The DOI matches its Crossref record; 118 of the 118 references it cites were found in a registry or an index.
TH17 cells in development: an updated view of their molecular identity and genetic programming
Abstract
Following activation, CD4+ T cells differentiate into different lineages of helper T (T(H)) cells that are characterized by distinct developmental regulation and biological functions. T(H)17 cells have recently been identified as a new lineage of effector T(H) cells, and they have been shown to be important in immune responses to infectious agents, as well as in various immune diseases. Over the past two to three years, there has been a rapid progress in our understanding of the differentiation programme of T(H)17 cells. Here, I summarize our current knowledge of the unique gene expression, cytokine-mediated regulation and transcriptional programming of T(H)17 cells, and provide my personal perspectives on the future studies that are required to elucidate this lineage in more detail.
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“TH17 and Treg cells share a common requirement for TGF-p in their differentiation requirements despite expressing distinct transcriptional regulators (RORγt vs. Foxp3 respectively) and demonstrating opposing functions (inflammatory vs. anti-inflammatory)(Bettelli et al., 2006; Dong, 2008; Littman and Rudensky, 2010; Mangan et al., 2006; O'Quinn et al., 2008; Veldhoen et al., 2006).”
From Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1 (2011) · cites this paper as Dong, 2008
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A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
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Self-citationIL-23 drives a pathogenic T cell population that induces autoimmune inflammation
Langrish, C. L., Chen, Y., Blumenschein, W. M., Mattson, J., Basham, B., Sedgwick, J. D., McClanahan, T., Kastelein, R. A., & Cua, D. J. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041257 · Cited by 4,099
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Transforming growth factor-β induces development of the TH17 lineage
Mangan, P. R., Harrington, L. E., O'Quinn, D. B., Helms, W. S., Bullard, D. C., Elson, C. O., Hatton, R. D., Wahl, S. M., Schoeb, T. R., & Weaver, C. T. (2006) · Nature · doi:10.1038/nature04754 · Cited by 3,087
A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene
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NF-κB signaling in inflammation
Liu, T., Zhang, L., Joo, D., & Sun, S.-C. (2017) · Signal Transduction and Targeted Therapy · doi:10.1038/sigtrans.2017.23 · Cited by 8,791
Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
Dang, E. V., Barbi, J., Yang, H.-Y., Jinasena, D., Yu, H., Zheng, Y., Bordman, Z., Fu, J., Kim, Y., Yen, H.-R., et al. (2011) · Cell · doi:10.1016/j.cell.2011.07.033 · Cited by 1,595
DeNardo, D. G., Barreto, J., Andreu, P., Vásquez, L. J., Tawfik, D., Kolhatkar, N. S., & Coussens, L. M. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.06.018 · Cited by 1,395
Reboldi, A., Coisne, C., Baumjohann, D., Benvenuto, F., Bottinelli, D., Lira, S., Uccelli, A., Lanzavecchia, A., Engelhardt, B., & Sallusto, F. (2009) · Nature Immunology · doi:10.1038/ni.1716 · Cited by 1,206
Nurieva, R. I., Chung, Y., Hwang, D., Yang, X. O., Kang, H. S., Ma, L., Wang, Y.-H., Watowich, S. S., Jetten, A. M., Tian, Q., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.05.009 · Cited by 1,205
Self-citation
Metadata
- Authors
- Dong, C.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- Corresponding author
- Dong, Chen
- ORCID
- Dong, Chen
- Venue
- Nature reviews. Immunology
- Published
- 2008-05
- Volume
- 8
- Issue
- 5
- Pages
- 337-348
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2074067501
- Cited by
- 1,064
- References
- 118
- Citations by year
- 2026: 21 · 2025: 18 · 2024: 22 · 2023: 29 · 2022: 36 · 2021: 45 · 2020: 35 · 2019: 37 · 2018: 48 · 2017: 50 · 2016: 56 · 2015: 62 · 2014: 76 · 2013: 72 · 2012: 88
- FWCI
- 9.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Keywords
- Th17 cells, T helper cell differentiation, CD4+ T cells, transcriptional regulation, cytokine signaling, gene expression, immune disorders
- MeSH terms
- Animals, Autoimmune Diseases, Cell Differentiation, Communicable Diseases, Gene Expression Regulation, T-Lymphocytes, Helper-Inducer, Humans, Inflammation, Transcription Factors, Transcription, Genetic, Gene Expression, Cytokines, Cell Lineage, Interleukin-17
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