The regulation of immune tolerance by FOXP3

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., et al. (2013) · Nature · doi:10.1038/nature12721 · Cited by 5,549

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

Arpaia, N., Campbell, C., Fan, X., Dikiy, S., van der Veeken, J., deRoos, P., Liu, H., Cross, J. R., Pfeffer, K., Coffer, P. J., et al. (2013) · Nature · doi:10.1038/nature12726 · Cited by 4,838

The Role of Tumoral FOXP3 on Cell Proliferation, Migration, and Invasion in Gastric Cancer

Zhang, L., Xu, J., Zhang, X., Zhang, Y., Wang, L., Huang, X., & Xu, Z. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479442 · Cited by 4,090

Commensal Bifidobacterium promotes antitumor immunity and facilitates anti–PD-L1 efficacy

Sivan, A., Corrales, L., Hubert, N., Williams, J. B., Aquino-Michaels, K., Earley, Z. M., Benyamin, F. W., Man Lei, Y., Jabri, B., Alegre, M.-L., et al. (2015) · Science · doi:10.1126/science.aac4255 · Cited by 3,888

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

Bennett, C. L., Christie, J., Ramsdell, F., Brunkow, M., Ferguson, P., Whitesell, L., Kelly, T., Saulsbury, F., Chance, P., & Ochs, H. (2001) · Nature Genetics · doi:10.1038/83713 · Cited by 3,576

How regulatory T cells work

Vignali, D. A. A., Collison, L. W., & Workman, C. J. (2008) · Nature Reviews Immunology · doi:10.1038/nri2343 · Cited by 3,463

Regulatory T cells: mechanisms of differentiation and function

Josefowicz, S. Z., Lu, L.-F., & Rudensky, A. Y. (2012) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141623 · Cited by 2,866

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

Brunkow, M. E., Jeffery, E. W., Hjerrild, K. A., Paeper, B. W., Clark, L. B., Yasayko, S.-A., Wilkinson, J. E., Galas, D. J., Ziegler, S. F., & Ramsdell, F. (2001) · Nature Genetics · doi:10.1038/83784 · Cited by 2,628

Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

Deaglio, S., Dwyer, K. M., Gao, W., Friedman, D. J., Usheva, A., Erat, A., Chen, J., Enjyoji, K., Linden, J. M., Oukka, M., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20062512 · Cited by 2,613

Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor

Miyara, M., Yoshioka, Y., Kitoh, A., Shima, T., Wing, K., Niwa, A., Parizot, C., Taflin, C., Heike, T., Valeyre, D., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.03.019 · Cited by 2,291

The Biology of NKT Cells

Bendelac, A. S., Savage, P. B., & Teyton, L. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141711 · Cited by 2,169

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

Feuerer, M., Herrero, L., Cipolletta, D., Naaz, A., Wong, J., Nayer, A., Lee, J., Goldfine, A. B., Benoist, C., Shoelson, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.2002 · Cited by 2,145

The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation

Wang, R., Dillon, C. P., Shi, L. Z., Milasta, S., Carter, R., Finkelstein, D., McCormick, L. L., Fitzgerald, P., Chi, H., Munger, J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.021 · Cited by 2,140

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

Michalek, R. D., Gerriets, V. A., Jacobs, S. R., Macintyre, A. N., MacIver, N. J., Mason, E. F., Sullivan, S. A., Nichols, A. G., & Rathmell, J. C. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003613 · Cited by 2,091

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

Salomon, B. L., Lenschow, D. J., Rhee, L., Ashourian, N., Singh, B., Sharpe, A. H., & Bluestone, J. A. (2000) · Immunity · doi:10.1016/s1074-7613(00)80195-8 · Cited by 2,058

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

Shi, L. Z., Wang, R., Huang, G., Vogel, P., Neale, G., Green, D. R., & Chi, H. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20110278 · Cited by 1,803

Mechanisms of Foxp3+ T Regulatory Cell-Mediated Suppression

Shevach, E. M. (2009) · Immunity · doi:10.1016/j.immuni.2009.04.010 · Cited by 1,787

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

Dang, E. V., Barbi, J., Yang, H.-Y., Jinasena, D., Yu, H., Zheng, Y., Bordman, Z., Fu, J., Kim, Y., Yen, H.-R., et al. (2011) · Cell · doi:10.1016/j.cell.2011.07.033 · Cited by 1,595

Regulatory B Cells: Origin, Phenotype, and Function

Rosser, E. C., & Mauri, C. (2015) · Immunity · doi:10.1016/j.immuni.2015.04.005 · Cited by 1,455

Epigenetic Control of the foxp3 Locus in Regulatory T Cells

Floess, S., Freyer, J., Siewert, C., Baron, U., Olek, S., Polansky, J. K., Schlawe, K., Chang, H., Bopp, T., Schmitt, E., et al. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050038 · Cited by 1,296

mTOR differentially regulates effector and regulatory T cell lineage commitment

Delgoffe, G. M., Kole, T., Zheng, Y., Zarek, P. E., Matthews, K., Xiao, B., Worley, P., Kozma, S., & Powell, J. (2009) · Immunity · doi:10.1016/j.immuni.2009.04.014 · Cited by 1,293

A Special Population of Regulatory T Cells Potentiates Muscle Repair

Burzyn, D., Kuswanto, W., Kolodin, D., Shadrach, J. L., Cerletti, M., Jang, Y., Sefik, E., Tan, T. G., Wagers, A. J., Benoist, C., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.054 · Cited by 1,234

FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT

Wu, Y., Borde, M., Heissmeyer, V., Feuerer, M., Lapan, A. D., Stroud, J. C., Bates, D. L., Guo, L., Han, A., Ziegler, S. F., et al. (2006) · Cell · doi:10.1016/j.cell.2006.05.042 · Cited by 1,229

Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

Zheng, Y., Josefowicz, S. Z., Chaudhry, A., Peng, X. P., Forbush, K. A., & Rudensky, A. Y. (2010) · Nature · doi:10.1038/nature08750 · Cited by 1,170

Granzyme B and Perforin Are Important for Regulatory T Cell-Mediated Suppression of Tumor Clearance

