Cited by 940Inflammatory Bowel DiseaseGenetic Associations and EpidemiologyOcular Diseases and Behçet’s Syndrome

The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.

The genetics and immunopathogenesis of inflammatory bowel disease

Cho, Judy H.·2008·Nature Reviews Immunology

Open this paper in CoChat — free account

Abstract

Genome-wide association studies efficiently and powerfully assay common genetic variation. The application of these studies to Crohn's disease has provided insight into the immunopathogenesis of this disease, implicating a role for genes of the innate and adaptive immune systems. In this Review, I discuss our current understanding of the genetics and immunopathogenesis of Crohn's disease and ulcerative colitis. Crohn's disease, but not ulcerative colitis, is associated with genetic variation in NOD2 and an autophagy gene, ATG16L1, both of which affect the intracellular processing of bacterial components. By contrast, variation in the gene encoding the interleukin-23 (IL-23) receptor subunit, as well as in the IL12B, STAT3 and NKX2-3 gene regions, is associated with both Crohn's disease and ulcerative colitis. Comparative analyses of gene associations between these two inflammatory bowel diseases reveal common and unique mechanisms of their immunopathogenesis.

Integrity signals

Registry

Crossref · 10.1038/nri2340

Cites

99 of 99 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
Hugot, J.-P., Chamaillard, M., Zouali, H., Lesage, S., Cézard, J.-P., Belaiche, J., Almer, S., Tysk, C., O'Morain, C. A., Gassull, M., et al. (2001) · Nature · doi:10.1038/35079107 · Cited by 5,591
The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells
Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
Ogura, Y., Bonen, D. K., Inohara, N., Nicolae, D. L., Chen, F. F., Ramos, R., Britton, H., Moran, T., Karaliuskas, R., Duerr, R. H., et al. (2001) · Nature · doi:10.1038/35079114 · Cited by 5,030
Self-citation
A second generation human haplotype map of over 3.1 million SNPs
The International HapMap Consortium (2007) · Nature · doi:10.1038/nature06258 · Cited by 4,438
Unravelling the pathogenesis of inflammatory bowel disease
Xavier, R. J., & Podolsky, D. K. (2007) · Nature · doi:10.1038/nature06005 · Cited by 4,364
TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells
Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., & Stockinger, B. (2006) · Immunity · doi:10.1016/j.immuni.2006.01.001 · Cited by 3,605
Inflammatory Bowel Disease
Podolsky, D. K. (2002) · New England Journal of Medicine · doi:10.1056/nejmra020831 · Cited by 3,183
Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences
Loftus, E. V. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.01.063 · Cited by 3,106

Flagged first, then by citations

Show all 99 references

Research works printed but not linked: 2

Binder, V. Genetic epidemiology in inflammatory bowel disease. Digest. Dis. 16, 351–355 (1998). · DOI
Yang, H. & Rotter, J. I. in Inflammatory Bowel Disease (eds Kirsner, J. B. & Shorter, R. G.) 301–331 (Williams & Wilkins, Baltimore, 1995).

