The DOI matches its Crossref record; 125 of the 125 references it cites were found in a registry or an index.
MHC class I molecules and kirs in human history, health and survival
Abstract
MHC class I molecules are ligands for the killer-cell immunoglobulin-like receptors (KIRs), which are expressed by natural killer cells and T cells. The interactions between these molecules contribute to both innate and adaptive immunity. KIRs and MHC class I molecules are encoded by unlinked polymorphic gene families that distinguish all but the most related individuals. Combinations of MHC class I and KIR variants influence resistance to infections, susceptibility to autoimmune diseases and complications of pregnancy, as well as outcome after haematopoietic stem-cell transplantation. Such correlations raise the possibility that interplay between KIR and MHC class I polymorphisms has facilitated human survival in the presence of epidemic infections and has influenced both reproduction and population growth.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Similarly significant differences were seen following genotyping of the mothers, suggesting a broad influence of the genetic background of NK activity, especially given that KIR/HLA complexes are expressed and active in the placenta (Guerini et al, 2014;Parham, 2005).”
From The Role of the Immune System in Autism Spectrum Disorder (2017) · cites this paper as Parham, 2005
Citations
Cites
Initial sequencing and comparative analysis of the mouse genome
Mouse Genome Sequencing Consortium (2002) · Nature · doi:10.1038/nature01262 · Cited by 7,187
Of Mice and Not Men: Differences between Mouse and Human Immunology
Mestas, J., & Hughes, C. C. W. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.5.2731 · Cited by 3,822
Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants
Ruggeri, L., Capanni, M., Urbani, E., Perruccio, K., Shlomchik, W. D., Tosti, A., Posati, S., Rogaia, D., Frassoni, F., Aversa, F., et al. (2002) · Science · doi:10.1126/science.1068440 · Cited by 3,380
Natural killer cells and pregnancy
Moffett-King, A. (2002) · Nature Reviews Immunology · doi:10.1038/nri886 · Cited by 1,235
HLA and NK Cell Inhibitory Receptor Genes in Resolving Hepatitis C Virus Infection
Khakoo, S. I., Thio, C. L., Martin, M. P., Brooks, C., Gao, X., Astemborski, J. A., Cheng, J., Goedert, J. J., Vlahov, D., Hilgartner, M. W., et al. (2004) · Science · doi:10.1126/science.1097670 · Cited by 1,178
Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS
Martin, M. P., Gao, X., Lee, J.-H., Nelson, G. W., Detels, R., Goedert, J. J., Buchbinder, S., Hoots, K. W., Vlahov, D., Trowsdale, J., et al. (2002) · Nature Genetics · doi:10.1038/ng934 · Cited by 1,173
Hiby, S. E., Walker, J. J., O’Shaughnessy, K. M., Redman, C. W. G., Carrington, M. N., Trowsdale, J., & Moffett, A. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20041214 · Cited by 1,134
Human Diversity in Killer Cell Inhibitory Receptor Genes
Uhrberg, M., Valiante, N. M., Shum, B. P., Shilling, H. G., Lienert-Weidenbach, K., Corliss, B. C., Tyan, D. B., Lanier, L. L., & Parham, P. (1997) · Immunity · doi:10.1016/s1074-7613(00)80394-5 · Cited by 1,060
Self-citationKIR: Diverse, Rapidly Evolving Receptors of Innate and Adaptive Immunity
Vilches, C., & Parham, P. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.092501.134942 · Cited by 984
Self-citationAshkar, A. A., Santo, J. P. D., & Croy, B. A. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.2.259 · Cited by 847
Flagged first, then by citations
Cited by
Sorted by citations
Items 301–400 of 1,000