Cao, X., Cai, S. F., Fehniger, T. A., Song, J., Collins, L. I., Piwnica-Worms, D. R., & Ley, T. J. (2007) · Immunity · doi:10.1016/j.immuni.2007.08.014 · Cited by 1,117

Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation

Ianni, M. D., Falzetti, F., Carotti, A., Terenzi, A., Castellino, F., Bonifacio, E., Papa, B. D., Zei, T., Ostini, R. I., Cecchini, D., et al. (2011) · Blood · doi:10.1182/blood-2010-10-311894 · Cited by 1,065

Natural and Adaptive Foxp3+ Regulatory T Cells: More of the Same or a Division of Labor?

de Lafaille, M. A. C., & Lafaille, J. J. (2009) · Immunity · doi:10.1016/j.immuni.2009.05.002 · Cited by 1,055

Type 1 diabetes immunotherapy using polyclonal regulatory T cells

Bluestone, J. A., Buckner, J. H., Fitch, M., Gitelman, S. E., Gupta, S., Hellerstein, M. K., Herold, K. C., Lares, A., Lee, M. R., Li, K., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aad4134 · Cited by 1,033

Transient expression of FOXP3 in human activated nonregulatory CD4 + T cells

Wang, J., Ioan‐Facsinay, A., van der Voort, E. I. H., Huizinga, T. W. J., & Toes, R. E. M. (2007) · European Journal of Immunology · doi:10.1002/eji.200636435 · Cited by 1,011

Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control TH2 responses

Zheng, Y., Chaudhry, A., Kas, A., deRoos, P., Kim, J. M., Chu, T.-T., Corcoran, L., Treuting, P., Klein, U., & Rudensky, A. Y. (2009) · Nature · doi:10.1038/nature07674 · Cited by 958

Deacetylase inhibition promotes the generation and function of regulatory T cells

Tao, R. N., de Zoeten, E. F., Özkaynak, E., Chen, C., Wang, L., Porrett, P. M., Li, B., Turka, L. A., Olson, E. N., Greene, M. I., et al. (2007) · Nature Medicine · doi:10.1038/nm1652 · Cited by 927

Extrathymically generated regulatory T cells control mucosal TH2 inflammation

Josefowicz, S. Z., Niec, R. E., Kim, H. Y., Treuting, P. M., Chinen, T., Zheng, Y., Umetsu, D. T., & Rudensky, A. Y. (2012) · Nature · doi:10.1038/nature10772 · Cited by 862

Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells

Zheng, Y., Josefowicz, S. Z., Kas, A., Chu, T.-T., Gavin, M. A., & Rudensky, A. Y. (2007) · Nature · doi:10.1038/nature05563 · Cited by 835

mTORC1 couples immune signals and metabolic programming to establish Treg-cell function

Zeng, H., Yang, K., Cloer, C., Neale, G. A. M., Vogel, P., & Chi, H. (2013) · Nature · doi:10.1038/nature12297 · Cited by 806

A ubiquitin ligase complex assembles linear polyubiquitin chains

Kirisako, T., Kamei, K., Murata, S., Kato, M., Fukumoto, H., Kanie, M., Sano, S., Tokunaga, F., Tanaka, K., & Iwaï, K. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601360 · Cited by 803

Mechanisms of impaired regulation by CD4+CD25+FOXP3+ regulatory T cells in human autoimmune diseases

Buckner, J. H. (2010) · Nature reviews. Immunology · doi:10.1038/nri2889 · Cited by 790

DNA methylation controls Foxp3 gene expression

Polansky, J. K., Kretschmer, K., Freyer, J., Floess, S., Garbe, A. I., Baron, U., Olek, S., Hamann, A., von Boehmer, H., & Huehn, J. (2008) · European Journal of Immunology · doi:10.1002/eji.200838105 · Cited by 784

Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development

Gavin, M. A., Torgerson, T. R., Houston, E., DeRoos, P. C., Ho, W., Stray‐Pedersen, A., Ocheltree, E., Greenberg, P. D., Ochs, H. D., & Rudensky, A. Y. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509484103 · Cited by 779

T Cell Receptor Stimulation-Induced Epigenetic Changes and Foxp3 Expression Are Independent and Complementary Events Required for Treg Cell Development

Ohkura, N., Hamaguchi, M., Morikawa, H., Sugimura, K., Tanaka, A., Ito, Y., Osaki, M., Tanaka, Y., Yamashita, R., Nakano, N., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.09.010 · Cited by 756

Foxp3 occupancy and regulation of key target genes during T-cell stimulation

Marson, A., Kretschmer, K., Frampton, G. M., Jacobsen, E. S., Polansky, J. K., MacIsaac, K. D., Levine, S. S., Fraenkel, E., von Boehmer, H., & Young, R. A. (2007) · Nature · doi:10.1038/nature05478 · Cited by 724

Regulatory T cells in cancer immunotherapy

Nishikawa, H., & Sakaguchi, S. (2014) · Current Opinion in Immunology · doi:10.1016/j.coi.2013.12.005 · Cited by 721

Tumor-Evoked Regulatory B Cells Promote Breast Cancer Metastasis by Converting Resting CD4+ T Cells to T-Regulatory Cells

Olkhanud, P. B., Damdinsuren, B., Bodogai, M., Gress, R. E., Sen, R., Wejksza, K., Malchinkhuu, E., Wersto, R. P., & Biragyn, A. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-4316 · Cited by 689

Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

Ono, M., Yaguchi, H., Ohkura, N., Kitabayashi, I., Nagamura, Y., Nomura, T., Miyachi, Y., Tsukada, T., & Sakaguchi, S. (2007) · Nature · doi:10.1038/nature05673 · Cited by 683

HECT and RING finger families of E3 ubiquitin ligases at a glance

Metzger, M. B., Hristova, V. A., & Weissman, A. M. (2012) · Journal of Cell Science · doi:10.1242/jcs.091777 · Cited by 659

Extrathymic Generation of Regulatory T Cells in Placental Mammals Mitigates Maternal-Fetal Conflict

