Cited by 580T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisFOXO transcription factor regulation

The DOI matches its Crossref record; 158 of the 158 references it cites were found in a registry or an index.

The regulation of immune tolerance by FOXP3

Open access

Lu, Ling, Barbi, Joseph, Pan, Fan·2017·Nature Reviews Immunology

DOI 10.1038/nri.2017.75PMC PMC5793224

Open this paper in CoChat — free account

Abstract

The proper restraint of the destructive potential of the immune system is essential for maintaining health. Regulatory T (T reg) cells ensure immune homeostasis through their defining ability to suppress the activation and function of other leukocytes. The expression of the transcription factor forkhead box protein P3 (FOXP3) is a well-recognized characteristic of T reg cells, and FOXP3 is centrally involved in the establishment and maintenance of the T reg cell phenotype. In this Review, we summarize how the expression and activity of FOXP3 are regulated across multiple layers by diverse factors. The therapeutic implications of these topics for cancer and autoimmunity are also discussed.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nri.2017.75

Cites

158 of 158 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

RETRACTED: Foxp3-positive macrophages display immunosuppressive properties and promote tumor growth
Manrique, S. Z., Correa, M. A. D., Hoelzinger, D. B., Dominguez, A. L., Mirza, N. N., Lin, H., Stein‐Streilein, J., Gordon, S., & Lustgarten, J. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20100730 · Cited by 72
Retracted
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., et al. (2013) · Nature · doi:10.1038/nature12721 · Cited by 5,549
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
Arpaia, N., Campbell, C., Fan, X., Dikiy, S., van der Veeken, J., deRoos, P., Liu, H., Cross, J. R., Pfeffer, K., Coffer, P. J., et al. (2013) · Nature · doi:10.1038/nature12726 · Cited by 4,838
The Role of Tumoral FOXP3 on Cell Proliferation, Migration, and Invasion in Gastric Cancer
Zhang, L., Xu, J., Zhang, X., Zhang, Y., Wang, L., Huang, X., & Xu, Z. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479442 · Cited by 4,090
Commensal Bifidobacterium promotes antitumor immunity and facilitates anti–PD-L1 efficacy
Sivan, A., Corrales, L., Hubert, N., Williams, J. B., Aquino-Michaels, K., Earley, Z. M., Benyamin, F. W., Man Lei, Y., Jabri, B., Alegre, M.-L., et al. (2015) · Science · doi:10.1126/science.aac4255 · Cited by 3,888
The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
Bennett, C. L., Christie, J., Ramsdell, F., Brunkow, M., Ferguson, P., Whitesell, L., Kelly, T., Saulsbury, F., Chance, P., & Ochs, H. (2001) · Nature Genetics · doi:10.1038/83713 · Cited by 3,576
How regulatory T cells work
Vignali, D. A. A., Collison, L. W., & Workman, C. J. (2008) · Nature Reviews Immunology · doi:10.1038/nri2343 · Cited by 3,463
Regulatory T cells: mechanisms of differentiation and function
Josefowicz, S. Z., Lu, L.-F., & Rudensky, A. Y. (2012) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141623 · Cited by 2,866
Self-citation
Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
Brunkow, M. E., Jeffery, E. W., Hjerrild, K. A., Paeper, B. W., Clark, L. B., Yasayko, S.-A., Wilkinson, J. E., Galas, D. J., Ziegler, S. F., & Ramsdell, F. (2001) · Nature Genetics · doi:10.1038/83784 · Cited by 2,628
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
Deaglio, S., Dwyer, K. M., Gao, W., Friedman, D. J., Usheva, A., Erat, A., Chen, J., Enjyoji, K., Linden, J. M., Oukka, M., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20062512 · Cited by 2,613

