The DOI matches its Crossref record; 158 of the 158 references it cites were found in a registry or an index.
The regulation of immune tolerance by FOXP3
Open accessAbstract
The proper restraint of the destructive potential of the immune system is essential for maintaining health. Regulatory T (T reg) cells ensure immune homeostasis through their defining ability to suppress the activation and function of other leukocytes. The expression of the transcription factor forkhead box protein P3 (FOXP3) is a well-recognized characteristic of T reg cells, and FOXP3 is centrally involved in the establishment and maintenance of the T reg cell phenotype. In this Review, we summarize how the expression and activity of FOXP3 are regulated across multiple layers by diverse factors. The therapeutic implications of these topics for cancer and autoimmunity are also discussed.
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“The X chromosome‐encoded transcription factor forkhead box P3 (Foxp3), identified as a lineage‐specific transcription factor of Tregs, is centrally involved in the development of Tregs and the maintenance of the Treg phenotype.[ 10 ]”
From Ccl2-Induced Regulatory T Cells Balance Inflammation Through Macrophage Polarization During Liver Reconstitution (2024) · cites this paper as [10]
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1 retracted
RETRACTED: Foxp3-positive macrophages display immunosuppressive properties and promote tumor growth
Manrique, S. Z., Correa, M. A. D., Hoelzinger, D. B., Dominguez, A. L., Mirza, N. N., Lin, H., Stein‐Streilein, J., Gordon, S., & Lustgarten, J. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20100730 · Cited by 72
RetractedCommensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., et al. (2013) · Nature · doi:10.1038/nature12721 · Cited by 5,549
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
Arpaia, N., Campbell, C., Fan, X., Dikiy, S., van der Veeken, J., deRoos, P., Liu, H., Cross, J. R., Pfeffer, K., Coffer, P. J., et al. (2013) · Nature · doi:10.1038/nature12726 · Cited by 4,838
The Role of Tumoral FOXP3 on Cell Proliferation, Migration, and Invasion in Gastric Cancer
Zhang, L., Xu, J., Zhang, X., Zhang, Y., Wang, L., Huang, X., & Xu, Z. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479442 · Cited by 4,090
Commensal Bifidobacterium promotes antitumor immunity and facilitates anti–PD-L1 efficacy
Sivan, A., Corrales, L., Hubert, N., Williams, J. B., Aquino-Michaels, K., Earley, Z. M., Benyamin, F. W., Man Lei, Y., Jabri, B., Alegre, M.-L., et al. (2015) · Science · doi:10.1126/science.aac4255 · Cited by 3,888
Bennett, C. L., Christie, J., Ramsdell, F., Brunkow, M., Ferguson, P., Whitesell, L., Kelly, T., Saulsbury, F., Chance, P., & Ochs, H. (2001) · Nature Genetics · doi:10.1038/83713 · Cited by 3,576
Vignali, D. A. A., Collison, L. W., & Workman, C. J. (2008) · Nature Reviews Immunology · doi:10.1038/nri2343 · Cited by 3,463
Regulatory T cells: mechanisms of differentiation and function
Josefowicz, S. Z., Lu, L.-F., & Rudensky, A. Y. (2012) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141623 · Cited by 2,866
Self-citationBrunkow, M. E., Jeffery, E. W., Hjerrild, K. A., Paeper, B. W., Clark, L. B., Yasayko, S.-A., Wilkinson, J. E., Galas, D. J., Ziegler, S. F., & Ramsdell, F. (2001) · Nature Genetics · doi:10.1038/83784 · Cited by 2,628
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Wang, R., Liang, Q., Zhang, Q., Zhao, S., Lin, Y., Liu, B., Ma, Y., Mai, X., Fu, Q., Bao, X., et al. (2024) · Advanced Science · doi:10.1002/advs.202403849 · Cited by 25
Herzog, R. W., Kuteyeva, V., Saboungi, R., Terhorst, C., & Biswas, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00274 · Cited by 24
The role of FOXP3 in non-small cell lung cancer and its therapeutic potentials
Peng, J., Yang, S., Ng, C. S. H., & Chen, G. G. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108333 · Cited by 21
Metadata
- Authors
- Lu, L., Barbi, J., & Pan, F.
- Affiliations
- Jiangsu Province Hospital (CN)
- Roswell Park Comprehensive Cancer Center (US)
- Johns Hopkins University (US)
- Corresponding author
- Lu, Ling
- Barbi, Joseph
- Pan, Fan
- Venue
- Nature Reviews Immunology
- Published
- 2017-07-31
- Volume
- 17
- Issue
- 11
- Pages
- 703-717
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- PMC
- PMC5793224
- OpenAlex
- W2740495409
- Cited by
- 580
- References
- 158
- Citations by year
- 2026: 52 · 2025: 53 · 2024: 59 · 2023: 64 · 2022: 65 · 2021: 96 · 2020: 69 · 2019: 53 · 2018: 58 · 2017: 10
- FWCI
- 5.34
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (P30CA016056, P30CA006973)
- National Institute of Allergy and Infectious Diseases (R01AI089830, R01AI099300)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › FOXO transcription factor regulation
- Keywords
- Foxp3, regulatory T cells, immune tolerance, transcriptional regulation, post-translational modification, immune homeostasis, cancer immunotherapy, autoimmunity
- MeSH terms
- Animals, Gene Expression Regulation, Humans, Immune Tolerance, Protein Processing, Post-Translational, T-Lymphocyte Subsets, T-Lymphocytes, Regulatory, Forkhead Transcription Factors, Immunomodulation
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