The TIM gene family: emerging roles in immunity and disease

Kuchroo, Vijay K., Umetsu, Dale T., DeKruyff, Rosemarie H., Freeman, Gordon J.·2003·Nature Reviews Immunology
DOI 10.1038/nri1111

Cited by (388)

Items 201–300 of 388

  1. High Interleukin-37 (IL-37) Expression and Increased Mucin-Domain Containing-3 (TIM-3) on Peripheral T Cells in Patients with Rheumatoid Arthritis
    Lijun Song, Yunqing Wang, Yameng Sui, Jiao Sun, Dong Li, Guosheng Li, Jianwei Liu, T W LI, Qiang Shu · 2018 · Medical Science Monitor
  2. Screening for asthma in Cantonese-speaking immigrant children
    Robyn O Greenfield, Angela C. Lee, Roland Tang, Doug Brugge · 2005 · BMC Public Health
  3. Absence of association between two insertion/deletion coding genetic polymorphisms of TIM‐1 gene and asthma in Chinese Han population
    J. S. Li, Qun Liu, Ping Wang, H. C. Li, Chunhua Wei, Chun Hua Guo, Yaoqin Gong · 2006 · International Journal of Immunogenetics
  4. Axotrophin and leukaemia inhibitory factor (LIF) in transplantation tolerance
    Su M Metcalfe · 2005 · Philosophical Transactions of the Royal Society B Biological Sciences
  5. Novel Roles of the Tim Family in Immune Regulation and Autoimmune Diseases
    Yikai Liu, Hongzhi Chen, Zhiying Chen, Junlin Qiu, Haipeng Pang, Zhiguang Zhou · 2021 · Frontiers in Immunology
  6. Polymorphisms of the TIM-1 and TIM-3 genes are not associated with systemic lupus erythematosus in a Chinese population
    W.-X. Li, Guilin Chen, Hui Yuan, Yingshui Yao, Rui Li, Hai‐Feng Pan, Xiaomei Li, Jian Hua Xu, Jin‐Hui Tao, Dong‐Qing Ye · 2011 · Mutagenesis
  7. Targeting Myeloid-Derived Suppressor Cells Is a Novel Strategy for Anti-Psoriasis Therapy
    Chao Chen, Lirong Tan, Wu Zhu, Li Lei, Yehong Kuang, Panpan Liu, Jie Li, Xiang Chen, Cong Peng · 2020 · Mediators of Inflammation
  8. Inhibition of in vitro and in vivo T cell responses by recombinant human Tim-1 extracellular domain proteins
    Mehdi Mesri, Glennda M. Smithson, Ashwini Ghatpande, Andrei I. Chapoval, Suresh G. Shenoy, Ferenc L. Boldog, Craig Hackett, Carol E. Peña, Catherine Burgess, Alison M. Bendele et al. · 2006 · International Immunology
  9. Tim3 Is Upregulated and Protective in Nephrotoxic Serum Nephritis
    Andrea Schroll, Kathrin Eller, Julia Huber, Igor Theurl, Anna Maria Wolf, Günter Weiß, Alexander R. Rosenkranz · 2010 · American Journal Of Pathology
  10. Inhibition of T cell immunoglobulin and mucin-1 (TIM-1) protects against cerebral ischemia-reperfusion injury
    Yueying Zheng, Liqing Wang, Manli Chen, Lu Liu, Aijie Pei, Rong Zhang, Shuyuan Gan, Shengmei Zhu · 2019 · Cell Communication and Signaling
  11. The Association of a Single‐Nucleotide Polymorphism of the IL‐2 Inducible T‐cell Kinase Gene with Asthma
    Shin‐Hwa Lee, Hun Soo Chang, An‐Soo Jang, Sung‐Woo Park, Jong‐Sook Park, Soo‐Taek Uh, Yong Hoon Kim, Bermseok Oh, Jong‐Keuk Lee, Byung‐Lae Park et al. · 2011 · Annals of Human Genetics
  12. Association analysis of TIM-1 -232G > A and 5383_5397 insertion/deletion polymorphisms with childhood asthma and total serum immunoglobulin E levels in middle China.
