The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Unveiling the roles of autophagy in innate and adaptive immunity
Open accessAbstract
Cells digest portions of their interiors in a process known as autophagy to recycle nutrients, remodel and dispose of unwanted cytoplasmic constituents. This ancient pathway, conserved from yeast to humans, is now emerging as a central player in the immunological control of bacterial, parasitic and viral infections. The process of autophagy may degrade intracellular pathogens, deliver endogenous antigens to MHC-class-II-loading compartments, direct viral nucleic acids to Toll-like receptors and regulate T-cell homeostasis. This Review describes the mechanisms of autophagy and highlights recent advances relevant to the role of autophagy in innate and adaptive immunity.
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Cites
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
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Self-citationReactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4
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HSV-1 ICP34.5 Confers Neurovirulence by Targeting the Beclin 1 Autophagy Protein
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Self-citationBeclin–phosphatidylinositol 3‐kinase complex functions at the trans‐Golgi network
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Cited by
Autophagy in the Pathogenesis of Disease
Levine, B., & Kroemer, G. (2008) · Cell · doi:10.1016/j.cell.2007.12.018 · Cited by 7,069
Self-citationAutophagy fights disease through cellular self-digestion
Mizushima, N., Levine, B., Cuervo, A. M., & Klionsky, D. J. (2008) · Nature · doi:10.1038/nature06639 · Cited by 6,452
Self-citationEndoplasmic reticulum stress and the inflammatory basis of metabolic disease
Hotamisligil, G. S. (2010) · Cell · doi:10.1016/j.cell.2010.02.034 · Cited by 2,802
Abraham, C., & Cho, J. H. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804647 · Cited by 2,712
Komatsu, M., Kurokawa, H., Waguri, S., Taguchi, K., Kobayashi, A., Ichimura, Y., Sou, Y.-S., Ueno, I., Sakamoto, A., Tong, K. I., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2021 · Cited by 2,288
Metadata
- Authors
- Levine, B., & Deretic, V.
- Venue
- Nature Reviews Immunology
- Published
- 2007-10
- Volume
- 7
- Issue
- 10
- Pages
- 767-777
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2021490026
- Cited by
- 906
- References
- 12
- FWCI
- 9.40
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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