Samstein, R. M., Josefowicz, S. Z., Arvey, A. J., Treuting, P. M., & Rudensky, A. Y. (2012) · Cell · doi:10.1016/j.cell.2012.05.031 · Cited by 650

Anti-CCR4 mAb selectively depletes effector-type FoxP3 + CD4 + regulatory T cells, evoking antitumor immune responses in humans

Sugiyama, D., Nishikawa, H., Maeda, Y., Nishioka, M., Tanemura, A., Katayama, I., Ezoe, S., Kanakura, Y., Sato, E., Fukumori, Y., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1316796110 · Cited by 638

CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2

Tai, X., Cowan, M. L., Feigenbaum, L., & Singer, A. (2005) · Nature Immunology · doi:10.1038/ni1160 · Cited by 613

CREB/ATF-dependent T cell receptor–induced FoxP3 gene expression: a role for DNA methylation

Kim, H., & Leonard, W. J. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070109 · Cited by 590

Epigenetic Regulation of Foxp3 Expression in Regulatory T Cells by DNA Methylation

Lal, G., Zhang, N., van der Touw, W., Ding, Y., Ju, W., Böttinger, E. P., Reid, S. P., Levy, D. E., & Bromberg, J. S. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.1.259 · Cited by 564

Cutting Edge: IL-2 Is Critically Required for the In Vitro Activation of CD4+CD25+ T Cell Suppressor Function

Thornton, A. M., Donovan, E. E., Piccirillo, C. A., & Shevach, E. M. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.11.6519 · Cited by 559

A critical function for TGF-β signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells

Liu, Y., Zhang, P., Li, J., Kulkarni, A. B., Perruche, S., & Chen, W. (2008) · Nature Immunology · doi:10.1038/ni.1607 · Cited by 547

Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression

Gerriets, V. A., Kishton, R. J., Johnson, M. O., Cohen, S., Siska, P. J., Nichols, A., Warmoes, M. O., de Cubas, A. A., MacIver, N. J., Locasale, J. W., et al. (2016) · Nature Immunology · doi:10.1038/ni.3577 · Cited by 545

Retinoic Acid Increases Foxp3+ Regulatory T Cells and Inhibits Development of Th17 Cells by Enhancing TGF-β-Driven Smad3 Signaling and Inhibiting IL-6 and IL-23 Receptor Expression

Xiao, S., Jin, H., Korn, T., Liu, S. M., Oukka, M., Lim, B., & Kuchroo, V. K. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.4.2277 · Cited by 538

Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?

Huehn, J., Polansky, J. K., & Hamann, A. (2008) · Nature reviews. Immunology · doi:10.1038/nri2474 · Cited by 524

Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans

Roncarolo, M., & Battaglia, M. (2007) · Nature reviews. Immunology · doi:10.1038/nri2138 · Cited by 521

Interactions among the transcription factors Runx1, RORγt and Foxp3 regulate the differentiation of interleukin 17–producing T cells

Zhang, F., Meng, G., & Strober, W. (2008) · Nature Immunology · doi:10.1038/ni.1663 · Cited by 518

Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis

Nie, H., Zheng, Y., Li, R., Guo, T. B., He, D., Fang, L., Liu, X., Xiao, L., Chen, X. X., Wan, B., et al. (2013) · Nature Medicine · doi:10.1038/nm.3085 · Cited by 516

Th1/Th2/Th17/Treg cytokine imbalance in systemic lupus erythematosus (SLE) patients: Correlation with disease activity

Talaat, R. M., Mohamed, S. F., Bassyouni, I. H., & Raouf, A. A. (2015) · Cytokine · doi:10.1016/j.cyto.2014.12.027 · Cited by 494

Foxp3 Exploits a Pre-Existent Enhancer Landscape for Regulatory T Cell Lineage Specification

Samstein, R. M., Arvey, A., Josefowicz, S. Z., Peng, X., Reynolds, A., Sandstrom, R., Neph, S., Sabo, P., Kim, J. M., Liao, W., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.053 · Cited by 472

Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells

Ouyang, W., Beckett, O. R., Ma, Q., Paik, J.-H., DePinho, R. A., & Li, M. O. (2010) · Nature Immunology · doi:10.1038/ni.1884 · Cited by 467

Transcription factor Foxp3 and its protein partners form a complex regulatory network

Rudra, D., DeRoos, P. C., Chaudhry, A., Niec, R. E., Arvey, A. J., Samstein, R. M., Leslie, C. S., Shaffer, S. A., Goodlett, D. R., & Rudensky, A. Y. (2012) · Nature Immunology · doi:10.1038/ni.2402 · Cited by 448

FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression

Li, B., Samanta, A., Song, X., Iacono, K. T., Bembas, K., Tao, R. N., Basu, S., Riley, J. L., Hancock, W. W., Shen, Y., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700298104 · Cited by 410

FOXP3 Is an X-Linked Breast Cancer Suppressor Gene and an Important Repressor of the HER-2/ErbB2 Oncogene

Zuo, T., Wang, L., Morris, Q., Chang, X., Zhang, H., Li, J. W., Liu, Y., Wang, Y., Liu, X., Chan, M. W., et al. (2007) · Cell · doi:10.1016/j.cell.2007.04.034 · Cited by 403

Regulatory functions of ubiquitination in the immune system

Ben‐Neriah, Y. (2002) · Nature Immunology · doi:10.1038/ni0102-20 · Cited by 403

HLA-haploidentical transplantation with regulatory and conventional T-cell adoptive immunotherapy prevents acute leukemia relapse

Martelli, M. F., Ianni, M. D., Ruggeri, L., Falzetti, F., Carotti, A., Terenzi, A., Pierini, A., Massei, M. S., Amico, L., Urbani, E., et al. (2014) · Blood · doi:10.1182/blood-2014-03-564401 · Cited by 402

Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization

van Loosdregt, J., Vercoulen, Y., Guichelaar, T., Gent, Y. Y. J., Beekman, J. M., van Beekum, O., Brenkman, A. B., Hijnen, D., Mutis, T., Kalkhoven, E., et al. (2009) · Blood · doi:10.1182/blood-2009-02-207118 · Cited by 399

Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants

Rosa, V. D., Galgani, M., Porcellini, A., Colamatteo, A., Santopaolo, M., Zuchegna, C., Romano, A., Simone, S. D., Procaccini, C., Rocca, C. L., et al. (2015) · Nature Immunology · doi:10.1038/ni.3269 · Cited by 397

Development of Foxp3+ Regulatory T Cells Is Driven by the c-Rel Enhanceosome

Ruan, Q., Kameswaran, V., Tone, Y., Li, L., Liou, H., Greene, M. I., Tone, M., & Chen, Y. H. (2009) · Immunity · doi:10.1016/j.immuni.2009.10.006 · Cited by 397

Safety and Efficacy of Antigen-Specific Regulatory T-Cell Therapy for Patients With Refractory Crohn's Disease

Desreumaux, P., Foussat, A., Allez, M., Beaugerie, L., Hébuterne, X., Bouhnik, Y., Nachury, M., Brun, V., Bastian, H., Belmonte, N., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.07.116 · Cited by 386

Therapy of type 1 diabetes with CD4+CD25highCD127-regulatory T cells prolongs survival of pancreatic islets — Results of one year follow-up

Marek-Trzonkowska, N., Myśliwiec, M., Dobyszuk, A., Grabowska, M., Derkowska, I., Juścińska, J., Owczuk, R., Szadkowska, A., Witkowski, P., Młynarski, W., et al. (2014) · Clinical Immunology · doi:10.1016/j.clim.2014.03.016 · Cited by 384

Regulatory T cells – a brief history and perspective

Sakaguchi, S., Wing, K., & Miyara, M. (2007) · European Journal of Immunology · doi:10.1002/eji.200737593 · Cited by 375

Retinoic Acid Enhances Foxp3 Induction Indirectly by Relieving Inhibition from CD4+CD44hi Cells

Hill, J. A., Hall, J. A., Sun, C., Cai, Q., Ghyselinck, N. B., Chambon, P., Belkaid, Y., Mathis, D. J., & Benoist, C. O. (2008) · Immunity · doi:10.1016/j.immuni.2008.09.018 · Cited by 370

Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses

Shrestha, S., Yang, K., Guy, C. S., Vogel, P., Neale, G. A. M., & Chi, H. (2015) · Nature Immunology · doi:10.1038/ni.3076 · Cited by 362

CD8+ Foxp3+ Regulatory T Cells Mediate Immunosuppression in Prostate Cancer

Kiniwa, Y., Miyahara, Y., Wang, H. Y., Peng, W., Peng, G., Wheeler, T. M., Thompson, T. C., Old, L. J., & Wang, R. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-0842 · Cited by 362

Control of Foxp3 stability through modulation of TET activity

Yue, X., Trifari, S., Äijö, T., Tsagaratou, A., Pastor, W. A., Zepeda-Martínez, J. A., Lio, C.-W. J., Li, X., Huang, Y., Vijayanand, P., et al. (2016) · Journal of Experimental Medicine · doi:10.1084/jem.20151438 · Cited by 355

CD25 Blockade Depletes and Selectively Reprograms Regulatory T Cells in Concert with Immunotherapy in Cancer Patients

Rech, A. J., Mick, R., Martin, S., Recio, A., Aqui, N. A., Powell, D. J., Colligon, T. A., Trosko, J. A., Leinbach, L. I., Pletcher, C. H., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003330 · Cited by 344

Eos Mediates Foxp3-Dependent Gene Silencing in CD4 + Regulatory T Cells

Pan, F., Yu, H., Dang, E. V., Barbi, J. J., Pan, X., Grosso, J. F., Jinasena, D., Sharma, S. M., McCadden, E., Getnet, D., et al. (2009) · Science · doi:10.1126/science.1176077 · Cited by 335

The chromatin-modifying enzyme Ezh2 is critical for the maintenance of regulatory T cell identity after activation

DuPage, M., Chopra, G., Quiros, J., Rosenthal, W. L., Morar, M. M., Holohan, D., Zhang, R., Turka, L., Marson, A., & Bluestone, J. A. (2015) · Immunity · doi:10.1016/j.immuni.2015.01.007 · Cited by 332

Stabilization of the Transcription Factor Foxp3 by the Deubiquitinase USP7 Increases Treg-Cell-Suppressive Capacity

van Loosdregt, J., Fleskens, V., Fu, J. L., Brenkman, A. B., Bekker, C. P. J., Pals, C. E. G. M., Meerding, J., Berkers, C. R., Barbi, J. J., Gröne, A., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.05.018 · Cited by 321

Vitamin A Metabolites Induce Gut-Homing FoxP3+ Regulatory T Cells

Kang, S. G., Lim, H. W., ANDRISANI, O. M., Broxmeyer, H. E., & Kim, C. H. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.6.3724 · Cited by 313

A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells

Fu, W., Ergün, A., Lu, T., Hill, J. A., Haxhinasto, S. A., Fassett, M. S., Gazit, R., Adoro, S., Glimcher, L. H., Chan, S. H., et al. (2012) · Nature Immunology · doi:10.1038/ni.2420 · Cited by 301

The Ubiquitin Ligase Stub1 Negatively Modulates Regulatory T Cell Suppressive Activity by Promoting Degradation of the Transcription Factor Foxp3

Chen, Z., Barbi, J. J., Bu, S., Yang, H., Li, Z., Gao, Y., Jinasena, D., Fu, J. L., Lin, F., Chen, C., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.006 · Cited by 300

Defects in IL-2R Signaling Contribute to Diminished Maintenance of FOXP3 Expression in CD4+CD25+ Regulatory T-Cells of Type 1 Diabetic Subjects

Long, S. A., Cerosaletti, K. M., Bollyky, P. L., Tatum, M., Shilling, H. G., Zhang, S., Zhang, Z., Pihoker, C., Sanda, S., Greenbaum, C. J., et al. (2009) · Diabetes · doi:10.2337/db09-0694 · Cited by 296