    Qiwen Wu, Liqin Hu, Ping Cai, Y Li, F Chen, L Kong · 2009 · PubMed
  13. Function and characteristics of TIM‑4 in immune regulation and disease (Review)
    Ziyao Wang, Chen Chen, Yingzhen Su, Nengwen Ke · 2022 · International Journal of Molecular Medicine
  14. Increased CD45RO+ CD62L+ CD4+ T-cell subpopulation responsible for Th2 response in Kimura’s disease
    Kazuko Yamazaki, Hisashi Kawashima, Satoshi Sato, Hiroyuki Tsunoda, Yasuo Yoshimura, Makoto Higuchi, Sho Hokibara, Takashi Yamazaki, Kazunaga Agematsu · 2013 · Human Immunology
  15. Biomarkers for early detection of acute kidney injury
    Won Kon Han · 2012 · Current Biomarker Findings
  16. Kidney injury molecule-1 as an early detection tool for acute kidney injury and other kidney diseases
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  17. HAVcR-1 expression in human colorectal cancer and its effects on colorectal cancer cells in vitro.
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  18. Costimulatory Pathways in Kidney Transplantation: Pathogenetic Role, Clinical Significance and New Therapeutic Opportunities
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  19. Polarization of Th1/Th2 in human CD4+ T cells separated by CD62L: analysis by transcription factors
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  20. Diagnostic role of kidney injury molecule-1 in renal cell carcinoma
    Kevin Juan Zhang, George David Wilson, Sam Kara, Audrey J. Majeske, Ping L. Zhang, Jason M. Hafron · 2019 · International Urology and Nephrology
  21. Tim-3: An inhibitory immune checkpoint is associated with maternal-fetal tolerance and recurrent spontaneous abortion
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  22. Exosome-inspired targeting of cancer cells with enhanced affinity
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  23. What Does Iron Mean to an Oligodendrocyte?
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  24. Serum Levels of T Cell Immunoglobulin and Mucin-Domain Containing Molecule 3 in Patients with Systemic Lupus Erythematosus
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  25. Sequential Monitoring of TIM-3 Gene Expression in Peripheral Blood for Diagnostic and Prognostic Evaluation of Acute Rejection in Renal Graft Recipients
    Y. Luo, Bingyi Shi, Y. Qian, Hongwei Bai, Jessica J. Chang · 2011 · Transplantation Proceedings
  26. Influenza virus surveillance in migratory ducks and sentinel ducks at Poyang Lake, China.
    Lian Duan, Huachen Zhu, Jia Wang, Kai Huang, Chung-Lam Cheung, Joseph Sriyal Malik Peiris, Honglin Chen, Yi Guan · 2011 · PubMed
  27. Peritubular Ischemia Contributes More to Tubular Damage than Proteinuria in Immune-Mediated Glomerulonephritis
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  28. TIM-4 is differentially expressed in the distinct subsets of dendritic cells in skin and skin-draining lymph nodes and controls skin Langerhans cell homeostasis
    Xilin Zhang, Queping Liu, Jie Wang, Guihua Li, Matthew J. Weiland, Fu‐Shin X. Yu, Qing‐Sheng Mi, Jun Gu, Li Zhou · 2016 · Oncotarget
  29. Family-Based Association Study of Tim-1 and Tim-3 Gene Polymorphisms with Childhood Asthma in Chinese Trios
    Qiwen Wu, Pengcheng Cai, Ling Wang, Yirong Li, Ling-Ling Kong, Lihua Hu · 2009 · International Archives of Allergy and Immunology
  30. Tim-3 promotes tube formation and decreases tight junction formation in vascular endothelial cells
    Yizi Cong, Xingmiao Wang, Suxia Wang, Guangdong Qiao, Yalun Li, Jianqiao Cao, Wen G. Jiang, Yuxin Cui · 2020 · Bioscience Reports
  31. Decreased Tim-3 and its correlation with Th1 cells in patients with immune thrombocytopenia
    Ning‐ning Shan, Yu Hu, Ming Hou, Juan Gao, Xin Wang, Xin Liu, Ying Li · 2013 · Thrombosis Research
