Cited by 481Chemokine receptors and signalingImmune Response and InflammationInflammation biomarkers and pathways

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Tuning inflammation and immunity by chemokine sequestration: decoys and more

Mantovani, Alberto, Bonecchi, Raffaella, Locati, Massimo·2006·Nature Reviews Immunology

DOI 10.1038/nri1964

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Abstract

A set of chemokine receptors are structurally unable to elicit migration or conventional signalling responses after ligand engagement. These 'silent' (non-signalling) chemokine receptors regulate inflammatory and immune reactions in different ways, including by acting as decoys and scavengers. Chemokine decoy receptors recognize distinct and complementary sets of ligands and are strategically expressed in different cellular contexts. Importantly, viruses and parasites have evolved multiple strategies to elude chemokines, including the expression of decoy receptors. So, decoy receptors for chemokines represent a general strategy to tune, shape and temper innate and adaptive immunity.

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Chemokines
Zlotnik, A., & Yoshie, O. (2000) · Immunity · doi:10.1016/s1074-7613(00)80165-x · Cited by 3,923
Chemokines — Chemotactic Cytokines That Mediate Inflammation
Luster, A. D. (1998) · New England Journal of Medicine · doi:10.1056/nejm199802123380706 · Cited by 3,633
The many roles of chemokines and chemokine receptors in inflammation
Charo, I. F., & Ransohoff, R. M. (2006) · New England Journal of Medicine · doi:10.1056/nejmra052723 · Cited by 2,523
Chemokines
Rollins, B. J. (1997) · Blood · doi:10.1182/blood.v90.3.909.909_909_928 · Cited by 2,126
The Resistance Factor toPlasmodium vivaxin Blacks
Miller, L. H., Mason, S. J., CLYDE, D. F., & McGinniss, M. H. (1976) · New England Journal of Medicine · doi:10.1056/nejm197608052950602 · Cited by 1,259
The Molecular Biology of Leukocyte Chemoattractant Receptors
Murphy, P. M. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.003113 · Cited by 1,197
Interleukin-1 Type II Receptor: A Decoy Target for IL-1 That Is Regulated by IL-4
Colotta, F., Re, F., Muzio, M., Bertini, R., Polentarutti, N., Sironi, M., Giri, J. G., Dower, S., Sims, J. E., & Mantovani, A. (1993) · Science · doi:10.1126/science.8332913 · Cited by 979
Self-citation
Anti-Immunology: Evasion of the Host Immune System by Bacterial and Viral Pathogens
Finlay, B. B., & McFadden, G. (2006) · Cell · doi:10.1016/j.cell.2006.01.034 · Cited by 917
Chemokine receptors: multifaceted therapeutic targets
Proudfoot, A. E. I. (2002) · Nature reviews. Immunology · doi:10.1038/nri722 · Cited by 755
Transcytosis and Surface Presentation of IL-8 by Venular Endothelial Cells
Middleton, J., Neil, S. J. D., Wintle, J., Clark‐Lewis, I., Moore, H. D., Lam, C., Auer, M., Hub, E., & Rot, A. (1997) · Cell · doi:10.1016/s0092-8674(00)80422-5 · Cited by 729

Show all 106 references

Research works printed but not linked: 1

Rollins, B. J. Chemokines. Blood 90, 909–928 (1997). · DOI

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Cord immunoproteins as predictors of respiratory outcome in preterm infants
Kaukola, T., Tuimala, J., Herva, R., Kingsmore, S. F., & Hallman, M. (2008) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2008.07.070 · Cited by 49
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Pathogen-imposed skewing of mouse chemokine and cytokine expression at the infected tissue site.
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Yapa, S., Mulla, O., Green, V., England, J. A., & Greenman, J. (2017) · Thyroid · doi:10.1089/thy.2016.0660 · Cited by 43
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Russo, R. C., Garcia, C. C., & Teixeira, M. M. (2010) · PubMed · Cited by 43
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Hsu, D. S., Kim, M. K., Balakumaran, B. S., Acharya, C. R., Anders, C. K., Clay, T. M., Lyerly, H. K., Drake, C. G., Morse, M. A., & Febbo, P. G. (2010) · Cancer Investigation · doi:10.3109/07357900903095755 · Cited by 43
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Xue, X., Lu, Q., Wei, H., Wang, D., Chen, D., He, G., Huang, L., Wang, H., & Wang, X. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002162 · Cited by 42
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Authors: Mantovani, A., Bonecchi, R., & Locati, M.
Affiliations: University of Milan (IT)
Corresponding author: Mantovani, Alberto
ORCID: Mantovani, Alberto
Bonecchi, Raffaella
Locati, Massimo
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2006-12-01
Volume: 6
Issue: 12
Pages: 907-918
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri1964
OpenAlex: W1970170374
Cited by: 481
References: 106
Citations by year: 2026: 5 · 2025: 11 · 2024: 8 · 2023: 14 · 2022: 16 · 2021: 21 · 2020: 22 · 2019: 17 · 2018: 21 · 2017: 27 · 2016: 22 · 2015: 29 · 2014: 24 · 2013: 39 · 2012: 39
FWCI: 3.10
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: Ministero della Salute
Ministero dell'Università e della Ricerca
Topics: Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Keywords: chemokine receptors, leukocyte recruitment, inflammation regulation, immunomodulation, parasite evasion, innate immunity, adaptive immunity
MeSH terms: Animals, Cell Movement, Immunity, Inflammation, Parasites, Protein Conformation, Viruses, Chemokines, Receptors, Chemokine, Mice

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Tuning inflammation and immunity by chemokine sequestration: decoys and more

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