The TIM gene family: emerging roles in immunity and disease

Kuchroo, Vijay K., Umetsu, Dale T., DeKruyff, Rosemarie H., Freeman, Gordon J.·2003·Nature Reviews Immunology
DOI 10.1038/nri1111

Cited by (388)

Items 301–388 of 388

  1. Lineage-specific evolution of T-cell immunoglobulin and mucin domain 1 gene in the primates
    Hitoshi Ohtani, Taeko K. Naruse, Yuki Iwasaki, Hirofumi Akari, Takafumi Ishida, Tetsuro Matano, Akinori Kimura · 2012 · Immunogenetics
  2. Altered expression of Tim family molecules and an imbalanced ratio of Tim-3 to Tim-1 expression in patients with type 1 diabetes
    Yikai Liu, Zhiying Chen, Yang Xiao, Hongzhi Chen, Zhiguang Zhou · 2022 · Frontiers in Endocrinology
  3. Pooled-analysis of the association between TIM-1 5383_5397 insertion/deletion polymorphism and asthma susceptibility
    Jiangang Xu, Ping Jiang, Jiangbo Liu · 2014 · Molecular Biology Reports
  4. Expression of Tim-3 Is Transiently Increased before Development of Anterior Chamber-Associated Immune Deviation
    Yuqin Wang, Peizeng Yang, Bing Li, Hongyan Zhou, Xiangkun Huang, Yulin Wang, Wei Chi, Xuefei Zhu, Lianxiang Zhu, Aize Kijlstra · 2006 · Ocular Immunology and Inflammation
  5. Effects of Perilla frutescens L. on anti-oxidant and anti-inflammation activity
    Hyeong-U Son, Jin-Chul Heo, Myung-Sun Seo, Sang‐Han Lee · 2010 · Korean Journal of Food Preservation
  6. Incomplete clearance of apoptotic cells by core 1-derived O-glycan-deficient resident peritoneal macrophages
    Hiromasa Wakui, Sayaka Fuseya, Riku Suzuki, Miki Shimbo, Risa Okada, Mitchito Hamada, Akihiro Kuno, Kozue Hagiwara, Takashi Sato, Hisashi Narimatsu et al. · 2017 · Biochemical and Biophysical Research Communications
  7. Comment on “Tim-3 Directly Enhances CD8 T Cell Responses to Acute Listeria monocytogenes Infection”
    Vijay Kumar Kuchroo, Ana Carrizosa Anderson, Gordon James Freeman · 2014 · The Journal of Immunology
  8. Tim-1 mucin domain-mutant mice display exacerbated atherosclerosis
    Hidde Douna, Virginia Smit, Gijs H.M. van Puijvelde, Máté G. Kiss, Christoph J. Binder, llze Bot, Vijay Kumar Kuchroo, Andrew H. Lichtman, Johan Kuiper, Amanda C. Foks · 2022 · Atherosclerosis
  9. Overproduction of CXC chemokines CXCL1, CXCL9, CXCL10 and CXCL12 in β-thalassemia major or patients
    Hamid Najmaddini, Gholamhossein Hassanshahi, Hamid Ostadebrahimi, Hoda Barkhordari, Habibeh Mashayekhi‐Sardoo, Mina Nazari, Mozhgan Moogooei, Yassin Safari Arababadi, Fatemeh Peighambari, Mojgan Noroozi Karimabad · 2014 · Annals of Saudi Medicine
  10. Non-invasive messenger RNA transcriptional evaluation in human kidney allograft dysfunction
    Gabriel Joelsons, Tuany Di Domenico, Luiz Felipe Santos Gonçalves, Roberto Ceratti Manfro · 2018 · Brazilian Journal of Medical and Biological Research
  11. Associação entre o polimorfismo rs7700944 no gene TIM-4 e artrite reumatoide em Zahedan, sudeste do Irã
    Zahra Zakeri, Mohammad Mostakhdem Hashemi, Seyed Mohammad Ebrahim Pourhosseini, Ebrahim Eskandari‐Nasab, Gholamreza Bahari, Mohsen Taheri · 2013 · Revista Brasileira de Reumatologia
  12. Association between the rs7700944 polymorphism in the TIM-4 gene and rheumatoid arthritis in Zahedan, southeast Iran
    Zahra Zakeri, Mohammad Mostakhdem Hashemi, Seyed Mohammad Ebrahim Pourhosseini, Ebrahim Eskandari‐Nasab, Gholamreza Bahari, Mohsen Taheri · 2013 · Revista Brasileira de Reumatologia (English Edition)
  13. Association analysis of −416 G>C polymorphism of T‐cell immunoglobulin and mucin domain‐1 gene with asthma in Iran
