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The genetics and immunopathogenesis of inflammatory bowel disease
Abstract
Genome-wide association studies efficiently and powerfully assay common genetic variation. The application of these studies to Crohn's disease has provided insight into the immunopathogenesis of this disease, implicating a role for genes of the innate and adaptive immune systems. In this Review, I discuss our current understanding of the genetics and immunopathogenesis of Crohn's disease and ulcerative colitis. Crohn's disease, but not ulcerative colitis, is associated with genetic variation in NOD2 and an autophagy gene, ATG16L1, both of which affect the intracellular processing of bacterial components. By contrast, variation in the gene encoding the interleukin-23 (IL-23) receptor subunit, as well as in the IL12B, STAT3 and NKX2-3 gene regions, is associated with both Crohn's disease and ulcerative colitis. Comparative analyses of gene associations between these two inflammatory bowel diseases reveal common and unique mechanisms of their immunopathogenesis.
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“Moreover, the expansion of Proteobacteria could facilitate a mucosal immune response in genetically predisposed individuals, leading to the development and continuation of chronic intestinal inflammation[133,142,143].”
From Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified (2019) · cites this paper as [143]
Citations
Cites
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442
Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
Hugot, J.-P., Chamaillard, M., Zouali, H., Lesage, S., Cézard, J.-P., Belaiche, J., Almer, S., Tysk, C., O'Morain, C. A., Gassull, M., et al. (2001) · Nature · doi:10.1038/35079107 · Cited by 5,591
Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
Ogura, Y., Bonen, D. K., Inohara, N., Nicolae, D. L., Chen, F. F., Ramos, R., Britton, H., Moran, T., Karaliuskas, R., Duerr, R. H., et al. (2001) · Nature · doi:10.1038/35079114 · Cited by 5,030
Self-citationA second generation human haplotype map of over 3.1 million SNPs
The International HapMap Consortium (2007) · Nature · doi:10.1038/nature06258 · Cited by 4,438
Unravelling the pathogenesis of inflammatory bowel disease
Xavier, R. J., & Podolsky, D. K. (2007) · Nature · doi:10.1038/nature06005 · Cited by 4,364
Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., & Stockinger, B. (2006) · Immunity · doi:10.1016/j.immuni.2006.01.001 · Cited by 3,605
Podolsky, D. K. (2002) · New England Journal of Medicine · doi:10.1056/nejmra020831 · Cited by 3,183
Loftus, E. V. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.01.063 · Cited by 3,106
Flagged first, then by citations
Research works printed but not linked: 2
- Binder, V. Genetic epidemiology in inflammatory bowel disease. Digest. Dis. 16, 351–355 (1998). · DOI
- Yang, H. & Rotter, J. I. in Inflammatory Bowel Disease (eds Kirsner, J. B. & Shorter, R. G.) 301–331 (Williams & Wilkins, Baltimore, 1995).
Cited by
Sorted by citations
Items 601–700 of 939
Samson, C. M., Jurickova, I., Molden, E. K., Schreiner, W., Colliver, J., Bonkowski, E. L., Han, X., Trapnell, B. C., & Denson, L. A. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21672 · Cited by 13
Chen, L., Li, X., & Gu, Q. (2023) · Food Science & Nutrition · doi:10.1002/fsn3.3282 · Cited by 12
Tews, H. C., Elger, T., Gunawan, S., Fererberger, T., Sommersberger, S., Loibl, J., Huss, M., Liebisch, G., Müller, M., Kandulski, A., et al. (2023) · Lipids in Health and Disease · doi:10.1186/s12944-023-01929-6 · Cited by 13
Ghosh, N., Chaki, R., Mandal, V., Lin, G. D., & Mandal, S. C. (2010) · International Reviews of Immunology · doi:10.3109/08830180903437212 · Cited by 12
RetractedWip 1 inhibits intestinal inflammation in inflammatory bowel disease
Zhang, Q., Zhang, C., Chang, F., Liang, K., Yin, X., Li, X., Zhao, K., Niu, Q., & Tian, Z. (2016) · Cellular Immunology · doi:10.1016/j.cellimm.2016.07.012 · Cited by 12
Yu, H. M., Zhang, Z., Li, G., Feng, Y., Xian, L., Bakhsh, F., Xu, D., Xu, C., Vong, T., Wu, B., et al. (2022) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2022.12.013 · Cited by 12