Flagged first, then by citations

Show all 158 references

Sorted by citations

Regulatory T Cells and Human Disease
Sakaguchi, S., Mikami, N., Wing, J. B., Tanaka, A., Ichiyama, K., & Ohkura, N. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042718-041717 · Cited by 1,163
Regulatory T cells in tumor microenvironment: new mechanisms, potential therapeutic strategies and future prospects
Li, C., Jiang, P., Wei, S., Xu, X., & Wang, J. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01234-1 · Cited by 972
Tumor metabolite lactate promotes tumorigenesis by modulating MOESIN lactylation and enhancing TGF-β signaling in regulatory T cells
Gu, J., Zhou, J., Chen, Q., Xu, X., Gao, J., Li, X., Shao, Q., Zhou, B., Zhou, H., Wei, S., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110986 · Cited by 529
Mitochondrial complex III is essential for suppressive function of regulatory T cells
Weinberg, S. E., Singer, B. D., Steinert, E. M., Martinez, C. A., Mehta, M., Martínez‐Reyes, I., Gao, P., Helmin, K. A., Abdala‐Valencia, H., Sena, L. A., et al. (2019) · Nature · doi:10.1038/s41586-018-0846-z · Cited by 505
Intricacies of TGF-β signaling in Treg and Th17 cell biology
Wang, J., Zhao, X., & Wan, Y. Y. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-01036-7 · Cited by 404
NLRP3 Inflammasome Regulates Development of Systemic Inflammatory Response and Compensatory Anti-Inflammatory Response Syndromes in Mice With Acute Pancreatitis
Sendler, M., van den Brandt, C., Glaubitz, J., Wilden, A., Golchert, J., Weiß, F. U., Homuth, G., Chama, L. L. D. F., Mishra, N., Mahajan, U. M., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.09.040 · Cited by 352
Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct
Ferreira, M. A. R., Mathur, R., Vonk, J. M., Szwajda, A., Brumpton, B. M., Granell, R., Brew, B. K., Ullemar, V., Lu, Y., Jiang, Y., et al. (2019) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2019.02.022 · Cited by 311
Parkinson’s disease patients have a complex phenotypic and functional Th1 bias: cross-sectional studies of CD4+ Th1/Th2/T17 and Treg in drug-naïve and drug-treated patients
Kuštrimović, N. Z., Comi, C., Magistrelli, L., Rasini, E., Legnaro, M., Bombelli, R., Aleksić, I., Blandini, F., Minafra, B., Riboldazzi, G., et al. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1248-8 · Cited by 291
Emerging Functions of Regulatory T Cells in Tissue Homeostasis
Sharma, A., & Rudra, D. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00883 · Cited by 273
Trial watch: TLR3 agonists in cancer therapy
Le Naour, J., Galluzzi, L., Zitvogel, L., Kroemer, G., & Vacchelli, E. (2020) · OncoImmunology · doi:10.1080/2162402x.2020.1771143 · Cited by 239
Molecular and Cellular Pathways Contributing to Joint Damage in Rheumatoid Arthritis
Fang, Q., Zhou, C., & Nandakumar, K. S. (2020) · Mediators of Inflammation · doi:10.1155/2020/3830212 · Cited by 227
The regulation and differentiation of regulatory T cells and their dysfunction in autoimmune diseases
Sumida, T. S., Cheru, N. T., & Hafler, D. A. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-00994-x · Cited by 229
Tregs: Where We Are and What Comes Next?
Hai, Z., Liao, X., & Kang, Y. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01578 · Cited by 200
Control of regulatory T‐cell differentiation and function by T‐cell receptor signalling and Foxp3 transcription factor complexes
Ono, M. (2020) · Immunology · doi:10.1111/imm.13178 · Cited by 187
Short Chain Fatty Acid Metabolism in Relation to Gut Microbiota and Genetic Variability
Meyers, G. R., Samouda, H., & Bohn, T. (2022) · Nutrients · doi:10.3390/nu14245361 · Cited by 208
What’s Sex Got to Do With COVID-19? Gender-Based Differences in the Host Immune Response to Coronaviruses
Gadi, N., Wu, S., Spihlman, A. P., & Moulton, V. R. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02147 · Cited by 188
Multispectral imaging for quantitative and compartment‐specific immune infiltrates reveals distinct immune profiles that classify lung cancer patients
Mezheyeuski, A., Bergsland, C. H., Backman, M., Djureinovic, D., Sjöblom, T., Bruun, J., & Micke, P. (2017) · The Journal of Pathology · doi:10.1002/path.5026 · Cited by 182
