NOX enzymes and the biology of reactive oxygen

Superoxide Dismutase

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Cell transformation by the superoxide-generating oxidase Mox1

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Superoxide and hydrogen peroxide in relation to mammalian cell proliferation

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Killing activity of neutrophils is mediated through activation of proteases by K+ flux

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Reversible Inactivation of the Tumor Suppressor PTEN by H2O2

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Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo

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Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1

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The Neutrophil NADPH Oxidase

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Involvement of Rac1 in Activation of Multicomponent Nox1- and Nox3-Based NADPH Oxidases

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Oxidative Stress Is a Key Modulator in the Development of Nonalcoholic Fatty Liver Disease

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Nox2 and Rac1 Regulate H2O2-Dependent Recruitment of TRAF6 to Endosomal Interleukin-1 Receptor Complexes

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Reactive Oxygen Production Induced by the Gut Microbiota: Pharmacotherapeutic Implications

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Point Mutations in the Proline-rich Region of p22 Are Dominant Inhibitors of Nox1- and Nox2-dependent Reactive Oxygen Generation

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Reactive oxygen species in phagocytic leukocytes

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Expression and Modulation of an NADPH Oxidase in Mammalian Astrocytes

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NADPH oxidases and cancer

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Mechanism of All-trans-retinal Toxicity with Implications for Stargardt Disease and Age-related Macular Degeneration

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Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis

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Toxic Effects of Nanoplastics with Different Sizes and Surface Charges on Epithelial-to-Mesenchymal Transition in A549 Cells and the Potential Toxicological Mechanism

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Redox signaling in cardiovascular health and disease

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Oxidative stress and chronic inflammation in osteoarthritis: can NRF2 counteract these partners in crime?

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Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity

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Redox Regulation of Nuclear Post-Translational Modifications During NF-κB Activation

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Role of NADPH Oxidases in Liver Fibrosis

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A Porous Au@Rh Bimetallic Core–Shell Nanostructure as an H 2 O 2 ‐Driven Oxygenerator to Alleviate Tumor Hypoxia for Simultaneous Bimodal Imaging and Enhanced Photodynamic Therapy

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Oxidative stress, free radicals and bone remodeling

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Toll-like receptor 4 deficiency causes pulmonary emphysema

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NADPH oxidases: New kids on the block

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Neutrophils: important contributors to tumor progression and metastasis

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Role of DUOX in gut inflammation: lessons from Drosophila model of gut-microbiota interactions

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Oxidative Stress Enzymes Are Required for DAF-16-Mediated Immunity Due to Generation of Reactive Oxygen Species by Caenorhabditis elegans

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Interleukin-1β Induction of NFκB Is Partially Regulated by H2O2-mediated Activation of NFκB-inducing Kinase

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Helicobacter pylori: a ROS-inducing bacterial species in the stomach

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Regulation of the phagocyte NADPH oxidase activity: phosphorylation of gp91 phox /NOX2 by protein kinase C enhances its diaphorase activity and binding to Rac2, p67 phox , and p47 phox

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Riboflavin kinase couples TNF receptor 1 to NADPH oxidase

Yazdanpanah, B., Wiegmann, K., Tchikov, V., Krut, O., Pongratz, C., Schramm, M., Kleinridders, A., Wunderlich, T., Kashkar, H., Utermöhlen, O., et al. (2009) · Nature · doi:10.1038/nature08206 · Cited by 218

Mutual interplay of Ca2+ and ROS signaling in plant immune response

Marcec, M. J., Gilroy, S., Poovaiah, B. W., & Tanaka, K. (2019) · Plant Science · doi:10.1016/j.plantsci.2019.03.004 · Cited by 218

Signaling Components of Redox Active Endosomes: The Redoxosomes

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Ceria‐Based Therapeutic Antioxidants for Biomedical Applications

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ROS and innate immunity.