Active Demethylation of the Foxp3 Locus Leads to the Generation of Stable Regulatory T Cells within the Thymus

Toker, A., Engelbert, D., Garg, G., Polansky, J. K., Floess, S., Miyao, T., Baron, U., Düber, S., Geffers, R., Giehr, P., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203473 · Cited by 283

Essential role of mitochondrial energy metabolism in Foxp3 + T‐regulatory cell function and allograft survival

Beier, U. H., Angelin, A., Akimova, T., Wang, L., Liu, Y., Xiao, H., Koike, M. A., Hancock, S. A., Bhatti, T. R., Han, R., et al. (2015) · The FASEB Journal · doi:10.1096/fj.14-268409 · Cited by 282

Analysis of FOXP3 Reveals Multiple Domains Required for Its Function as a Transcriptional Repressor

Lopes, J. E., Torgerson, T. R., Schubert, L. A., Anover-Sombke, S. D., Ocheltree, E., Ochs, H. D., & Ziegler, S. F. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.5.3133 · Cited by 274

IL-2 Controls the Stability of Foxp3 Expression in TGF-β–Induced Foxp3+ T Cells In Vivo

Chen, Q., Kim, Y. C., Laurence, A. D. J., Punkosdy, G. A., & Shevach, E. M. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100061 · Cited by 263

Expansion of functional endogenous antigen-specific CD4+CD25+ regulatory T cells from nonobese diabetic mice

Masteller, E. L., Warner, M. R., Tang, Q., Tarbell, K. V., McDevitt, H., & Bluestone, J. A. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.5.3053 · Cited by 260

Transforming Growth Factor-β Signaling Curbs Thymic Negative Selection Promoting Regulatory T Cell Development

Ouyang, W., Beckett, O. R., Ma, Q., & Li, M. O. (2010) · Immunity · doi:10.1016/j.immuni.2010.04.012 · Cited by 256

Inflammation-induced repression of chromatin bound by the transcription factor Foxp3 in regulatory T cells

Arvey, A. J., van der Veeken, J., Samstein, R. M., Feng, Y., Stamatoyannopoulos, J. A., & Rudensky, A. Y. (2014) · Nature Immunology · doi:10.1038/ni.2868 · Cited by 247

Transcriptional Regulation by Foxp3 Is Associated with Direct Promoter Occupancy and Modulation of Histone Acetylation

Chen, C., Rowell, E. A., Thomas, R. M., Hancock, W. W., & Wells, A. D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m608848200 · Cited by 233

Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1α but not HIF-2α

Luo, W., Zhong, J., Chang, R., Hu, H., Pandey, A., & Semenza, G. L. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.068577 · Cited by 232

Targeting regulatory T cells in tumors

Liu, C., Workman, C. J., & Vignali, D. A. A. (2016) · The FEBS Journal · doi:10.1111/febs.13656 · Cited by 228

FOXP3 and scurfy: how it all began

Ramsdell, F., & Ziegler, S. F. (2014) · Nature reviews. Immunology · doi:10.1038/nri3650 · Cited by 225

Somatic Single Hits Inactivate the X-Linked Tumor Suppressor FOXP3 in the Prostate

Wang, L., Liu, R., Li, W., Chen, C., Katoh, H., Chen, G., McNally, B. A., Lin, L., Zhou, P., Zuo, T., et al. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.08.016 · Cited by 218

Cutting Edge: All-Trans Retinoic Acid Sustains the Stability and Function of Natural Regulatory T Cells in an Inflammatory Milieu

Zhou, X., Kong, N., Wang, J., Fan, H., Zou, H., Horwitz, D. A., Brand, D. D., Liu, Z., & Zheng, S. G. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000598 · Cited by 218

E3 Ubiquitin Ligase VHL Regulates Hypoxia-Inducible Factor-1α to Maintain Regulatory T Cell Stability and Suppressive Capacity

Lee, J. H., Elly, C., Park, Y., & Liu, Y. (2015) · Immunity · doi:10.1016/j.immuni.2015.05.016 · Cited by 211

Inhibition of p300 impairs Foxp3+ T regulatory cell function and promotes antitumor immunity

Liu, Y., Wang, L., Predina, J. D., Han, R., Beier, U. H., Wang, L. S., Kapoor, V., Bhatti, T. R., Akimova, T., Singhal, S. K., et al. (2013) · Nature Medicine · doi:10.1038/nm.3286 · Cited by 207

Sirtuin-1 Targeting Promotes Foxp3 + T-Regulatory Cell Function and Prolongs Allograft Survival

Beier, U. H., Wang, L., Bhatti, T. R., Liu, Y., Han, R., Ge, G., & Hancock, W. W. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.01206-10 · Cited by 204

Regulatory B cells in autoimmune diseases

Yang, M., Rui, K., Wang, S., & Lu, L. (2013) · Cellular and Molecular Immunology · doi:10.1038/cmi.2012.60 · Cited by 202

STAT3 transcription factor promotes instability of nTreg cells and limits generation of iTreg cells during acute murine graft-versus-host disease

Laurence, A., Amarnath, S., Mariotti, J., Kim, Y. C., Foley, J., Eckhaus, M., O'Shea, J. J., & Fowler, D. H. (2012) · Immunity · doi:10.1016/j.immuni.2012.05.027 · Cited by 201

Immunomodulatory effects of deacetylase inhibitors: therapeutic targeting of FOXP3+ regulatory T cells

Wang, L., de Zoeten, E. F., Greene, M. I., & Hancock, W. W. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd3031 · Cited by 186

Anti-TNF drives regulatory T cell expansion by paradoxically promoting membrane TNF–TNF-RII binding in rheumatoid arthritis

Nguyen, D. X., & Ehrenstein, M. R. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20151255 · Cited by 185

Cutting Edge: Foxp3-Mediated Induction of Pim 2 Allows Human T Regulatory Cells to Preferentially Expand in Rapamycin

Basu, S., Golovina, T. N., Mikheeva, T., June, C. H., & Riley, J. L. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.9.5794 · Cited by 183

Genetic and epigenetic basis of Treg cell development and function: from a FoxP3‐centered view to an epigenome‐defined view of natural Treg cells

