The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Liver autophagy: much more than just taking out the trash
Open accessAbstract
Studies performed in the liver in the 1960s led to the identification of lysosomes and the discovery of autophagy, the process by which intracellular proteins and organelles are degraded in lysosomes. Early studies in hepatocytes also uncovered how nutritional status regulates autophagy and how various circulating hormones modulate the activity of this catabolic process in the liver. The intensive characterization of hepatic autophagy over the years has revealed that lysosome-mediated degradation is important not only for maintaining liver homeostasis in normal physiological conditions, but also for an adequate response of this organ to stressors such as proteotoxicity, metabolic dysregulation, infection and carcinogenesis. Autophagic malfunction has also been implicated in the pathogenesis of common liver diseases, suggesting that chemical manipulation of this process might hold potential therapeutic value. In this Review—intended as an introduction to the topic of hepatic autophagy for clinical scientists—we describe the different types of hepatic autophagy, their role in maintaining homeostasis in a healthy liver and the contribution of autophagic malfunction to liver disease.
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Cites
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Self-citationParkin is recruited selectively to impaired mitochondria and promotes their autophagy
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Self-citationAutophagy and the Integrated Stress Response
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Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
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Cited by
Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles
Galluzzi, L., Bravo-San Pedro, J. M., Levine, B., Green, D. R., & Kroemer, G. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.22 · Cited by 842
Autophagy in the liver: functions in health and disease
Ueno, T., & Komatsu, M. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.185 · Cited by 500
Developmental origins of metabolic diseases
Hoffman, D. J., Powell, T. L., Barrett, E. S., & Hardy, D. B. (2021) · Physiological Reviews · doi:10.1152/physrev.00002.2020 · Cited by 466
Autophagy in liver diseases: Time for translation?
Allaire, M., Rautou, P.-E., Codogno, P., & Lotersztajn, S. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.01.026 · Cited by 378
DeBosch, B. J., Heitmeier, M. R., Mayer, A. L., Higgins, C. B., Crowley, J. R., Kraft, T. E., Chi, M., Newberry, E. P., Chen, Z., Finck, B. N., et al. (2016) · Science Signaling · doi:10.1126/scisignal.aac5472 · Cited by 280
Metadata
- Authors
- Schneider, J. L., & Cuervo, A. M.
- Venue
- Nature Reviews Gastroenterology & Hepatology
- Published
- 2013-11-05
- Volume
- 11
- Issue
- 3
- Pages
- 187-200
- ISSN
- 1759-5045 (ISSN-L)
- 1759-5053
- OpenAlex
- W2078881478
- Cited by
- 189
- References
- 36
- FWCI
- 2.26
- Type
- journal article
- Language
- en
- Open access
- green
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- Schneider, J. L., & Cuervo, A. M. (2014). Liver autophagy: much more than just taking out the trash. Nature Reviews Gastroenterology & Hepatology. https://doi.org/10.1038/nrgastro.2013.211
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