    Hedayatollah Shirzad, Rezvan Meshkat, Mazdak Ganjalıkhani-Hakemi, Ali Mosayebian, Ramin Ghasemi, F. Deress, Shahrbanou Parchami Barjui, Maryam Sadri, Rasoul Salehi · 2015 · International Journal of Immunogenetics
  14. T-cell Ig and mucin domain-containing protein (Tim)-2 regulates murine allergic conjunctivitis during the effector phase
    Atsuki Fukushima, Tamaki Sumi, Ken Fukuda, Naoki Kumagai, Teruo Nishida, Ko Okumura, Hisaya Akiba, Hideo Yagita∥, Hisayuki Ueno · 2007 · Immunology Letters
  15. Differential expression of T cell immunoglobulin- and mucin-domain-containing molecule-3 (TIM-3) according to activity of Behçet's disease
    Joong Sun Lee, Mi Jin Park, Sun Park, Eun‐So Lee · 2012 · Journal of Dermatological Science
  16. Factors Underlying the Increasing Incidence and Prevalence of Allergic Diseases
    Dennis R. Ownby, Christine Cole Johnson · 2009 · Elsevier eBooks
  17. T-Cell Costimulation and Coinhibition in Graft-Versus-Host Disease and Graft-Versus-Leukemia Effect
    Yongxia Wu, Claudio Anasetti, Xue‐Zhong Yu · 2019 · Elsevier eBooks
  18. Molecular Characterization of the Porcine TIM‐3 Gene
    W. Zhao, Yunlei Li, Z. Wang, Kebin Li, Shulin Yang · 2010 · Scandinavian Journal of Immunology
  19. Fine mapping of T-cell immunoglobulin mucin domain gene 1 failed to detect a significant association with multiple sclerosis
    Christoph Grabmer, Wolfgang Nachbauer, Kathrin Schanda, P. Feurle, Klaus Loacker, Erika Scholz, Harald Schennach, Thomas Berger, Markus Reindl, Christoph Gassner · 2010 · Tissue Antigens
  20. The TIM Family of Cosignaling Receptors: Emerging Targets for the Regulation of Autoimmune Disease and Transplantation Tolerance
    Wayne Truong, A. M. James Shapiro · 2007 · Cell Transplantation
  21. Role of Cytokines in Liver Fibrosis
    Merve Anapalı, Eda Balkan · 2021 · Kafkas Journal of Medical Sciences
  22. Rheumatoid arthritis: immunogenetic factors and immune therapies
    Parveena Firdous, Kamran Nissar, Shafat Ali · 2022 · Elsevier eBooks
  23. Tim-4 alleviates acute hepatic injury by modulating homeostasis and function of NKT cells
    Yingchun Wang, Yuzhen Wang, Yutong Ge, Zhuanchang Wu, Xuetian Yue, Chunyang Li, Xiaohong Liang, Chunhong Ma, Pei Wang, Lifen Gao · 2024 · Clinical & Experimental Immunology
  24. Dipalmitoyl-phosphatidylserine-filled cationic maltodextrin nanoparticles exhibit enhanced efficacy for cell entry and intracellular protein delivery in phagocytic THP-1 cells
    Clément Brinkhuizen, Damien Shapman, Alexis Lebon, Magalie Bénard, Meryem Tardivel, Laurent Dubuquoy, Ludovic Galas, Rodolphe Carpentier · 2023 · BioMolecular Concepts
  25. Discovery of TIM-3: Beyond a Th1 Regulator
    Ana Carrizosa Anderson · 2024 · The Journal of Immunology
  26. Tim-1-mediated extracellular matrix promotes the development of hepatocellular carcinoma
    Ruheng Hua, Pengfei Yu, Wanting Zheng, Nuwa Wu, Wangjianfei Yu, Qingyu Kong, Jun He, Lei Qin · 2024 · Acta Biochimica et Biophysica Sinica
  27. Unraveling the immunomodulatory role of TIM-3 in head and neck squamous cell carcinoma: implications for targeted therapy
    Shuang Xu, Luo Yang, Yuzhu He, Yuxiang Chen, Fengfeng Qin, Wenjian Hu · 2025 · Discover Oncology
  28. A Pan‐Cancer Study of Tumour‐Associated Efferocytosis Core Genes and Preliminary Exploration of TIMD4 in Renal Cell Carcinoma
    Hongze Li, Jiaqi Zhang, Yixiao Zhang, Zixuan Li, Yuxi Han, Yu Lun · 2025 · Journal of Cellular and Molecular Medicine