The mosaic of KIR haplotypes in rhesus macaques
Blokhuis, J. H., van der Wiel, M. K. H., Doxiadis, G. G. M., & Bontrop, R. E. (2010) · Immunogenetics · doi:10.1007/s00251-010-0434-3 · Cited by 59
KIR Polymorphisms Modulate Peptide-Dependent Binding to an MHC Class I Ligand with a Bw6 Motif
Colantonio, A. D., Bimber, B. N., Neidermyer, W. J., Reeves, R. K., Alter, G., Altfeld, M. A., Johnson, R. P., Carrington, M. N., O’Connor, D. H., & Evans, D. T. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1001316 · Cited by 59
Kuśnierczyk, P. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00008 · Cited by 59
Trydzenskaya, H., Jürchott, K., Lachmann, N., Kotsch, K., Kunert, K., Weist, B. J. D., Schönemann, C., Schindler, R., Nickel, P., Melzig, M. F., et al. (2013) · Kidney International · doi:10.1038/ki.2013.59 · Cited by 58
Murphy, W. J., Parham, P., & Miller, J. S. (2012) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2011.10.033 · Cited by 57
Self-citationHammond, J. A., Guethlein, L. A., Abi‐Rached, L., Moesta, A. K., & Parham, P. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803026 · Cited by 57
Self-citationEpigenetic regulation of killer immunoglobulin–like receptor expression in T cells
Li, G., Yu, M., Weyand, C. M., & Goronzy, J. J. (2009) · Blood · doi:10.1182/blood-2009-01-200170 · Cited by 57
Structural plasticity of KIR2DL2 and KIR2DL3 enables altered docking geometries atop HLA-C
Moradi, S., Stankovic, S., O’Connor, G. M., Pymm, P., MacLachlan, B. J., Faoro, C., Retière, C., Sullivan, L. C., Saunders, P. M., Widjaja, J. M. L., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22359-x · Cited by 56
Individual HLA heterogeneity and its implications for cellular immune evasion in cancer and beyond
Pagliuca, S., Gurnari, C., Rubio, M., Visconte, V., & Lenz, T. L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.944872 · Cited by 56
Differential and tumor-specific expression of CD160 in B-cell malignancies
Farren, T., Giustiniani, J., Liu, F., Tsitsikas, D. A., Macey, M. G., Cavenagh, J. D., Oakervee, H. E., Taussig, D. C., Newland, A. C., Calaminici, M., et al. (2011) · Blood · doi:10.1182/blood-2011-02-334326 · Cited by 56
Hov, J. R., Lleò, A., Selmi, C. F., Woldseth, B., Fabris, L., Strazzabosco, M., Karlsen, T. H., & Invernizzi, P. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2009.11.029 · Cited by 56
Molecular Recognition of Paired Receptors in the Immune System
Kuroki, K., Furukawa, A., & Maenaka, K. (2012) · Frontiers in Microbiology · doi:10.3389/fmicb.2012.00429 · Cited by 56
NLRP2 is a suppressor of NF-ƙB signaling and HLA-C expression in human trophoblasts†,‡
Tilburgs, T., Meissner, T. B., Ferreira, L. M. R., Mulder, A., Musunuru, K., Ye, J., & Strominger, J. L. (2017) · Biology of Reproduction · doi:10.1093/biolre/iox009 · Cited by 58
Characterization of rhesus macaque KIR genotypes and haplotypes
Kruse, P. H., Rosner, C., & Walter, L. (2010) · Immunogenetics · doi:10.1007/s00251-010-0433-4 · Cited by 56
Faridi, R. M., Das, V., Tripthi, G., Talwar, S., Parveen, F., & Agrawal, S. (2009) · Human Reproduction · doi:10.1093/humrep/dep047 · Cited by 57
The Hardy-Weinberg principle and its applications in modern population genetics
Chen, J. J.-W. (2010) · Frontiers in Biology · doi:10.1007/s11515-010-0580-x · Cited by 55
Littera, R., Chessa, L., Deidda, S., Angioni, G., Campagna, M., Lai, S., Melis, M., Cipri, S., Firinu, D., Santus, S., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0255608 · Cited by 57
NK Cell Recognition of Mouse Cytomegalovirus-Infected Cells
Vidal, S. M., & Lanier, L. L. (2005) · Springer eBooks · doi:10.1007/3-540-27743-9_10 · Cited by 55
Compound KIR‐HLA genotype analyses in the Iranian population by a novel PCR–SSP assay
Tajik, N., Shahsavar, F., Nasiri, M., & Radjabzadeh, M. F. (2010) · International Journal of Immunogenetics · doi:10.1111/j.1744-313x.2010.00906.x · Cited by 55
Genetics of graft-versus-host disease: The major histocompatibility complex
Petersdorf, E. W. (2012) · Blood Reviews · doi:10.1016/j.blre.2012.10.001 · Cited by 59
Mapping the serum proteome to neurological diseases using whole genome sequencing
Png, G., Barysenka, A., Repetto, L., Navarro, P., Shen, X., Pietzner, M., Wheeler, E., Wareham, N. J., Langenberg, C., Tsafantakis, E., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-27387-1 · Cited by 55
El‐Jawhari, J. J., El-Sherbiny, Y. M., Scott, G. B., Morgan, R. S. M., Prestwich, R. J. D., Bowles, P. A., Blair, G. E., Tanaka, T. U., Rabbitts, T. H., Meade, J. L., et al. (2013) · Molecular Immunology · doi:10.1016/j.molimm.2013.11.020 · Cited by 54
Alomar, S. Y., Middleton, D., Marshall, E., Porter, D., Xinarianos, G., Raji, O. Y., Field, J. K., & Christmas, S. E. (2010) · Human Immunology · doi:10.1016/j.humimm.2010.06.019 · Cited by 54
At the Bedside: Innate immunity as an immunotherapy tool for hematological malignancies
Locatelli, F., Merli, P., & Rutella, S. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.0613343 · Cited by 55
Sharma, D., Bastard, K., Guethlein, L. A., Norman, P. J., Yawata, N., Yawata, M., Pando, M. J., Thananchai, H., Dong, T., Rowland-Jones, S. L., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901734 · Cited by 54
Self-citationHaspels, H. N., Rahman, M. A., Joseph, J. V., Navarro, A. G., & Chekenya, M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01345 · Cited by 55
Cariani, E., Pilli, M., Zerbini, A., Rota, C., Olivani, A., Zanelli, P., Zanetti, A., Trenti, T., Ferrari, C. I., & Missale, G. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-0986 · Cited by 54
Pathogenesis of psoriatic arthritis
Ritchlin, C. T. (2005) · Current Opinion in Rheumatology · doi:10.1097/01.bor.0000167752.93543.76 · Cited by 54
Faridi, R. M., & Agrawal, S. (2009) · Human Reproduction · doi:10.1093/humrep/dep217 · Cited by 54
Saito, H., Takaya, S., Osaki, T., & Ikeguchi, M. (2012) · Gastric Cancer · doi:10.1007/s10120-012-0210-1 · Cited by 53
The haploidentical option for high-risk haematological malignancies
Aversa, F., Reisner, Y., & Martelli, M. F. (2007) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2007.07.004 · Cited by 53
Natural Killer Cells: From Basic Research to Treatments
Vivier, É., & Ugolini, S. (2011) · Frontiers in Immunology · doi:10.3389/fimmu.2011.00018 · Cited by 53
How does variability of immune system genes affect placentation?
Colucci, F., Boulenouar, S., Kieckbusch, J., & Moffett, A. (2011) · Placenta · doi:10.1016/j.placenta.2011.05.001 · Cited by 55
Impact of KIR/HLA ligand combinations on immune responses in malignant melanoma
Naumova, E. J., Mihaylova, A., Ivanova, M., & Mihailova, S. M. (2006) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-006-0151-9 · Cited by 53
New insights into the functional role of the rheumatoid arthritis shared epitope
de Almeida, D. E., Ling, S., & Holoshitz, J. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.03.035 · Cited by 53
Holmes, T. D., El-Sherbiny, Y. M., Davison, A., Clough, S. L., Blair, G. E., & Cook, G. P. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1000951 · Cited by 52
Role of HLA in Hematopoietic Stem Cell Transplantation
Park, M., & Seo, J. J. (2012) · Bone Marrow Research · doi:10.1155/2012/680841 · Cited by 52