Verdier, J., Deroche, L., Allez, M., Loy, C., Biet, F., Bodier, C. C., Bay, S., Ganneau, C., Matysiak‐Budnik, T., Reyrat, J. M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062780 · Cited by 12
Tan, G., Liang, E., Liao, K., Deng, F., Zhang, W., Chen, Y., Xu, J., & Zhi, F. (2016) · Oncotarget · doi:10.18632/oncotarget.11467 · Cited by 12
A Novel Rare Missense Variation of the NOD2 Gene: Evidences of Implication in Crohn’s Disease
Frade-Proud’hon-Clerc, S., Smol, T., Frénois, F., Sand, O., Vaillant, E., Dhennin, V., Bonnefond, A., Froguel, P., Fuméry, M., Guillon-Dellac, N., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040835 · Cited by 13
Chen, X., Li, M., Li, D., Luo, T. L., Xie, Y., Gao, L., Zhang, Y., Chen, S., Li, S., Huang, G., et al. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110212 · Cited by 12
Chemerin, a novel player in inflammatory bowel disease
Buechler, C. (2014) · Cellular and Molecular Immunology · doi:10.1038/cmi.2014.14 · Cited by 12
Kabuki Syndrome and Crohn Disease in a Child with Familial Hypocalciuric Hypercalcemia
Ho, J., Fox, D. A., Innes, A. M., McLeod, R., Butzner, D., Johnson, N. A., Trevenen, C., Kendrick, V., & Cole, D. E. C. (2010) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.2010.156 · Cited by 12
Up-regulation of IGF Binding Protein-3 Inhibits Colonic Inflammatory Response
Kim, S. C., & Hwang, P. H. (2018) · Journal of Korean Medical Science · doi:10.3346/jkms.2018.33.e110 · Cited by 12
Bell, J. I. (2010) · Clinical Medicine · doi:10.7861/clinmedicine.10-6-584 · Cited by 12
Extraintestinal Manifestations of Inflammatory Bowel Disease
Al-Quorain, A. A. (2019) · Saudi Journal of Medicine and Medical Sciences · doi:10.4103/sjmms.sjmms_111_19 · Cited by 12
Liang, W., Zhang, W., Tian, J., Zhang, X., Lv, X., Qu, A., Chen, J., & Wu, Z. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.136392 · Cited by 11
Bezzio, C., Cavalli, C. A. M., Franchellucci, G., Buono, A. D., Gabbiadini, R., Scalvini, D., Manara, S. A. A. M., Narcisi, A., Armuzzi, A., & Saibeni, S. (2024) · Therapeutic Advances in Gastroenterology · doi:10.1177/17562848241299564 · Cited by 11
Brandhorst, G., Weigand, S., Eberle, C., Raddatz, D., Karaus, M., Oellerich, M., & Walson, P. D. (2013) · Clinica Chimica Acta · doi:10.1016/j.cca.2013.02.016 · Cited by 11
Papillary thyroid cancer and inflammatory bowel disease: Is there a relationship?
Sonu, I. S. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i7.1079 · Cited by 11
Structural Evolution of the Spleen in Man and Mouse
Balogh, P., & Lábadi, Á. (2010) · Springer eBooks · doi:10.1007/978-3-642-14429-5_11 · Cited by 11
Osman, N. M., Shawky, A.-E.-M., & Bryliński, M. (2022) · BMC Genomic Data · doi:10.1186/s12863-021-01021-x · Cited by 11
Li, T., Han, B., Wang, L., Sun, L., Cai, Y., Yu, M., Xiao, W., & Yang, H. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-023-04789-x · Cited by 11
Gologan, S., Iacob, R. A., Preda, C. M., Vădan, R., Cotruţă, B., Catuneanu, A.-M., Iacob, S., Constantinescu, I., Gheorghe, L. S., Iobagiu, S., et al. (2012) · PubMed · Cited by 11
Jiang, T., Ge, L., Zhi Tao, C. H. E. N., Li, C., Zhou, F., Luo, Y., & Xia, B. (2010) · Journal of Digestive Diseases · doi:10.1111/j.1751-2980.2010.00462.x · Cited by 11
Jiang, K., Krous, L. C., Knowlton, N. S., Chen, Y., Frank, M. B., Cadwell, C., Centola, M. B., & Jarvis, J. N. (2009) · Placenta · doi:10.1016/j.placenta.2009.06.006 · Cited by 11
Therapy of inflammatory bowel diseases in pregnancy and lactation
Cassina, M., Fabris, L., Okolicsànyi, L., Gervasi, M. T., Memmo, A., Tiboni, G. M., Gianantonio, E. D., & Clementi, M. (2009) · Expert Opinion on Drug Safety · doi:10.1517/14740330903357463 · Cited by 11
Chulkina, M., Av, P., & Ataullakhanov, R. I. (2020) · Peptides · doi:10.1016/j.peptides.2020.170364 · Cited by 11
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Schrodi, S. J. (2008) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.4.5.565 · Cited by 11
Targeting the innate immune system in pediatric inflammatory bowel disease
Schirbel, A., & Fiocchi, C. (2011) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/egh.10.76 · Cited by 11
Park, J. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i37.13466 · Cited by 11
Inflammatory bowel disease: recent advances on genetics and innate immunity.