Sorted by citations

Items 401–500 of 939

Barrier immunity and IL-17
Marks, B. R., & Craft, J. E. (2009) · Seminars in Immunology · doi:10.1016/j.smim.2009.03.001 · Cited by 33
Human genetics offers an emerging picture of common pathways and mechanisms in autoimmunity
Voight, B. F., & Cotsapas, C. J. (2012) · Current Opinion in Immunology · doi:10.1016/j.coi.2012.07.013 · Cited by 33
Functional Analyses of the Crohn’s Disease Risk Gene LACC1
Assadi, G., Vesterlund, L., Bonfiglio, F., Mazzurana, L., Cordeddu, L., Schepis, D., Mjösberg, J., Ruhrmann, S., Fabbri, A., Vukojević, V. B., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0168276 · Cited by 33
Comorbid immune‐mediated diseases in inflammatory bowel disease: a nation‐wide population‐based study
Park, S., Kim, T. J., Lee, J., Kim, E. R., Hong, S. N., Chang, D. K., Yang, M. R., Kim, S., Shin, M., & Kim, Y. (2018) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15076 · Cited by 33
CTLA4 CT60 Single-Nucleotide Polymorphism Is Associated with Slovenian Inflammatory Bowel Disease Patients and Regulates Expression of CTLA4 Isoforms
Repnik, K., & Potočnik, U. (2010) · DNA and Cell Biology · doi:10.1089/dna.2010.1021 · Cited by 32
Protein kinase 2 (CK2) controls CD4+ T cell effector function in the pathogenesis of colitis
Yang, W., Gibson, S. A., Yan, Z., Wei, H., Tao, J., Sha, B., Qin, H., & Benveniste, E. N. (2020) · Mucosal Immunology · doi:10.1038/s41385-020-0258-x · Cited by 35
Blockade of CXCR2 suppresses proinflammatory activities of neutrophils in ulcerative colitis.
Zhu, F., He, H., Fan, L., Ma, C., Xu, Z., Xue, Y., Wang, Y., Zhang, C., & Zhou, G. (2020) · PubMed Central · Cited by 32
IL-1 receptor-associated kinase M downregulates DSS-induced colitis†
Berglund, M., Melgar, S., Kobayashi, K. S., Flavell, R. A., Hörnquist, E. H., & Hultgren, O. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21287 · Cited by 32
Higher Revision and Complication Rates Following Total Hip Arthroplasty in Patients With Inflammatory Bowel Disease
Kapadia, B. H., Issa, K., Nagrare, N., Pivec, R., Banerjee, S., & Mont, M. A. (2013) · The Journal of Arthroplasty · doi:10.1016/j.arth.2013.07.011 · Cited by 32
Therapeutic potential of chloroquine in a murine model of inflammatory bowel disease
Nagar, J., Ranade, S., Kamath, V., Singh, S., Karunanithi, P., Subramani, S., Venkatesh, K., Srivastava, R., Dudhgaonkar, S. P., & Vikramadithyan, R. K. (2014) · International Immunopharmacology · doi:10.1016/j.intimp.2014.05.005 · Cited by 32
Relationship between levels of angiogenic and lymphangiogenic factors and the endoscopic, histological and clinical activity, and acute-phase reactants in patients with inflammatory bowel disease
Algaba, A., Linares, P. M., Fernández-Contreras, M. E., Ordóñez, A. F., Trápaga, J., Guerra, I., Chaparro, M., de la Poza, G., Gisbert, J. P., & Bermejo, F. (2013) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2013.04.005 · Cited by 32
Severity of innate immune-mediated colitis is controlled by the cytokine deficiency-induced colitis susceptibility-1 ( Cdcs1 ) locus
Ermann, J., Garrett, W. S., Kuchroo, J. R., Rourida, K., Glickman, J. N., Bleich, A., & Glimcher, L. H. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1104234108 · Cited by 32
Toll-like receptor activation by helminths or helminth products to alleviate inflammatory bowel disease
Sun, S., Wang, X., Wu, X., Zhao, Y. L., Wang, F., Liu, X., Song, Y., Wu, Z., & Liu, M. (2011) · Parasites & Vectors · doi:10.1186/1756-3305-4-186 · Cited by 32
Reduced numbers of mucosal DRintmacrophages and increased numbers of CD103+dendritic cells during anti-TNF-α treatment in patients with Crohn’s disease
Dige, A. K., Magnusson, M. K., Öhman, L., Hvas, C. L., Kelsen, J., Wick, M. J., & Agnholt, J. S. (2016) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521.2015.1134649 · Cited by 32
C3435T Polymorphism of the ABCB1/MDR1 gene encoding P-glycoprotein in patients with inflammatory bowel disease in a Polish population
Dudarewicz, M., Barańska, M., Rychlik‐Sych, M., Trzciński, R., Dziki, A. J., & Skrętkowicz, J. (2012) · Pharmacological Reports · doi:10.1016/s1734-1140(12)70774-0 · Cited by 31
Human cord blood-derived platelet lysate enhances the therapeutic activity of adipose-derived mesenchymal stromal cells isolated from Crohn’s disease patients in a mouse model of colitis
Forte, D., Ciciarello, M., Valerii, M. C., Fazio, L. D., Cavazza, E., Giordano, R., Parazzi, V., Lazzari, L., Laureti, S., Rizzello, F., et al. (2015) · Stem Cell Research & Therapy · doi:10.1186/s13287-015-0166-2 · Cited by 31