Juul‐Madsen, H. R., Viertlboeck, B. C., Härtle, S., Smith, A. L., & Göbel, T. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-396965-1.00007-8 · Cited by 58
The Development and Diversity of ILCs, NK Cells and Their Relevance in Health and Diseases
Zhang, Y., & Huang, B. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-5987-2_11 · Cited by 60
Åkesson, C. P., Uvebrant, K., Oderup, C., Lynch, K. F., Harris, R. A., Lernmark, Å., Agardh, C. –., & Cilio, C. (2010) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2010.04114.x · Cited by 53
The Role of Natural Killer Cells in Human Solid Organ and Tissue Transplantation
Villard, J. (2011) · Journal of Innate Immunity · doi:10.1159/000324400 · Cited by 52
Costimulatory Pathways in Rheumatoid Synovitis and T‐Cell Senescence
Goronzy, J. J., Henel, G., Sawai, H., Singh, K., Lee, E. B., Pryshchep, S., & Weyand, C. M. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1358.022 · Cited by 52
Fully functional NK cells after unrelated cord blood transplantation
Béziat, V., Nguyen, S., Lapusan, S., Hervier, B., Dhédin, N., Bories, D., Uzunov, M., Boudifa, A., Trebeden‐Negre, H., Norol, F., et al. (2009) · Leukemia · doi:10.1038/leu.2008.343 · Cited by 52
Kaufman, J. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-396965-1.00008-x · Cited by 53
Francisco, R. D. S., Bühler, S., Nunes, J. M., Bitarello, B. D., França, G. S., Meyer, D., & Sanchez‐Mazas, A. (2015) · Immunogenetics · doi:10.1007/s00251-015-0875-9 · Cited by 51
Education of hyporesponsive NK cells by cytokines
Juelke, K., Killig, M., Thiel, A., Dong, J., & Romagnani, C. (2009) · European Journal of Immunology · doi:10.1002/eji.200939307 · Cited by 51
Impact of HCMV Infection on NK Cell Development and Function after HSCT
Chiesa, M. D., Falco, M., Muccio, L., Bertaina, A., Locatelli, F., & Moretta, A. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00458 · Cited by 51
Natural killer cell adoptive immunotherapy: Coming of age
Baggio, L., Laureano, Á. M., Silla, L. M. D. R., & Lee, D. A. (2016) · Clinical Immunology · doi:10.1016/j.clim.2016.02.003 · Cited by 51
The zebrafish activating immune receptor Nitr9 signals via Dap12
Wei, S., Zhou, J., Chen, X., Shah, R. N., Liu, J., Orcutt, T. M., Traver, D. J., Djeu, J. Y., Litman, G. W., & Yoder, J. A. (2007) · Immunogenetics · doi:10.1007/s00251-007-0250-6 · Cited by 51
Sim, M. J. W., Malaker, S. A., Khan, A., Stowell, J. M., Shabanowitz, J., Peterson, M., Rajagopalan, S., Hunt, D. F., Altmann, D. M., Long, E. O., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00193 · Cited by 50
Majorczyk, E., Pawlik, A., Łuszczek, W., Nowak, I., Wiśniewski, A., Jasek, M., & Kuśnierczyk, P. (2007) · Genes and Immunity · doi:10.1038/sj.gene.6364433 · Cited by 51
Barão, I., Álvarez, M., Ames, E., Orr, M. T., Stefanski, H. E., Blazar, B. R., Lanier, L. L., Anderson, S. K., Redelman, D. D., & Murphy, W. J. (2011) · Blood · doi:10.1182/blood-2010-11-316653 · Cited by 49
Post-translational modifications of cancer immune checkpoints: mechanisms and therapeutic strategies
Jia, H., Jiang, L., Shen, X., Ye, H., Li, X., Zhang, L., Hu, Y., Song, D., Jia, H., & Wang, Z. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02397-5 · Cited by 49
Brodin, P., Lakshmikanth, T., Kärre, K., & Höglund, P. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102801 · Cited by 49
Natural killer cell alloreactivity 10 years later
Velardi, A. (2012) · Current Opinion in Hematology · doi:10.1097/moh.0b013e3283590395 · Cited by 48
The Functional Significance of Cattle Major Histocompatibility Complex Class I Genetic Diversity