Karantanos, T., & Gazouli, M. (2011) · Europe PMC (PubMed Central) · Cited by 11
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Impellizzeri, D., Campolo, M., Paola, R. D., Bruschetta, G., Stefano, D. D., Esposito, E., & Cuzzocrea, S. (2015) · European Journal of Inflammation · doi:10.1177/1721727x15575869 · Cited by 11
Li, J., Yu, Y., Miao, T., Wang, H., Wei, F., Li, L., & Wang, X. (2006) · PubMed · Cited by 11
White, J. H. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-381978-9.10091-5 · Cited by 11
Cytokines and Chemokines in Mucosal Homeostasis
Maillard, M. H., & Snapper, S. B. (2010) · Wiley eBooks · doi:10.1002/9781444318418.ch10 · Cited by 11
Tang, D., Huang, Y., Che, Y., Yang, C., Pu, B., Liu, S., & Li, H. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1323418 · Cited by 10
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Garrido, I., Lopes, S., & Macedo, G. (2021) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izab037 · Cited by 10
Zhao, S., Zhu, L., Feng, W., Zhang, L., Chen, D., Hu, Y.-C., & Shen, H. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.10808 · Cited by 10
Guo, W., Wang, X., Liu, F., Chen, S., Wang, S., Zhang, Q., Yuan, L., & Du, S. (2022) · Molecular Medicine Reports · doi:10.3892/mmr.2022.12877 · Cited by 10
Hematopoietic SCT modulates gut inflammation in experimental inflammatory bowel disease
Godoi, D. F., Cardoso, C. R. D. B., Ferraz, D. B., Provinciatto, P. R., Cunha, F. Q., Silva, J. S., & Voltarelli, J. C. (2010) · Bone Marrow Transplantation · doi:10.1038/bmt.2010.6 · Cited by 10
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Ao, S.-I. (2008) · Lecture notes in electrical engineering · doi:10.1007/978-1-4020-8975-6 · Cited by 10
Zhang, W., Zhang, G., Peng, J., Zhang, J., Yang, Y., & Lai, S. (2013) · Gene · doi:10.1016/j.gene.2012.12.091 · Cited by 10
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Vinod, J., Vadada, D., Korelitz, B. I., Sonpal, N., Panagopoulos, G., & Baiocco, P. J. (2012) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e31825003cc · Cited by 10
Composite lymphoma in a patient with ulcerative colitis: a case report.
