Bile acid receptors as targets for drug development

Bile salt biotransformations by human intestinal bacteria

Ridlon, J. M., Kang, D.-J., & Hylemon, P. B. (2006) · Journal of Lipid Research · doi:10.1194/jlr.r500013-jlr200 · Cited by 2,829

Identification of a nuclear receptor for bile acids

Makishima, M., Okamoto, A. Y., Repa, J. J., Tu, H., Learned, R. M., Luk, A., Hull, M. V., Lustig, K. D., Mangelsdorf, D. J., & Shan, B. (1999) · Science · doi:10.1126/science.284.5418.1362 · Cited by 2,714

Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist

Sayin, S. I., Wahlström, A., Felin, J., Jäntti, S., Marschall, H.-U., Bamberg, K., Angelin, B., Hyötyläinen, T., Orešič, M., & Bäckhed, F. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.01.003 · Cited by 2,331

Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

Watanabe, M., Houten, S. M., Mataki, C., Christoffolete, M. A., Kim, B. W., Sato, H., Messaddeq, N., Harney, J. W., Ezaki, O., Kodama, T., et al. (2006) · Nature · doi:10.1038/nature04330 · Cited by 2,220

The Enzymes, Regulation, and Genetics of Bile Acid Synthesis

Russell, D. W. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161712 · Cited by 2,069

A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

Goodwin, B., Jones, S. A., Price, R. R., Watson, M. A., McKee, D. D., Moore, L. B., Galardi, C., Wilson, J. G., Lewis, M. C., Roth, M. E., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00051-4 · Cited by 1,940

TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

Thomas, C., Gioiello, A., Noriega, L., Strehle, A., Oury, J., Rizzo, G., Macchiarulo, A., Yamamoto, H., Mataki, C., Pruzanski, M., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.08.001 · Cited by 1,885

Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

Inagaki, T., Choi, M., Moschetta, A., Peng, L., Cummins, C. L., McDonald, J. G., Luo, G., Jones, S. A., Goodwin, B., Richardson, J. A., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.09.001 · Cited by 1,865

EASL Clinical Practice Guidelines: management of cholestatic liver diseases

European Association for the Study of the Liver (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2009.04.009 · Cited by 1,729

A G Protein-coupled Receptor Responsive to Bile Acids

Kawamata, Y., Fujii, R., Hosoya, M., Harada, M., Yoshida, H., Miwa, M., Fukusumi, S., Habata, Y., Itoh, T., Shintani, Y., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209706200 · Cited by 1,628

Chemical exploration of TGR5 functional hot-spots: Synthesis and structure-activity relationships of C7- and C23-Substituted cholic acid derivatives

Rosatelli, E., Carotti, A., Cerra, B., Franco, F., Passeri, D., Pellicciari, R., & Gioiello, A. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115851 · Cited by 6

An overview of recent treatment options for primary sclerosing cholangitis

Mousavere, I. (2023) · Annals of Gastroenterology · doi:10.20524/aog.2023.0834 · Cited by 8

Bridging cell surface receptor with nuclear receptors in control of bile acid homeostasis

Li, S., Ni, A., & Feng, G. (2014) · Acta Pharmacologica Sinica · doi:10.1038/aps.2014.118 · Cited by 6

Design, synthesis and evaluation of 3-phenoxypyrazine-2-carboxamide derivatives as potent TGR5 agonists

Zhao, S., Wang, L., Wang, J., Wang, C., Zheng, S., Fu, Y., Li, Y., Chen, W., Hou, R., Yang, D., et al. (2022) · RSC Advances · doi:10.1039/d1ra08867j · Cited by 6

Diagnostic and molecular portraits of microbiome and metabolomics of short-chain fatty acids and bile acids in liver disease

Ganesan, R., & Suk, K. T. (2022) · Process Biochemistry · doi:10.1016/j.procbio.2022.10.031 · Cited by 6

Enteroendocrine peptides, growth, and the microbiome during the porcine weaning transition

Ramsay, T. G., Arfken, A. M., & Summers, K. L. (2022) · Animal Microbiome · doi:10.1186/s42523-022-00206-8 · Cited by 6

Pioneer Factor Foxa2 Mediates Chromatin Conformation Changes for Activation of Bile Acid Targets of FXR

Hao, Y., Han, L., Wu, A., & Bochkis, I. M. (2023) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2023.10.009 · Cited by 6

Systems genetics approach reveals cross-talk between bile acids and intestinal microbes

Fu, J., & Kuipers, F. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1008307 · Cited by 6

Molecular Mechanisms Involved in MAFLD in Cholecystectomized Patients: A Cohort Study

Pal, S. C., Castillo-Castañeda, S. M., Díaz-Orozco, L. E., Ramírez-Mejía, M. M., Dorantes-Heredia, R., Alonso-Morales, R. A., Eslam, M., Lammert, F., & Méndez‐Sánchez, N. (2023) · Genes · doi:10.3390/genes14101935 · Cited by 6

Non-Alcoholic Fatty Liver Disease, Bile Acids and Intestinal Microbiota

Maslennikov, R. V., & Evsyutina, Y. V. (2018) · Russian Journal of Gastroenterology Hepatology Coloproctology · doi:10.22416/1382-4376-2018-28-4-84-90 · Cited by 6

Targeting Bile Acid-Activated Receptors in Bariatric Surgery

Ding, L., Fang, Z., Liu, Y., Zhang, E., Huang, T., Yang, L., Wang, Z., & Huang, W. (2019) · Handbook of experimental pharmacology · doi:10.1007/164_2019_229 · Cited by 6

A pilot metabolomic study of drug interaction with the immune response to seasonal influenza vaccination

Siddiqa, A., Wang, Y., Thapa, M., Martin, D. E., Cadar, A. N., Bartley, J. M., & Li, S. (2023) · npj Vaccines · doi:10.1038/s41541-023-00682-2 · Cited by 5

An Update on Role of Bile Acids in Neurological Functions and Neurodegenerative Diseases: A Narrative Review

Kaur, K. K., Allahbadia, G., & Singh, M. (2023) · Journal of Clinical and Biomedical Investigation · doi:10.52916/jcbi234026 · Cited by 6

Modular Assembly of Heterotrifunctional Molecules Enabled by Iodosulfonylation of Allenes and Subsequent Amination

Lin, X., Peng, C., Liu, S., Xiang, J., Lin, B., Zhan, Q., Cao, P., & Cao, T. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c02114 · Cited by 5

Drug Disposition Considerations in Pharmaceutical Product

Maheshwari, R., Sharma, P. A., Seth, A., Taneja, N., Tekade, M., & Tekade, R. K. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814423-7.00010-1 · Cited by 5

A Serum Metabolomic Study on Rats Induced by Polygoni Multiflori Radix and Polygoni Multiflori Radix Preparata by Pattern Recognition and Pathways Analysis

Zhang, Z., Yang, L., Huang, X., & Gao, Y. (2019) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b19-00630 · Cited by 5

Pharmacologic Treatment Strategies for Nonalcoholic Steatohepatitis

Esteban, J. P., & Asgharpour, A. (2020) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2019.10.003 · Cited by 5

Mechanism and Active Components of Qingre Lidan Tablets Alleviate Intrahepatic Cholestasis by Activating the Farnesoid X Receptor

Xia, Y., Yan, S., Chang, Y., Yin, J., Li, H., & Yan, S. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/1589388 · Cited by 5

Enhancing the Therapeutic Efficacy of GLP-1 for Hyperglycemia Treatment: Overcoming Barriers of Oral Gene Therapy with Taurocholic Acid-Conjugated Protamine Sulfate and Calcium Phosphate

Shahriar, S. M. S., An, J. M., Surwase, S. S., Lee, D. Y., & Lee, Y.-K. (2024) · ACS Nanoscience Au · doi:10.1021/acsnanoscienceau.3c00035 · Cited by 5

Fecal Bile Acids in Canine Chronic Liver Disease: Results from 46 Dogs

Habermaass, V., Bartoli, F., Gori, E., Dini, R., Cogozzo, A., Puccinelli, C., Pierini, A., & Marchetti, V. (2024) · Animals · doi:10.3390/ani14213051 · Cited by 5

Nonclinical toxicology studies with sodium taurodeoxycholate: acute and subacute toxicity in dogs

Choi, H.-J., Yun, J.-W., Kim, Y.-H., Kwon, E., Hyon, M.-K., Kim, J. Y., Che, J., Park, J., Kim, H.-C., Kim, W. H., et al. (2019) · Drug and Chemical Toxicology · doi:10.1080/01480545.2019.1566352 · Cited by 5

Decreased serum fibroblast growth factor 19 level is a risk factor for type 1 diabetes

