NOX enzymes and the biology of reactive oxygen

Superoxide Dismutase

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Superoxide and hydrogen peroxide in relation to mammalian cell proliferation

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Killing activity of neutrophils is mediated through activation of proteases by K+ flux

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Reversible Inactivation of the Tumor Suppressor PTEN by H2O2

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Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo

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Reversible inactivation of protein-tyrosine phosphatase 1B in A431 cells stimulated with epidermal growth factor

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Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1

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The Neutrophil NADPH Oxidase

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NADPH oxidases: new actors in thyroid cancer?

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Calcium/Calmodulin-Dependent Kinase II Mediates the Phosphorylation and Activation of NADPH Oxidase 5

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Mitigating the Impact of Antibacterial Drug Resistance through Host-Directed Therapies: Current Progress, Outlook, and Challenges

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NOX signaling in molecular cardiovascular mechanisms involved in the blood pressure homeostasis

Santillo, M., Colantuoni, A., Mondola, P., Guida, B., & Damiano, S. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00194 · Cited by 95

Inducible nitric oxide synthase is key to peroxynitrite-mediated, LPS-induced protein radical formation in murine microglial BV2 cells

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NOX1 loss-of-function genetic variants in patients with inflammatory bowel disease

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Atractylenolide III Attenuates Muscle Wasting in Chronic Kidney Disease via the Oxidative Stress-Mediated PI3K/AKT/mTOR Pathway

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NOX4 as a critical effector mediating neuroinflammatory cytokines, myeloperoxidase and osteopontin, specifically in astrocytes in the hippocampus in Parkinson's disease

Boonpraman, N., Yoon, S., Kim, C. Y., Moon, J., & Yi, S. S. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102698 · Cited by 95

Pharmacological inhibition of TLR4-NOX4 signal protects against neuronal death in transient focal ischemia

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Pivotal role of NOX‐2‐containing NADPH oxidase in early ischemic preconditioning

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The Rac activator Tiam1 prevents keratinocyte apoptosis by controlling ROS-mediated ERK phosphorylation

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Chronic Granulomatous Disease and Other Disorders of Phagocyte Function

Dinauer, M. C. (2005) · Hematology · doi:10.1182/asheducation-2005.1.89 · Cited by 95

Targeting inflammation and oxidative stress in atrial fibrillation: role of 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibition with statins

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Cellular Compartmentalization, Glutathione Transport and Its Relevance in Some Pathologies

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Role of Angiotensin II type 1 receptor on renal NAD(P)H oxidase, oxidative stress and inflammation in nitric oxide inhibition induced-hypertension

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Autophagy: Dual Response in the Development of Hepatocellular Carcinoma

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Les Nox/Duox : une nouvelle famille de NADPH oxydases

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Alsin and SOD1G93A Proteins Regulate Endosomal Reactive Oxygen Species Production by Glial Cells and Proinflammatory Pathways Responsible for Neurotoxicity

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Molecular evolution of Phox-related regulatory subunits for NADPH oxidase enzymes

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NOX enzymes and Toll-like receptor signaling

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Altered mitochondrial metabolism in the insulin‐resistant heart

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Biocommunication of Fungi

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Simultaneous Detection of Reactive Oxygen and Nitrogen Species Released by a Single Macrophage by Triple Potential-Step Chronoamperometry

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Cytosolic phospholipase A2, lipoxygenase metabolites, and reactive oxygen species

Kim, C.-M., Kim, J., & Kim, J. (2008) · BMB Reports · doi:10.5483/bmbrep.2008.41.8.555 · Cited by 93

Impact of hypothalamic reactive oxygen species in the regulation of energy metabolism and food intake

Drougard, A., Fournel, A., Valet, P., & Knauf, C. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00056 · Cited by 93

ATP released from β‐amyloid-stimulated microglia induces reactive oxygen species production in an autocrine fashion

Kim, S. Y., Moon, J. H., Lee, H. G., Kim, S. U., & Lee, Y. B. (2007) · Experimental & Molecular Medicine · doi:10.1038/emm.2007.89 · Cited by 93

