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Tuning inflammation and immunity by chemokine sequestration: decoys and more
Abstract
A set of chemokine receptors are structurally unable to elicit migration or conventional signalling responses after ligand engagement. These 'silent' (non-signalling) chemokine receptors regulate inflammatory and immune reactions in different ways, including by acting as decoys and scavengers. Chemokine decoy receptors recognize distinct and complementary sets of ligands and are strategically expressed in different cellular contexts. Importantly, viruses and parasites have evolved multiple strategies to elude chemokines, including the expression of decoy receptors. So, decoy receptors for chemokines represent a general strategy to tune, shape and temper innate and adaptive immunity.
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“As they persist in tissues, senescent cells likely create a proinflammatory tissue environment, which is known to be protumorigenic [ 3 , 64 ].”
From Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor (2008) · cites this paper as [64]
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“Actually, MCP1 and MUC5AC are responsible for inflammatory cells infiltration[37] and hypersecretion of mucus [38].”
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Metadata
- Authors
- Mantovani, A., Bonecchi, R., & Locati, M.
- Affiliations
- University of Milan (IT)
- Corresponding author
- Mantovani, Alberto
- Venue
- Nature Reviews Immunology
- Published
- 2006-12-01
- Volume
- 6
- Issue
- 12
- Pages
- 907-918
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W1970170374
- Cited by
- 481
- References
- 106
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 8 · 2023: 14 · 2022: 16 · 2021: 21 · 2020: 22 · 2019: 17 · 2018: 21 · 2017: 27 · 2016: 22 · 2015: 29 · 2014: 24 · 2013: 39 · 2012: 39
- FWCI
- 3.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministero della Salute
- Ministero dell'Università e della Ricerca
- Topics
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Keywords
- chemokine receptors, leukocyte recruitment, inflammation regulation, immunomodulation, parasite evasion, innate immunity, adaptive immunity
- MeSH terms
- Animals, Cell Movement, Immunity, Inflammation, Parasites, Protein Conformation, Viruses, Chemokines, Receptors, Chemokine, Mice
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