Microbiota biodiversity in inflammatory bowel disease
Comito, D., Cascio, A., & Romano, C. (2014) · The Italian Journal of Pediatrics/Italian journal of pediatrics · doi:10.1186/1824-7288-40-32 · Cited by 31
Effect of Trichinella spiralis intervention on TNBS-induced experimental colitis in mice
Xu, J., Yu, P., Wu, L., Liu, M., & Lu, Y. (2018) · Immunobiology · doi:10.1016/j.imbio.2018.09.005 · Cited by 31
High-fructose corn syrup promotes proinflammatory Macrophage activation via ROS-mediated NF-κB signaling and exacerbates colitis in mice
Wang, L., Ji, T., Yuan, Y., Fu, H., Wang, Y., Tian, S., Hu, J., Wang, L., & Wang, Z. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108814 · Cited by 31
Management of gut inflammation through the manipulation of intestinal dendritic cells and macrophages?
Bar‐On, L., Zigmond, E., & Jung, S. (2011) · Seminars in Immunology · doi:10.1016/j.smim.2011.01.002 · Cited by 31
Cytokine IL9 Triggers the Pathogenesis of Inflammatory Bowel Disease Through the miR21-CLDN8 Pathway
Li, L., Huang, S., Wang, H., Chao, K., Ding, L., Feng, R., Qiu, Y., Feng, T., Zhou, G., Hu, J., et al. (2018) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izy187 · Cited by 31
Genetic profile of patients with early onset inflammatory bowel disease
Girardelli, M., Basaldella, F., Paolera, S. D., Vuch, J., Tommasini, A., Martelossi, S., Crovella, S., & Bianco, A. M. (2017) · Gene · doi:10.1016/j.gene.2017.12.029 · Cited by 32
Treatment of experimental murine colitis with CD40 antisense oligonucleotides delivered in amphoteric liposomes
Arranz, A., Reinsch, C., Papadakis, K. A., Dieckmann, A., Rauchhaus, U., Androulidaki, A., Zacharioudaki, V., Margioris, A. N., Tsatsanis, C., & Panzner, S. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.11.008 · Cited by 30
Hirschsprung-associated enterocolitis develops independently of NOD2 variants
Lacher, M., Fitze, G., Helmbrecht, J., Schroepf, S., Berger, M., Lohse, P., Koletzko, S., Ballauff, A., Grote, V., Goedeke, J., et al. (2010) · Journal of Pediatric Surgery · doi:10.1016/j.jpedsurg.2010.02.039 · Cited by 30
NKX2-3 Transcriptional Regulation of Endothelin-1 and VEGF Signaling in Human Intestinal Microvascular Endothelial Cells
Yu, W., Hegarty, J. P., Berg, A. S., Chen, X., West, G. A., Kelly, A. A., Wang, Y., Poritz, L. S., Koltun, W. A., & Lin, Z. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020454 · Cited by 30
Prostaglandin E2 and IL-23 plus IL-1β Differentially Regulate the Th1/Th17 Immune Response of Human CD161+CD4+ Memory T Cells
Barrie, A. M., Khare, A., Henkel, M., Zhang, Y., Barmada, M. M., Duerr, R. H., & Ray, A. (2011) · Clinical and Translational Science · doi:10.1111/j.1752-8062.2011.00300.x · Cited by 30
Mind–Body Interventions for Pediatric Inflammatory Bowel Disease
Yeh, A. M., Wren, A. A., & Golianu, B. J. (2017) · Children · doi:10.3390/children4040022 · Cited by 33
The socio-economic impact of work disability due to inflammatory bowel disease in Brazil
Fróes, R. D. S. B., Carvalho, A. T. P., Carneiro, A. J., Moreira, A. M. H. D. B., Moreira, J. P. D. L., Luiz, R. R., & de Souza, H. S. P. (2017) · The European Journal of Health Economics · doi:10.1007/s10198-017-0896-4 · Cited by 30
Genipin attenuates dextran sulfate sodium-induced colitis via suppressing inflammatory and oxidative responses
Li, Z., Ma, T., Zhang, W. Y., Shang, Y., Zhang, Y., & Ma, Y. (2019) · Inflammopharmacology · doi:10.1007/s10787-019-00639-9 · Cited by 30
OCTN1 variant L503F is associated with familial and sporadic inflammatory bowel disease
Lin, Z., Nelson, L. S., Franke, A., Poritz, L. S., Li, T.-Y., Wu, R., Wang, Y., MacNeill, C., Thomas, N. J., Schreiber, S., et al. (2009) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2009.09.003 · Cited by 29
Novel Therapeutic Options for People with Ulcerative Colitis: An Update on Recent Developments with Janus Kinase (JAK) Inhibitors
Troncone, E., Marafini, I., Blanco, G. D. V., Grazia, A. D., & Monteleone, G. (2020) · Clinical and Experimental Gastroenterology · doi:10.2147/ceg.s208020 · Cited by 29
A case-only study of gene-environment interaction between genetic susceptibility variants in NOD2 and cigarette smoking in Crohn's disease aetiology
Helbig, K. L., Nothnagel, M., Hampe, J., Balschun, T. C., Nikolaus, S., Schreiber, S., Franke, A., & Nöthlings, U. (2012) · BMC Medical Genetics · doi:10.1186/1471-2350-13-14 · Cited by 29
Role of epithelial integrin-linked kinase in promoting intestinal inflammation: effects on CCL2, fibronectin and the T cell repertoire