Involvement of NADPH Oxidases in Cardiac Remodelling and Heart Failure

Sirker, A. A., Zhang, M., Murdoch, C. E., & Shah, A. M. (2007) · American Journal of Nephrology · doi:10.1159/000109148 · Cited by 93

Rhinovirus infection liberates planktonic bacteria from biofilm and increases chemokine responses in cystic fibrosis airway epithelial cells

Chattoraj, S. S., Ganesan, S., Jones, A. M., Helm, J. M., Comstock, A. T., Bright-Thomas, R. J., LiPuma, J. J., Hershenson, M. B., & Sajjan, U. S. (2011) · Thorax · doi:10.1136/thx.2010.151431 · Cited by 93

Biological signaling by small inorganic molecules

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Nadph oxidase 1 in liver macrophages promotes inflammation and tumor development in mice

Liang, S., Ma, H.-Y., Zhong, Z., Dhar, D., Liu, X., Xu, J., Koyama, Y., Nishio, T., Karin, D., Karin, G., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2018.11.019 · Cited by 92

Melatonin: A novel candidate for the treatment of osteoarthritis

Zhang, Y., Liu, T., Yang, H., He, F., & Zhu, X. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101635 · Cited by 92

The protective role of nutritional antioxidants against oxidative stress in thyroid disorders

Mačvanin, M., Gluvic, Z. M., Zafirovic, S. S., Gao, X., Essack, M., & Isenović, E. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1092837 · Cited by 92

Activation of NADPH oxidase and extracellular superoxide production in seizure‐induced hippocampal damage

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ROS, Notch, and Wnt Signaling Pathways: Crosstalk between Three Major Regulators of Cardiovascular Biology

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G6PC3 mutations are associated with a major defect of glycosylation: a novel mechanism for neutrophil dysfunction

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Polypyrrole Nanotube Embedded Reduced Graphene Oxide Transducer for Field-Effect Transistor-Type H2O2 Biosensor

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New Insights Into the Roles of NADPH Oxidases in Sexual Development and Ascospore Germination in Sordaria macrospora

Nordzieke, D. E., Nowrousian, M., Cano-Domínguez, N., Aguirre, J., Teichert, I., & Kück, U. (2014) · Genetics · doi:10.1534/genetics.113.159368 · Cited by 91

The role of NOX inhibitors in neurodegenerative diseases

Barua, S., Kim, J. Y., Yenari, M. A., & Lee, J. E. (2019) · IBRO Reports · doi:10.1016/j.ibror.2019.07.1721 · Cited by 91

The NADPH Oxidase Family and Its Inhibitors

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Effect of Reactive Oxygen Species on the Endoplasmic Reticulum and Mitochondria during Intracellular Pathogen Infection of Mammalian Cells

Lee, J., & Song, C. (2021) · Antioxidants · doi:10.3390/antiox10060872 · Cited by 91

Macrophage acetyl-CoA carboxylase regulates acute inflammation through control of glucose and lipid metabolism

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Targeting oxidative stress-mediated regulated cell death as a vulnerability in cancer

Chen, D., Guo, Z., Yao, L., Sun, Y., Dian, Y., Zhao, D., Ke, Y., Zeng, F., Zhang, C., Deng, G., et al. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103686 · Cited by 95

Role of the small GTPase Rac in p22 -dependent NADPH oxidases

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Heat shock protein gp96 and NAD(P)H oxidase 4 play key roles in Toll-like receptor 4-activated apoptosis during renal ischemia/reperfusion injury

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A Porous Bimetallic Au@Pt Core–Shell Oxygen Generator to Enhance Hypoxia-Dampened Tumor Chemotherapy Synergized with NIR-II Photothermal Therapy

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Multifaceted mitochondria in innate immunity

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CARD9 facilitates microbe-elicited production of reactive oxygen species by regulating the LyGDI-Rac1 complex

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Histone Deacetylase Inhibitors Impair Antibacterial Defenses of Macrophages

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Hydrogen peroxide reactivity and specificity in thiol-based cell signalling

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Activin and NADPH-oxidase in preeclampsia: insights from in vitro and murine studies

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Silencing Nox4 in the Paraventricular Nucleus Improves Myocardial Infarction–Induced Cardiac Dysfunction by Attenuating Sympathoexcitation and Periinfarct Apoptosis

Infanger, D. W., Cao, X., Butler, S. D., Burmeister, M. A., Zhou, Y., Stupinski, J. A., Sharma, R. V., & Davisson, R. L. (2010) · Circulation Research · doi:10.1161/circresaha.109.213025 · Cited by 89

Actin filaments—A target for redox regulation

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Oxidative stress and hepatic Nox proteins in chronic hepatitis C and hepatocellular carcinoma

Choi, J., Corder, N. L. B., Koduru, B., & Wang, Y. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.04.020 · Cited by 88

Maintaining system homeostasis: the third law of Newtonian immunology

Germain, R. N. (2012) · Nature Immunology · doi:10.1038/ni.2404 · Cited by 88

The Pivotal Role of Reactive Oxygen Species Generation in the Hypoxia-Induced Stimulation of Adipose-Derived Stem Cells

Kim, J. H., Park, S.-H., Park, S. G., Choi, J.-S., Xia, Y., & Sung, J.-H. (2011) · Stem Cells and Development · doi:10.1089/scd.2010.0469 · Cited by 88

Looking beyond death: a morphogenetic role for the TNF signalling pathway

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Vav proteins control MyD88-dependent oxidative burst

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Calcium microdomains and oxidative stress

Davidson, S. M., & Duchen, M. R. (2006) · Cell Calcium · doi:10.1016/j.ceca.2006.08.017 · Cited by 88

Opposing Actions of Heat Shock Protein 90 and 70 Regulate Nicotinamide Adenine Dinucleotide Phosphate Oxidase Stability and Reactive Oxygen Species Production

Chen, F., Yu, Y., Qian, J., Wang, Y., Cheng, B., Dimitropoulou, C., Patel, V. S., Chadli, A., Rudic, R. D., Stepp, D. W., et al. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.300361 · Cited by 88

Transforming growth factor β1 (TGFβ1)-induced CD44V6-NOX4 signaling in pathogenesis of idiopathic pulmonary fibrosis

Ghatak, S., Hascall, V., Markwald, R. R., Feghali‐Bostwick, C. A., Artlett, C. M., Gooz, M. B., Bogatkevich, G. S., Atanelishvili, I., Silver, R. M., Wood, J. M., et al. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.752469 · Cited by 88

Redox Signaling of NADPH Oxidases Regulates Oxidative Stress Responses, Immunity and Aging

Ewald, C. Y. (2018) · Antioxidants · doi:10.3390/antiox7100130 · Cited by 88

Targeting reactive oxygen species in hypertension

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Urothelial cells produce hydrogen peroxide through the activation of duox1

Donkó, Á., Ruisanchez, É., Orient, A., Enyedi, B., Kapui, R., Péterfi, Z., de Deken, X., Benyó, Z., & Geiszt, M. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.09.027 · Cited by 87

NADPH-oxidase-dependent reactive oxygen species mediate EGFR transactivation by FPRL1 in WKYMVm-stimulated human lung cancer cells

Cattaneo, F., Iaccio, A., Guerra, G., Montagnani, S., & Ammendola, R. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.05.040 · Cited by 87

Cellular redox dysfunction in the development of cardiovascular diseases

Kanaan, G. N., & Harper, M. (2017) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2017.07.027 · Cited by 87

Neuroinflammation, oxidative stress, and blood-brain barrier (BBB) disruption in acute Utah electrode array implants and the effect of deferoxamine as an iron chelator on acute foreign body response

Bennett, C., Mohammed, F. S., Álvarez-Ciara, A., Nguyen, M. A., Dietrich, W. D., Rajguru, S. M., Streit, W. J., & Prasad, A. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.09.040 · Cited by 87

High generation of reactive oxygen species from neutrophils in patients with severe COVID-19

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Bis-chalcones: A review of synthetic methodologies and anti-inflammatory effects

Pereira, R., Silva, A. M. S., Ribeiro, D., Silva, V. L. M., & Fernandes, E. G. R. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115280 · Cited by 87

Synergistic activation of glucose-6-phosphate dehydrogenase and NAD(P)H oxidase by Src kinase elevates superoxide in type 2 diabetic, Zucker fa/fa, rat liver

Gupte, R. S., Floyd, B. C., Kozicky, M., George, S., Ungvari, Z. I., Neito, V., Wolin, M. S., & Gupte, S. A. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.01.028 · Cited by 87

Novel sources of reactive oxygen species in the human body

Orient, A., Donkó, Á., Szabo, A. J., Leto, T. L., & Geiszt, M. (2007) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfm077 · Cited by 88

Lipopolysaccharides Trigger Two Successive Bursts of Reactive Oxygen Species at Distinct Cellular Locations

Shang‐Guan, K., Wang, M., Htwe, N. M. P. S., Li, P., Li, Y., Qi, F., Zhang, D., Cao, M., Kim, C., Weng, H., et al. (2018) · PLANT PHYSIOLOGY · doi:10.1104/pp.17.01637 · Cited by 87

Architecture of the NADPH oxidase family of enzymes

Ogboo, B. C., Grabovyy, U. V., Maini, A., Scouten, S., van der Vliet, A., Mattevi, A., & Heppner, D. E. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102298 · Cited by 86

NADPH Oxidase and Cardiac Failure

Kuroda, J., & Sadoshima, J. (2010) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-010-9184-8 · Cited by 86

The CD14+CD16+ Inflammatory Monocyte Subset Displays Increased Mitochondrial Activity and Effector Function During Acute Plasmodium vivax Malaria

Antonelli, L. R. D. V., Leoratti, F. M. S., Costa, P. A. C., Rocha, B. C., Diniz, S. Q., Tada, M. S., Pereira, D. B., Teixeira‐Carvalho, A., Golenbock, D. T., Gonçalves, R., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004393 · Cited by 86

Production of Reactive Oxygen Species Is Turned On and Rapidly Shut Down in Epithelial Cells Infected with Chlamydia trachomatis

Boncompain, G., Schneider, B., Delevoye, C., Kellermann, O., Dautry‐Varsat, A., & Subtil, A. (2009) · Infection and Immunity · doi:10.1128/iai.00725-09 · Cited by 86

NADPH Oxidases NOXs and DUOXs as Putative Targets for Cancer Therapy

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Oxidants and Redox Signaling in Acute Lung Injury

Sarma, J. V., & Ward, P. A. (2011) · Comprehensive physiology · doi:10.1002/cphy.c100068 · Cited by 86

Identification of the hallmarks of necroptosis and ferroptosis by transmission electron microscopy

Miyake, S., Murai, S., Kakuta, S., Uchiyama, Y., & Nakano, H. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.04.127 · Cited by 85

Unraveling the role of FoxOs in bone—Insights from mouse models

Almeida, M. (2011) · Bone · doi:10.1016/j.bone.2011.05.023 · Cited by 85

Roles of reactive oxygen species in hepatocarcinogenesis and drug resistance gene expression in liver cancers

Kuo, M. T., & Savaraj, N. (2006) · Molecular Carcinogenesis · doi:10.1002/mc.20240 · Cited by 85

NAD(P)H Oxidase Activity of Nox4 in Chondrocytes Is Both Inducible and Involved in Collagenase Expression

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Myeloperoxidase-induced Genomic DNA-centered Radicals

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Recognition of apoptotic cells by macrophages activates the peroxisome proliferator-activated receptor-γ and attenuates the oxidative burst

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