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NOX enzymes and the biology of reactive oxygen
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“In the rest of the non-phagocytic cells, NADP oxidase is represented by NOX (non-phagocytic NADPH oxidase), enzymes producing small constitutive pulses of O2•−, which are key players in cell signalling [30], Figure 12.”
From Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity (2023) · cites this paper as [30]
In the citing paper
“No off-target effects were detected against a panel of 135 enzymes, including XO and eNOS (545).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [545]
In the citing paper
“GKT-136901 was first characterized as a selective NOX1 and NOX4 inhibitor, although it can also inhibit NOX 2 at higher concentrations (545).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [545]
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Metadata
- Authors
- Lambeth, J. D.
- Affiliations
- Emory University (US)
- Corresponding author
- Lambeth, J. David
- Venue
- Nature Reviews Immunology
- Published
- 2004-03
- Volume
- 4
- Issue
- 3
- Pages
- 181-189
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2102619095
- Cited by
- 3,125
- References
- 68
- Citations by year
- 2026: 72 · 2025: 83 · 2024: 79 · 2023: 119 · 2022: 125 · 2021: 131 · 2020: 133 · 2019: 152 · 2018: 122 · 2017: 153 · 2016: 151 · 2015: 150 · 2014: 185 · 2013: 181 · 2012: 173
- FWCI
- 11.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Keywords
- NADPH oxidase, gp91phox, reactive oxygen species, superoxide, phagocytes, innate immunity, signal transduction, extracellular matrix modification, non-phagocytic cells
- MeSH terms
- Animals, Cell Division, Humans, Phagocytes, Signal Transduction, Apoptosis, Reactive Oxygen Species, NADPH Oxidases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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