Assi, K., Patterson, S., Dedhar, S., Owen, D. A., Levings, M. K., & Salh, B. S. (2011) · BMC Immunology · doi:10.1186/1471-2172-12-42 · Cited by 29
DNA-driven nutritional therapy of inflammatory bowel disease
Lee, G., & Buchman, A. L. (2009) · Nutrition · doi:10.1016/j.nut.2009.06.011 · Cited by 29
Mast Cells Infiltrating Inflamed or Transformed Gut Alternatively Sustain Mucosal Healing or Tumor Growth
Rigoni, A., Bongiovanni, L., Burocchi, A., Sangaletti, S., Danelli, L., Guarnotta, C., Lewis, A., Rizzo, A. G., Silver, A. R., Tripodo, C., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-3767 · Cited by 29
Anti-Colitic Effects of Ethanol Extract of Persea americana Mill. through Suppression of Pro-Inflammatory Mediators via NF-κB/STAT3 Inactivation in Dextran Sulfate Sodium-Induced Colitis Mice
Hong, J. Y., Chung, K., Shin, J., Park, G., Jang, Y. P., & Lee, K. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20010177 · Cited by 29
Immunopathogenèse des maladies inflammatoires chroniques de l’intestin
Matricon, J. (2010) · médecine/sciences · doi:10.1051/medsci/2010264405 · Cited by 29
Pharmacogenomics of multiple sclerosis: in search for a personalized therapy
Martínez‐Forero, I., Peláez, A., & Villoslada, P. (2008) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656560802515553 · Cited by 29
Anti-inflammatory effects of methanolic extract of green algae Caulerpa mexicana in a murine model of ulcerative colitis
Bitencourt, M. A. O., Silva, H. M. D., Abílio, G. M. F., de Miranda, G. E. C., de Moura, A. M. A., de Araújo‐Júnior, J. X., da Silveira, É. J. D., Santos, B. V. D. O., & de Souto, J. T. (2015) · Revista Brasileira de Farmacognosia · doi:10.1016/j.bjp.2015.10.001 · Cited by 28
Impaired Peripheral Th1 CD4+ T Cell Response to Escherichia coli Proteins in Patients with Crohn’s Disease and Ankylosing Spondylitis
Ergin, A., Syrbe, U., Scheer, R., Thiel, A., Adam, T., Büssow, K., Duchmann, R., Zeitz, M., & Sieper, J. (2011) · Journal of Clinical Immunology · doi:10.1007/s10875-011-9575-x · Cited by 28
Association of Single Nucleotide Polymorphisms of IL23R and IL17 with Ulcerative Colitis Risk in a Chinese Han Population
Yu, P., Shen, F.-C., Zhang, X., Cao, R., Zhao, X., Liu, P., Tu, H., Yang, X., Shi, R., & Zhang, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044380 · Cited by 28
ATG16L1 negatively regulates RICK/RIP2-mediated innate immune responses
Honjo, H., Watanabe, T., Arai, Y., Kamata, K., Minaga, K., Komeda, Y., Yamashita, K., & Kudo, M. (2020) · International Immunology · doi:10.1093/intimm/dxaa062 · Cited by 28
DNA Damage-Regulated Autophagy Modulator 1 (DRAM1) Mediates Autophagy and Apoptosis of Intestinal Epithelial Cells in Inflammatory Bowel Disease
Zhang, Y., Li, X., Li, Y., Li, Y., Wang, Y., Zhu, L., Chen, P., Tian, Z., Qiu, Y., Feng, R., et al. (2020) · Digestive Diseases and Sciences · doi:10.1007/s10620-020-06697-2 · Cited by 28
DOK3 maintains intestinal homeostasis by suppressing JAK2/STAT3 signaling and S100a8/9 production in neutrophils
Loh, J. T., Lee, K.-G., Lee, A., Teo, J. K. H., Lim, H. L., Kim, S. S.-Y., Tan, A. H., & Lam, K. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04357-5 · Cited by 28
Chitosan functionalized Mn3O4 nanoparticles counteracts ulcerative colitis in mice through modulation of cellular redox state
Mondal, S., Das, M., Ghosh, R., Singh, M., Adhikari, A., Darbar, S., Das, A. K., Bhattacharya, S. S., Pal, D., Bhattacharyya, D., et al. (2023) · Communications Biology · doi:10.1038/s42003-023-05023-6 · Cited by 28
Animal Models of Inflammatory Bowel Disease at the Dawn of the New Genetics Era
Sollid, L. M., & Johansen, F. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050198 · Cited by 29
Delayed Resolution of Acute Inflammation in Ulcerative Colitis Is Associated with Elevated Cytokine Release Downstream of TLR4
Rahman, F. Z., Smith, A. M., Hayee, B., Marks, D. J., Bloom, S. L., & Segal, A. W. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009891 · Cited by 28
Genetic and pharmacological targeting of TPL-2 kinase ameliorates experimental colitis: a potential target for the treatment of Crohn's disease?
Lawrenz, M. B., Visekruna, A., Kühl, A. A., Schmidt, N., Kaufmann, S. H. E., & Steinhoff, U. (2011) · Mucosal Immunology · doi:10.1038/mi.2011.57 · Cited by 30
Oral Delivery of Particulate Transforming Growth Factor Beta 1 and All-Trans Retinoic Acid Reduces Gut Inflammation in Murine Models of Inflammatory Bowel Disease
Conway, T. F., Hammer, L. A., Furtado, S., Mathiowitz, E., Nicoletti, F., Mangano, K., Egilmez, N. K., & Auci, D. L. (2015) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjv089 · Cited by 28