  29. The Role of Semaphorins and their Receptors in the Immune System and their Relation to Multiple Sclerosis
    Ramin Lotfi, Kheirollah Yari · 2018 · The Neuroscience Journal of Shefaye Khatam
  30. Advances in the study of TIM3 in myelodysplastic syndrome
    Xinyu Guo, Shunjie Yu, Jinglian Tao, Yingshuai Wang, Zonghong Shao, Rong Fu, Lijuan Li · 2025 · Frontiers in Immunology
  31. Molecular Characteristics of the Porcine TIMD4 Gene and Its Association Analysis
    Jing Yuan, Zhonglin Tang, Shulin Yang, Jiyue Cao, Kui Li · 2012 · Biochemical Genetics
  32. Noninvasive Prediction of Immune Rejection After Liver Transplantation with T cell immunoglobulin domain, and mucin domain-3
    Qin Li, Weixiong Zheng, Shiming Jiang, Hao Thi Tang, Meng Cai, Anke Chen, Yong Chen · 2022 · Transplantation Proceedings
  33. TIM proteins and microRNAs: distinct impact and promising interactions on transplantation immunity
    Jialing Tao, Xiaoxuan Shen, Haiqing Qian, Qing Ding, Lihong Wang · 2024 · Frontiers in Immunology
  34. HAVCR1 in cancer: A systematic review of its dual-faceted role as a biomarker and therapeutic target
    Amirali Soltaninegar, Fatemeh Sadat Jalilzadeh Ghahi, Sepideh Hosseini, Najaf Allahyari Fard · 2025 · Gene Reports
  35. Altered expression of T cell Immunoglobulin-Mucin (Tim) molecules in peripheral blood mononuclear cells in aplastic anemia
    Xin Liu, Xin Cui, Dai Yuan, Ying Li, Ning‐ning Shan, Xin Wang, Yu Hu · 2014 · Cancer Cell International
  36. Application of circuit simulation method for differential modeling of TIM-2 iron uptake and metabolism in mouse kidney cells
    Zhijian Xie, Scott Henry Harrison, Suzy V. Torti, Frank M. Torti, Jian Han · 2013 · Frontiers in Physiology
  37. Differential analysis of CD4+ Th memory clones with identical T‐cell receptor (TCR)‐αβ rearrangement (non‐transgenic), but distinct lymphokine phenotype, reveals diverse and novel gene expression
    Christine M. Graham, D. Brian Thomas · 2004 · Immunology
  38. Screening and identification of miRNAs regulating the toxicological mechanism of four toxins of Clostridium perfringens in silico
    Milad Rafat, Seyed Ali Mirhosseini, Jafar Amani · 2025 · Microbial Pathogenesis
  39. Immune checkpoints and immunoregulation in metabolic diseases and cancers: pathological mechanisms and therapeutic potential
    Minmin Xiang, Shuang Liu, Desheng Xiao, Yongguang Tao · 2026 · Signal Transduction and Targeted Therapy
  40. Distribution characteristics and linkage disequilibrium of TIM4 promoter polymorphisms in asthma patients of Chinese Han population
    Pengcheng Cai, Qiwen Wu, Lin Wang, Juan Xiong, Fenghua Chen, Lihua Hu · 2008 · Journal of Huazhong University of Science and Technology [Medical Sciences]
  41. Interactions of human T cell immunoglobin mucins with apoptotic cells
    Zhizhong Chen, Jilin Qing, Lihua Hu · 2012 · Journal of Huazhong University of Science and Technology [Medical Sciences]
  42. Immune Pathogenesis of Viral Hepatitis B and C
    Kyong‐Mi Chang · 2012 · Elsevier eBooks
  43. Hepatitis A Virus Cellular Receptor 1 (HAVcr-1) Initiates Prostate Cancer Progression in Human Cells via Hepatocyte Growth Factor (HGF)-Induced Changes in Junctional Integrity
    Emily Telford, Andrew James Sanders, Sioned Owen, Fiona Ruge, Gregory M. Harrison, Wen G. Jiang, Tracey Amanda Martin · 2022 · Biomolecules
  44. Association between two TIM-1 Promoter SNPs (-416G>C and -1454G>A) and Allergic Rhinitis in Egyptian Patients