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Coupling of transcriptional response to oxidative stress and secondary metabolism regulation in filamentous fungi

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C. elegans Epidermal Wounding Induces a Mitochondrial ROS Burst that Promotes Wound Repair

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Cytokine Activation of Nuclear Factor κB in Vascular Smooth Muscle Cells Requires Signaling Endosomes Containing Nox1 and ClC-3

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Causes and consequences of plant-associated biofilms

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Specificity in reactive oxidant signaling: think globally, act locally

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Molecular aspects in pathogen-fruit interactions: Virulence and resistance

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Activation of Dual Oxidases Duox1 and Duox2

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Phagocyte NADPH oxidase: a multicomponent enzyme essential for host defenses.

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TNFα and reactive oxygen species in necrotic cell death

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Graphene/Intermetallic PtPb Nanoplates Composites for Boosting Electrochemical Detection of H 2 O 2 Released from Cells

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Nox enzymes as novel targets for drug development

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Dual oxidase in mucosal immunity and host–microbe homeostasis

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Vanillic Acid Inhibits Inflammatory Pain by Inhibiting Neutrophil Recruitment, Oxidative Stress, Cytokine Production, and NFκB Activation in Mice

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Hypoosmotic swelling and ammonia increase oxidative stress by NADPH oxidase in cultured astrocytes and vital brain slices

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Novel Mechanism of Activation of NADPH Oxidase 5

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Expression of NOX1 , a superoxide‐generating NADPH oxidase, in colon cancer and inflammatory bowel disease

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Redox signaling mediated by the gut microbiota

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Acute Effects of Heat‐Not‐Burn, Electronic Vaping, and Traditional Tobacco Combustion Cigarettes: The Sapienza University of Rome‐Vascular Assessment of Proatherosclerotic Effects of Smoking (SUR‐VAPES) 2 Randomized Trial

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NLRP3 inflammasome activation by mitochondrial ROS in bronchial epithelial cells is required for allergic inflammation

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Role of NADPH oxidase 4 in lipopolysaccharide-induced proinflammatory responses by human aortic endothelial cells

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Nonreceptor Protein-Tyrosine Phosphatases in Immune Cell Signaling

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Live Imaging of Innate Immune Cell Sensing of Transformed Cells in Zebrafish Larvae: Parallels between Tumor Initiation and Wound Inflammation

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Protein Quality Control under Oxidative Stress Conditions

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Oxidative damage pathways in relation to normal tissue injury

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Synaptic localization of a functional NADPH oxidase in the mouse hippocampus

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Reprogramming Tumor-Associated Macrophages by Nanoparticle-Based Reactive Oxygen Species Photogeneration

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The NADPH Oxidase Nox3 Constitutively Produces Superoxide in a p22 -dependent Manner

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Reactive Oxygen Species in TNFα-Induced Signaling and Cell Death

Morgan, M. J., & Liu, Z.-G. (2010) · Molecules and Cells · doi:10.1007/s10059-010-0105-0 · Cited by 203

Regulation of NF-B-Induced Inflammatory Signaling by Lipid Peroxidation-Derived Aldehydes

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Angiotensin II and the vascular phenotype in hypertension

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Impact of airborne particulate matter on skin: a systematic review from epidemiology to in vitro studies

Dijkhoff, I. M., Drasler, B., Karakocak, B. B., Petri-Fink, A., Valacchi, G., Eeman, M., & Rothen-Rutishauser, B. (2020) · Particle and Fibre Toxicology · doi:10.1186/s12989-020-00366-y · Cited by 202

NADPH oxidases in lung biology and pathology: Host defense enzymes, and more

van der Vliet, A. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.11.016 · Cited by 202

The evolution of reactive oxygen species metabolism

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Reactive oxygen species metabolism and plant-fungal interactions

Segal, L., & Wilson, R. A. (2017) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2017.12.003 · Cited by 202

Critical role of AMPK in redox regulation under glucose starvation

Ren, Y., & Shen, H. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101154 · Cited by 201

NADPH Oxidases in Heart Failure: Poachers or Gamekeepers?

Zhang, M., Perino, A., Ghigo, A., Hirsch, E., & Shah, A. M. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4550 · Cited by 200

NOX2 Complex–Derived ROS as Immune Regulators

Sareila, O., Kelkka, T., Pizzolla, A., Hultqvist, M. H., & Holmdahl, R. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3635 · Cited by 200

DUOX2-derived reactive oxygen species are effectors of NOD2-mediated antibacterial responses

Lipinski, S., Till, A., Sina, C., Arlt, A., Grasberger, H., Schreiber, S., & Rosenstiel, P. C. (2009) · Journal of Cell Science · doi:10.1242/jcs.050690 · Cited by 200

A Transverse Tubule NADPH Oxidase Activity Stimulates Calcium Release from Isolated Triads via Ryanodine Receptor Type 1 S -Glutathionylation

Hidalgo, C., Sánchez, G., Barrientos, G. C., & Aracena-Parks, P. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600451200 · Cited by 199

Reactive oxygen species: A radical role in development?

Hernández-García, D., Wood, C. D., Castro‐Obregón, S., & Covarrubias, L. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.03.020 · Cited by 199

Crosstalk Between Calcium and Redox Signaling: From Molecular Mechanisms to Health Implications

Hidalgo, C., & Donoso, P. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1886 · Cited by 199

Redox Regulation of Epidermal Growth Factor Receptor Signaling through Cysteine Oxidation

Truong, T. H., & Carroll, K. S. (2012) · Biochemistry · doi:10.1021/bi301441e · Cited by 199

NADPH Oxidases NOX-1 and NOX-2 Require the Regulatory Subunit NOR-1 To Control Cell Differentiation and Growth in Neurospora crassa

Cano-Domínguez, N., Álvarez-Delfín, K., Hansberg, W., & Aguirre, J. (2008) · Eukaryotic Cell · doi:10.1128/ec.00137-08 · Cited by 198

Requirement of Reactive Oxygen Species-dependent Activation of ASK1-p38 MAPK Pathway for Extracellular ATP-induced Apoptosis in Macrophage

Noguchi, T., Ishii, K. J., Fukutomi, H., Naguro, I., Matsuzawa, A., Takeda, K., & Ichijo, H. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m708402200 · Cited by 197

Roles of Nox1 and other Nox isoforms in cancer development

Kamata, T. (2009) · Cancer Science · doi:10.1111/j.1349-7006.2009.01207.x · Cited by 197

Modulation of Antioxidant Defense in Aspergillus parasiticus Is Involved in Aflatoxin Biosynthesis: a Role for the Ap yapA Gene

Reverberi, M., Zjalić, S., Ricelli, A., Punelli, F., Camera, E., Fabbri, C., Picardo, M., Fanelli, C., & Fabbri, A. (2008) · Eukaryotic Cell · doi:10.1128/ec.00228-07 · Cited by 197

A Cerium Vanadate Nanozyme with Specific Superoxide Dismutase Activity Regulates Mitochondrial Function and ATP Synthesis in Neuronal Cells

Singh, N., NaveenKumar, S. K., Geethika, M., & Mugesh, G. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202011711 · Cited by 197

Oxidative stress, Noxs, and hypertension: Experimental evidence and clinical controversies

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NADPH Oxidase-Dependent Reactive Oxygen Species Mediate Amplified TLR4 Signaling and Sepsis-Induced Mortality in Nrf2-Deficient Mice

Kong, X., Thimmulappa, R. K., Kombairaju, P., & Biswal, S. S. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902315 · Cited by 195

Nox4 and Nox2 NADPH Oxidases Mediate Distinct Cellular Redox Signaling Responses to Agonist Stimulation

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Nox1-Based NADPH Oxidase Is the Major Source of UVA-Induced Reactive Oxygen Species in Human Keratinocytes

Valencia, A., & Kochevar, I. E. (2008) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700960 · Cited by 194

Sleep Fragmentation Induces Cognitive Deficits Via Nicotinamide Adenine Dinucleotide Phosphate Oxidase–dependent Pathways in Mouse

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Endothelial Dysfunction and Elevated Blood Pressure in Mas Gene-Deleted Mice

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Principles in Redox Signaling: From Chemistry to Functional Significance

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Phenotypes of Mice Lacking Extracellular Superoxide Dismutase and Copper- and Zinc-containing Superoxide Dismutase

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A Novel and Specific NADPH Oxidase-1 (Nox1) Small-Molecule Inhibitor Blocks the Formation of Functional Invadopodia in Human Colon Cancer Cells

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