The TIM gene family: emerging roles in immunity and disease

Kuchroo, Vijay K., Umetsu, Dale T., DeKruyff, Rosemarie H., Freeman, Gordon J.·2003·Nature Reviews Immunology
DOI 10.1038/nri1111

Cited by (388)

Items 101–200 of 388

  1. Bimodal regulation of T cell-mediated immune responses by TIM-4
    Masayuki Mizui, T. Shikina, Hisashi Arase, K. Suzuki, Takeshi Yasui, Paul D. Rennert, Atsushi Kumanogoh, Hitoshi Kikutani · 2008 · International Immunology
  2. Blockade of Tim-1 and Tim-4 Enhances Atherosclerosis in Low-Density Lipoprotein Receptor–Deficient Mice
    Foks, Amanda C., Engelbertsen, Daniel, Kuperwaser, Felicia, Alberts-Grill, Noah, Gonen, Ayelet, Witztum, Joseph L., Lederer, James, Jarolim, Petr, DeKruyff, Rosemarie H., Freeman, Gordon J. et al. · 2016 · Arteriosclerosis, Thrombosis, and Vascular Biology
  3. Extracellular Matrix and Oxidative Stress Following Traumatic Spinal Cord Injury: Physiological and Pathophysiological Roles and Opportunities for Therapeutic Intervention
    Jonathon Chon Teng Chio, Nayaab Punjani, Nader Hejrati, Mohammad-Masoud Zavvarian, James Hong, Michael George Fehlings · 2021 · Antioxidants and Redox Signaling
  4. High Expression of Tim-3 mRNA in Urinary Cells from Kidney Transplant Recipients with Acute Rejection
    Paulo Guilherme Renesto, Viviane Campos Ponciano, Marcos Antônio Cenedeze, Niels Olsen Saraiva Câmara, Álvaro Pacheco‐Silva · 2007 · American Journal of Transplantation
  5. TIM-3 expression in human osteosarcoma: Correlation with the expression of epithelial-mesenchymal transition-specific biomarkers
    Yongjun Shang, ZHANYONG LI, Hong Li, Haibo Xia, Zhenhua Lin · 2013 · Oncology Letters
  6. The association of the exon 4 variations of Tim-1 gene with allergic diseases in a Korean population
    Soo‐Cheon Chae, Juhee Song, Yong‐Chul Lee, Jin‐Wou Kim, Hun‐Taeg Chung · 2003 · Biochemical and Biophysical Research Communications
  7. Germline and somatic diversification of immune recognition elements in Metazoa
    Louis Du Pasquier · 2005 · Immunology Letters
  8. TIM-1 serves as a receptor for Ebola virus in vivo, enhancing viremia and pathogenesis
    Bethany A. Brunton, Kai J. Rogers, Elisabeth K. Phillips, Rachel B. Brouillette, Ruayda Bouls, Noah S. Butler, Wendy J. Maury · 2019 · PLoS neglected tropical diseases
  9. TIMs: central regulators of immune responses
    David A. Hafler, Vijay Kumar Kuchroo · 2008 · The Journal of Experimental Medicine
  10. Receptors and ligands implicated in human T cell costimulatory processes
    Judith Maria Leitner, Katharina Grabmeier‐Pfistershammer, Peter Steinberger · 2009 · Immunology Letters
  11. T Cell Ig and Mucin Domain-1-Mediated T Cell Activation Requires Recruitment and Activation of Phosphoinositide 3-Kinase
    Anjali J. de Souza, Jean S. Oak, Ryan Jordanhazy, Rosemarie H. DeKruyff, David A Fruman, Larry Kane · 2008 · The Journal of Immunology
  12. Keeping Tumors in Check: A Mechanistic Review of Clinical Response and Resistance to Immune Checkpoint Blockade in Cancer
    Nicholas C. Borcherding, Ryan H. Kolb, Jodi A. Gullicksrud, Praveen Vikas, Yuwen Zhu, Weizhou Zhang · 2018 · Journal of Molecular Biology
  13. Immunoglobulin A (IgA) Is a Natural Ligand of Hepatitis A Virus Cellular Receptor 1 (HAVCR1), and the Association of IgA with HAVCR1 Enhances Virus-Receptor Interactions
    Cecilia Tami, Erica Silberstein, Mohanraj Manangeeswaran, Gordon James Freeman, Sarah E. Umetsu, Rosemarie H. DeKruyff, Dale T. Umetsu, Gerardo G. Kaplan · 2007 · Journal of Virology
