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NOX enzymes and the biology of reactive oxygen
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“In the rest of the non-phagocytic cells, NADP oxidase is represented by NOX (non-phagocytic NADPH oxidase), enzymes producing small constitutive pulses of O2•−, which are key players in cell signalling [30], Figure 12.”
From Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity (2023) · cites this paper as [30]
In the citing paper
“No off-target effects were detected against a panel of 135 enzymes, including XO and eNOS (545).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [545]
In the citing paper
“GKT-136901 was first characterized as a selective NOX1 and NOX4 inhibitor, although it can also inhibit NOX 2 at higher concentrations (545).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [545]
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Metadata
- Authors
- Lambeth, J. D.
- Affiliations
- Emory University (US)
- Corresponding author
- Lambeth, J. David
- Venue
- Nature Reviews Immunology
- Published
- 2004-03
- Volume
- 4
- Issue
- 3
- Pages
- 181-189
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2102619095
- Cited by
- 3,125
- References
- 68
- Citations by year
- 2026: 72 · 2025: 83 · 2024: 79 · 2023: 119 · 2022: 125 · 2021: 131 · 2020: 133 · 2019: 152 · 2018: 122 · 2017: 153 · 2016: 151 · 2015: 150 · 2014: 185 · 2013: 181 · 2012: 173
- FWCI
- 11.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Keywords
- NADPH oxidase, gp91phox, reactive oxygen species, superoxide, phagocytes, innate immunity, signal transduction, extracellular matrix modification, non-phagocytic cells
- MeSH terms
- Animals, Cell Division, Humans, Phagocytes, Signal Transduction, Apoptosis, Reactive Oxygen Species, NADPH Oxidases
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