  32. Tim Protein Structures Reveal a Unique Face for Ligand Binding
    Ana Carrizosa Anderson, Sheng Xiao, Vijay Kumar Kuchroo · 2007 · Immunity
  33. Immune Checkpoints in Pediatric Solid Tumors: Targetable Pathways for Advanced Therapeutic Purposes
    Claudia Cocco, Fabio Morandi, Irma Airoldi · 2021 · Cells
  34. Role of Tim-3 in regulating tumorigenesis, inflammation, and antitumor immunity therapy
    Yuting Cao, Qiang Li, Huihui Liu, Xianglei He, Fang Huang, Yigang Wang · 2021 · Cancer Biomarkers
  35. Immunoregulation effects of TIM-3 on tumors
    C. C. Sheng, Fuyan Han · 2018 · Neoplasma
  36. CID16020046, a GPR55 antagonist, attenuates sepsis‑induced acute kidney injury
    Rongxin Chen, Hailin Xu, Zebin Guo, Peng Zhāng, Jianxia Chen, Zheng Chen · 2022 · Molecular Medicine Reports
  37. Noninvasive detection of acute renal allograft rejection by measurement of soluble Tim-3 in urine
    Dajin Chen, Wenhan Peng, Hong Jiang, Hao Yang, Jianyong Wu, Huiping Wang, Jianghua Chen · 2017 · Molecular Medicine Reports
  38. Under-Evaluated or Unassessed Pathogenic Pathways in Autoimmune Hepatitis and Implications for Future Management
    Albert J. Czaja · 2018 · Digestive Diseases and Sciences
  39. Association of Serum T cell Immunoglobulin Domain and Mucin-3 and Interleukin-17 with Systemic Lupus Erythematosus
    Lairun Jin, Ran Bai, Jun Liang Zhou, Wei Shi, Liang Xu, Jun Sheng, Hui Chin Peng, Yuelong Jin, Hui Yuan · 2018 · Medical science monitor basic research/Medical science monitor. Basic research
  40. Experimental Models of Mucosal Inflammation
    Warren Strober, Ivan J. Fuss · 2006 · Advances in experimental medicine and biology
  41. Role of TIM-4 in innate or adaptive immune response
    Natasha Nurtanio, Ping–Chang Yang · 2011 · North American Journal of Medical Sciences
  42. Monoclonal antibody against human Tim‐3 enhances antiviral immune response
    Ge Li, Chunmei Hou, Shuaijie Dou, Jiacheng Zhang, Yanling Zhang, Yiqiong Liu, Zhiding Wang, Xiao He, Renxi Wang, Guojiang Chen et al. · 2018 · Scandinavian Journal of Immunology
  43. TIM family gene polymorphism and susceptibility to rheumatoid arthritis: Systematic review and meta-analysis
    Bahman Razi, Samira Esmaeili Reykande, Shahab Alizadeh, Aliakbar Amirzargar, Amene Saghazadeh, Nima Rezaei · 2019 · PLoS ONE
  44. An Integrated Proteomics and Metabolomics Strategy for the Mechanism of Calcium Oxalate Crystal-Induced Kidney Injury
    Songyan Gao, Yufan Chao, Na Li, Heng‐Hui Li, Hongxia Zhao, Xinru Liu, Wei Chen, Xin Wen Dong · 2022 · Frontiers in Medicine
  45. TIM4 Regulates the Anti-Islet Th2 Alloimmune Response
    Andrea Vergani, Francesca Gatti, Kang M. Lee, Francesca D’Addio, Sara Tezza, Melissa Chin, Roberto Bassi, Ze Tian, Erxi Wu, Paola Maffi et al. · 2014 · Cell Transplantation
  46. Expression of Tim-3 in peripheral blood mononuclear cells and placental tissue in unexplained recurrent spontaneous abortion
    Xuewei Zhuang, Xiyan Xia, Lingxiao Liu, Yi Zhang, Xin Zhang, Chuanxin Wang · 2018 · Medicine
  47. IL-4R polymorphism in regulation of IL-4 synthesis by T cells: implication in susceptibility to a subset of murine lupus
    Wakana Shiroiwa, K. Tsukamoto, Mareki Ohtsuji, Qing Shun Lin, Akinori Ida, Sanki Kodera, Naomi Ohtsuji, K. Nakamura, Hiromichi Tsurui, K. Kinoshita et al. · 2006 · International Immunology
  48. Imbalanced Expression of T-bet and T Cell Immunoglobulin Mucin-3 in Patients with Aplastic Anaemia
    Ning‐ning Shan, Yu Hu, Xin Liu, Xin Wang, Dai Yuan, Ying Li · 2013 · Journal of Clinical Immunology
  49. Aberrant Alteration of Circulating Lymphocyte Subsets in Small Cell Lung Cancer Patients Treated with Radiotherapy
    Hui Li, Hong Yu, Shaowei Lan, Dandan Zhao, Yan Liu, Ying Cheng · 2021 · Technology in Cancer Research & Treatment
  50. Global Loss of Core 1-Derived O-Glycans in Mice Leads to High Mortality Due to Acute Kidney Failure and Gastric Ulcers
    Riku Suzuki, Yuki Nakamura, Rikako Koiwai, Sayaka Fuseya, Yuka Murakami, Kozue Hagiwara, Takashi Sato, Satoru Takahashi, Takashi Kudo · 2022 · International Journal of Molecular Sciences
  51. Combined Immune Checkpoint Blockade Enhances Antiviral Immunity against Bovine Leukemia Virus
    Hayato Nakamura, Satoru Konnai, Tomohiro Okagawa, Naoya Maekawa, Yamato Sajiki, Kei Watari, Kana KAMITANI, Maya Saito, Yukinari Kato, Yasuhiko Suzuki et al. · 2023 · Journal of Virology
  52. Suppression of Allograft Rejection by Tim-1-Fc through Cross-Linking with a Novel Tim-1 Binding Partner on T Cells
    Liang Xiao, Zhiren Fu, Fang Liu, Luding Zhang, Xiao-min Shi, Xiaoyun Shen, Zhijia Ni, Hong Yu Fu, Ruidong Li, Xuetao Cao et al. · 2011 · PLoS ONE
  53. Increased Expression of T Cell Immunoglobulin and Mucin Domain 4 Is Positively Associated with the Disease Severity of Patients with Ankylosing Spondylitis
    Dongdong Chen, Jian-Ying He, Changchang Lu, Jihang Zhou, Kexin Fang, Xiaoguang Liu, Liyun Xu · 2014 · Inflammation
  54. TIM-4 is expressed on invariant NKT cells but dispensable for their development and function
    Xilin Zhang, Jun Gu, Li Zhou, Qing‐Sheng Mi · 2016 · Oncotarget
  55. Sequential monitoring of TIM-3 mRNA expression in blood and urine samples of renal transplant recipients
    Sanaz Keshavarz Shahbaz, Mehri Barabadi, Pedram Ahmadpour, Fatemeh Pour-Reza-Gholi, Mohesn Nafar, Farshad Foroughi, Morteza Hosseinzadeh, Mina Ghorbanpour, Mir Saeed Yekaninejad, Aliakbar Amirzargar · 2018 · Transplant Immunology
  56. Distinct expression of Tim-3 during different stages of rat experimental autoimmune neuritis
    Zhiyuan Zhang, Hermann J. Schluesener, Zhiren Zhang · 2011 · Brain Research Bulletin
  57. Unveiling Tim-3 immune checkpoint expression in hepatocellular carcinoma through abdominal contrast-enhanced CT habitat radiomics
    Zhishen Tang, Wei Wang, Bo Gao, Xuyang Liu, Xiangyu Liu, Yingquan Zhuo, Jun Du, Fujun Ai, Xianwu Yang, Huajian Gu · 2024 · Frontiers in Oncology
  58. Involvement of Tim-3 in Maternal-fetal Tolerance: A Review of Current Understanding
    Xinhang Meng, Yujie Luo, Liyuan Cui, Songcun Wang · 2025 · International Journal of Biological Sciences
  59. Association of Hepatitis A Exposure and TIM-1 with Childhood Allergic Asthma
    Jianping Chen, Wenli Zhao, He Nianhai, Qin Gui, Jian-Ping Xiong, Hongmei Zhou, Yu Wang, Sheng Chen, Ping Zhou · 2012 · Journal of Asthma
  60. Structure and Functions of T-cell Immunoglobulin-domain and Mucin- domain Protein 3 in Cancer
    Xinjie Lu · 2021 · Current Medicinal Chemistry
  61. Dysregulated expression of T cell immunoglobulin and mucin domain 3 is associated with the disease severity and the outcome of patients with spontaneous intracerebral hemorrhage
    Xiao Liu, Junyu You, Di Zhao, Min Guo, Yingfang Pan, Lifen Gao, Xiaohong Liang, Chunhong Ma · 2013 · Clinical Biochemistry
  62. Patients with BRCA mutated ovarian cancer may have fewer circulating MDSC and more peripheral CD8+ T cells compared with women with BRCA wild‑type disease during the early disease course
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  63. Aberrant Genetic Control of Invariant TCR-Bearing NKT Cell Function in New Zealand Mouse Strains: Possible Involvement in Systemic Lupus Erythematosus Pathogenesis
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  64. The Role of T Cell Immunoglobulin Mucin Domains 1 and 4 in a Herpes Simplex Virus-Induced Behçet’s Disease Mouse Model
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  73. Protective Association of TIM1−1454G>A Polymorphism with Asthma in a North Indian Population
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