What did we learn from CTLA ‐4 insufficiency on the human immune system?
Mitsuiki, N., Schwab, C., & Grimbacher, B. (2018) · Immunological Reviews · doi:10.1111/imr.12721 · Cited by 187
Connecting blood and intratumoral Treg cell activity in predicting future relapse in breast cancer
Wang, L., Simons, D. L., Lu, X., Tu, T. Y., Solomon, S. T., Wang, R., Rosario, A., Avalos, C., Schmolze, D. B., Yim, J. H., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0429-7 · Cited by 174
Cellular consequences of arginine methylation
Lorton, B. M., & Shechter, D. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03140-2 · Cited by 169
Sex steroids and autoimmune rheumatic diseases: state of the art
Cutolo, M., & Straub, R. H. (2020) · Nature Reviews Rheumatology · doi:10.1038/s41584-020-0503-4 · Cited by 174
Disease tolerance: concept and mechanisms
McCarville, J. L., & Ayres, J. S. (2017) · Current Opinion in Immunology · doi:10.1016/j.coi.2017.12.003 · Cited by 154
Trial watch: Peptide-based vaccines in anticancer therapy
Bezu, L., Kepp, O., Cerrato, G., Pol, J. G., Fucikova, J. P., Špíšek, R., Zitvogel, L., Kroemer, G., & Galluzzi, L. (2018) · OncoImmunology · doi:10.1080/2162402x.2018.1511506 · Cited by 158
Role of Regulatory T Cells in Regulating Fetal-Maternal Immune Tolerance in Healthy Pregnancies and Reproductive Diseases
Huang, N., Chi, H., & Qiao, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01023 · Cited by 174
Activation of immunosuppressive network in the aging process
Salminen, A. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100998 · Cited by 155
The forkhead-box family of transcription factors: key molecular players in colorectal cancer pathogenesis
Laissue, P. (2019) · Molecular Cancer · doi:10.1186/s12943-019-0938-x · Cited by 147
The Interplay between Glioblastoma and Its Microenvironment
Dapash, M., Hou, D., Castro, B. A., Lee-Chang, C., & Lesniak, M. S. (2021) · Cells · doi:10.3390/cells10092257 · Cited by 159
Histone deacetylase function in CD4+ T cells
Ellmeier, W., & Seiser, C. (2018) · Nature reviews. Immunology · doi:10.1038/s41577-018-0037-z · Cited by 146
Itaconate ameliorates autoimmunity by modulating T cell imbalance via metabolic and epigenetic reprogramming
Aso, K., Kono, M., Kanda, M., Kudo, Y., Sakiyama, K., Hisada, R., Karino, K., Ueda, Y., Nakazawa, D., Fujieda, Y., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36594-x · Cited by 143
CCL17 Aggravates Myocardial Injury by Suppressing Recruitment of Regulatory T Cells
Feng, G., Bajpai, G., Ma, P., Koenig, A. L., Bredemeyer, A. L., Lokshina, I., Lai, L., Förster, I., Leuschner, F., Kreisel, D., et al. (2022) · Circulation · doi:10.1161/circulationaha.121.055888 · Cited by 143
Type 1 Diabetes: A Chronic Anti-Self-Inflammatory Response
Clark, M., Kroger, C. J., & Tisch, R. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01898 · Cited by 149
IL-10-producing T cells and their dual functions
Bedke, T., Muscate, F., Soukou, S., Gagliani, N., & Huber, S. (2019) · Seminars in Immunology · doi:10.1016/j.smim.2019.101335 · Cited by 145
Molecular Mechanisms Controlling Foxp3 Expression in Health and Autoimmunity: From Epigenetic to Post-translational Regulation
Colamatteo, A., Carbone, F., Bruzzaniti, S., Galgani, M., Fusco, C., Maniscalco, G. T., Rella, F. D., de Candia, P., & Rosa, V. D. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2019.03136 · Cited by 147
Role of Bifidobacteria on Infant Health
Saturio, S., Nogacka, A. M., Alvarado-Jasso, G. M., Salazar, N., Reyes‐Gavilán, C. G. D. L., Gueimonde, M., & Arboleya, S. (2021) · Microorganisms · doi:10.3390/microorganisms9122415 · Cited by 148
The role of transcription factors in shaping regulatory T cell identity
Trujillo-Ochoa, J. L., Kazemian, M., & Afzali, B. (2023) · Nature reviews. Immunology · doi:10.1038/s41577-023-00893-7 · Cited by 142
Trial Watch: Immunomodulatory monoclonal antibodies for oncological indications
Buqué, A., Bloy, N., Aranda, F., Castoldi, F., Eggermont, A. M. M., Cremer, I., Fridman, W. H., Fucikova, J. P., Galon, J., Marabelle, A., et al. (2015) · OncoImmunology · doi:10.1080/2162402x.2015.1008814 · Cited by 132