Ellis, S. A., & Hammond, J. A. (2013) · Annual Review of Animal Biosciences · doi:10.1146/annurev-animal-022513-114234 · Cited by 48
Human NK Cells and Herpesviruses: Mechanisms of Recognition, Response and Adaptation
Chiesa, M. D., Maria, A. D., Muccio, L., Bozzano, F., Sivori, S., & Moretta, L. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02297 · Cited by 44
Gagne, K., Busson, M., Bignon, J., Balère, M.-L., Loiseau, P., Dormoy, A., Dubois, V., Perrier, P., Jollet, I., Bois, M., et al. (2009) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2009.06.015 · Cited by 47
Rajalingam, R. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00585 · Cited by 47
Peptide-specific engagement of the activating NK cell receptor KIR2DS1
Chapel, A., García-Beltrán, W. F., Hölzemer, A., Ziegler, M. C., Lunemann, S., Martrus, G., & Altfeld, M. A. (2017) · Scientific Reports · doi:10.1038/s41598-017-02449-x · Cited by 47
Mobbs, J. I., Illing, P. T., Dudek, N. L., Brööks, A. G., Baker, D. G., Purcell, A. W., Rossjohn, J., & Vivian, J. P. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.806976 · Cited by 47
Gabriel, I. H., Sergeant, R., Szydlo, R., Apperley, J. F., deLavallade, H., Alsuliman, A., Khoder, A., Marín, D., Kanfer, E., Cooper, N., et al. (2010) · Blood · doi:10.1182/blood-2010-03-273706 · Cited by 48
Activating KIR genes are associated with ankylosing spondylitis in Asian populations
Díaz‐Peña, R., Blanco-Gelaz, M. Á., Suárez-Álvarez, B., Martı́nez-Borra, J., López‐Vázquez, A., Alonso‐Arias, R., Bruges‐Armas, J., Vidal-Castiñeira, J. R., & López‐Larrea, C. (2008) · Human Immunology · doi:10.1016/j.humimm.2008.04.012 · Cited by 47
Ludajic, K., Balavarca, Y., Bickeböller, H., Rosenmayr, A., Faé, I., Fischer, G., Kouba, M., Pohlreich, D., Kalhs, P., & Greinix, H. (2009) · Bone Marrow Transplantation · doi:10.1038/bmt.2008.432 · Cited by 47
A Bony Fish Immunological Receptor of the NITR Multigene Family Mediates Allogeneic Recognition
Cannon, J. P., Haire, R. N., Magis, A. T., Eason, D. D., Winfrey, K. N., Prada, J. A. H., Bailey, K. M., Jakoncic, J., Litman, G. W., & Ostrov, D. A. (2008) · Immunity · doi:10.1016/j.immuni.2008.05.018 · Cited by 48
Genetics of psoriatic arthritis
O’Rielly, D. D., & Rahman, P. (2014) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2014.10.010 · Cited by 48
Hunting for clinical translation with innate-like immune cells and their receptors
Scheper, W., Gründer, C., Straetemans, T., Sebestyén, Z., & Kuball, J. H. E. (2013) · Leukemia · doi:10.1038/leu.2013.378 · Cited by 48
Corrah, T., Goonetilleke, N. P., Kopycinski, J. T., Deeks, S. G., Cohen, M. S., Borrow, P., McMichael, A. J., & Brackenridge, S. (2011) · Journal of Virology · doi:10.1128/jvi.02276-10 · Cited by 47
Moreland, A. J., Guethlein, L. A., Reeves, R. K., Broman, K. W., Johnson, R. P., Parham, P., O’Connor, D. H., & Bimber, B. N. (2011) · BMC Genomics · doi:10.1186/1471-2164-12-295 · Cited by 46
Self-citationThe yin‐yang of the interaction between myelomonocytic cells and NK cells
Molgora, M., Supino, D., Mavilio, D., Santoni, A., Moretta, L., Mantovani, A., & Garlanda, C. (2018) · Scandinavian Journal of Immunology · doi:10.1111/sji.12705 · Cited by 46
Chalandon, Y., Tiercy, J.-M., Schanz, U., Güngör, T., Seger, R. A., Halter, J. P., Helg, C., Chapuis, B., Gratwohl, A. A., Tichelli, A., et al. (2006) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1705353 · Cited by 46
Vacher-Coponat, H., Brunet, C., Moal, V., Loundou, A., Bonnet, E., Lyonnet, L., Ravet, S., Sampol-Manos, E., Sampol, J., Berland, Y., et al. (2006) · Transplantation · doi:10.1097/01.tp.0000229390.01369.4a · Cited by 46
Cellular Immunotherapy of Cancer
Okur, F. V., & Brenner, M. K. (2010) · Methods in molecular biology · doi:10.1007/978-1-60761-786-0_19 · Cited by 46
The New Kid on the Block: HLA-C, a Key Regulator of Natural Killer Cells in Viral Immunity
Vollmers, S., Lobermeyer, A., & Körner, C. (2021) · Cells · doi:10.3390/cells10113108 · Cited by 45
Genetic differences between smokers and never-smokers with lung cancer
Kuśnierczyk, P. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1063716 · Cited by 47
KIR2DL3 and KIR2DL1 show similar impact on licensing of human NK cells
Sim, M. J. W., Stowell, J. M., Sergeant, R., Altmann, D. M., Long, E. O., & Boyton, R. J. (2015) · European Journal of Immunology · doi:10.1002/eji.201545757 · Cited by 45
HLA-C and KIR Genes in Hepatitis C Virus Infection
Montes‐Cano, M. A., Caro-Oleas, J. L., Romero‐Gómez, M., Diago, M., Andrade, R. J., Carmona, I., Reina, J. A., Núñez‐Roldán, A., & González‐Escribano, M. F. (2005) · Human Immunology · doi:10.1016/j.humimm.2006.02.001 · Cited by 45
de Smith, A. J., Walsh, K. M., Ladner, M. B., Zhang, S., Xiao, C., Cohen, F., Moore, T. B., Chokkalingam, A. P., Metayer, C., Buffler, P. A., et al. (2014) · Blood · doi:10.1182/blood-2013-11-540625 · Cited by 45
Meehan, A. C., Mifsud, N. A., Nguyen, T. H. O., Levvey, B. J., Snell, G. I., Kotsimbos, T. C., & Westall, G. P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060144 · Cited by 45
The MHC class I genes of zebrafish
Ackerman, H. D., McConnell, S. C., Yoder, J. A., & de Jong, J. L. O. (2014) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2014.02.018 · Cited by 46
The role of SLAM/CD2 polymorphisms in systemic autoimmunity
Wang, A., Batteux, F., & Wakeland, E. K. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.10.014 · Cited by 45
Multiple sclerosis associates with LILRA3 deletion in Spanish patients
Ordóñez, D., Sánchez, A., Rodríguez, J., Cisneros, E., Ramil, E., Romo, N., Moraru, M., Munteis, E., López‐Botet, M., Roquer, J., et al. (2009) · Genes and Immunity · doi:10.1038/gene.2009.34 · Cited by 45
Natural Killer Cell Education Is Associated With a Distinct Glycolytic Profile
Pfeifer, C., Highton, A. J., Peine, S., Sauter, J., Schmidt, A. H., Bunders, M. J., Altfeld, M. A., & Körner, C. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.03020 · Cited by 45
CD160-activating NK cell effector functions depend on the phosphatidylinositol 3-kinase recruitment
Rabot, M., Costa, H. E., Polgár, B., Marie‐Cardine, A., Aguerre‐Girr, M., Barakonyi, A., Valitutti, S., Bensussan, A., & Bouteiller, P. L. (2007) · International Immunology · doi:10.1093/intimm/dxm005 · Cited by 45
The Intergenic Recombinant HLA-B∗46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands
Hilton, H. G., McMurtrey, C., Han, A. S., Djaoud, Z., Guethlein, L. A., Blokhuis, J. H., Pugh, J. L., Goyos, A., Horowitz, A., Buchli, R., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.04.059 · Cited by 45
Self-citationAdam, S. G., Caraux, A., Fodil-Cornu, N., Loredo‐Osti, J. C., Lesjean‐Pottier, S., Jaubert, J., Bubić, I., Jonjić, S., Guénet, J., Vidal, S. M., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.9.5478 · Cited by 45
Korbel, D. S., Norman, P. J., Newman, K. C., Horowitz, A., Gendzekhadze, K., Parham, P., & Riley, E. M. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0804224 · Cited by 44
Self-citationSun, K., Álvarez, M., Ames, E., Barão, I., Chen, M., Longo, D. L., Redelman, D. D., & Murphy, W. J. (2011) · Blood · doi:10.1182/blood-2011-08-374314 · Cited by 44
Innate receptors with high specificity for HLA class I–peptide complexes
Sim, M. J. W., Brennan, P., Wahl, K. L., Lu, J., Rajagopalan, S., Sun, P. D., & Long, E. O. (2023) · Science Immunology · doi:10.1126/sciimmunol.adh1781 · Cited by 43
David, G., Morvan, M. G., Gagne, K., Kerdudou, N., Willem, C., Devys, A., Bonneville, M., Folléa, G., Bignon, J., & Retière, C. (2009) · Immunology · doi:10.1111/j.1365-2567.2009.03085.x · Cited by 43
Natural killer cell-based therapies
Romagné, F., & Vivier, É. (2011) · F1000 Medicine Reports · doi:10.3410/m3-9 · Cited by 43
Thiruchelvam‐Kyle, L., Hoelsbrekken, S. E., Saether, P. C., Bjørnsen, E. G., Pende, D., Fossum, S., Daws, M. R., & Dissen, E. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1600930 · Cited by 44
Functional Killer Ig-Like Receptors on Human Memory CD4+ T Cells Specific for Cytomegalovirus
van Bergen, J., Kooy-Winkelaar, E. M. C., van Dongen, H., van Gaalen, F. A., Thompson, A., Huizinga, T. W. J., Feltkamp, M. C. W., Toes, R. E. M., & Koning, F. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0800455 · Cited by 43
Natural killer cell recognition of missing self and haploidentical hematopoietic transplantation
Ruggeri, L., Mancusi, A., Burchielli, E., Perruccio, K., Aversa, F., Martelli, M. F., & Velardi, A. (2006) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2006.07.007 · Cited by 43
Immunopathogenesis of Ocular Behçet’s Disease
Park, U. C., Kim, T., & Yu, H. G. (2014) · Journal of Immunology Research · doi:10.1155/2014/653539 · Cited by 42
Bühler, S., Nunes, J. M., & Sanchez‐Mazas, A. (2016) · Immunogenetics · doi:10.1007/s00251-016-0918-x · Cited by 42
A systematic review and meta‐analysis of HCV clearance
Gauthiez, É., Habfast-Robertson, I., Rüeger, S., Kutalik, Z., Aubert, V., Berg, T., Cerny, A., Gorgievski, M., George, J., Heim, M. H., et al. (2017) · Liver International · doi:10.1111/liv.13401 · Cited by 42
Comprehensive Phenotyping of Human PB NK Cells by Flow Cytometry
Zotto, G. D., Antonini, F., Pesce, S., Moretta, F., Moretta, L., & Marcenaro, E. (2020) · Cytometry Part A · doi:10.1002/cyto.a.24001 · Cited by 42
Gombos, I., Kiss, E., Detre, C., László, G., & Matkó, J. (2005) · Immunology Letters · doi:10.1016/j.imlet.2005.11.021 · Cited by 42
Hamby, K., Trexler, A. M., Pearson, T. C., Larsen, C. P., Rigby, M. R., & Kean, L. S. (2007) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2007.01864.x · Cited by 42
Metadata
- Authors
- Parham, P.
- Affiliations
- Stanford University (US)
- Corresponding author
- Parham, Peter
- ORCID
- Parham, Peter
- Venue
- Nature Reviews Immunology
- Published
- 2005-02-18
- Volume
- 5
- Issue
- 3
- Pages
- 201-214
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2008919922
- Cited by
- 1,203
- References
- 125
- Citations by year
- 2026: 28 · 2025: 36 · 2024: 35 · 2023: 23 · 2022: 44 · 2021: 38 · 2020: 43 · 2019: 54 · 2018: 46 · 2017: 50 · 2016: 57 · 2015: 55 · 2014: 57 · 2013: 95 · 2012: 77
- FWCI
- 5.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Keywords
- MHC class I, killer cell immunoglobulin-like receptors, natural killer cells, T cells, infection resistance, autoimmune disease susceptibility, pregnancy complications, hematopoietic stem cell transplantation, human survival, immune system evolution, reproduction
- MeSH terms
- Animals, Autoimmune Diseases, Communicable Diseases, Humans, Lymphocytes, Neoplasms, Receptors, Immunologic, Histocompatibility Antigens Class I, Models, Immunological, Evolution, Molecular, Receptors, KIR
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review