Morikawa, H., & Sakaguchi, S. (2014) · Immunological Reviews · doi:10.1111/imr.12174 · Cited by 176

CD8 + T regulatory cells express the Ly49 Class I MHC receptor and are defective in autoimmune prone B6-Yaa mice

Kim, H., Wang, X., Radfar, S., Sproule, T. J., Roopenian, D. C., & Cantor, H. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018974108 · Cited by 175

Loss of Epigenetic Modification Driven by the Foxp3 Transcription Factor Leads to Regulatory T Cell Insufficiency

Bettini, M. L., Pan, F., Bettini, M., Finkelstein, D., Rehg, J. E., Floess, S., Bell, B. D., Ziegler, S. F., Huehn, J., Pardoll, D. M., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.03.020 · Cited by 171

TGF-β and IL-6 signals modulate chromatin binding and promoter occupancy by acetylated FOXP3

Samanta, A., Li, B., Song, X., Bembas, K., Zhang, G., Katsumata, M., Saouaf, S. J., Wang, Q., Hancock, W. W., Shen, Y., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806726105 · Cited by 166

Smad3 binding to the foxp3 enhancer is dispensable for the development of regulatory T cells with the exception of the gut

Schlenner, S., Weigmann, B., Ruan, Q., Chen, Y., & von Boehmer, H. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20112646 · Cited by 165

Three Novel Acetylation Sites in the Foxp3 Transcription Factor Regulate the Suppressive Activity of Regulatory T Cells

Kwon, H.-S., Lim, H. W., Wu, J. J., Schnölzer, M., Verdin, E. M., & Ott, M. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1100903 · Cited by 162

A mechanism for expansion of regulatory T-cell repertoire and its role in self-tolerance

Feng, Y., van der Veeken, J., Shugay, M., Putintseva, E. V., Osmanbeyoglu, H. U., Dikiy, S., Hoyos, B. E., Moltedo, B., Hemmers, S., Treuting, P., et al. (2015) · Nature · doi:10.1038/nature16141 · Cited by 157

Identification of Regulatory Foxp3+ Invariant NKT Cells Induced by TGF-β

Monteiro, M., Almeida, C. F., Caridade, M., Ribot, J. C., Duarte, J., Agua‐Doce, A., Wollenberg, I., Silva‐Santos, B., & Graça, L. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000359 · Cited by 153

Treg Cells, Life History, and DiversityPreprint

Benoist, C. O., & Mathis, D. J. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a007021 · Cited by 147

Mst1/Mst2 Regulate Development and Function of Regulatory T Cells through Modulation of Foxo1/Foxo3 Stability in Autoimmune Disease

Du, X., Shi, H., Li, J., Dong, Y., Liang, J., Ye, J., Kong, S., Zhang, S., Zhong, T. P., Yuan, Z., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1301060 · Cited by 144

TSC1 regulates the balance between effector and regulatory T cells

Park, Y., Jin, H., Lopez, J. M., Elly, C., Kim, G., Murai, M., Kronenberg, M., & Liu, Y. (2013) · Journal of Clinical Investigation · doi:10.1172/jci69751 · Cited by 140

IL-1β promotes Th17 differentiation by inducing alternative splicing of FOXP3

Mailer, R. K., Joly, A.-L., Liu, S., Éliás, S., Tegner, J. N., & Andersson, J. (2015) · Scientific Reports · doi:10.1038/srep14674 · Cited by 140

FOXP3 is a homo-oligomer and a component of a supramolecular regulatory complex disabled in the human XLAAD/IPEX autoimmune disease

Li, B., Samanta, A., Song, X., Iacono, K. T., Brennan, P. J., Chatila, T. A., Roncador, G., Banham, A. H., Riley, J. L., Wang, Q., et al. (2007) · International Immunology · doi:10.1093/intimm/dxm043 · Cited by 135

Ubiquitin-specific Protease-7 Inhibition Impairs Tip60-dependent Foxp3 + T-regulatory Cell Function and Promotes Antitumor Immunity

Wang, L., Kumar, S., Dahiya, S., Wang, F., Wu, J., Newick, K., Han, R., Samanta, A., Beier, U. H., Akimova, T., et al. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.10.018 · Cited by 125

All-Trans Retinoic Acid Promotes TGF-β-Induced Tregs via Histone Modification but Not DNA Demethylation on Foxp3 Gene Locus

Lu, L., Ma, J., Li, Z., Lan, Q., Chen, M., Liu, Y., Xia, Z., Wang, J., Han, Y., Shi, W., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024590 · Cited by 118

CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation

Li, X., Huang, M., Zheng, H., Wang, Y., Ren, F., Shang, Y., Zhai, Y., Irwin, D. M., Shi, Y., Chen, D., et al. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200711044 · Cited by 117

Rapid Temporal Control of Foxp3 Protein Degradation by Sirtuin-1

van Loosdregt, J., Brunen, D., Fleskens, V., Pals, C. E. G. M., Lam, E. W. ‐., & Coffer, P. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019047 · Cited by 116

Foxp3 Protein Stability Is Regulated by Cyclin-dependent Kinase 2*

Morawski, P. A., Mehra, P., Chen, C., Bhatti, T. R., & Wells, A. D. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.467704 · Cited by 114

An N-Terminal Mutation of the Foxp3 Transcription Factor Alleviates Arthritis but Exacerbates Diabetes

Darce, J. R., Rudra, D., Li, L., Nishio, J., Cipolletta, D., Rudensky, A. Y., Mathis, D. J., & Benoist, C. O. (2012) · Immunity · doi:10.1016/j.immuni.2012.04.007 · Cited by 113

PIM1 Kinase Phosphorylates the Human Transcription Factor FOXP3 at Serine 422 to Negatively Regulate Its Activity under Inflammation

Li, Z., Lin, F., Zhuo, C., Deng, G., Chen, Z., Yin, S., Gao, Z., Piccioni, M., Tsun, A., Cai, S., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.586651 · Cited by 110

Dynamic Interactions between TIP60 and p300 Regulate FOXP3 Function through a Structural Switch Defined by a Single Lysine on TIP60