Spatially mapping the immune landscape of melanoma using imaging mass cytometry
Moldoveanu, D., Ramsay, L., Lajoie, M., Anderson-Trocmé, L., Lingrand, M., Berry, D., Perus, L. J. M., Wei, Y., Moraes, C., Alkallas, R., et al. (2022) · Science Immunology · doi:10.1126/sciimmunol.abi5072 · Cited by 125
HIF-2α is indispensable for regulatory T cell function
Hsu, T.-S., Lin, Y.-L., Wang, Y.-A., Mo, S.-T., Chi, P.-Y., Lai, A. C.-Y., Pan, H.-Y., Chang, Y.-J., & Lai, M.-Z. (2020) · Nature Communications · doi:10.1038/s41467-020-18731-y · Cited by 126
Tcf1 and Lef1 are required for the immunosuppressive function of regulatory T cells
Xing, S.-J., Gai, K., Li, X., Shao, P., Zeng, Z., Zhao, X.-D., Zhao, X., Chen, X., Paradee, W., Meyerholz, D., et al. (2019) · Journal of Experimental Medicine · doi:10.1084/jem.20182010 · Cited by 101
How to Hit Mesenchymal Stromal Cells and Make the Tumor Microenvironment Immunostimulant Rather Than Immunosuppressive
Poggi, A. D., Varesano, S., & Zocchi, M. R. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00262 · Cited by 113
Controlling the Immune Suppressor: Transcription Factors and MicroRNAs Regulating CD73/NT5E
Kordaß, T., Osen, W., & Eichmüller, S. B. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00813 · Cited by 115
Intrinsic TNFR2 signaling in T regulatory cells provides protection in CNS autoimmunity
Atretkhany, K. N., Mufazalov, I. A., Dunst, J., Kuchmiy, A. A., Gogoleva, V. S., Andruszewski, D., Drutskaya, M. S., Faustman, D. L., Schwabenland, M., Prinz, M., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1807499115 · Cited by 109
Glycan utilisation system in Bacteroides and Bifidobacteria and their roles in gut stability and health
Singh, R. P. (2019) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-019-10012-z · Cited by 109
Epigenetic modifiers as new immunomodulatory therapies in solid tumours
Aspeslagh, S., Morel, D., Soria, J., & Postel-Vinay, S. C. (2018) · Annals of Oncology · doi:10.1093/annonc/mdy050 · Cited by 105
Maternal and fetal T cells in term pregnancy and preterm labor
Miller, D., Gershater, M., Slutsky, R., Romero, R. J., & Gomez‐Lopez, N. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-0471-2 · Cited by 107
A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells
Van Gool, F., Nguyen, M. L. T., Mumbach, M. R., Satpathy, A. T., Rosenthal, W. L., Giacometti, S., Le, D. T., Liu, W., Brusko, T. M., Anderson, M. S., et al. (2019) · Immunity · doi:10.1016/j.immuni.2018.12.016 · Cited by 102
Molecular networks of FOXP family: dual biologic functions, interplay with other molecules and clinical implications in cancer progression
Kim, J., Hwang, J., Jung, J. H., Lee, H., Lee, D., & Kim, S. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1110-3 · Cited by 102
Th17 and Treg lymphocytes in obesity and Type 2 diabetic patients
Wang, M., Chen, F., Wang, J., Zeng, Z., Yang, Q., & Shao, S. (2018) · Clinical Immunology · doi:10.1016/j.clim.2018.09.005 · Cited by 102
Activation of Resolution Pathways to Prevent and Fight Chronic Inflammation: Lessons From Asthma and Inflammatory Bowel Disease
Barnig, C., Bezema, T., Calder, P. C., Charloux, A., Frossard, N., Garssen, J., Haworth, O., Dilevskaya, K., Levi‐Schaffer, F., Lonsdorfer‐Wolf, E., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01699 · Cited by 104
Balancing cancer immunotherapy and immune-related adverse events: The emerging role of regulatory T cells
Alissafi, T., Hatzioannou, A., Legaki, A. I., Varveri, A., & Verginis, P. (2019) · Journal of Autoimmunity · doi:10.1016/j.jaut.2019.102310 · Cited by 98
TRAF6 directs FOXP3 localization and facilitates regulatory T‐cell function through K63‐linked ubiquitination
Ni, X., Kou, W., Gu, J. H., Wei, P., Wu, X. F., Peng, H., Tao, J., Yan, W., Yang, X., Lebid, A., et al. (2019) · The EMBO Journal · doi:10.15252/embj.201899766 · Cited by 98
Self-citation
Single-cell transcriptomic analysis reveals disparate effector differentiation pathways in human Treg compartment
Luo, Y., Xu, Z., Wang, B., Niu, Q., Su, X., Bai, Y., Zhu, S., Zhao, C., Sun, Y., Wang, J., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24213-6 · Cited by 96
Immunological Mechanisms in Allergic Diseases and Allergen Tolerance: The Role of Treg Cells
Calzada, D., Baos, S., Cremades‐Jimeno, L., & Cárdaba, B. (2018) · Journal of Immunology Research · doi:10.1155/2018/6012053 · Cited by 92
Sensory Neurons, Neuroimmunity, and Pain Modulation by Sex Hormones
Lenert, M. E., Avona, A., Garner, K. M., Barron, L. R., & Burton, M. D. (2021) · Endocrinology · doi:10.1210/endocr/bqab109 · Cited by 97
Immunotherapy via PD-L1–presenting biomaterials leads to long-term islet graft survival
Coronel, M. M., Martin, K. E., Hunckler, M. D., Barber, G., O’Neill, E. B., Medina, J. D., Opri, E., McClain, C. A., Batra, L., Weaver, J. D., et al. (2020) · Science Advances · doi:10.1126/sciadv.aba5573 · Cited by 89
Role of orally induced regulatory T cells in immunotherapy and tolerance
Bertolini, T. B., Biswas, M., Terhorst, C., Daniell, H., Herzog, R. W., & Piñeros, A. R. (2020) · Cellular Immunology · doi:10.1016/j.cellimm.2020.104251 · Cited by 89
Regulatory T Cells in Autoimmunity and Cancer: A Duplicitous Lifestyle
Hatzioannou, A., Boumpas, A., Papadopoulou, M., Papafragkos, I., Varveri, A., Alissafi, T., & Verginis, P. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.731947 · Cited by 93
When the balance is broken: X-linked gene dosage from two X chromosomes and female-biased autoimmunity
Syrett, C. M., & Anguera, M. C. (2019) · Journal of Leukocyte Biology · doi:10.1002/jlb.6ri0319-094r · Cited by 81
Post-Translational Regulations of Foxp3 in Treg Cells and Their Therapeutic Applications
Dong, Y. W., Yang, C., & Pan, F. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.626172 · Cited by 88
Self-citation
Transient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced dysfunction
Lamarthée, B., Marchal, A., Charbonnier, S., Blein, T., Léon, J., Martin, E., Rabaux‐Eygasier, L., Vogt, K., Titeux, M., Delville, M., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26844-1 · Cited by 84
DNA Methyltransferase Inhibitors: Catalysts For Antitumour Immune Responses
Dan, H., Zhang, S., Zhou, Y., & Guan, Q. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s217767 · Cited by 83
Targeting Sirt-1 controls GVHD by inhibiting T-cell allo-response and promoting Treg stability in mice
Daenthanasanmak, A., Iamsawat, S., Chakraborty, P., Nguyen, H. D., Bastian, D. A., Liu, C., Mehrotra, S., & Yu, X. (2018) · Blood · doi:10.1182/blood-2018-07-863233 · Cited by 79
Ahr-Foxp3-RORγt axis controls gut homing of CD4 + T cells by regulating GPR15
Xiong, L., Dean, J. W., Fu, Z., Oliff, K. N., Bostick, J. W., Ye, J., Chen, Z. E., Mühlbauer, M., & Zhou, L. (2020) · Science Immunology · doi:10.1126/sciimmunol.aaz7277 · Cited by 76
The Role of Gut Microbiota-Derived Lithocholic Acid, Deoxycholic Acid and Their Derivatives on the Function and Differentiation of Immune Cells
Kiriyama, Y., & Nochi, H. (2023) · Microorganisms · doi:10.3390/microorganisms11112730 · Cited by 77
Gallic acid induces T-helper-1-like T reg cells and strengthens immune checkpoint blockade efficacy
Deng, B., Yang, B., Chen, J., Wang, S., Zhang, W., Guo, Y., Han, Y., Li, H., Dang, Y., Yuan, Y., et al. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-004037 · Cited by 75
Alternative Splicing of FOXP3—Virtue and Vice
Mailer, R. K. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00530 · Cited by 74
Alternative Splicing of FOXP3 Controls Regulatory T Cell Effector Functions and Is Associated With Human Atherosclerotic Plaque Stability
Joly, A.-L., Seitz, C., Liu, S., Kuznetsov, N. V., Gertow, K., Westerberg, L. S., Paulsson‐Berne, G., Hansson, G. K., & Andersson, J. (2018) · Circulation Research · doi:10.1161/circresaha.117.312340 · Cited by 70
Clinical, Immunological, and Genetic Features in Patients with Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-linked (IPEX) and IPEX-like Syndrome
Jamee, M., Zaki‐Dizaji, M., Lo, B., Abolhassani, H., Aghamahdi, F., Moosavian, M., Nademi, Z., Mohammadi, H., Jadidi‐Niaragh, F., Rojas, M., et al. (2020) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2020.04.070 · Cited by 69
