patients

Takeyama, Y., Uehara, Y., Anan, A., Morihara, D., Yokoyama, K., Takata, K., Tanaka, T., Irie, M., Iwata, K., Shakado, S., et al. (2017) · Medical Molecular Morphology · doi:10.1007/s00795-017-0166-7 · Cited by 14

Enhancement of anti-inflammatory effect of cattle bile by fermentation and its inhibition of neuroinflammation on microglia by inhibiting NLRP3 inflammasome

Pei, Y., Cheng, F., Li, W., Yu, Q., Ma, C., Zou, Y., Xu, T., Liu, S., Zhang, S., & Wang, Q. (2021) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2021.11.003 · Cited by 14

Discovery of (E)-3-(3-((2-Cyano-4′-dimethylaminobiphenyl-4-ylmethyl)cyclohexanecarbonylamino)-5-fluorophenyl)acrylic Acid Methyl Ester, an Intestine-Specific, FXR Partial Agonist for the Treatment of Nonalcoholic Steatohepatitis

Shim, S., Krishnaiah, M., Sankham, M. R., Kim, I., Lee, Y., Shin, I., Oh, A., Lee, H. J., Vu, T. N. L., Park, J., et al. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c00641 · Cited by 14

Therapeutic Potential of Human Microbiome-Based Short-Chain Fatty Acids and Bile Acids in Liver Disease

Ganesan, R., & Suk, K. T. (2022) · Livers · doi:10.3390/livers2030012 · Cited by 16

Multiscale Element-Doped Nanowire Array-Coupled Machine Learning Reveals Metabolic Fingerprints of Nonreversible Liver Diseases

Shi, F., Huang, C., Ren, Y., Deng, C., Sun, N., & Shen, X. (2022) · Analytical Chemistry · doi:10.1021/acs.analchem.2c03743 · Cited by 14

The ileum-liver Farnesoid X Receptor signaling axis mediates the compensatory mechanism of 17α-ethynylestradiol-induced cholestasis via increasing hepatic biosynthesis of chenodeoxycholic acids in rats

Zhang, F., Xi, L., Duan, Y., Qin, H., Wei, M., Wu, Y., Li, B., Zhou, Y., & Wu, X. (2018) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2018.08.005 · Cited by 14

Regulation of Chromatin Accessibility by the Farnesoid X Receptor Is Essential for Circadian and Bile Acid Homeostasis In Vivo

Hassan, H. M., Onabote, O., Isovic, M., Passos, D. T., Dick, F. A., & Torchia, J. (2022) · Cancers · doi:10.3390/cancers14246191 · Cited by 13

Recent advances in anticoagulant drug delivery

Park, J., & Byun, Y. (2015) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2016.1125880 · Cited by 13

Gallbladder Dyskinesia Is Associated With an Impaired Postprandial Fibroblast Growth Factor 19 Response in Critically Ill Patients

Koelfat, K. V. K., Plummer, M. P., Schaap, F. G., Leníček, M., Jansen, P. L. M., Deane, A. M., & Damink, S. W. M. O. (2019) · Hepatology · doi:10.1002/hep.30629 · Cited by 13

Impaired vagus function in rats suppresses bile acid synthesis in the liver by disrupting tight junctions and activating Fxr-Fgf15 signaling in the intestine

Wang, F., Lu, Z., Wang, X., & Zhang, Y. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.11.201 · Cited by 13

Clinical Experience of Acupuncture Treatment for Non-Alcoholic Fatty Liver Disease

Hong, K.-D., Wan, T., & Lu, S.-Y. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/2447529 · Cited by 12

Discovery of novel pyrimidine and malonamide derivatives as TGR5 agonists

Park, E. J., Ahn, Y., Jung, S., Bang, H., Kim, M., Hong, D. J., Kim, J., Suh, K. H., Kim, Y. J., Kim, D., et al. (2014) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2014.07.026 · Cited by 12

A sequence symmetry analysis of the interrelationships between statins, diabetes and skin infections

Ko, H. H. T., Lareu, R. R., Dix, B. R., Hughes, J., & Parsons, R. W. (2019) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.14077 · Cited by 12

Farnesoid X receptor-dependent and -independent pathways mediate the transcriptional control of human fibroblast growth factor 19 by vitamin A

Jahn, D., Sutor, D., Dorbath, D., Weiß, J., Götze, O., Schmitt, J., Hermanns, H. M., & Geier, A. (2015) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2015.12.007 · Cited by 12

Regulation of Ca2+-Sensitive K+ Channels by Cholesterol and Bile Acids via Distinct Channel Subunits and Sites

Dopico, A. M., & Bukiya, A. N. (2017) · Current topics in membranes · doi:10.1016/bs.ctm.2017.07.001 · Cited by 13

Microbiome and gut-liver interactions: From mechanisms to therapies

Anis, M. A., Shahid, Y., Majeed, A. A., & Abid, S. (2025) · World Journal of Gastroenterology · doi:10.3748/wjg.v31.i40.111409 · Cited by 12

The Role of Mass Spectrometry in Hepatocellular Carcinoma Biomarker Discovery

Shen, E. Y.-L., Mei Ran Abellona, U., Cox, I. J., & Taylor-Robinson, S. D. (2023) · Metabolites · doi:10.3390/metabo13101059 · Cited by 11

Bioequivalence and Pharmacokinetic Profiles of Generic and Branded Obeticholic Acid in Healthy Chinese Subjects Under Fasting and Fed Conditions

Wang, M.-N., Yu, H., Li, Y., Zeng, Y., Yang, S. C., Yang, G., Pei, Q., & Huang, J. (2021) · Drug Design Development and Therapy · doi:10.2147/dddt.s289016 · Cited by 11

Altered bile acid metabolism in skin tissues in response to ionizing radiation: deoxycholic acid (DCA) as a novel treatment for radiogenic skin injury

Zhang, Y., Yan, T., Mo, W., Song, B., Zhang, Y., Geng, F., Hu, Z., Yu, D., & Zhang, S. (2023) · International Journal of Radiation Biology · doi:10.1080/09553002.2023.2245461 · Cited by 13

Bidirectional associations among gallstone disease, non-alcoholic fatty liver disease, kidney stone disease

Jiang, G.-H., Li, S., Li, H., Xie, L., Li, S., Yan, Z.-T., Yu, W., Luo, J., Bai, X., Kong, L., et al. (2024) · World Journal of Gastroenterology · doi:10.3748/wjg.v30.i46.4914 · Cited by 11

Gut microbiota and immune system in liver cancer: Promising therapeutic implication from development to treatment

Bartolini, I., Risaliti, M., Tucci, R., Muiesan, P., Ringressi, M. N., Taddei, A., & Amedei, A. (2021) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v13.i11.1616 · Cited by 12

Obeticholic acid attenuates the intestinal barrier disruption in a rat model of short bowel syndrome

Hou, L., Wang, H., Yan, M., Cai, Y., Zheng, R., Ma, Y., Tang, W., & Jiang, W. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167221 · Cited by 11

Glycodeoxycholic Acid Inhibits Primary Bile Acid Synthesis With Minor Effects on Glucose and Lipid Homeostasis in Humans

Meessen, E. C. E., Majait, S., Ay, Ü., Damink, S. W. M. O., Romijn, J. A., Holst, J. J., Hartmann, B., Kuipers, F., Nieuwdorp, M., Schaap, F. G., et al. (2024) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgae399 · Cited by 10

Inflammatory and Proliferative Pathway Activation in Human Esophageal Myofibroblasts Treated with Acidic Bile Salts

Patankar, M., Li, M., Khalatbari, A., Castle, J. D., Hu, L., Zhang, C., & Shaker, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810371 · Cited by 10

Future of bariatric surgery beyond simple weight loss: Metabolic surgery

Caiazzo, R. J., Marciniak, C., Rémond, A., Baud, G., & Pattou, F. N. (2023) · Journal of Visceral Surgery · doi:10.1016/j.jviscsurg.2023.01.005 · Cited by 11

Prophylactic and abundant intake of α‐lipoic acid causes hepatic steatosis and should be reconsidered in usage as an anti‐aging drug

Kuhla, A., Derbenev, M., Shih, H. Y., & Vollmar, B. (2016) · BioFactors · doi:10.1002/biof.1262 · Cited by 10

Decreased Expression of TGR5 in Vogt-Koyanagi-Harada (VKH) Disease

Yang, J., Hu, J., Feng, L., Yi, S., Ye, Z., Lin, M. C., Liu, X., Pu, Y., Kijlstra, A., Yang, P., et al. (2019) · Ocular Immunology and Inflammation · doi:10.1080/09273948.2018.1560477 · Cited by 10

Update on Emerging Treatment Options for Primary Biliary Cholangitis

Aguilar, M. T., & Chascsa, D. M. H. (2020) · Hepatic Medicine Evidence and Research · doi:10.2147/hmer.s205431 · Cited by 10

The Beneficial Effects of Apical Sodium‐Dependent Bile Acid Transporter Inactivation Depend on Dietary Fat Composition

van de Peppel, I. P., Rao, A., Dommerholt, M. B., Bongiovanni, L., Thomas, R., de Bruin, A., Karpen, S. J., Dawson, P. A., Verkade, H. J., & Jonker, J. W. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202000750 · Cited by 11

Integrative Multiomics Profiling Unveils the Protective Function of Ulinastatin against Dextran Sulfate Sodium-Induced Colitis

Yu, T., Yan, J., Wang, R., Zhang, L., Hu, X., Xu, J., Li, F., & Sun, Q. (2024) · Antioxidants · doi:10.3390/antiox13020214 · Cited by 9

Interactions of bile acids and gut microbiota modulate neurological health: a comprehensive review on mechanisms and therapeutic potential of dietary phytochemicals

Wang, J., Zhang, Y., Wu, Q., Zhong, Y., Xu, Z., & Yang, J. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1757551 · Cited by 10

FXR agonism protects against liver injury in a rat model of intestinal failure-associated liver disease

Koelfat, K. V. K., Visschers, R. G. J., Hodin, C. M. I. M., de Waart, D. R., van Gemert, W. G., Cleutjens, J. P. M., Gijbels, M. J., Shiri‐Sverdlov, R., Mookerjee, R. P., Lenaerts, K., et al. (2017) · Journal of Clinical and Translational Research · doi:10.18053/jctres.03.201703.004 · Cited by 9

The mechanism of increased biliary lipid secretion in mice with genetic inactivation of bile salt export pump

Gooijert, K. E. R., Havinga, R., Wolters, H., Wang, R., Ling, V. W. T., Tazuma, S., & Verkade, H. J. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00391.2014 · Cited by 9

Urine and serum NMR-based metabolomics in pre-procedural prediction of contrast-induced nephropathy

Dalili, N., Chashmniam, S., Khoormizi, S. M. H., Salehi, L., Jamalian, S. A., Nafar, M., & Kalantari, S. (2019) · Internal and Emergency Medicine · doi:10.1007/s11739-019-02128-x · Cited by 9

Identification of the expression of farnesoid X receptor in astrocytes

He, H., Chen, Z., Chen, D., Lu, X., Huang, C., & Chen, J. (2021) · Neuroreport · doi:10.1097/wnr.0000000000001717 · Cited by 9

Selective Photoaffinity Probe for Monitoring Farnesoid X Receptor Expression in Cultured Cells

Xu, X., Zhu, Y., Song, J.-Z., Zou, G., Hao, H., Zheng, Q., Cao, L., Wang, G., Wang, H., & Hao, H. (2022) · Analytical Chemistry · doi:10.1021/acs.analchem.2c01206 · Cited by 9

The future R&D landscape in non-alcoholic steatohepatitis (NASH)

Black, D., Brockbank, S., Cruwys, S., Goldenstein, K., Hein, P., & Humphries, B. (2018) · Drug Discovery Today · doi:10.1016/j.drudis.2018.09.020 · Cited by 9

Review article: the impact of liver‐directed therapies on the atherogenic risk profile in non‐alcoholic steatohepatitis

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