Two sides of a cellular coin: CD4(+)CD3- cells regulate memory responses and lymph-node organization

Lane, Peter J. L.; Gaspal, Fabrina M. C.; Kim, Mi-Yeon

doi:10.1038/nri1665

Cited by 76T-cell and B-cell ImmunologyHIV Research and TreatmentImmunotherapy and Immune Responses

Two sides of a cellular coin: CD4(+)CD3- cells regulate memory responses and lymph-node organization

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Lane, Peter J. L., Gaspal, Fabrina M. C., Kim, Mi-Yeon·2005·Nature Reviews Immunology

DOI 10.1038/nri1665PMC PMC1351344

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Abstract

We propose that CD4(+)CD3(-) cells have two functions: a well-established role in organizing lymphoid tissue during development, and a newly discovered role in supporting T-cell help for B cells both during affinity maturation in germinal centres and for memory antibody responses. As CD4(+)CD3(-) cells express the HIV co-receptors CD4 and CXC-chemokine receptor 4, we think that infection of these cells by HIV, and their subsequent destruction by the host immune system, could help to explain the loss of memory antibody responses and the destruction of lymphoid architecture that occur during disease progression to AIDS.

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LTi cells are CD3−CD4+ and play a role in promoting the survival of T cells that support memory B cells within lymphoid tissue.
“These might represent a small subset of ILCs, called lymphoid tissue-inducer (LTi) cells, which are CD3−CD4+ and play a role in promoting the survival of T cells that support memory B cells within lymphoid tissue.38”
From Characterizing the cellular immune response to subretinal AAV gene therapy in the murine retina (2021) · cites this paper as [38]
The Abstract proposes that adult CD4+CD3− cells promote T-cell survival, and ‘T-cell help for memory antibody responses’ links their survival signals to memory T cells that help B cells. ‘Lymph-node organogenesis’ identifies inducer cells with a similar CD4+CD3− phenotype but says their relationship to the adult cells is contentious. The paper therefore supports the proposed function of adult cells, not an established survival role for LTi cells as such. (LLM, conf=0.84)
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CD4 + CD3 - Cells Regulate the Organization of Lymphoid Tissue and T-Cell Memory for Antibody Responses
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Authors: Lane, P. J. L., Gaspal, F. M. C., & Kim, M.-Y.
Affiliations: University of Birmingham (GB)
Corresponding author: Lane, Peter J. L.
ORCID: Lane, Peter J. L.
Gaspal, Fabrina M. C.
Kim, Mi-Yeon
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2005-07-20
Volume: 5
Issue: 8
Pages: 655-660
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri1665
PMC: PMC1351344
OpenAlex: W1528686575
Cited by: 76
References: 61
Citations by year: 2025: 3 · 2024: 1 · 2023: 2 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 7 · 2012: 6
FWCI: 0.58
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Funders: Wellcome Trust (065695)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: thymic stromal cells, lymphoid organogenesis, germinal center, B cell help, affinity maturation, memory B cells, HIV infection, CCR4, CD4, AIDS, immunosenescence
MeSH terms: Animals, HIV, Immunologic Memory, Lymph Nodes, CD4-Positive T-Lymphocytes, CD4 Antigens, CD3 Complex, Organogenesis, Mice

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Two sides of a cellular coin: CD4(+)CD3- cells regulate memory responses and lymph-node organization

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