Xiao, Y., Nagai, Y., Deng, G., Ohtani, T., Zhu, Z., Zhou, Z., Zhang, H., Ji, M. Q., Lough, J., Samanta, A., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.04.021 · Cited by 109

Mbd2 Promotes Foxp3 Demethylation and T-Regulatory-Cell Function

Wang, L., Liu, Y., Han, R., Beier, U. H., Thomas, R. M., Wells, A. D., & Hancock, W. W. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00144-13 · Cited by 105

Forced overexpression of either of the two common human Foxp3 isoforms can induce regulatory T cells from CD4 + CD25 – cells

Aarts‐Riemens, T., Emmelot, M. E., Verdonck, L. F., & Mutis, T. (2008) · European Journal of Immunology · doi:10.1002/eji.200737590 · Cited by 103

USP21 prevents the generation of T-helper-1-like Treg cells

Li, Y., Lu, Y., Wang, S., Han, Z., Zhu, F., Ni, Y., Liang, R., Zhang, Y., Leng, Q., Wei, G., et al. (2016) · Nature Communications · doi:10.1038/ncomms13559 · Cited by 97

Pim-2 Kinase Influences Regulatory T Cell Function and Stability by Mediating Foxp3 Protein N-terminal Phosphorylation

Deng, G., Nagai, Y., Xiao, Y., Li, Z., Dai, S., Ohtani, T., Banham, A. H., Li, B., Wu, S., Hancock, W. W., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.638221 · Cited by 93

Histone acetyltransferase mediated regulation of FOXP3 acetylation and Treg function

Xiao, Y., Li, B., Zhou, Z., Hancock, W. W., Zhang, H., & Greene, M. I. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.08.013 · Cited by 92

CD8+Foxp3+ T cells share developmental and phenotypic features with classical CD4+Foxp3+ regulatory T cells but lack potent suppressive activity

Mayer, C. T., Floess, S., Baru, A. M., Lahl, K., Huehn, J., & Sparwasser, T. D. (2011) · European Journal of Immunology · doi:10.1002/eji.201040913 · Cited by 90

Splice variants of human FOXP3 are functional inhibitors of human CD4+ T‐cell activation

Smith, E., Finney, H. M., Nesbitt, A. M., Ramsdell, F., & Robinson, M. K. (2006) · Immunology · doi:10.1111/j.1365-2567.2006.02425.x · Cited by 87

Identification of the E3 Deubiquitinase Ubiquitin-specific Peptidase 21 (USP21) as a Positive Regulator of the Transcription Factor GATA3

Zhang, J., Chen, C., Hou, X., Gao, Y., Lin, F., Yang, J. C., Gao, Z., Pan, L., Tao, L., Wen, C., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.374744 · Cited by 85

Cyclin-Dependent Kinase 2 Controls Peripheral Immune Tolerance

Chunder, N., Wang, L., Chen, C., Hancock, W. W., & Wells, A. D. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1202313 · Cited by 75

DNA Demethylation of the Foxp3 Enhancer Is Maintained through Modulation of Ten-Eleven- Translocation and DNA Methyltransferases

Nair, V. S., Song, M. H., Ko, M., & Oh, K. I. (2016) · Molecules and Cells · doi:10.14348/molcells.2016.0276 · Cited by 67

Human CD8+ T lymphocyte clones specific for T cell receptor Vβ families expressed on autologous CD4+ T cells

Ware, R., Jiang, H., Braunstein, N. S., Kent, J. R., Wiener, E., Pernis, B., & Chess, L. (1995) · Immunity · doi:10.1016/s1074-7613(95)80066-2 · Cited by 63

New regulatory CD19+CD25+ B-cell subset in clinically isolated syndrome and multiple sclerosis relapse. Changes after glucocorticoids

de Andrés, C., Tejera‐Alhambra, M., Alonso, B., Valor, L., Teijeiro, R., Ramos‐Medina, R., Mateos, D., Faure, F., & Sánchez‐Ramón, S. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.02.003 · Cited by 60

Allergen-specific responses of CD19(+)CD5(+)Foxp3(+) regulatory B cells (Bregs) and CD4(+)Foxp3(+) regulatory T cell (Tregs) in immune tolerance of cow milk allergy of late eczematous reactions

Noh, J., Noh, G., Kim, H. S., Kim, A.-R., & Choi, W. S. (2012) · Cellular Immunology · doi:10.1016/j.cellimm.2012.01.005 · Cited by 60

T Cell Receptor (TCR) and Transforming Growth Factor β (TGF-β) Signaling Converge on DNA (Cytosine-5)-methyltransferase to Control forkhead box protein 3 (foxp3) Locus Methylation and Inducible Regulatory T Cell Differentiation

Li, C., Ebert, P. J. R., & Li, Q.-J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.453357 · Cited by 59

Mammalian Sterile 20-like Kinase 1 (Mst1) Enhances the Stability of Forkhead Box P3 (Foxp3) and the Function of Regulatory T Cells by Modulating Foxp3 Acetylation

Li, J., Du, X., Shi, H., Deng, K., Chi, H., & Tao, W. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.668442 · Cited by 59

Regulatory T cell defects in rheumatoid arthritis

Sarkar, S., & Fox, D. A. (2007) · Arthritis & Rheumatism · doi:10.1002/art.22415 · Cited by 51

The Expansion of CD25highIL-10highFoxP3highB Regulatory Cells Is in Association with SLE Disease Activity

Vadasz, Z., Peri, R., Eiza, N., Slobodin, G., Balbir‐Gurman, A., & Toubi, E. (2015) · Journal of Immunology Research · doi:10.1155/2015/254245 · Cited by 47

Phosphorylation of FOXP3 by LCK Downregulates MMP9 Expression and Represses Cell Invasion

Nakahira, K., Morita, A., Kim, N.-S., & Yanagihara, I. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077099 · Cited by 45

Characterisation of Foxp3 splice variants in human CD4+ and CD8+ T cells—Identification of Foxp3Δ7 in human regulatory T cells