Gliadins as versatile biomaterials for drug delivery applications
Voci, S., Fresta, M., & Cosco, D. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.11.048 · Cited by 69
Interactions of IDO and the Kynurenine Pathway with Cell Transduction Systems and Metabolism at the Inflammation–Cancer Interface
Stone, T. W., & Williams, R. O. (2023) · Cancers · doi:10.3390/cancers15112895 · Cited by 67
Lactate supports Treg function and immune balance via MGAT1 effects on N-glycosylation in the mitochondria
Zhou, J., Gu, J., Qian, Q., Zhang, Y., Huang, T., Li, X., Liu, Z., Shao, Q., Liang, Y., Qiao, L., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci175897 · Cited by 67
Epigenetic regulation and T-cell responses in endometriosis – something other than autoimmunity
Szukiewicz, D. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.943839 · Cited by 65
MUC16 C terminal-induced secretion of tumor-derived IL-6 contributes to tumor-associated Treg enrichment in pancreatic cancer
Fan, K., Yang, C., Fan, Z., Huang, Q., Zhang, Y., Cheng, H., Jin, K., Yu, L., Wang, Z., Luo, G., et al. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.01.017 · Cited by 66
A comprehensive profile of TCF1+ progenitor and TCF1− terminally exhausted PD-1+CD8+ T cells in head and neck squamous cell carcinoma: implications for prognosis and immunotherapy
Wang, D.-K., Fang, J., Wen, S., Li, Q., Wang, J., Yang, L., Dai, W., Lu, H., Guo, J., Shan, Z., et al. (2022) · International Journal of Oral Science · doi:10.1038/s41368-022-00160-w · Cited by 67
Regulatory T cells in peripheral tissue tolerance and diseases
Cheru, N. T., Hafler, D. A., & Sumida, T. S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1154575 · Cited by 67
Prognostic value of tumor-infiltrating Foxp3+ regulatory T cells in patients with breast cancer: a meta-analysis
Zhou, Y., Shao, N., AiErken, N., Xie, C., Ye, R., Qian, X., Hu, Z., Zhang, J., & Lin, Y. (2017) · Journal of Cancer · doi:10.7150/jca.21030 · Cited by 64
An Immune Atlas of T Cells in Transplant Rejection: Pathways and Therapeutic Opportunities
Short, S., Lewik, G., & Issa, F. (2023) · Transplantation · doi:10.1097/tp.0000000000004572 · Cited by 66
The rationale for selenium supplementation in inflammatory bowel disease: A mechanism-based point of view
Ala, M., & Kheyri, Z. (2021) · Nutrition · doi:10.1016/j.nut.2021.111153 · Cited by 60
Engineered Tolerance: Tailoring Development, Function, and Antigen-Specificity of Regulatory T Cells
Dawson, N. A. J., Vent‐Schmidt, J., & Levings, M. K. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01460 · Cited by 56
IL-27 targets Foxp3+ Tregs to mediate antiinflammatory functions during experimental allergic airway inflammation
Nguyen, Q. T., Jang, E., Le, H. T., Kim, S., Kim, D., Dvorina, N., Aronica, M. A., Baldwin, W. M., Asosingh, K., COMHAIR, S. A. A., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.123216 · Cited by 55
The Impact of Dietary Components on Regulatory T Cells and Disease
Hornero, R. A., Hamad, I., Côrte‐Real, B. F., & Kleinewietfeld, M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00253 · Cited by 61
Postbiotics: An alternative and innovative intervention for the therapy of inflammatory bowel disease
Kavita, K., Om, H., Chand, U., & Kushawaha, P. K. (2023) · Microbiological Research · doi:10.1016/j.micres.2023.127550 · Cited by 63
Trial Watch: Immunostimulation with recombinant cytokines for cancer therapy
García-Martínez, E., Smith, M. M., Buqué, A., Aranda, F., de la Peña, F. A., Rubio, A. I., Cánovas, M. S., Conesa, M. A. V., Fucikova, J. P., Špíšek, R., et al. (2018) · OncoImmunology · doi:10.1080/2162402x.2018.1433982 · Cited by 56
T Cells in Adipose Tissue in Aging
Antony, A. K., Lian, Z., & Wu, H. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02945 · Cited by 57
Splicing factor SRSF1 is indispensable for regulatory T cell homeostasis and function
Katsuyama, T., & Moulton, V. R. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109339 · Cited by 56