    Amal A. Ibrahim Amin, Marian Asaad Gerges · 2016 · International Journal of Current Microbiology and Applied Sciences
  45. Transplantation Immunobiology
    Mohamed H. Sayegh, Anil K. Chandraker · 2012 · Elsevier eBooks
  46. Semaphorins in the immune system
    Atsusi Kumanogoh, T. Shikina, Kazuya Suzuki, M. Yamamoto, H. Takamatsu, Noriko Takegahara, Satoko Marukawa, I. Ishida, Durbaka V. R. Prasad, Toshihiko Toyofuku et al. · 2005 · International Congress Series
  47. Kidney Injury Molecule-1 Signalling in Ischemic Acute Kidney Injury and Phagocytosis
    Ola Z. Ismail · 2015 · Scholarship@Western (Western University)
  48. Modulation de la synthèse de l'IgE chez l'homme
    Jean‐Paul Dessaint · 2004 · Revue Française d Allergologie et d Immunologie Clinique
  49. Background and References
    Predicted N-terminus Glu · 2014
  50. T-Cell Costimulatory Molecules
    Qiquan Sun, X.C. Li · 2022 · Springer eBooks
  51. Análise quantitativa do RNA mensageiro associada aos diferentes esquemas imunossupressores em pacientes transplantados renais : avaliação pela reação em cadeia da polimerase em tempo real em células sanguíneas e do sedimento urinário
    Caroline Rech · 2011 · Americanae (AECID Library)
  52. The Role of TIM-4 in the Intestinal Inflammation
    Natasha Nurtanio · 2012 · MacSphere (McMaster University)
  53. New Markers of Kidney Injury
    Sven A. Beushausen · 2010 · Pharmaceutical Sciences Encyclopedia
  54. T-Cell Costimulatory Molecules
    Qiquan Sun, X.C. Li · 2014 · Springer eBooks
  55. Molecular characterization of T‐cell immunoglobulin mucin domain‐3 and Galectin‐9 genes of swamp‐ and riverine‐type water buffaloes
    P. L. H. Duran, Ryan Bismark C. Padiernos, Evaristo A. Abella, Satoru Konnai, Claro N. Mingala · 2015 · International Journal of Immunogenetics
  56. Involvement of semaphorins in autoimmunity
    Hyota Takamatsu, Atsushi Kumanogoh · 2005 · Japanese Journal of Clinical Immunology
  57. Regulation of transplantation tolerance by antigen-presenting cells
    Reginald M. Gorczynski · 2005 · Transplantation Reviews
  58. Role of TIM family members in immune regulation: recent progress
    Liang Xiao, Jiayong Dong, Fang Liu, Quanxing Wang, Guoshan Ding, Zhiren Fu · 2010 · Academic Journal of Second Military Medical University
  59. IDENTIFICATION OF GENES THAT REGULATE ARTHRITIS AND IgE PRODUCTION IN RAT AND HUMAN
    Ulrica Ribbhammar · 2005 · Figshare
  60. Concurrent exposure to microbial products and food antigens triggers initiation of food allergy.
    Xiao Chen, Pingchang Yang · 2009 · Europe PMC (PubMed Central)
  61. Notice of Retraction: Ectopic Expression of Tim-3 Induces Tumor-Specific Antitumor Immunity
    Osama A. O. Elhag, Xiaojing Hu, Weiying Zhang, Li Xiong, Yongze Yuan, Lingfeng Deng, Deli Liu, Yingle Liu, Hui Geng · 2011 · International Conference on Bioinformatics and Biomedical Engineering · Retracted
  62. Klonierung, Expression und initiale Charakterisierung vom humanen TIM3
    Zhang, Shengtao · 2004
  63. Original articles Anti-T-cell Ig and mucin domain-containing protein 1 antibody decreases T H 2 airway inflammation in a mouse model of asthma
    Jeffrey A. Encinas, Edith M. Janssen, David B. Weiner, Thomas Moll, Dennis J. Carlo, Ronald B. Moss · 2005
  64. Cellular and molecular events controlling acquisition of cytotoxic activity by melanoma-reactive CD4⁺ T cells in vivo
    Katharina F. Bergerhoff · 2016 · UCL Discovery (University College London)