Kaur, G., Goodall, J. C., Jarvis, L. B., & Hill Gaston, J. S. (2010) · Molecular Immunology · doi:10.1016/j.molimm.2010.07.008 · Cited by 45

Foxp3 Expression in Macrophages Associated with RENCA Tumors in Mice

Devaud, C., Yong, C. S. M., John, L. B., Westwood, J. A., Duong, C. P. M., House, C. M., Denoyer, D., Li, J., Darcy, P. K., & Kershaw, M. H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108670 · Cited by 43

The Regulatory T Cell Lineage Factor Foxp3 Regulates Gene Expression through Several Distinct Mechanisms Mostly Independent of Direct DNA Binding

Xie, X., Stubbington, M. J. T., Nissen, J. K., Andersen, K. G., Hebenstreit, D., Teichmann, S. A., & Betz, A. G. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005251 · Cited by 43

Three Distinct Domains Contribute to Nuclear Transport of Murine Foxp3

Hancock, W. W., & Özkaynak, E. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007890 · Cited by 42

mTORC2-PKBα/Akt1 Serine 473 Phosphorylation Axis Is Essential for Regulation of FOXP3 Stability by Chemokine CCL3 in Psoriasis

Chen, L., Wu, J., Pier, E., Zhao, Y., & Shen, Z. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.333 · Cited by 37

Synergy between IL-6 and TGF-β signaling promotes FOXP3 degradation.

Gao, Z., Gao, Y., Li, Z., Chen, Z., Lu, D., Tsun, A., & Li, B. (2012) · Europe PMC (PubMed Central) · Cited by 32

The Foxp3 interactome: a network perspective of Treg cells

Hori, S. (2012) · Nature Immunology · doi:10.1038/ni.2424 · Cited by 30

Foxp3 Interacts with c-Rel to Mediate NF-κB Repression

Loizou, L., Andersen, K. G., & Betz, A. G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018670 · Cited by 30

Molecular and biological role of the FOXP3 N-terminal domain in immune regulation by T regulatory/suppressor cells

Deng, G., Xiao, Y., Zhou, Z., Nagai, Y., Zhang, H., Li, B., & Greene, M. I. (2012) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2012.09.013 · Cited by 28

CD8+Foxp3+ tumor infiltrating lymphocytes accumulate in the context of an effective anti‐tumor response

Le, D. T., Ladle, B. H., Lee, T. T., Weiss, V. L., Yao, X., Leubner, A., Armstrong, T. D., & Jaffee, E. M. (2010) · International Journal of Cancer · doi:10.1002/ijc.25693 · Cited by 28

FoxP3 mRNA splice forms in synovial CD4+ T cells in rheumatoid arthritis and psoriatic arthritis

Ryder, L. R., Bartels, E. M., Woetmann, A., MADSEN, H. O., Ødum, N., Bliddal, H., Danneskiold‐Samsøe, B., Ribel-Madsen, S. M., & Ryder, L. P. (2011) · Apmis · doi:10.1111/j.1600-0463.2011.02848.x · Cited by 27

Lack of Foxp3+ macrophages in both untreated and B16 melanoma-bearing mice

Mayer, C. T., Kühl, A. A., Loddenkemper, C., & Sparwasser, T. D. (2012) · Blood · doi:10.1182/blood-2011-11-392266 · Cited by 21

Raf Signaling but not the ERK Effector SAP-1 Is Required for Regulatory T Cell Development

Willoughby, J. E., Costello, P. S., Nicolas, R. H., Robinson, N. J., Stamp, G., Powrie, F. M., & Treisman, R. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.10.6836 · Cited by 19

Macrophages have no lineage history of Foxp3 expression

Put, S., Avau, A., Humblet‐Baron, S., Schurgers, E., Liston, A., & Matthys, P. (2012) · Blood · doi:10.1182/blood-2011-11-391755 · Cited by 16

Regulatory T Cells and Human Disease

Sakaguchi, S., Mikami, N., Wing, J. B., Tanaka, A., Ichiyama, K., & Ohkura, N. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042718-041717 · Cited by 1,163

Regulatory T cells in tumor microenvironment: new mechanisms, potential therapeutic strategies and future prospects

Li, C., Jiang, P., Wei, S., Xu, X., & Wang, J. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01234-1 · Cited by 972

Tumor metabolite lactate promotes tumorigenesis by modulating MOESIN lactylation and enhancing TGF-β signaling in regulatory T cells

Gu, J., Zhou, J., Chen, Q., Xu, X., Gao, J., Li, X., Shao, Q., Zhou, B., Zhou, H., Wei, S., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110986 · Cited by 529

Mitochondrial complex III is essential for suppressive function of regulatory T cells

Weinberg, S. E., Singer, B. D., Steinert, E. M., Martinez, C. A., Mehta, M., Martínez‐Reyes, I., Gao, P., Helmin, K. A., Abdala‐Valencia, H., Sena, L. A., et al. (2019) · Nature · doi:10.1038/s41586-018-0846-z · Cited by 505

Intricacies of TGF-β signaling in Treg and Th17 cell biology

Wang, J., Zhao, X., & Wan, Y. Y. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-01036-7 · Cited by 404

Regulatory T Cell and Forkhead Box Protein 3 as Modulators of Immune Homeostasis

Pereira, L. M. S., Gomes, S. T. M., Ishak, R., & Vallinoto, A. C. R. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00605 · Cited by 121

Regulatory T Cells: the Many Faces of Foxp3

Georgiev, P., Charbonnier, L., & Chatila, T. A. (2019) · Journal of Clinical Immunology · doi:10.1007/s10875-019-00684-7 · Cited by 253

The Regulation of FoxP3-Expressing Regulatory T Cells

Haque, R., Lei, F., Xiong, X., & Song, J. J. (2011) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/187153011797881157 · Cited by 15

FOXP3~+ regulatory T cells

Li, B. (2010) · Shengming kexue · Cited by 35

FoxP3 in Treg cell biology: a molecular and structural perspective

Deng, G., Song, X., & Greene, M. I. (2019) · Clinical & Experimental Immunology · doi:10.1111/cei.13357 · Cited by 50