Hu, J., Tang, Y., Liu, H., Li, Y., Li, X., Huang, G., Xiao, Y., & Zhou, Z. (2021) · Annals of Translational Medicine · doi:10.21037/atm-20-5203 · Cited by 5

Computational study of new 1,2,3-triazole derivative of lithocholic acid: Structural aspects, non-linear optical properties and molecular docking studies as potential PTP 1B enzyme inhibitor

Singh, A., Singh, H., & Khurana, J. M. (2018) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2018.11.016 · Cited by 5

Using sodium glycodeoxycholate to develop a temporary infant-like gut barrier model, in vitro

Bietto, F., Arranz, E., Miralles, B., Gómez-Marín, C., Rath, E., Lucey, A. J., & Giblin, L. M. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1577369 · Cited by 4

Secondary bile acid lithocholic acid attenuates neurally evoked ion transport in the rat distal colon

Takahashi, K., Kuwahara, Y., Kato, I., Asano, S., Kozakai, T., Marunaka, Y., & Kuwahara, A. (2022) · Biomedical Research · doi:10.2220/biomedres.43.223 · Cited by 4

Glycochenodeoxycholic acid induces the release of IL-1beta from L02 cells via the NLRP3/caspase-1/GSDMD pathway to activate LX2 cells

Li, J., Han, L., Feng, S. Y., Lin, G., Zou, G.-L., Huang, T., Ran, T., & Zhao, X. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s532042 · Cited by 4

Synergistic effects of ferulic acid and wogonin on cholestatic liver injury via gut microbiota modulation

Luo, X., Mao, T., Wang, X., Cheng, P., Liu, M., Tao, R., Wang, F., Zhao, L., Shan, Y., Lu, Y., et al. (2025) · npj Biofilms and Microbiomes · doi:10.1038/s41522-025-00862-z · Cited by 4

The role of PYY in improving insulin resistance

Liu, C., Na, R., Zhang, H., & Ma, J. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1784709 · Cited by 4

Altered Serum Bile Acid Profile Associated with Chronic Allograft Dysfunction in Kidney Transplant Recipients

Li, Y., Zhang, H., Dai, X., An, Y., Li, Y., Lin, Y., Shi, Y., Fan, J., Gong, X., Zhang, L., et al. (2022) · Annals of Transplantation · doi:10.12659/aot.937974 · Cited by 4

Emerging trends and hotspots in the links between the bile acids and NAFLD from 2002 to 2022: A bibliometric analysis

Cong, S., Wang, S., Qiao, Y., Gu, S., Susu, L., Chai, X., & Yongsheng, Z. (2023) · Endocrinology Diabetes & Metabolism · doi:10.1002/edm2.460 · Cited by 4

Probucol-bile acid nanoparticles: a novel approach and promising solution to prevent cellular oxidative stress in sensorineural hearing loss

Wagle, S. R., Kovačević, B., Foster, T., Ionescu, C. M., Jones, M., Mikov, M., Wise, A. K., Mooranian, A., & Al‐Salami, H. (2024) · Journal of drug targeting · doi:10.1080/1061186x.2024.2349111 · Cited by 4

Burgeoning momentum: the present and future of hyodeoxycholic acid in host microbiome dynamics

Zhan, Z., Chen, R., Deng, Z., & Gao, J. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117133 · Cited by 4

Shades of Yellow: Monitoring Nutritional Needs and Hepatobiliary Function in the Critically III

Bauer, M. W., & Kiehntopf, M. (2014) · Hepatology · doi:10.1002/hep.27076 · Cited by 4

The Role of Bile Acid Receptors in Chronic Inflammatory Diseases

Park, R., & Ji, J. D. (2017) · Journal of Rheumatic Diseases · doi:10.4078/jrd.2017.24.5.253 · Cited by 4

Hepatobiliary Complications of Intestinal Failure and Home Parenteral Nutrition

Huijbers, A., & Wanten, G. J. A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814330-8.00010-x · Cited by 4

Pyrazinamide alleviates rifampin-induced steatohepatitis in mice by regulating the activities of cholesterol-activated 7α-hydroxylase and lipoprotein lipase

Tan, W., Zhao, K. Z., Xiang, J., Zhou, X., Cao, F., Song, W., Liu, Q., Xiu, Z., Li, X., & Tan, Z. (2020) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2020.105402 · Cited by 4

The effect of exenatide on fasting bile acids in newly diagnosed type 2 diabetes mellitus patients, a pilot study

Li, B., Hu, Y., Wang, G., & Liu, L. (2020) · BMC Pharmacology and Toxicology · doi:10.1186/s40360-020-00422-5 · Cited by 4

Bile Acids as Metabolic Inducers of Hepatocyte Proliferation and Liver Regeneration

Kaur, I., Tiwari, R., Naidu, V., Ramakrishna, S., Tripathi, D. M., & Kaur, S. (2021) · Regenerative Engineering and Translational Medicine · doi:10.1007/s40883-021-00221-2 · Cited by 4

Investigation of dysregulated lipid metabolism in diabetic mice via targeted metabolomics of bile acids in enterohepatic circulation

Ruan, Y., Liu, R., & Gong, L. (2021) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.9236 · Cited by 4

Intestinal Digestion and Absorption

Honda, A., Ikegami, T., & Matsuzaki, Y. (2017) · Springer eBooks · doi:10.1007/978-4-431-56062-3_3 · Cited by 4

Epoxide functionalization on cholane side chains in the identification of G-protein coupled bile acid receptor (GPBAR1) selective agonists

Marino, S. D., Carino, A., Masullo, D., Finamore, C., Sepe, V., Marchianò, S., Leva, F. S. D., Limongelli, V., Fiorucci, S., & Zampella, A. (2017) · RSC Advances · doi:10.1039/c7ra04922f · Cited by 4

Novel Bile Acid Therapies for Liver Disease.

Karpen, S. J. (2018) · Europe PMC (PubMed Central) · Cited by 4

Progress in the Treatment of Diabetes Mellitus Based on Intestinal Flora Homeostasis and the Advancement of Holistic Analysis Methods

Bi, R., Gao, J., Pan, L., & Lai, X. (2020) · Natural Product Communications · doi:10.1177/1934578x20918418 · Cited by 4

Bile acid-inspired oral small molecules drug delivery

Nafiujjaman, M., Shahriar, S. M. S., & Hasan, M. N. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821352-0.00017-4 · Cited by 4

A molecular mechanism of UDCA engagement with GPBAR and subsequent G protein interaction revealed by scattered alanine scanning

Lu, R., Yan, X., Fang, G., Zhuang, Y., Guo, L., Zhang, C., Wu, X. Y., Xiao, P., Cao, Y., Yang, F., et al. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.02.030 · Cited by 4

Pituitary TSH controls bile salt synthesis

Jansen, P. L. M., & Schaap, F. G. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.02.003 · Cited by 4

Unravelling the gut-liver axis: The role of gut microbiota-mitochondria interactions in the pathogenesis and management of metabolic-associated fatty liver disease (MAFLD)

Zhang, B., Luo, X., Lei, S., Gao, W., Chen, Z., Zhu, Q., Huang, L., & Long, Q. (2025) · Journal of Holistic Integrative Pharmacy · doi:10.1016/j.jhip.2025.02.001 · Cited by 3

Cholinergic G protein‐coupled bile acid receptor 1 (TGR5/GPBA) in the medial septal orchestrates adult hippocampal neurogenesis and cognition in Alzheimer's disease mice

Nie, R., Zhang, Q., Tan, X., Hu, S., Zhou, X., Jiang, W., Guo, B., Cao, X., Yuan, D., Long, Y., et al. (2025) · British Journal of Pharmacology · doi:10.1111/bph.70185 · Cited by 3

Potential role of bile acids as a microbiome-derived mechanism in synovitis of knee osteoarthritis synovitis

Murillo‐Saich, J., Mannochio-Russo, H., Sala‐Climent, M., Argel, N., Quan, A. M., Hose, M. K., Paz-González, R., Akkati, M., Chang, E. Y., Cutuk, A., et al. (2026) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2026.02.011 · Cited by 3

Oxysterols and bile acids - From intertwined biosynthesis to combined quantification

Roumain, M., & Muccioli, G. G. (2026) · Progress in Lipid Research · doi:10.1016/j.plipres.2026.101385 · Cited by 4

Proanthocyanidin B2 derived metabolites may be ligands for bile acid receptors S1PR2, PXR and CAR: an in silico approach

Hoang, S. H., Tveter, K. M., Mezhibovsky, E., & Roopchand, D. E. (2023) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2023.2224886 · Cited by 3

Serum bile acids associate with liver volume in polycystic liver disease and decrease upon treatment with lanreotide

Dekker, S. E. I., Bierau, J., Giera, M. A., Blomberg, N., Drenth, J. P. H., Mayboroda, O. A., de Fijter, J. W., & Soonawala, D. (2023) · European Journal of Clinical Investigation · doi:10.1111/eci.14147 · Cited by 3

Nuclear receptor gene expression during early gametogenesis in sea urchin Mesocentrotus nudus gonads

Watanabe, S., Matsuzaki, K., Shimizu, U., Higuchi, I., Todo, T., Takagi, Y., & Ura, K. (2024) · Fisheries Science · doi:10.1007/s12562-024-01802-0 · Cited by 3

Effects of Synbiotic Administration on Gut Microbiome and Fecal Bile Acids in Dogs with Chronic Hepatobiliary Disease: A Randomized Case–Control Study

Habermaass, V., Biolatti, C., Bartoli, F., Gori, E., Bruni, N., Olivero, D., & Marchetti, V. (2024) · Veterinary Sciences · doi:10.3390/vetsci11080364 · Cited by 3

Safety, Tolerability and Pharmacokinetics of Intravenous Sodium Taurodeoxycholate, HY209, a GPCR19 Agonist Inhibiting Inflammasomal Activation

Chung, W. K., Jeon, I., Jang, I., Seong, S., Han, S. A., & Yu, K. (2024) · Drug Design Development and Therapy · doi:10.2147/dddt.s438507 · Cited by 3

Cholestasis in Alcohol-Associated Liver Disease

Yan, S., & Yin, X. (2025) · American Journal Of Pathology · doi:10.1016/j.ajpath.2025.04.015 · Cited by 3

Recent Advances in Primary Biliary Cholangitis Treatment

Das, T. S., & Vuppalanchi, R. (2025) · Clinics in Liver Disease · doi:10.1016/j.cld.2025.06.008 · Cited by 3

Implications for Farnesoid X Receptor Signaling on Bile Acid Metabolism as a Potential Therapeutic Strategy for Nonalcoholic Fatty Liver Disease

Yang, H., & Park, C. (2016) · The Korean Journal of Obesity · doi:10.7570/kjo.2016.25.4.167 · Cited by 3

Novel adefovir mono L-amino acid ester, mono bile acid ester derivatives: Design, synthesis, biological evaluation, and molecular docking study

Chen, Y., Zhang, W. Z., Li, J., Xiao, T., Liu, J. X., Luo, M., Su, H., Fu, X., Liu, T., Dong, Y., et al. (2017) · Medicinal Chemistry Research · doi:10.1007/s00044-017-1892-z · Cited by 3

Effect of Bile Salt Aggregates on the Prototropic Equilibria of Harmine, a Fluorescent β‐Carboline Alkaloid

Das, K., Satpathi, S., & Hazra, P. (2018) · ChemistrySelect · doi:10.1002/slct.201702817 · Cited by 3

High concentration of serum FGF19 at ICU admission is associated with 28-day mortality in sepsis patients

Li, X., Zhou, T., Zhu, Z., & Xu, B. (2021) · Clinica Chimica Acta · doi:10.1016/j.cca.2021.11.002 · Cited by 3

The Synthesis and Pharmacokinetics of a Novel Liver-Targeting Cholic Acid-Conjugated Carboplatin in Rats

Lan, Y., Han, F., Gao, A., Fan, X., Hao, Y., Wang, Z., Liu, W., Jiang, J., & Liu, Q. (2024) · Inorganics · doi:10.3390/inorganics12070184 · Cited by 3

Gut Microbes Take It to the Next Level? First Insights Into Farnesoid X Receptor Agonists of Microbial Origin

Leníček, M., Damink, S. W. M. O., & Schaap, F. G. (2020) · Hepatology · doi:10.1002/hep.31455 · Cited by 3

Identification of degradation impurity of TGR5 receptor agonist-ZY12201 by LC–MS technique during force degradation study

Sojitra, C., Dholakia, C., Sudhakar, P. P., Singh, K. K., & Agarwal, S. (2021) · SN Applied Sciences · doi:10.1007/s42452-021-04660-y · Cited by 3

Enhancing Pathogen Resistance: The Gut Microbiota and Malaria

Moore, J. M., & Aparicio, J. C. M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819265-8.00097-8 · Cited by 3

Pharmacology of Gut Hormone Mimetics for Obesity and Diabetes

Lafferty, R. A., O'Harte, F. P. M., Irwin, N., Flatt, P. R., & Gault, V. A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820472-6.00035-9 · Cited by 3

Bile acid transporter as a bioinspired method for oral therapeutics delivery system

Shahriar, S. M. S., Hasan, M. N., Nurunnabi, M., & Lee, Y.-K. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821352-0.00008-3 · Cited by 3

Jaundice and Cholestasis

Jansen, P. L. M. (2018) · Wiley eBooks · doi:10.1002/9781119237662.ch13 · Cited by 3

Gut microbial metabolites-mediated modulation of colitis in mice by three geographically varied dietary patterns

Yu, W., Zhao, Y., Zhang, Y., Li, Y., Yang, Y., Wang, J., Wang, H., Shi, H. Y., Xiao, C., Zhao, M., et al. (2024) · Food Science and Human Wellness · doi:10.26599/fshw.2024.9250420 · Cited by 2

Hepatic Lamp2a deficiency promotes inflammation of murine autoimmune cholangitis via affecting bile acid metabolism

Fan, Q., Guo, G., Hu, Y., Lu, Y., Su, R., Yang, J., Xia, E., Ma, S., Zhang, M., Wang, J., et al. (2025) · iScience · doi:10.1016/j.isci.2025.111804 · Cited by 2

Effect of traditional Chinese medicine on disturbances of untargeted metabolomics in ulcerative colitis.

Jiang, L., Xue, T., Zhang, H., Zhang, Q.-Y., & Deng, H.-L. (2026) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2026.121250 · Cited by 2

The impact of gut microbiome on intrahepatic cholestasis of pregnancy—systematic literature review

Donzé, F. J., Eli, N., Simone, N. D., Cavegn, B. B., & Mueller, M. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1859397 · Cited by 2

Activation of constitutive androstane receptor inhibits intestinal CFTR-mediated chloride transport

Kittayaruksakul, S., Sawasvirojwong, S., Noitem, R., Pongkorpsakol, P., Muanprasat, C., & Chatsudthipong, V. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.01.015 · Cited by 2

The Interconnection Between the Liver and Other Organs: Insights for Hepatic Long–Term Normothermic Machine Perfusion

Cai, R., Liu, Z., Feng, Z., Qin, M., Li, J., Zhao, Q., & He, X. (2024) · Organ medicine. · doi:10.1002/orm2.8 · Cited by 2

Amino Acids, Protein, and the Gastrointestinal Tract

Bruins, M. J., Koelfat, K. V. K., & Soeters, P. B. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802167-5.00013-x · Cited by 2

A convenient and efficient 4-(diethylamino)-butylamine-labeled polarity-response-homodispersed strategy for absolute quantification of carboxyl submetabolome: Monitoring the whole progressive course of hepatocellular carcinoma

Tong, M., Zhang, Q., Zhang, Y., Xing, L., Bi, K., & Li, Q. (2022) · Journal of Chromatography A · doi:10.1016/j.chroma.2022.463504 · Cited by 2

Quantitative comparison of bile acid glucuronides sub-metabolome between intrahepatic cholestasis and healthy pregnant women

Li, W., Gong, X., Niu, X., Zhou, Y., Ren, L., Man, Z., Tu, P., Xiong, X., Liu, W., & Song, Y. (2024) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-024-05430-6 · Cited by 2

Hepatic Gα13 ablation shifts region-specific colonic inflammatory status by modulating the bile acid synthetic pathway in mice

Kwon, S. J., Kim, Y., Tak, J., Lee, S. G., Lee, E. B., & Kim, S. G. (2024) · Scientific Reports · doi:10.1038/s41598-024-70254-4 · Cited by 3

Regulation of Intestinal GLP-1 and GLUT2 genes underlie hypoglycemia in Desplatsia subericarpa (Bocq)-Fed Wistar Rats

Omotuyi, O. I., Oghale, O.-U., & MacDonald, I. (2017) · Journal of Herbal Drugs: International Journal on Medicinal Herbs · doi:10.18869/jhd.2017.79 · Cited by 2

Metformin as a drug modifyinggut microbiota

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High Levels of Akkermansia muciniphilia Growth Associated With Spring Water Ingestion Prevents Obesity and Hyperglycemia in a High-fat Diet-Induced Mouse Model

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