  65. Viruses as initiators, accelerators or terminators of autoimmunity? — a question of time and location of infection
    Urs Christen, Matthias G. von Herrath · 2005 · Springer eBooks
  66. Sema4A and Chronic Inflammation
    Daisuke Ito, Atsushi Kumanogoh · 2016 · Springer eBooks
  67. Tim3 – tolerance's little helper!
    Jenny Buckland · 2003 · Nature reviews. Immunology
  68. Disease in a Changing Ocean: Ecoimmunological Approaches to Coral Reef Ecology
    Lauren E. Fuess · 2018 · UTA ResearchCommons (University of Texas Arlington)
  69. Immunology of Melanoma
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  70. New Markers of Kidney Injury
    Sven A. Beushausen · 2020
  71. Evasion of type I IFN signaling by the small hydrophobic protein of HMPV and the implications for viral replication and pathogenesis
    Andrew K. Hastings · 2015
  72. IMMUNE RESPONSES IN CLINICALLY AND GENETICALLY DEFINED SUBGROUPS OF PATIENTS WITH PULMONARY SARCOIDOSIS
    Farah Idali · 2008
  73. Immunology of Melanoma
    Paul F. Robbins, Yong‐Chen Lu · 2020 · Springer eBooks
  74. Proteína TIM-3 solúvel (sTIM-3) e carcinoma mamário
    Laura Maciel Rocha Penteado de Aguiar · 2021
  75. Cytokine Production in Reinfection BCG Lesions and in Tuberculin Reactions
    Arthur M. Dannenberg · 2014 · ASM Press eBooks
  76. Faculty Opinions recommendation of Binding and uptake of H-ferritin are mediated by human transferrin receptor-1.
    Grant A. Ramm · 2010 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  77. Modulating the function of T cell immunoglobulin mucin cell surface proteins for therapeutic immunoregulation
    2006 · Expert Opinion on Therapeutic Patents
  78. Japanese Encephalitis Virus NS1’ Protein regulates the expression and distribution of TIM-1 to promote viral infection
    Zhenjie Liang, Shengda Xie, Junhui Pan, Xingmiao Yang, Wenlong Jiao, Rui Cao · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  79. Bregs Correction of Th17/Tregs Imbalance Regulates Systemic Lupus Erythematosus Complicated with Atherosclerosis
    Zhen‐Zhen Zhu, Xiaolan Yang, Si‐Ru Wei, Yahui Wang, Hailu Mo, Hanyou Mo · 2025 · Research Square
  80. Knockdown of TIM1 enhances platinum chemosensitivity and inhibits progression through the MAPK signaling pathway in gastric cancer
    Congkai Zhang · 2025 · American Journal of Translational Research
  81. TIM-4 Regulates Allergic Airway Inflammation and Mast Cell Activation by Binding to CD300b
    Yuki Tanabe, Fumitaka Kamachi, Jun Ito, Norihiro Harada, Sonoko Harada, Fumihiko Makino, Yoshiyuki Abe, Nobuhiro Nakano, Kumi Izawa, François Niyonsaba et al. · 2025 · Journal of Asthma and Allergy
  82. Additional file 1 of Knockdown of ELF4 aggravates renal injury in ischemia/reperfusion mice through promotion of pyroptosis, inflammation, oxidative stress, and endoplasmic reticulum stress
    Li Li, Shunying Wang, Wang, Wenming · 2023 · Figshare
  83. Bibliometric analysis of knowledge maps and future trends of TIM-3 in cancer
    Shuchi Lv, Shanchuan Huang, Li Li, Kaifeng Lisa Lin, H Q Zhang, Yuqi Huang · 2026 · Frontiers in Oncology
  84. Immunomodulation de l'arthrite expérimentale par les cellules dendritiques tolérogènes.
    Julie Quentin · 2011 · theses.fr (ABES)
  85. Association entre polymorphisme de gènes de l'immunité et évènements cliniques post-transplantation rénale
    Thomas Hoffmann · 2009
  86. Molecular and cellular basis of phosphatidylserine receptors mediated flavivirus infection
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  87. KIM-1 as a Biomarker in Genitourinary Neoplasms
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  88. Multi-omics integration reveals TIM-4 as a master regulatory hub of neuroinflammation and neuronal cell death
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