Cited by 1,203Immune Cell Function and InteractionReproductive System and Pregnancyinterferon and immune responses

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MHC class I molecules and kirs in human history, health and survival

Parham, Peter·2005·Nature Reviews Immunology

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Abstract

MHC class I molecules are ligands for the killer-cell immunoglobulin-like receptors (KIRs), which are expressed by natural killer cells and T cells. The interactions between these molecules contribute to both innate and adaptive immunity. KIRs and MHC class I molecules are encoded by unlinked polymorphic gene families that distinguish all but the most related individuals. Combinations of MHC class I and KIR variants influence resistance to infections, susceptibility to autoimmune diseases and complications of pregnancy, as well as outcome after haematopoietic stem-cell transplantation. Such correlations raise the possibility that interplay between KIR and MHC class I polymorphisms has facilitated human survival in the presence of epidemic infections and has influenced both reproduction and population growth.

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Authors: Parham, P.
Affiliations: Stanford University (US)
Corresponding author: Parham, Peter
ORCID: Parham, Peter
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2005-02-18
Volume: 5
Issue: 3
Pages: 201-214
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri1570
OpenAlex: W2008919922
Cited by: 1,203
References: 125
Citations by year: 2026: 28 · 2025: 36 · 2024: 35 · 2023: 23 · 2022: 44 · 2021: 38 · 2020: 43 · 2019: 54 · 2018: 46 · 2017: 50 · 2016: 57 · 2015: 55 · 2014: 57 · 2013: 95 · 2012: 77
FWCI: 5.61
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Keywords: MHC class I, killer cell immunoglobulin-like receptors, natural killer cells, T cells, infection resistance, autoimmune disease susceptibility, pregnancy complications, hematopoietic stem cell transplantation, human survival, immune system evolution, reproduction
MeSH terms: Animals, Autoimmune Diseases, Communicable Diseases, Humans, Lymphocytes, Neoplasms, Receptors, Immunologic, Histocompatibility Antigens Class I, Models, Immunological, Evolution, Molecular, Receptors, KIR

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MHC class I molecules and kirs in human history, health and survival

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