A central role for STAT5 in the transcriptional programing of T helper cell metabolism
Villarino, A. V., Laurence, A. D. J., Davis, F. P., Nivelo, L. A., Brooks, S. R., Sun, H., Jiang, K., Afzali, B., Frasca, D., Hennighausen, L. G., et al. (2022) · Science Immunology · doi:10.1126/sciimmunol.abl9467 · Cited by 56
Effects of MicroRNA on Regulatory T Cells and Implications for Adoptive Cellular Therapy to Ameliorate Graft-versus-Host Disease
Hippen, K. L., Loschi, M. L., Nicholls, J., MacDonald, K. P. A., & Blazar, B. R. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00057 · Cited by 57
Safety, tolerability, and immune-biomarker profiling for year-long sargramostim treatment of Parkinson's disease
Olson, K. E., Namminga, K. L., Lu, Y., Schwab, A. D., Thurston, M. J., Abdelmoaty, M. M., Kumar, V. S., Wojtkiewicz, M. S., Obaro, H., Santamaria, P. M., et al. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103380 · Cited by 53
The persistent inflammation in COPD: is autoimmunity the core mechanism?
Dong, L., Liu, Z., Chen, K.-J., Li, Z., Zhou, J.-S., Shen, H., & Chen, Z. (2024) · European Respiratory Review · doi:10.1183/16000617.0137-2023 · Cited by 61
Single‐cell transcriptomics reveal the intratumoral landscape of infiltrated T‐cell subpopulations in oral squamous cell carcinoma
Chen, J., Yang, J., Li, H., Yang, Z., Zhang, X., Li, X., Wang, J., Zhang, Y., Chen, S., & Song, M. (2021) · Molecular Oncology · doi:10.1002/1878-0261.12910 · Cited by 57
Immunomodulatory Properties of Mesenchymal Stromal Cells: Still Unresolved “Yin and Yang”
Poggi, A. D., & Zocchi, M. R. (2018) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x14666181205115452 · Cited by 51
Targeting the metabolism of tumor-infiltrating regulatory T cells
Wang, Y., Huang, T., Gu, J., & Lu, L. (2023) · Trends in Immunology · doi:10.1016/j.it.2023.06.001 · Cited by 54
Self-citation
Role of Treg cell subsets in cardiovascular disease pathogenesis and potential therapeutic targets
Xia, Y., Gao, D., Wang, X., Liu, B., Shan, X., Sun, Y., & Ma, D. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1331609 · Cited by 58
The role of regulatory T cells in graft-versus-host disease management
Whangbo, J., Antin, J. H., & Koreth, J. (2019) · Expert Review of Hematology · doi:10.1080/17474086.2020.1709436 · Cited by 51
Nemo-like Kinase Drives Foxp3 Stability and Is Critical for Maintenance of Immune Tolerance by Regulatory T Cells
Fleskens, V., Minutti, C. M., Wu, X., Wei, P., Pals, C. E. G. M., McCrae, J., Hemmers, S., Groenewold, V., Vos, H.-J., Rudensky, A., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.02.087 · Cited by 49
Self-citation
Protective properties of combined fungal polysaccharides from Cordyceps sinensis and Ganoderma atrum on colon immune dysfunction
Fan, S., Nie, S., Huang, X., Wang, S., Hu, J., Xie, J.-H., Nie, Q., & Xie, M. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.04.004 · Cited by 50
The Sufficient Immunoregulatory Effect of Autologous Bone Marrow‐Derived Mesenchymal Stem Cell Transplantation on Regulatory T Cells in Patients with Refractory Rheumatoid Arthritis
Ghoryani, M., Shariati‐Sarabi, Z., Tavakkol‐Afshari, J., & Mohammadi, M. (2020) · Journal of Immunology Research · doi:10.1155/2020/3562753 · Cited by 49
Perspective: The Role of Human Breast-Milk Extracellular Vesicles in Child Health and Disease
O’Reilly, D. P., Dorodnykh, D., Avdeenko, N. V., Nekliudov, N. A., Garssen, J., Elolimy, A. A., Petrou, L., Simpson, M. R., Yeruva, L., & Munblit, D. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa094 · Cited by 49
The DEL-1/β3 integrin axis promotes regulatory T cell responses during inflammation resolution
Li, X., Colamatteo, A., Kalafati, L., Kajikawa, T., Wang, H., Lim, J., Bdeir, K., Chung, K., Yu, X., Fusco, C., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci137530 · Cited by 50
Regulatory T lymphocytes/Th17 lymphocytes imbalance in autism spectrum disorders: evidence from a meta-analysis
Ellul, P., Rosenzwajg, M., Peyre, H., Fourcade, G., Mariotti‐Ferrandiz, E., Trebossen, V., Klatzmann, D., & Delorme, R. (2021) · Molecular Autism · doi:10.1186/s13229-021-00472-4 · Cited by 51