  14. Immune checkpoint proteins: exploring their therapeutic potential to regulate atherosclerosis
    Amanda C. Foks, Johan Kuiper · 2017 · British Journal of Pharmacology
  15. Associations between transcriptional changes and protein phenotypes provide insights into immune regulation in corals
    Lauren E. Fuess, Jorge H. Pinzón, Ernesto F. Weil, Laura D. Mydlarz · 2016 · Developmental & Comparative Immunology
  16. The TIM-1
    Song Rong, Joon-Keun Park, Torsten Kirsch, Hideo Yagita∥, Hisaya Akiba, Olaf Boenisch, Hermann G. Haller, Nader Najafian, Antje Habicht · 2011 · Journal of the American Society of Nephrology
  17. Involvement of Galectin-9/TIM-3 Pathway in the Systemic Inflammatory Response in Early-Onset Preeclampsia
    Éva Mikó, Mátyás Meggyes, Barbara Bogar, Nora Schmitz, Alíz Barakonyi, Ákos Várnagy, Bálint Farkas, Péter Tamás, József Bódis, Júlia Szekeres‐Barthó et al. · 2013 · PLoS ONE
  18. T-Cell Immunoglobulin and Mucin Domain 3 Acts as a Negative Regulator of Atherosclerosis
    Amanda C. Foks, Ingrid A. Ran, Loes Wasserman, Vanessa Frodermann, Mariëtte N. D. ter Borg, Saskia C.A. de Jager, Peter J. van Santbrink, Hideo Yagita∥, Hisaya Akiba, Ilze Bot et al. · 2013 · Arteriosclerosis Thrombosis and Vascular Biology
  19. Glycoproteomic landscape and structural dynamics of TIM family immune checkpoints enabled by mucinase SmE
    Chongsaritsinsuk, Joann, Steigmeyer, Alexandra D., Mahoney, Keira E., Rosenfeld, Mia A., Lucas, Taryn M., Smith, Courtney M., Li, Alice, Ince, Deniz, Kearns, Fiona L., Battison, Alexandria S. et al. · 2023 · Nature Communications
  20. TIM polymorphisms—genetics and function
    J Lee, Binh L. Phong, Ann Marie Egloff, Larry Kane · 2011 · Genes and Immunity
  21. The Phosphatidylserine Receptor TIM-1 Enhances Authentic Chikungunya Virus Cell Entry
    Jared Kirui, Yara Abidine, Annasara Lenman, Koushikul Islam, Yong-Dae Gwon, Lisa Laßwitz, Magnus Evander, Marta Bally, Gisa Gerold · 2021 · Cells
  22. CXCL10 Activities, Biological Structure, and Source Along with Its Significant Role Played in Pathophysiology of Type I Diabetes Mellitus
    Zahra Ahmadi, Mohammad Kazemi Arababadi, Gholamhossin Hassanshahi · 2012 · Inflammation
  23. Increased level of H-ferritin and its imbalance with L-ferritin, in bone marrow and liver of patients with adult onset Still's disease, developing macrophage activation syndrome, correlate with the severity of the disease
    Piero Ruscitti, Paola Cipriani, Paola Di Benedetto, Francesco Ciccia, Vasiliki Liakouli, Francesco Carubbi, Onorina Berardicurti, Aroldo Gabriele Rizzo, G Triolo, Roberto Giacomelli · 2015 · Autoimmunity Reviews
  24. Immune Semaphorins: Novel Features of Neural Guidance Molecules
    Masayuki Mizui, Atsushi Kumanogoh, Hitoshi Kikutani · 2008 · Journal of Clinical Immunology
  25. Immune plexins and semaphorins: old proteins, new immune functions
    Kelly E. Roney, Eda K. Holl, Jenny P.‐Y. Ting · 2013 · Protein & Cell
  26. Prognostic Values of TIM-3 Expression in Patients With Solid Tumors: A Meta-Analysis and Database Evaluation
    Shuang Qin, Bing Dong, Ming Yi, Qian Chu, Kongming Wu · 2020 · Frontiers in Oncology
  27. The Role of T Cells and Macrophages in Asthma Pathogenesis: A New Perspective on Mutual Crosstalk
    Xueyi Zhu, Jie Cui, La Yi, Jingjing Qin, Tulake Wuniqiemu, Fangzhou Teng, Weifeng Tang, Ying Wei, Jingcheng Dong · 2020 · Mediators of Inflammation
  28. The polymorphisms of Tim-1 promoter region are associated with rheumatoid arthritis in a Korean population
    Soo‐Cheon Chae, Youngran Park, Juhee Song, Seung Cheol Shim, Kyung‐Sik Yoon, Hun‐Taeg Chung · 2004 · Immunogenetics
  29. Molecular variations in the promoter and coding regions of human Tim-1 gene and their association in Koreans with asthma
    Soo‐Cheon Chae, Juhee Song, Jin-Chul Heo, Yong‐Chul Lee, Jin‐Wou Kim, Hun‐Taeg Chung · 2003 · Human Immunology
  30. TIM-1 acts a dual-attachment receptor for Ebolavirus by interacting directly with viral GP and the PS on the viral envelope
    Shuai Yuan, Lei Cao, Hui Ling, Minghao Dang, Yao Sun, Xuyuan Zhang, Yutao Chen, Liguo Zhang, Dan Su, Xiangxi Wang et al. · 2015 · Protein & Cell
  31. Anti–T-cell Ig and mucin domain–containing protein 1 antibody decreases TH2 airway inflammation in a mouse model of asthma
    Jeffrey A. Encinas, Edith M. Janssen, David B. Weiner, Sandra A. Calarota, D. Nieto, Thomas Moll, Dennis J. Carlo, Ronald B. Moss · 2005 · Journal of Allergy and Clinical Immunology
  32. SMUCKLER/TIM4 is a distinct member of TIM family expressed by stromal cells of secondary lymphoid tissues and associated with lymphotoxin signaling
    Alexander N. Shakhov, Рыбцов Станислав Александрович, Alexei V. Tumanov, Sergey Shulenin, Michael C. Dean, Dmitry V. Kuprash, Sergei A. Nedospasov · 2004 · European Journal of Immunology
  33. Immune Exhaustion and Immune Senescence: Two Distinct Pathways for HBV Vaccine Failure During HCV and/or HIV Infection
    Zhi Qiang Yao, Jonathan P. Moorman · 2013 · Archivum Immunologiae et Therapiae Experimentalis
  34. The association of TIM-3 gene polymorphism with atopic disease in Korean population
    Soo‐Cheon Chae, Youngran Park, Yong‐Chul Lee, Jae-Hoon Lee, Hun‐Taeg Chung · 2004 · Human Immunology
  35. Advances in diagnostics for transplant rejection
    Michael Nasr, Tara K. Sigdel, Minnie Sarwal · 2016 · Expert Review of Molecular Diagnostics
  36. Inflammation in Asthma Pathogenesis: Role of T Cells, Macrophages, Epithelial Cells and Type 2 Inflammation
    Amina Hamed Alobaidi, Abdulghani Mohamed Alsamarai, Mohamed Almoustafa Alsamarai · 2021 · Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
  37. Cis Association of Galectin-9 with Tim-3 Differentially Regulates IL-12/IL-23 Expressions in Monocytes via TLR Signaling
    Jun Cheng, Guang Y. Li, Yong Cheng, Jia M. Wang, Ruo S. Ying, Lei Shi, Xiao Y. Wu, Toshiro Niki, Mitsumi Hirashima, Chuan F. Li et al. · 2013 · PLoS ONE
  38. Semaphorin 4A, 4C, and 4D: Function comparison in the autoimmunity, allergy, and cancer
    Misagh Rajabinejad, Gelayol Asadi, Sedigheh Ranjbar, Leila Afshar Hezarkhani, Farhad Salari, Ali Gorgin Karaji, Alireza Rezaiemanesh · 2020 · Gene
  39. The exon 4 variations of Tim-1 gene are associated with rheumatoid arthritis in a Korean population
    Soo‐Cheon Chae, Juhee Song, Seung Cheol Shim, Kyung‐Sik Yoon, Hun‐Taeg Chung · 2004 · Biochemical and Biophysical Research Communications
  40. Synergistic effect of IL-12 and IL-18 induces TIM3 regulation of γδ T cell function and decreases the risk of clinical malaria in children living in Papua New Guinea
    Louis Schofield, Lisa J. Ioannidis, Stephan Karl, Leanne J. Robinson, Qiao Ye Tan, Daniel P. Poole, Inoni Betuela, Danika Lea Hill, Peter Max Siba, Diana S. Hansen et al. · 2017 · BMC Medicine
  41. Recent development in genomic and proteomic research for asthma
    Eva Charlotte Halapi, Hakon H. Hakonarson · 2003 · Current Opinion in Pulmonary Medicine
  42. Evidence for carbohydrate recognition and homotypic and heterotypic binding by the TIM family
    Peter R. Wilker, John R. Šedý, Vadim Grigura, Theresa L. Murphy, KENNETH M. M. MURPHY · 2007 · International Immunology