MAG-EPA reduces severity of DSS-induced colitis in rats
Morin, C., Blier, P. U., & Fortin, S. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00136.2015 · Cited by 28
The IL17A and IL17F loci have divergent histone modifications and are differentially regulated by prostaglandin E2 in Th17 cells
Adamik, J., Henkel, M., Ray, A., Auron, P. E., Duerr, R. H., & Barrie, A. M. (2013) · Cytokine · doi:10.1016/j.cyto.2013.05.010 · Cited by 27
Combined Infection of Human Herpes Viruses: A Risk Factor for Subsequent Colectomy in Ulcerative Colitis
Hosomi, S., Watanabe, K., Nishida, Y., Yamagami, H., Yukawa, T., Otani, K., Nagami, Y., Tanaka, F., Taira, K., Kamata, N., et al. (2018) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izy005 · Cited by 27
Modern Metaproteomics: A Unique Tool to Characterize the Active Microbiome in Health and Diseases, and Pave the Road towards New Biomarkers—Example of Crohn’s Disease and Ulcerative Colitis Flare-Ups
Henry, C., Bassignani, A., Berland, M., Langella, O., Sokol, H., & Juste, C. (2022) · Cells · doi:10.3390/cells11081340 · Cited by 28
Activation of nucleotide-binding oligomerization domain 2 by muramyl dipeptide negatively regulates Toll-like receptor 9-mediated colonic inflammation through the induction of deubiquitinating enzyme A expression
Masuta, Y., Minaga, K., Kurimoto, M., Sekai, I., Hara, A., Omaru, N., Okai, N., Otsuka, Y., Takada, R., Yoshikawa, T., et al. (2022) · International Immunology · doi:10.1093/intimm/dxac045 · Cited by 27
Hyperbaric oxygen therapy does not improve the effects of standardized treatment in a severe attack of ulcerative colitis: a prospective randomized study
Pagoldh, M., Hultgren, E., Arnell, P., & Eriksson, A. (2013) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521.2013.819443 · Cited by 27
A novel susceptibility locus for Takayasu arteritis in the IL12B region can be a genetic marker of disease severity
Matsumura, T., Amiya, E., Tamura, N., Maejima, Y., Komuro, I., & Isobe, M. (2015) · Heart and Vessels · doi:10.1007/s00380-015-0661-5 · Cited by 27
Importance of TLR9-IL23-IL17 axis in inflammatory bowel disease development: Gene expression profiling study
Dragašević, S., Stanković, B., Sokić-Milutinović, A., Milosavljević, T., Alempijevic, T. M., Lukić, S., Dražilov, S. S., Klaassen, K., Kotur, N., Pavlović, S., et al. (2018) · Clinical Immunology · doi:10.1016/j.clim.2018.09.001 · Cited by 27
Towards improved control of inflammatory bowel disease
Eberhardson, M., Hedin, C. R. H., Carlson, M., Tarnawski, L., Levine, Y. A., & Olofsson, P. S. (2018) · Scandinavian Journal of Immunology · doi:10.1111/sji.12745 · Cited by 28
Cdcs1 a major colitis susceptibility locus in mice; Subcongenic analysis reveals genetic complexity
Bleich, A., Büchler, G., Beckwith, J., Petell, L. M., Affourtit, J. P., King, B. L., Shaffer, D. J., Roopenian, D. C., Hedrich, H. J., Sundberg, J. P., et al. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21146 · Cited by 27
Designing 3D Mesenchymal Stem Cell Sheets Merging Magnetic and Fluorescent Features: When Cell Sheet Technology Meets Image-Guided Cell Therapy
Rahmi, G., Pidial, L., Silva, A. K. A., Blondiaux, E., Meresse, B., Gazeau, F., Autret, G., Balvay, D., Cuenod, C. A., Perretta, S., et al. (2016) · Theranostics · doi:10.7150/thno.14064 · Cited by 26
Vitamin D and the Immune System
Khorasanizadeh, M. H., Eskian, M., Camargo, C. A., & Rezaei, N. (2019) · Springer eBooks · doi:10.1007/978-3-030-16073-9_2 · Cited by 26
Role of Smad7 in inflammatory bowel diseases
Monteleone, G. (2012) · World Journal of Gastroenterology · doi:10.3748/wjg.v18.i40.5664 · Cited by 26
Special pro-resolving mediator (SPM) actions in regulating gastro-intestinal inflammation and gut mucosal immune responses
Wang, R. X., & Colgan, S. P. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.02.002 · Cited by 29
Clinical characteristics and validation of diagnosis in individuals with Hirschsprung disease and inflammatory bowel disease
Granström, A. L., Ludvigsson, J. F., & Wester, T. (2020) · Journal of Pediatric Surgery · doi:10.1016/j.jpedsurg.2020.11.015 · Cited by 26
Identification of a Novel 2,8-Diazaspiro[4.5]decan-1-one Derivative as a Potent and Selective Dual TYK2/JAK1 Inhibitor for the Treatment of Inflammatory Bowel Disease
Yang, T., Cui, X. J., Tang, M., Qi, W., Zhu, Z., Shi, M., Yang, L., Pei, H., Zhang, W., Xie, L., et al. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c01137 · Cited by 26
