The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Emerging roles of p53 and other tumour-suppressor genes in immune regulation
Open accessAbstract
Tumour-suppressor genes are indispensable for the maintenance of genomic integrity. Recently, several of these genes, including those encoding p53, PTEN, RB1 and ARF, have been implicated in immune responses and inflammatory diseases. In particular, the p53 tumour- suppressor pathway is involved in crucial aspects of tumour immunology and in homeostatic regulation of immune responses. Other studies have identified roles for p53 in various cellular processes, including metabolism and stem cell maintenance. Here, we discuss the emerging roles of p53 and other tumour-suppressor genes in tumour immunology, as well as in additional immunological settings, such as virus infection. This relatively unexplored area could yield important insights into the homeostatic control of immune cells in health and disease and facilitate the development of more effective immunotherapies. Consequently, tumour-suppressor genes are emerging as potential guardians of immune integrity.
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Cites
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Cited by
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“A role for DNA damage factors and particularly p53 in anti-viral defense and innate immunity has been proposed, because p53 is responsive to type I interferons, can act as a restriction factor for viruses and transposons, and is in turn targeted by multiple viral evasion mechanisms (Levine et al., 2016; Miciak and Bun…”
BackgroundMethotrexate and its mechanisms of action in inflammatory arthritis
Cronstein, B. N., & Aune, T. M. (2020) · Nature Reviews Rheumatology · doi:10.1038/s41584-020-0373-9 · Cited by 677
mRNA-based cancer therapeutics
Liu, C., Shi, Q., Huang, X., Koo, S., Kong, N., & Tao, W. (2023) · Nature Reviews Cancer · doi:10.1038/s41568-023-00586-2 · Cited by 500
Immunological impact of cell death signaling driven by radiation on the tumor microenvironment
Rodriguez-Ruiz, M. E., Vitale, I., Harrington, K. J., Melero, I., & Galluzzi, L. (2020) · Nature Immunology · doi:10.1038/s41590-019-0561-4 · Cited by 385
Ren, D., Hua, Y., Yu, B., Ye, X., He, Z., Li, C., Wang, J., Mo, Y., Wei, X., Chen, Y., et al. (2020) · Molecular Cancer · doi:10.1186/s12943-020-1144-6 · Cited by 316
Metadata
- Authors
- Muñoz-Fontela, C., Mandinova, A., Aaronson, S. A., & Lee, S. W.
- Venue
- Nature Reviews Immunology
- Published
- 2016-09-26
- Volume
- 16
- Issue
- 12
- Pages
- 741-750
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2527179423
- Cited by
- 341
- References
- 24
- FWCI
- 3.42
- Type
- journal article
- Language
- en
- Open access
- green
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