  43. Gene expression patterns associated with chicken jejunal development
    Dirkjan Schokker, Arjan J. W. Hoekman, Mari A. Smits, Johanna M.J. Rebel · 2009 · Developmental & Comparative Immunology
  44. Tim-4 in Health and Disease: Friend or Foe?
    Wen Liu, Liyun Xu, Xiaohong Liang, Xiaojun Liu, Yangbing Zhao, Chunhong Ma, Lifen Gao · 2020 · Frontiers in Immunology
  45. Emerging Biomarkers and Metabolomics for Assessing Toxic Nephropathy and Acute Kidney Injury (AKI) in Neonatology
    Michele Mussap, Antonio Noto, Vassilios Fanos, Johannes N. van den Anker · 2014 · BioMed Research International
  46. A cDNA macroarray approach to parasite‐induced gene expression changes in a songbird host: genetic response of house finches to experimental infection by Mycoplasma gallisepticum
    ZHENSHAN WANG, Kristy L. Farmer, Geoffrey E. Hill, Scott V. Edwards · 2005 · Molecular Ecology
  47. Genetic Association Studies between the T Cell Immunoglobulin Mucin (TIM) Gene Locus and Childhood Atopic Dermatitis
    Natalie S. Page, Graham J. Jones, Graeme J. Stewart · 2006 · International Archives of Allergy and Immunology
  48. Role of Type I Interferon Signaling in Human Metapneumovirus Pathogenesis and Control of Viral Replication
    Andrew K. Hastings, John J. Erickson, Jennifer E. Schuster, Kelli Lynn Boyd, Sharon J. Tollefson, Monika Johnson, Pavlo Gilchuk, Sebastian Joyce, John V. Williams · 2015 · Journal of Virology
  49. Immune Checkpoint Molecules, Personalized Immunotherapy, and Autoimmune Diabetes
    Ciriana Orabona, Giada Mondanelli, Paolo Puccetti, Ursula Grohmann · 2018 · Trends in Molecular Medicine
  50. Free radical theory of autoimmunity
    Subburaj Kannan · 2006 · Theoretical Biology and Medical Modelling
  51. The Expression of Tim-3 in Peripheral Blood of Ovarian Cancer
    Jie Wu, Cuiying Liu, Qian Shao, Hongchun Hou · 2013 · DNA and Cell Biology
  52. Multifaceted Roles of TIM-Family Proteins in Virus–Host Interactions
    John Parker Evans, Shan‐Lu Liu · 2019 · Trends in Microbiology
  53. T Cell Ig Domain and Mucin Domain 1 Engagement on Invariant NKT Cells in the Presence of TCR Stimulation Enhances IL-4 Production but Inhibits IFN-γ Production
    Hye Sung Kim, Hyun Soo Kim, Chang Woo Lee, Doo Hyun Chung · 2010 · The Journal of Immunology
  54. Expanding the spectrum of the hyperferritinemic syndrome, from pathogenic mechanisms to clinical observations, and therapeutic implications
    Piero Ruscitti, Ilenia Di Cola, Claudia Di Muzio, Noemi Italiano, Francesco Ursini, Roberto Giacomelli, Paola Cipriani · 2022 · Autoimmunity Reviews
  55. Endogenous Tim-1 (Kim-1) promotes T-cell responses and cell-mediated injury in experimental crescentic glomerulonephritis
    Yuji Nozaki, David J. Nikolic‐Paterson, Sarah L. Snelgrove, Hisaya Akiba, Hideo Yagita∥, Stephen Roger Holdsworth, Arthur Richard Kitching · 2011 · Kidney International
  56. Potential influences of complement factor H in autoimmune inflammatory and thrombotic disorders
    Janez Ferluga, Lubna Kouser, Valarmathy Murugaiah, Robert B. Sim, Uday Kishore · 2017 · Molecular Immunology
  57. Cutting Edge: Inhibition of T Cell Activation by TIM-2
    Jared E. Knickelbein, Anjali J. de Souza, Richard Tosti, Preeti Narayan, Larry Kane · 2006 · The Journal of Immunology
  58. Targeting TIM-1 on CD4 T Cells Depresses Macrophage Activation and Overcomes Ischemia-Reperfusion Injury in Mouse Orthotopic Liver Transplantation
    Y. Zhang, Haofeng Ji, X. Shen, Jinzhen Cai, F. Gao, K.M. Koenig, C.M. Batikian, Ronald W. Busuttil, Jerzy W. Kupiec-Weglinski · 2012 · American Journal of Transplantation
  59. Sensing Dying Cells in Health and Disease
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  60. Tim-3 alters the balance of IL-12/IL-23 and drives TH17 cells: Role in hepatitis B vaccine failure during hepatitis C infection
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  61. Immune Regulation and Antitumor Effect of TIM-1
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  62. Picomole-level mapping of protein disulfides by mass spectrometry following partial reduction and alkylation
    Susan F. Foley, Yaping Sun, Timothy S. Zheng, Dingyi Wen · 2008 · Analytical Biochemistry
  63. Ciliary calcium signaling is modulated by kidney injury molecule-1 (Kim1)
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  64. Evidence for natural selection in the HAVCR1 gene: high degree of amino-acid variability in the mucin domain of human HAVCR1 protein
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  65. A Soluble Form of LMIR5/CD300b Amplifies Lipopolysaccharide-Induced Lethal Inflammation in Sepsis
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  68. Expression of T cell immunoglobulin- and mucin-domain-containing molecules-1 and -3 (TIM-1 and -3) in the rat nervous and immune systems
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  69. Increased bovine Tim-3 and its ligand expressions during bovine leukemia virus infection
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  70. Increased T cell Immunoglobulin and Mucin Domain 3 Positively Correlate with Systemic IL-17 and TNF-α Level in the Acute Phase of Ischemic Stroke
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  71. Regulation of T cell dependent immune responses by TIM family members
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  72. The CD68+/H-ferritin+ cells colonize the lymph nodes of the patients with adult onset Still's disease and are associated with increased extracellular level of H-ferritin in the same tissue: correlation with disease severity and implication for pathogenesis
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  73. Expression analysis of PD‐1 and Tim‐3 immune checkpoint receptors in patients with vitiligo; positive association with disease activity
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  74. TIM-mediated inhibition of HIV-1 release is antagonized by Nef but potentiated by SERINC proteins
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  77. Expansion of Dysfunctional Tim-3–Expressing Effector Memory CD8+ T Cells during Simian Immunodeficiency Virus Infection in Rhesus Macaques
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  78. Peptides of CD200 Modulate LPS-Induced TNF-α Induction and Mortality In Vivo
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  84. TIM-1 signaling in B cells regulates antibody production
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  85. The −1541 C>T and +4259 G>T of TIM‐3 polymorphisms are associated with rheumatoid arthritis susceptibility in a Chinese Hui population
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  86. Helicobacter pyloriand Risk of Gastroenteritis
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  89. TIM-3 polymorphisms in type 1 diabetes families
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  90. Essential Roles of TIM-1 and TIM-4 Homologs in Adaptive Humoral Immunity in a Zebrafish Model
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  100. Tim-3 expression in human kidney allografts
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