Authors: Lu, L., Barbi, J., & Pan, F.
Affiliations: Jiangsu Province Hospital (CN)
Roswell Park Comprehensive Cancer Center (US)
Johns Hopkins University (US)
Corresponding author: Lu, Ling
Barbi, Joseph
Pan, Fan
ORCID: Barbi, Joseph
Pan, Fan
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2017-07-31
Volume: 17
Issue: 11
Pages: 703-717
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri.2017.75
PMC: PMC5793224
OpenAlex: W2740495409
Cited by: 580
References: 158
Citations by year: 2026: 52 · 2025: 53 · 2024: 59 · 2023: 64 · 2022: 65 · 2021: 96 · 2020: 69 · 2019: 53 · 2018: 58 · 2017: 10
FWCI: 5.34
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (P30CA016056, P30CA006973)
National Institute of Allergy and Infectious Diseases (R01AI089830, R01AI099300)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › FOXO transcription factor regulation
Keywords: Foxp3, regulatory T cells, immune tolerance, transcriptional regulation, post-translational modification, immune homeostasis, cancer immunotherapy, autoimmunity
MeSH terms: Animals, Gene Expression Regulation, Humans, Immune Tolerance, Protein Processing, Post-Translational, T-Lymphocyte Subsets, T-Lymphocytes, Regulatory, Forkhead Transcription Factors, Immunomodulation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The regulation of immune tolerance by FOXP3

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks