Cited by 1,064Psoriasis: Treatment and PathogenesisT-cell and B-cell ImmunologyIL-33, ST2, and ILC Pathways

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TH17 cells in development: an updated view of their molecular identity and genetic programming

Dong, Chen·2008·Nature reviews. Immunology

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Abstract

Following activation, CD4+ T cells differentiate into different lineages of helper T (T(H)) cells that are characterized by distinct developmental regulation and biological functions. T(H)17 cells have recently been identified as a new lineage of effector T(H) cells, and they have been shown to be important in immune responses to infectious agents, as well as in various immune diseases. Over the past two to three years, there has been a rapid progress in our understanding of the differentiation programme of T(H)17 cells. Here, I summarize our current knowledge of the unique gene expression, cytokine-mediated regulation and transcriptional programming of T(H)17 cells, and provide my personal perspectives on the future studies that are required to elucidate this lineage in more detail.

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Self-citation

Authors: Dong, C.
Affiliations: The University of Texas MD Anderson Cancer Center (US)
Corresponding author: Dong, Chen
ORCID: Dong, Chen
Venue: Nature reviews. Immunology
Publisher: Springer Science and Business Media LLC
Published: 2008-05
Volume: 8
Issue: 5
Pages: 337-348
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri2295
OpenAlex: W2074067501
Cited by: 1,064
References: 118
Citations by year: 2026: 21 · 2025: 18 · 2024: 22 · 2023: 29 · 2022: 36 · 2021: 45 · 2020: 35 · 2019: 37 · 2018: 48 · 2017: 50 · 2016: 56 · 2015: 62 · 2014: 76 · 2013: 72 · 2012: 88
FWCI: 9.10
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
Keywords: Th17 cells, T helper cell differentiation, CD4+ T cells, transcriptional regulation, cytokine signaling, gene expression, immune disorders
MeSH terms: Animals, Autoimmune Diseases, Cell Differentiation, Communicable Diseases, Gene Expression Regulation, T-Lymphocytes, Helper-Inducer, Humans, Inflammation, Transcription Factors, Transcription, Genetic, Gene Expression, Cytokines, Cell Lineage, Interleukin-17

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TH17 cells in development: an updated view of their molecular identity and genetic programming

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