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Unveiling the roles of autophagy in innate and adaptive immunity
Open accessAbstract
Cells digest portions of their interiors in a process known as autophagy to recycle nutrients, remodel and dispose of unwanted cytoplasmic constituents. This ancient pathway, conserved from yeast to humans, is now emerging as a central player in the immunological control of bacterial, parasitic and viral infections. The process of autophagy may degrade intracellular pathogens, deliver endogenous antigens to MHC-class-II-loading compartments, direct viral nucleic acids to Toll-like receptors and regulate T-cell homeostasis. This Review describes the mechanisms of autophagy and highlights recent advances relevant to the role of autophagy in innate and adaptive immunity.
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Metadata
- Authors
- Levine, B., & Deretic, V.
- Venue
- Nature Reviews Immunology
- Published
- 2007-10
- Volume
- 7
- Issue
- 10
- Pages
- 767-777
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2021490026
- Cited by
- 906
- References
- 12
- FWCI
- 9.40
- Type
- journal article
- Language
- en
- Open access
- bronze
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