CD4+ T Cells and Lactobacillus casei Control Relapsing Colitis Mediated by CD8+ T Cells
Hacini‐Rachinel, F., Nancey, S., Boschetti, G., Sardi, F., Doucet-Ladevèze, R., Durand, P.-Y., Flourié, B., & Kaiserlian, D. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0804267 · Cited by 26
Aberrant responses to TLR agonists in pediatric IBD patients; the possible association with increased production of Th1/Th17 cytokines in response to candida, a luminal antigen
Jyonouchi, H., Geng, L., Cushing‐Ruby, A., & Monteiro, I. M. (2009) · Pediatric Allergy and Immunology · doi:10.1111/j.1399-3038.2009.00923.x · Cited by 26
A two-marker haplotype in the IRF5 gene is associated with inflammatory bowel disease in a North American cohort
Gathungu, G. N., Zhang, C., Zhang, W., & Cho, J. H. (2012) · Genes and Immunity · doi:10.1038/gene.2011.90 · Cited by 26
Self-citation
Evidence for the involvement of mTOR inhibition and basal autophagy in familial Mediterranean fever phenotype
Mitroulis, I., Kourtzelis, I., Kambas, K., Chrysanthopoulou, A., & Ritis, K. (2010) · Human Immunology · doi:10.1016/j.humimm.2010.11.006 · Cited by 27
Specific neurophysiological mechanisms underlie cognitive inflexibility in inflammatory bowel disease
Petruo, V. A., Zeißig, S., Schmelz, R., Hampe, J., & Beste, C. (2017) · Scientific Reports · doi:10.1038/s41598-017-14345-5 · Cited by 27
The Unsolved Link of Genetic Markers and Crohn’s Disease Progression: A North American Cohort Experience
O’Donnell, S., Borowski, K., Espin‐Garcia, O., Milgrom, R., Kabakchiev, B., Stempak, J. M., Panikkath, D. R., Eksteen, B., Xu, W., Steinhart, A. H., et al. (2019) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izz016 · Cited by 26
Common NOD2 risk variants in African Americans with Crohnʼs disease are due exclusively to recent Caucasian admixture
Adeyanju, O., Okou, D. T., Huang, C. S., Kumar, A., Sauer, C. G., Galloway, C., Prasad, M., Waters, J. P., Cutler, D. J., Zwick, M. E., et al. (2012) · Inflammatory Bowel Diseases · doi:10.1002/ibd.22944 · Cited by 26
Neural Control of Inflammation: Bioelectronic Medicine in Treatment of Chronic Inflammatory DiseasePreprint
Eberhardson, M., Tarnawski, L., Centa, M., & Olofsson, P. S. (2019) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a034181 · Cited by 27
Immune‐mediated diseases and risk of Crohn’s disease or ulcerative colitis: a prospective cohort study
Lo, C., Khalili, H., Lochhead, P. J., Song, M., Lopes, E. W., Burke, K. E., Richter, J. M., Chan, A. T., & Ananthakrishnan, A. N. (2020) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.16210 · Cited by 25
Finding a Place for Genomics in Health Disparities Research
Fullerton, S. M., Knerr, S. A., & Burke, W. (2012) · Public Health Genomics · doi:10.1159/000334717 · Cited by 26
Defective Apoptosis in Intestinal and Mesenteric Adipose Tissue of Crohn’s Disease Patients
Dias, C. B., Milanski, M., Portovedo, M., Horita, V. N., Ayrizono, M. D. L. S., Planell, N., Coy, C. S. R., Velloso, L. A., de Meirelles, L. R., & Leal, R. F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098547 · Cited by 25
Can temperature explain the latitudinal gradient of ulcerative colitis? Cohort of Norway
Aamodt, G., Bengtson, M., & Vatn, M. H. (2013) · BMC Public Health · doi:10.1186/1471-2458-13-530 · Cited by 26
Granulomas of Intestinal Tuberculosis and Crohn's Disease Can Be Differentiated by CD73 Cell Surface Marker Expression: A Pilot Study
Banerjee, R., Balaji, M., Sasikala, M., Anuradha, S., Rao, G. V., & Reddy, D. N. (2013) · Digestive Diseases and Sciences · doi:10.1007/s10620-013-2667-0 · Cited by 25
Corticosteroid therapy in ulcerative colitis: Clinical response and predictors
Li, J. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i10.3005 · Cited by 25
HLA-C*01 is a Risk Factor for Crohnʼs Disease
Jung, E. S., Cheon, J. H., Lee, J. H., Park, S. J., Jang, H. W., Chung, S. H., Park, M. H., Kim, T.-G., Oh, H., Yang, S., et al. (2016) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000693 · Cited by 25
Using Zebrafish to Investigate Interactions Between Xenobiotics and Microbiota
Catron, T. R., Gaballah, S., & Tal, T. L. (2019) · Current Pharmacology Reports · doi:10.1007/s40495-019-00203-7 · Cited by 26
Association between genetic variants in NOD 2, C13orf31, and CCDC 122 genes and leprosy among the Chinese Yi population
Jun-hao, X., Mao, C., Sha, X., Jin, Z., Wang, H., Liu, Y., & Ning, Y. (2015) · International Journal of Dermatology · doi:10.1111/ijd.12981 · Cited by 24
Role of flagellin in Crohnʼs disease: Emblematic of the progress and enigmas in understanding inflammatory bowel disease
