The DOI matches its Crossref record; 127 of the 128 references it cites were found in a registry or an index.
Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections.
Open accessAbstract
A diverse and well-balanced repertoire of T cells is thought to be crucial for the efficacious defence against infection with new or re-emerging pathogens throughout life. In the last third of the mammalian lifespan, the maintenance of a balanced T-cell repertoire becomes highly challenging because of the changes in T-cell production and consumption. In this Review, I question whether latent persistent pathogens might be key factors that drive this imbalance and whether they determine the extent of age-associated immune deficiency.
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“The impact of HIV disease on this process is not known, but emerging data suggest that these co-infections interact in a potential negative manner (41–44).”
From HIV and Aging: State of Knowledge and Areas of Critical Need for Research. A Report to the NIH Office of AIDS Research by the HIV and Aging Working Group (2012) · cites this paper as [41]
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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846 · cited 1×
“Following encounter with antigen, naive T cells first generate effector T cells (CD69 hi CD25 hi CCR7 low CD62L low CD127 low CD27 low ) and then memory T cells, which can be broadly divided into central memory T cells (CD69 − CD25 − CCR7 hi CD62L hi CD127 hi CD27 hi ) and effector memory T cells (CD69 − CD25 − CCR7 h…”
BackgroundPD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
Day, C. L., Kaufmann, D. E., Kiepiela, P., Brown, J. A., Moodley, E. S., Reddy, S., Mackey, E. W., Miller, J. D., Leslie, A. J., DePierres, C., et al. (2006) · Nature · doi:10.1038/nature05115 · Cited by 2,680
Sylwester, A. W., Mitchell, B. L., Edgar, J. B., Taormina, C., Pelte, C., Ruchti, F., Sleath, P. R., Grabstein, K. H., Hosken, N. A., Kern, F., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050882 · Cited by 1,339
Age-related changes in lymphocyte development and function
Linton, P. J., & Dorshkind, K. A. (2004) · Nature Immunology · doi:10.1038/ni1033 · Cited by 1,199
The aging immune system: primer and prospectus
Miller, R. A. (1996) · Science · doi:10.1126/science.273.5271.70 · Cited by 1,165 · cited 1×
“jpg" NDATA ITEM> ]> Ageing of the immune system involves a complex set of changes that are collectively termed immune senescence (reviewed in Ref”
BackgroundBrenchley, J. M., Karandikar, N. J., Betts, M. R., Ambrozak, D. R., Hill, B. J., Crotty, L. E., Casazza, J. P., Kuruppu, J., Migueles, S. A., Connors, M., et al. (2003) · Blood · doi:10.1182/blood-2002-07-2103 · Cited by 1,073 · cited 1×
“, and CD57, which has been shown in HIV-infected subjects to mark replicatively senescent cells likely to undergo apoptosi”
BackgroundInterleukin-10 determines viral clearance or persistence in vivo
Brooks, D. G., Trifilo, M. J., Edelmann, K. H., Teyton, L., McGavern, D. B., & Oldstone, M. B. A. (2006) · Nature Medicine · doi:10.1038/nm1492 · Cited by 937 · cited 1×
“, as well as the blockade of IL-10, a cytokine often associated with inhibition of type 1 immunit”
BackgroundPD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection
Petrovas, C., Casazza, J. P., Brenchley, J. M., Price, D. A., Gostick, E., Adams, W. C., Precopio, M. L., Schacker, T., Roederer, M., Douek, D. C., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061496 · Cited by 889
Differential Requirements for Survival and Proliferation of CD8 Naïve or Memory T Cells
Tanchot, C., Lemonnier, F. A., Pérarnau, B., Freitas, A. A., & Rocha, B. (1997) · Science · doi:10.1126/science.276.5321.2057 · Cited by 856
Fuel feeds function: energy metabolism and the T-cell response
Fox, C. J., Hammerman, P. S., & Thompson, C. B. (2005) · Nature reviews. Immunology · doi:10.1038/nri1710 · Cited by 841 · cited 1×
“Although we have precise information on the role of cytokines (primarily IL-7, IL-15 and IL-2) and self-peptide–MHC complexes, it is less clear how metabolic signal”
Background
Research works printed but not linked: 2
- Mocarski, E. S. & Courcelle, C. T. Cytomegaloviruses and their replication, in Fields Virology 4th edn (eds Knipe, D. M. & Howley, P. M.) 2629–2674 (Lippincot Williams & Wilkins, Philadelphia, 2001).
- Pass, R. F. Cytomegalovirus, in Fields Virology 4th edn (eds Knipe, D. M. & Howley, P. M.) 2675–2706 (Lippincot Williams & Wilkins, Philadelphia, 2001).
Cited by
Sorted by citations
The role of senescent cells in ageing
van Deursen, J. M. (2014) · Nature · doi:10.1038/nature13193 · Cited by 2,623
A guide to vaccinology: from basic principles to new developments
Pollard, A. J., & Bijker, E. M. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-020-00479-7 · Cited by 1,593
Redefining Chronic Viral Infection
Virgin, H. W., Wherry, E. J., & Ahmed, R. (2009) · Cell · doi:10.1016/j.cell.2009.06.036 · Cited by 1,031
Immunosenescence: molecular mechanisms and diseases
Liu, Z., Liang, Q., Ren, Y., Guo, C., Ge, X., Wang, L., Cheng, Q., Luo, P., Zhang, Y., & Han, X. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01451-2 · Cited by 1,082
“Persistent antigen stimulation and stress-induced damage Numerous discoveries have generated a consensus that the antigen burden to which individuals are exposed during their lifetime is linked to immunosenescence.(60) Khan et al.”
BackgroundThe aging of the immune system
Weiskopf, D., Weinberger, B., & Grubeck-Loebenstein, B. (2009) · Transplant International · doi:10.1111/j.1432-2277.2009.00927.x · Cited by 908
Metadata
- Authors
- Nikolich-Žugich, J.
- Venue
- Nature reviews. Immunology
- Published
- 2008-07
- Volume
- 8
- Issue
- 7
- Pages
- 512-522
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- PMC
- PMC5573867
- OpenAlex
- W1926141441
- Cited by
- 463
- References
- 128
- Citations by year
- 2026: 23 · 2025: 28 · 2024: 18 · 2023: 26 · 2022: 28 · 2021: 30 · 2020: 24 · 2019: 17 · 2018: 28 · 2017: 20 · 2016: 21 · 2015: 24 · 2014: 35 · 2013: 35 · 2012: 23
- FWCI
- 2.05
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (n01ai50027-8-0-1)
- U.S. Public Health Service (N01 50027)
- National Institute on Aging (AG 20719, AG23664, P01AG023664, AG 21384, R01AG020719, U01AG021384, R37AG020719)
- National Institute of Allergy and Infectious Diseases (N01 AI050027)
- National Center for Research Resources (RR-0163, P51RR000163, K01RR000163)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Keywords
- immunosenescence, T cell homeostasis, T cell subsets, persistent viruses, T cell receptor repertoire, aging
- MeSH terms
- Aging, Animals, Cell Differentiation, Herpes Simplex, Homeostasis, Humans, Infections, Receptors, Antigen, T-Cell, Thymus Gland, T-Lymphocyte Subsets, Cellular Senescence
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