Ashrafi, F., Kowsari, F., Darakhshandeh, A., & Adibi, P. (2014) · Europe PMC (PubMed Central) · Cited by 10
Zong, C., Nie, X., Zhang, D., Ji, Q., Qin, Y., Wang, L., Jiang, D., Chen, G., Liu, Y., & Zhou, G.-X. (2015) · Pathology - Research and Practice · doi:10.1016/j.prp.2015.09.019 · Cited by 10
Molecular Mechanism Study of Dietary Fiber Lignin Intervention in Ulcerative Colitis through GPR37
Xie, H., Yang, J., Liu, T., Zhang, X., Zuo, S., Gao, Y., Kuang, X., & Zhang, T. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c01452 · Cited by 9
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Gibson, G. C., Rioux, J. D., Cho, J. H., Haritunians, T., Thoutam, A., Abreu, M. T., Brant, S. R., Kugathasan, S., McCauley, J. L., Silverberg, M. S., et al. (2024) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izae269 · Cited by 10
Self-citationUrinary chemerin as a potential biomarker for inflammatory bowel disease
Gunawan, S., Elger, T., Loibl, J., Fererberger, T., Sommersberger, S., Kandulski, A., Müller, M., Tews, H. C., & Buechler, C. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.1058108 · Cited by 9
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Lian, L. H., Lau, T.-P., Lee, V. L., Lee, W. S., Hilmi, I. N., Goh, K., & Chua, K. H. (2013) · Genetics and Molecular Research · doi:10.4238/2013.january.24.9 · Cited by 9
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Ranson, N., & Eri, R. D. (2013) · American journal of medical and biological research · doi:10.12691/ajmbr-1-3-3 · Cited by 9
Dudarewicz, M., Rychlik‐Sych, M., Barańska, M., Wojtczak, A., Trzciński, R., Dziki, A. J., & Skrętkowicz, J. (2014) · Pharmacological Reports · doi:10.1016/j.pharep.2014.04.002 · Cited by 9
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Soni, D., & Salh, B. (2012) · Scientifica · doi:10.6064/2012/757890 · Cited by 9
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Teimoori‐Toolabi, L., Samadpoor, S., Mehrtash, A., Ghadir, M., & Vahedi, H. (2018) · Gene · doi:10.1016/j.gene.2018.06.074 · Cited by 9
Gubatan, J. M. B., Sojwal, R. S., Ye, J., Boye, T. L., Hoang, J. N., Fardeen, T., Temby, M., Rubin, S. J. S., Spencer, S. P., Kotagiri, P., et al. (2026) · Cell Reports Medicine · doi:10.1016/j.xcrm.2026.102703 · Cited by 8
Vermeiren, J., Possemiers, S., Marzorati, M., & de Wiele, T. V. (2011) · InTech eBooks · doi:10.5772/27905 · Cited by 8
Vojkovics, D., Kellermayer, Z., Gábris, F., Schippers, A., Wagner, N., Berta, G., Farkas, N., & Balogh, P. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00366 · Cited by 8
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Oryoji, D., Hisamatsu, T., Tsuchiya, K., Umeno, J., Ueda, S., Yamamoto, K., Matsumoto, T., Watanabe, M., Hibi∥, T., & Sasazuki, T. (2014) · Genes and Immunity · doi:10.1038/gene.2014.61 · Cited by 8
RNA regulators of host immunity and pathogen adaptive responses in the oral cavity
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Imielinski, M. B., & Hakonarson, H. H. (2010) · Pharmacogenomics · doi:10.2217/pgs.10.56 · Cited by 8
Jiang, W., & Li, X. (2015) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-015-0142-7 · Cited by 8
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Lo, B. C., Shin, S. B., Messing, M., & McNagny, K. M. (2019) · Journal of Visualized Experiments · doi:10.3791/60068 · Cited by 7
Zhang, T., Zhang, R., Liu, W. C., Qi, Y., Wang, H., Zhang, H., Xiao, Z. J., Pandol, S. J., Han, Y., & Zheng, X. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167065 · Cited by 7
Lin, Z.-H., Li, C., Sun, C., Cho, D., Tsai, F., Yip, H., Chang, R., & Hung, Y. (2024) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izae053 · Cited by 7
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The genome, microbiome and evolutionary medicine
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da Silva, L. S., Santo, J. D. E., de Mesquita, T. G. R., Santos, V. A. M., de Souza, J. L., de Araújo, F. J., Júnior, C. M. D. S., da Silva, C. C., Queiroz, K. L. G. D., Sequera, H. D. G., et al. (2021) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiab320 · Cited by 7
Dunn, E. T. J., Taylor, E. S., Stebbings, S. M., Schultz, M., Butt, G., & Kemp, R. A. (2015) · Immunology and Cell Biology · doi:10.1038/icb.2015.112 · Cited by 7
Hammer, L. A., Furtado, S., Mathiowitz, E., & Auci, D. L. (2020) · World Journal of Gastrointestinal Pharmacology and Therapeutics · doi:10.4292/wjgpt.v11.i5.79 · Cited by 7
Bernick, S. J., & Kane, S. V. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-183-7_3 · Cited by 7
Auci, D. L. (2016) · Journal of Gastroenterology Pancreatology & Liver Disorders · doi:10.15226/2374-815x/3/4/00166 · Cited by 7
Pagotto, V. P. F., Camargo, C. P., Càceres, P., Altran, S. C., & Gemperli, R. (2023) · Acta Cirúrgica Brasileira · doi:10.1590/acb384523 · Cited by 6
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Oliveira, L. P. G., Xavier, R., Nora, C. C. V., Mangueira, C. L. P., Rosseto, E. A., Aloia, T. P. A., Gil, J. Z., Neto, A. S., Lopes, F. B. T. P., & Carvalho, K. I. (2025) · Human Immunology · doi:10.1016/j.humimm.2025.111257 · Cited by 6
Sysak, A., Obmińska‐Mrukowicz, B., Zaczyńska, E., Zimecki, M., Ryng, S., & Mą̨czyński, M. (2016) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12631 · Cited by 6
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Wei, Z., Baldassano, S. N., & Hakonarson, H. H. (2012) · Springer eBooks · doi:10.1007/978-1-4614-5061-0_1 · Cited by 6
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Promoter methylation cooperates with SNPs to modulate RAGE transcription and alter UC risk
Wang, J., Yan, Z., Zhou, Y., Yan, S., Jiang, L., & Zhang, L. (2018) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2018.11.001 · Cited by 6
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Tarbell, K. V., & Rahman, M. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-812102-3.00011-7 · Cited by 7
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Innate Immunity and Inflammation
McKarns, S. C. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.64228-9 · Cited by 6
Regulatory T Cells as Potential Targets for Immunotherapy in Inflammatory Bowel Disease
Strisciuglio, C., & van Deventer, S. J. H. (2010) · Immunotherapy · doi:10.2217/imt.10.63 · Cited by 6
Wang, Z., Fan, R., Wang, L., Zhou, J., Zheng, S., Hu, S., Chen, M., Zhang, T., Lin, Y., Zhang, M., et al. (2015) · PubMed Central · Cited by 6
Modeling the Association Between Clusters of SNPs and Disease Responses
Argiento, R., Guglielmi, A., Hsiao, C. K., Ruggeri, F., & Wang, C. I. (2015) · Springer eBooks · doi:10.1007/978-3-319-19518-6_6 · Cited by 5
Recapitulation of NOD/RIPK2 signaling in iPSC-derived macrophages
Harati, M. D., King, J., Langer, S., Binder, F. P. C., & Heilker, R. (2024) · SLAS DISCOVERY · doi:10.1016/j.slasd.2024.100185 · Cited by 5
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Metadata
- Authors
- Cho, J. H.
- Affiliations
- Yale University (US)
- Corresponding author
- Cho, Judy H.
- ORCID
- Cho, Judy H.
- Venue
- Nature Reviews Immunology
- Published
- 2008-06
- Volume
- 8
- Issue
- 6
- Pages
- 458-466
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2066203385
- Cited by
- 940
- References
- 99
- Citations by year
- 2026: 16 · 2025: 14 · 2024: 28 · 2023: 30 · 2022: 30 · 2021: 32 · 2020: 47 · 2019: 39 · 2018: 45 · 2017: 37 · 2016: 53 · 2015: 50 · 2014: 61 · 2013: 71 · 2012: 80
- FWCI
- 9.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Georgia Clinical and Translational Science Alliance
- National Institute of Diabetes and Digestive and Kidney Diseases (U01-DK62429, U01DK62422, R01DK072373, U01DK062429, U01DK062422)
- Topics
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Keywords
- inflammatory bowel disease, Crohn's disease, ulcerative colitis, genetic susceptibility, immunopathogenesis, NOD2, ATG16L1, autophagy, IL23R, IL12B, STAT3, NKX2-3, bacterial sensing, cytokine signaling, innate immunity, adaptive immunity, genome-wide association study
- MeSH terms
- Animals, Colitis, Ulcerative, Crohn Disease, Humans, Inflammatory Bowel Diseases, Genetic Predisposition to Disease
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