Vijay–Kumar, M., & Gewirtz, A. T. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20734 · Cited by 24
Nutritional treatment in inflammatory bowel disease: An update
Guagnozzi, D., González-Castillo, S., Olveira, A., & Lucendo, A. J. (2012) · Revista Española de Enfermedades Digestivas · doi:10.4321/s1130-01082012000900006 · Cited by 24
Mesenchymal stromal cells and chronic inflammatory bowel disease
Algeri, M., Conforti, A., Pitisci, A., Starc, N., Tomao, L., Bernardo, M. E., & Locatelli, F. (2015) · Immunology Letters · doi:10.1016/j.imlet.2015.06.018 · Cited by 24
Mucosal MicroRNAs Expression Profiles before and after Exclusive Enteral Nutrition Therapy in Adult Patients with Crohn’s Disease
Guo, Z., Gong, J., Li, Y., Gu, L., Cao, L., Wang, Z., Zhu, W., & Li, J. (2016) · Nutrients · doi:10.3390/nu8080519 · Cited by 24
Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model
Liang, J., van Abbema, A., Balázs, M., Barrett, K., Berezhkovsky, L., Blair, W. S., Chang, C. C., Delarosa, D., DeVoss, J., Driscoll, J., et al. (2017) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2017.08.022 · Cited by 24
NOD2-mediated dual negative regulation of inflammatory responses triggered by TLRs in the gastrointestinal tract
Masaki, S., Masuta, Y., Honjo, H., Kudo, M., & Watanabe, T. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1433620 · Cited by 24
Engineered and wild-type L. lactis promote anti-inflammatory cytokine signalling in inflammatory bowel disease patient’s mucosa
Simčič, S., Berlec, A., Stopinšek, S., Štrukelj, B., & Orel, R. (2019) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-019-2615-z · Cited by 23
Mesenchymal Stem Cells and Tuberculosis: Clinical Challenges and Opportunities
Zhang, X., Xie, Q., Ye, Z., Li, Y., Che, Z., Huang, M., & Zeng, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.695278 · Cited by 24
Toward a better understanding of the central consequences of intestinal inflammation
Nyuyki, K. D., & Pittman, Q. J. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12935 · Cited by 26
Over-Expression of CD200 Protects Mice from Dextran Sodium Sulfate Induced Colitis
Chen, Z., Yu, K., Zhu, F., & Gorczynski, R. M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146681 · Cited by 23
Thymol has beneficial effects on the experimental model of ulcerative colitis.
Tahmasebi, P., Froushani, S. M. A., & Ahangaran, N. A. (2019) · Europe PMC (PubMed Central) · doi:10.22038/ajp.2019.13383 · Cited by 23
Cannabinoid Receptor Activation on Haematopoietic Cells and Enterocytes Protects against Colitis
Becker, W., Alrafas, H. R., Busbee, P. B., Walla, M. D., Wilson, K. M., Miranda, K., Cai, G., Putluri, V., Putluri, N., Nagarkatti, M., et al. (2020) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjaa253 · Cited by 23
The effects of Foxp3-expressing regulatory T cells expanded with CD28 superagonist antibody in DSS-induced mice colitis
Chen, J., Xie, L., Toyama, S., Hünig, T., Takahara, S., Li, X., & Zhong, L. (2010) · International Immunopharmacology · doi:10.1016/j.intimp.2010.11.034 · Cited by 23
Characterization of an Interferon-stimulated Response Element (ISRE) in the Il23a Promoter
Sheikh, S. Z., Kobayashi, T., Matsuoka, K., Onyiah, J. C., & Plevy, S. E. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.147884 · Cited by 22
Direct Bacterial Killing In Vitro by Recombinant Nod2 Is Compromised by Crohn's Disease-Associated Mutations
Perez, L. H., Butler, M., Creasey, T., Dzink-Fox, J., Gounarides, J., Petit, S., Ropenga, A., Ryder, N. S., Smith, K., SMITH, P. F., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010915 · Cited by 22
Genes Regulated by Nkx2-3 in Sporadic and Inflammatory Bowel Disease-Associated Colorectal Cancer Cell Lines
Yu, W., Lin, Z., Pastor, D. M., Hegarty, J. P., Chen, X., Kelly, A. A., Wang, Y., Poritz, L. S., & Koltun, W. A. (2010) · Digestive Diseases and Sciences · doi:10.1007/s10620-010-1138-0 · Cited by 22
Reduced expression of basal and probiotic-inducible G-CSF in intestinal mononuclear cells is associated with inflammatory bowel disease
Martins, A. J., Colquhoun, P. H. D., Reid, G., & Kim, S. O. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20808 · Cited by 22
Disruption of the Hedgehog signaling pathway in inflammatory bowel disease fosters chronic intestinal inflammation
Buongusto, F., Bernardazzi, C., Yoshimoto, A. N., Nanini, H. F., Coutinho, R. L. M., Carneiro, A. J., Castelo-Branco, M. T. L., & de Souza, H. S. P. (2016) · Clinical and Experimental Medicine · doi:10.1007/s10238-016-0434-1 · Cited by 22

Authors: Cho, J. H.
Affiliations: Yale University (US)
Corresponding author: Cho, Judy H.
ORCID: Cho, Judy H.
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2008-06
Volume: 8
Issue: 6
Pages: 458-466
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri2340
OpenAlex: W2066203385
Cited by: 940
References: 99
Citations by year: 2026: 16 · 2025: 14 · 2024: 28 · 2023: 30 · 2022: 30 · 2021: 32 · 2020: 47 · 2019: 39 · 2018: 45 · 2017: 37 · 2016: 53 · 2015: 50 · 2014: 61 · 2013: 71 · 2012: 80
FWCI: 9.45
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: Georgia Clinical and Translational Science Alliance
National Institute of Diabetes and Digestive and Kidney Diseases (U01-DK62429, U01DK62422, R01DK072373, U01DK062429, U01DK062422)
Topics: Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Keywords: inflammatory bowel disease, Crohn's disease, ulcerative colitis, genetic susceptibility, immunopathogenesis, NOD2, ATG16L1, autophagy, IL23R, IL12B, STAT3, NKX2-3, bacterial sensing, cytokine signaling, innate immunity, adaptive immunity, genome-wide association study
MeSH terms: Animals, Colitis, Ulcerative, Crohn Disease, Humans, Inflammatory Bowel Diseases, Genetic Predisposition to Disease

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The genetics and immunopathogenesis of inflammatory bowel disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks