Cited by 940Inflammatory Bowel DiseaseGenetic Associations and EpidemiologyOcular Diseases and Behçet’s Syndrome

The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.

The genetics and immunopathogenesis of inflammatory bowel disease

Cho, Judy H.·2008·Nature Reviews Immunology

Open this paper in CoChat — free account

Abstract

Genome-wide association studies efficiently and powerfully assay common genetic variation. The application of these studies to Crohn's disease has provided insight into the immunopathogenesis of this disease, implicating a role for genes of the innate and adaptive immune systems. In this Review, I discuss our current understanding of the genetics and immunopathogenesis of Crohn's disease and ulcerative colitis. Crohn's disease, but not ulcerative colitis, is associated with genetic variation in NOD2 and an autophagy gene, ATG16L1, both of which affect the intracellular processing of bacterial components. By contrast, variation in the gene encoding the interleukin-23 (IL-23) receptor subunit, as well as in the IL12B, STAT3 and NKX2-3 gene regions, is associated with both Crohn's disease and ulcerative colitis. Comparative analyses of gene associations between these two inflammatory bowel diseases reveal common and unique mechanisms of their immunopathogenesis.

Integrity signals

Registry

Crossref · 10.1038/nri2340

Cites

99 of 99 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
Hugot, J.-P., Chamaillard, M., Zouali, H., Lesage, S., Cézard, J.-P., Belaiche, J., Almer, S., Tysk, C., O'Morain, C. A., Gassull, M., et al. (2001) · Nature · doi:10.1038/35079107 · Cited by 5,591
The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells
Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
Ogura, Y., Bonen, D. K., Inohara, N., Nicolae, D. L., Chen, F. F., Ramos, R., Britton, H., Moran, T., Karaliuskas, R., Duerr, R. H., et al. (2001) · Nature · doi:10.1038/35079114 · Cited by 5,030
Self-citation
A second generation human haplotype map of over 3.1 million SNPs
The International HapMap Consortium (2007) · Nature · doi:10.1038/nature06258 · Cited by 4,438
Unravelling the pathogenesis of inflammatory bowel disease
Xavier, R. J., & Podolsky, D. K. (2007) · Nature · doi:10.1038/nature06005 · Cited by 4,364
TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells
Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., & Stockinger, B. (2006) · Immunity · doi:10.1016/j.immuni.2006.01.001 · Cited by 3,605
Inflammatory Bowel Disease
Podolsky, D. K. (2002) · New England Journal of Medicine · doi:10.1056/nejmra020831 · Cited by 3,183
Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences
Loftus, E. V. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.01.063 · Cited by 3,106

Flagged first, then by citations

Show all 99 references

Research works printed but not linked: 2

Binder, V. Genetic epidemiology in inflammatory bowel disease. Digest. Dis. 16, 351–355 (1998). · DOI
Yang, H. & Rotter, J. I. in Inflammatory Bowel Disease (eds Kirsner, J. B. & Shorter, R. G.) 301–331 (Williams & Wilkins, Baltimore, 1995).

Sorted by citations

Pattern Recognition Receptors and Inflammation
Takeuchi, O., & Akira, S. (2010) · Cell · doi:10.1016/j.cell.2010.01.022 · Cited by 8,895
Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
Hindorff, L. A., Sethupathy, P., Junkins, H. A., Ramos, E. M., Mehta, J. P., Collins, F. S., & Manolio, T. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903103106 · Cited by 4,013
Role of the gut microbiota in immunity and inflammatory disease
Kamada, N., Seo, S.-U., Chen, G. Y., & Núñez, G. (2013) · Nature reviews. Immunology · doi:10.1038/nri3430 · Cited by 2,256
A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses
Wu, S., Rhee, K.-J., Albesiano, E., Rabizadeh, S., Wu, X., Yen, H.-R., Huso, D. L., Brancati, F. L., Wick, E., McAllister, F., et al. (2009) · Nature Medicine · doi:10.1038/nm.2015 · Cited by 1,812
Inflammatory bowel disease
Kaser, A., Zeissig, S., & Blumberg, R. S. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101225 · Cited by 1,806
The microbiome and cancer
Schwabe, R. F., & Jobin, C. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3610 · Cited by 1,689
Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor
Glocker, E., Kotlarz, D., Boztuǧ, K., Gertz, E. M., Schäffer, A. A., Noyan, F., Perro, M., Diestelhorst, J., Saborowski, A. L., Murugan, D., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0907206 · Cited by 1,452
Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions
Bouillon, R., Marcocci, C., Carmeliet, G., Bikle, D. D., White, J. H., Dawson-Hughes, B. F., Lips, P. T. A. M., Munns, C. F., Lazaretti‐Castro, M., Giustina, A., et al. (2018) · Endocrine Reviews · doi:10.1210/er.2018-00126 · Cited by 1,257
Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory Disease
Masters, S. L., Simon, A., Aksentijevich, I. A., & Kastner, D. L. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141627 · Cited by 1,083
Genomewide Association Study of Leprosy
Zhang, F., Huang, W., Chen, S., Sun, L., Liu, H. D., Li, Y., Cui, Y., Yan, X., Yang, H., Yang, R., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0903753 · Cited by 1,051
Genes and Molecules of Lactobacilli Supporting Probiotic Action
Lebeer, S., Vanderleyden, J., & De Keersmaecker, S. C. J. (2008) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00017-08 · Cited by 1,013
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility
Evans, D. M., Spencer, C. C. A., Pointon, J. J., Su, Z., Harvey, D., Kochan, G. T., Oppermann, U. C. T., Dilthey, A., Pirinen, M., Stone, M., et al. (2011) · Nature Genetics · doi:10.1038/ng.873 · Cited by 909
The inflammasome: an integrated view
Gross, O., Thomas, C. J., Guarda, G., & Tschopp, J. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01046.x · Cited by 778
The Gastrointestinal Microbiome: A Review
Barko, P. C., McMichael, M. A., Swanson, K. S., & Williams, D. A. (2018) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.14875 · Cited by 750
Ly6Chi Monocytes in the Inflamed Colon Give Rise to Proinflammatory Effector Cells and Migratory Antigen-Presenting Cells
Zigmond, E., Varol, C., Farache, J., Elmaliah, E., Satpathy, A. T., Friedlander, G., Mack, M., Shpigel, N. Y., Boneca, I. G., MURPHY, K. M. M., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.08.026 · Cited by 768
STAT3 signaling in immunity
Hillmer, E. J., Zhang, H., Li, H. S., & Watowich, S. S. (2016) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2016.05.001 · Cited by 740
High-throughput clone library analysis of the mucosa-associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease
Walker, A. W., Sanderson, J. D., Churcher, C. M., Parkes, G. C., Hudspith, B. N., Rayment, N. B., Brostoff, J., Parkhill, J., Dougan, G., & Petrovska, L. (2011) · BMC Microbiology · doi:10.1186/1471-2180-11-7 · Cited by 727
Pattern recognition receptors and control of adaptive immunity
Palm, N. W., & Medzhitov, R. M. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00731.x · Cited by 751
Microbiota organization is a distinct feature of proximal colorectal cancers
Dejea, C. M., Wick, E. C., Hechenbleikner, E. M., White, J. R., Mark Welch, J. L., Rossetti, B. J., Peterson, S. N., Snesrud, E. C., Borisy, G. G., Lazarev, M., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1406199111 · Cited by 700
Paneth Cells: Maestros of the Small Intestinal Crypts
Clevers, H. C., & Bevins, C. L. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183744 · Cited by 748
Crohn’s disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn’s disease
Brand, S. (2009) · Gut · doi:10.1136/gut.2008.163667 · Cited by 683
The CXCL8/IL-8 chemokine family and its receptors in inflammatory diseases
Russo, R. C., Garcia, C. C., Teixeira, M. M., & Amaral, F. A. (2014) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2014.894886 · Cited by 684
NF-κB in inflammation and cancer
Mao, H., Zhao, X., & Sun, S. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01310-w · Cited by 601
Nod2 is required for the regulation of commensal microbiota in the intestine
Petnicki-Ocwieja, T., Hrncir, T., Liu, Y.-J., Biswas, A., Hudcovic, T., Tlaskalova-Hogenova, H., & Kobayashi, K. S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907722106 · Cited by 564
Autologous bone marrow-derived mesenchymal stromal cells in the treatment of fistulising Crohn's disease
Ciccocioppo, R., Bernardo, M. E., Sgarella, A., Maccario, R., Avanzini, M. A., Ubezio, C., Minelli, A., Alvisi, C., Vanoli, A., Calliada, F., et al. (2011) · Gut · doi:10.1136/gut.2010.214841 · Cited by 557
Macrophage-Restricted Interleukin-10 Receptor Deficiency, but Not IL-10 Deficiency, Causes Severe Spontaneous Colitis
Zigmond, E., Bernshtein, B., Friedlander, G., Walker, C., Yona, S., Kim, K.-W., Brenner, O. J., Krauthgamer, R., Varol, C., Müller, W., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.03.012 · Cited by 578
Detecting shared pathogenesis from the shared genetics of immune-related diseases
Zhernakova, A., van Diemen, C. C., & Wijmenga, C. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2489 · Cited by 551
Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance
Nedjic, J., Aichinger, M., Emmerich, J., Mizushima, N., & Klein, L. (2008) · Nature · doi:10.1038/nature07208 · Cited by 552
Regulatory Lymphocytes and Intestinal Inflammation
Ízcue, A., Coombes, J. L., & Powrie, F. M. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132657 · Cited by 513
Common variants at five new loci associated with early-onset inflammatory bowel disease
Imielinski, M. B., Baldassano, R. N., Griffiths, A. M., Russell, R. K., Annese, V., Dubinsky, M. C., Kugathasan, S., Bradfield, J. P., Walters, T. D., Abou‐Sleiman, P. M., et al. (2009) · Nature Genetics · doi:10.1038/ng.489 · Cited by 484
Loss of Interleukin-10 Signaling and Infantile Inflammatory Bowel Disease: Implications for Diagnosis and Therapy
Kotlarz, D., Beier, R., Murugan, D., Diestelhorst, J., Jensen, O., Boztuǧ, K., Pfeifer, D., Kreipe, H. H., Pfister, E., Baumann, U., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.04.045 · Cited by 492
Stevioside and related compounds: Therapeutic benefits beyond sweetness
Chatsudthipong, V., & Muanprasat, C. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.09.007 · Cited by 483
Microbial translocation in HIV infection: causes, consequences and treatment opportunities
Utay, N. S., & Douek, D. C. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2848 · Cited by 486
Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation
Kleinschek, M. A., Boniface, K., Sadekova, S., Grein, J., Murphy, E. E., Turner, S. P., Raskin, L., Desai, B., Faubion, W. A., de Waal Malefyt, R., et al. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20081712 · Cited by 460
The Commensal Microbiota and Enteropathogens in the Pathogenesis of Inflammatory Bowel Diseases
Chassaing, B., & Darfeuille–Michaud, A. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.01.054 · Cited by 443
Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology
Rossin, E. J., Lage, K., Raychaudhuri, S., Xavier, R. J., Tatar, D., Benita, Y., Constortium, I. I. B. D. G., Cotsapas, C., & Daly, M. J. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1001273 · Cited by 438
Cellular Metabolism and Macrophage Functional Polarization
Zhu, L., Zhao, Q., Yang, T., Ding, W., & Zhao, Y. X. (2014) · International Reviews of Immunology · doi:10.3109/08830185.2014.969421 · Cited by 438
Animal Protein Intake and Risk of Inflammatory Bowel Disease: The E3N Prospective Study
Jantchou, P., Morois, S., Clavel‐Chapelon, F., Boutron‐Ruault, M., & Carbonnel, F. (2010) · The American Journal of Gastroenterology · doi:10.1038/ajg.2010.192 · Cited by 441
Recent Insights Into the Genetics of Inflammatory Bowel Disease
Cho, J. H., & Brant, S. R. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.02.046 · Cited by 442
Self-citation
A new genetic subgroup of chronic granulomatous disease with autosomal recessive mutations in p40phox and selective defects in neutrophil NADPH oxidase activity
Matute, J. D., Arias, A. A., Wright, N. A. M., Wrobel, I. T., Waterhouse, C. C. M., Li, X. J., Marchal, C. C., Stull, N. D., Lewis, D. B., Steele, M., et al. (2009) · Blood · doi:10.1182/blood-2009-07-231498 · Cited by 430
Innate immune mechanisms of colitis and colitis-associated colorectal cancer
Saleh, M., & Trinchieri, G. (2010) · Nature reviews. Immunology · doi:10.1038/nri2891 · Cited by 406
The impact of the microbiota on the pathogenesis of IBD: lessons from mouse infection models
Nell, S., Suerbaum, S., & Josenhans, C. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2403 · Cited by 407
Pharmacology and therapeutics of omega-3 polyunsaturated fatty acids in chronic inflammatory disease
Yates, C. M., Calder, P. C., & Rainger, G. E. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.10.010 · Cited by 410
A Cross-Talk Between Microbiota-Derived Short-Chain Fatty Acids and the Host Mucosal Immune System Regulates Intestinal Homeostasis and Inflammatory Bowel Disease
Gonçalves, P., Araújo, J. R., & Santo, J. P. D. (2018) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izx029 · Cited by 404
Dysbiosis of Salivary Microbiota in Inflammatory Bowel Disease and Its Association With Oral Immunological Biomarkers
Said, H. S., Suda, W., Nakagome, S., Chinen, H., Oshima, K., Kim, S., Kimura, R., Iraha, A., Ishida, H., Fujita, J., et al. (2013) · DNA Research · doi:10.1093/dnares/dst037 · Cited by 394
Direct and Indirect Induction by 1,25-Dihydroxyvitamin D3 of the NOD2/CARD15-Defensin β2 Innate Immune Pathway Defective in Crohn Disease
Wang, T. T., Dabbas, B., Laperrière, D., Bitton, A. J., Soualhine, H., Tavera-Mendoza, L. E., Dionne, S., Servant, M. J., Bitton, A., Seidman, E. G., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.c109.071225 · Cited by 395
CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity
Wang, C., Yosef, N., Gaublomme, J. T., Wu, C., Lee, Y., Clish, C. B., Kaminski, J., Xiao, S., zu Hörste, G. M., Pawlak, M., et al. (2015) · Cell · doi:10.1016/j.cell.2015.10.068 · Cited by 405
Butyricicoccus pullicaecorum in inflammatory bowel disease
Eeckhaut, V., Machiels, K., Perrier, C., Romero, C., Maes, S., Flahou, B., Steppe, M., Haesebrouck, F., Sas, B., Ducatelle, R., et al. (2012) · Gut · doi:10.1136/gutjnl-2012-303611 · Cited by 368
Regulation of the Antimicrobial Response by NLR Proteins
Elinav, E., Strowig, T., Henao‐Mejia, J., & Flavell, R. A. (2011) · Immunity · doi:10.1016/j.immuni.2011.05.007 · Cited by 355
Expanded allogeneic adipose-derived stem cells (eASCs) for the treatment of complex perianal fistula in Crohn’s disease: results from a multicenter phase I/IIa clinical trial
de la Portilla, F., Alba, F., García‐Olmo, D., Herrerías, J. M., González-Argente, X. F., & Galindo, A. (2012) · International Journal of Colorectal Disease · doi:10.1007/s00384-012-1581-9 · Cited by 354
Recent Advances in the Genetics of Autoimmune Disease
Gregersen, P. K., & Olsson, L. M. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132653 · Cited by 343
Human mucosal in vivo transcriptome responses to three lactobacilli indicate how probiotics may modulate human cellular pathways
van Baarlen, P., Troost, F. J., van Kraaij, C., Hooiveld, G. J. E. J., Boekschoten, M. V., Brummer, R. J., & Kleerebezem, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000079107 · Cited by 347
Dietary simple sugars alter microbial ecology in the gut and promote colitis in mice
Khan, S., Waliullah, S., Godfrey, V., Khan, M. A. W., Ramachandran, R. A., Cantarel, B. L., Behrendt, C. L., Peng, L., Hooper, L. V., & Zaki, H. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aay6218 · Cited by 322
Autoimmune diseases: insights from genome-wide association studies
Lettre, G., & Rioux, J. D. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn246 · Cited by 317
Mechanisms and pathways of innate immune activation and regulation in health and cancer
Cui, J., Chen, Y., Wang, H. Y., & Wang, R. (2014) · Human Vaccines & Immunotherapeutics · doi:10.4161/21645515.2014.979640 · Cited by 327
Intestinal microbiota in inflammatory bowel disease: Friend of foe?
Fava, F. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i5.557 · Cited by 297
Mitochondria: Sovereign of inflammation?
Tschopp, J. (2011) · European Journal of Immunology · doi:10.1002/eji.201141436 · Cited by 303
The NLRP3 inflammasome: Contributions to intestinal homeostasis
Zaki, M. H., Lamkanfi, M., & Kanneganti, T.-D. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.02.002 · Cited by 290
Association of Psoriasis With Inflammatory Bowel Disease
Fu, Y., Lee, C., & Chi, C. (2018) · JAMA Dermatology · doi:10.1001/jamadermatol.2018.3631 · Cited by 294
CD39 deletion exacerbates experimental murine colitis and human polymorphisms increase susceptibility to inflammatory bowel disease
Friedman, D. J., Künzli, B. M., A-Rahim, Y. I., Sevigny, J., Berberat, P. O., Enjyoji, K., Csizmadia, E., Friess, H., & Robson, S. C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902869106 · Cited by 284
Non-Invasive Mapping of the Gastrointestinal Microbiota Identifies Children with Inflammatory Bowel Disease
Papa, E., Docktor, M., Smillie, C. S., Weber, S., Preheim, S. P., Gevers, D., Giannoukos, G., Ciulla, D., Tabbaa, D., Ingram, J., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039242 · Cited by 279
Small-Molecule RORγt Antagonists Inhibit T Helper 17 Cell Transcriptional Network by Divergent Mechanisms
Xiao, S., Yosef, N., Yang, J., Wang, Y., Zhou, L., Zhu, C. Y., Wu, C., Baloglu, E., Schmidt, D. R., Ramesh, R., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.04.004 · Cited by 283
Butyrate suppresses colonic inflammation through HDAC1-dependent Fas upregulation and Fas-mediated apoptosis of T cells
Zimmerman, M. A., Singh, N., Martin, P. M., Thangaraju, M., Ganapathy, V., Waller, J. L., Shi, H., Robertson, K. D., Munn, D. H., & Liu, K. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00543.2011 · Cited by 281
Protective role of 1,25(OH)2vitamin D3 in the mucosal injury and epithelial barrier disruption in DSS-induced acute colitis in mice
Zhao, H., Zhang, H., Wu, H., Li, H., Liu, L., Guo, J. X., Li, C., Shih, D. Q., & Zhang, X. (2012) · BMC Gastroenterology · doi:10.1186/1471-230x-12-57 · Cited by 272
IL‐10 and IL‐10 receptor defects in humans
Glocker, E., Kotlarz, D., Klein, C., Shah, N., & Grimbacher, B. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06339.x · Cited by 270
Insulin-Like Growth Factor-I Regulation of Immune Function: A Potential Therapeutic Target in Autoimmune Diseases?
Smith, T. J. (2010) · Pharmacological Reviews · doi:10.1124/pr.109.002469 · Cited by 274
The host selects mucosal and luminal associations of coevolved gut microorganisms: a novel concept
den Abbeele, P. V., de Wiele, T. V., Verstraete, W., & Possemiers, S. (2011) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2011.00270.x · Cited by 273
Vitamin D metabolism and signaling in the immune system
White, J. H. (2011) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-011-9195-z · Cited by 265
Development and function of TH17 cells in health and disease
Louten, J., Boniface, K., & Malefyt, R. D. W. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.04.003 · Cited by 267
Heterogeneity of autoimmune diseases: pathophysiologic insights from genetics and implications for new therapies
Cho, J. H., & Feldman, M. A. (2015) · Nature Medicine · doi:10.1038/nm.3897 · Cited by 267
Self-citation
Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified
Bruno, G., Zaccari, P., Rocco, G., Scalese, G., Panetta, C., Porowska, B., Pontone, S., & Severi, C. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i22.2706 · Cited by 258
Inflammatory Bowel Disease: An Overview of Immune Mechanisms and Biological Treatments
de Mattos, B. R. R., Garcia, M. P. G., Bier, J., Paiatto, L. N., Albuquerque, C. G., Souza, C. L., Fernandes, L. G. R., Tamashiro, W. M. D. S. C., & Simioni, P. U. (2015) · Mediators of Inflammation · doi:10.1155/2015/493012 · Cited by 257
Nanoparticulate drug delivery systems targeting inflammation for treatment of inflammatory bowel disease
Zhang, S., Langer, R., & Traverso, G. (2017) · Nano Today · doi:10.1016/j.nantod.2017.08.006 · Cited by 258
Scalable Variational Inference for Bayesian Variable Selection in Regression, and Its Accuracy in Genetic Association Studies
Carbonetto, P. S., & Stephens, M. (2012) · Bayesian Analysis · doi:10.1214/12-ba703 · Cited by 267
Changes of the cytokine profile in inflammatory bowel diseases
Műzes, G. (2012) · World Journal of Gastroenterology · doi:10.3748/wjg.v18.i41.5848 · Cited by 258
Dysbiotic Events in Gut Microbiota: Impact on Human Health
Schippa, S., & Conte, M. (2014) · Nutrients · doi:10.3390/nu6125786 · Cited by 256
Air pollution: An environmental factor contributing to intestinal disease
Beamish, L. A., Osornio-Vargas, Á. R., & Wine, E. (2011) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2011.02.017 · Cited by 237
Immunopathogenesis of inflammatory bowel disease
Matricon, J., Barnich, N., & Ardid, D. (2010) · Self/Nonself · doi:10.4161/self.1.4.13560 · Cited by 236
Identification of an innate T helper type 17 response to intestinal bacterial pathogens
Geddes, K., Rubino, S. J., Magalhaes, J. G., Streutker, C., Bourhis, L. L., Cho, J., Robertson, S. J., Kim, C. J., Kaul, R., Philpott, D. J., et al. (2011) · Nature Medicine · doi:10.1038/nm.2391 · Cited by 235
Self-citation
Regulation of interleukin‐12/interleukin‐23 production and the T‐helper 17 response in humans
Lyakh, L. A., Trinchieri, G., Provezza, L., Carra, G., & Gerosa, F. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00700.x · Cited by 237
Inside the Mucosal Immune System
McGhee, J. R., & Fujihashi, K. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001397 · Cited by 233
The Microbiome and Inflammatory Bowel Disease: Is There a Therapeutic Role for Fecal Microbiota Transplantation?
Damman, C. J., Miller, S. I., Surawicz, C. M., & Zisman, T. L. (2012) · The American Journal of Gastroenterology · doi:10.1038/ajg.2012.93 · Cited by 229
Revisiting Mendelian disorders through exome sequencing
Ku, C., Naidoo, N., & Yudi Pawitan, Y. (2011) · Human Genetics · doi:10.1007/s00439-011-0964-2 · Cited by 230
NOD2, an intracellular innate immune sensor involved in host defense and Crohn's disease
Strober, W., & Watanabe, T. (2011) · Mucosal Immunology · doi:10.1038/mi.2011.29 · Cited by 231
STAT3 in CD4+ T helper cell differentiation and inflammatory diseases
Egwuagu, C. E. (2009) · Cytokine · doi:10.1016/j.cyto.2009.07.003 · Cited by 219
Securing the immune tightrope: mononuclear phagocytes in the intestinal lamina propria
Varol, C., Zigmond, E., & Jung, S. (2010) · Nature reviews. Immunology · doi:10.1038/nri2778 · Cited by 222
Intestinal Effector T Cells in Health and Disease
Maynard, C. L., & Weaver, C. T. (2009) · Immunity · doi:10.1016/j.immuni.2009.08.012 · Cited by 215
Review: Mammalian peptidoglycan recognition proteins (PGRPs) in innate immunity
Dziarski, R., & Gupta, D. (2010) · Innate Immunity · doi:10.1177/1753425910366059 · Cited by 203
NOD-like receptors and the innate immune system: Coping with danger, damage and death
Kersse, K., Bertrand, M. J. M., Lamkanfi, M., & Vandenabeele, P. (2011) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2011.09.003 · Cited by 214
Th17 Cells Induce Colitis and Promote Th1 Cell Responses through IL-17 Induction of Innate IL-12 and IL-23 Production
Feng, T., Qin, H., Wang, L., Benveniste, E. N., Elson, C. O., & Cong, Y. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1001454 · Cited by 201
Psoriasis, psoriatic arthritis and increased risk of incident Crohn's disease in US women
Li, W., Han, J., Chan, A. T., & Qureshi, A. A. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2012-202143 · Cited by 195
Psoriasis associated with ulcerative colitis and Crohn's disease
Cohen, A., Dreiher, J., & Birkenfeld, S. (2009) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2008.03031.x · Cited by 194
Pro-inflammatory miR-223 mediates the cross-talk between the IL23 pathway and the intestinal barrier in inflammatory bowel disease
Wang, H., Chao, K., Ng, S. C., Bai, A. H. C., Yu, Q., Yu, J. Q., Li, M., Cui, Y., Chen, M., Hu, J., et al. (2016) · Genome biology · doi:10.1186/s13059-016-0901-8 · Cited by 186
Rapidly expanding knowledge on the role of the gut microbiome in health and disease
Cénit, M. C., Matzaraki, V., Tigchelaar, E. F., & Zhernakova, A. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.05.023 · Cited by 197
IL-21 and T follicular helper cells
Spolski, R. J., & Leonard, W. J. (2009) · International Immunology · doi:10.1093/intimm/dxp112 · Cited by 192
The pursuit of genome-wide association studies: where are we now?
Ku, C., Loy, E. Y., Yudi Pawitan, Y., & Chia, K. S. (2010) · Journal of Human Genetics · doi:10.1038/jhg.2010.19 · Cited by 184
The involvement of gut microbiota in inflammatory bowel disease pathogenesis: Potential for therapy
Cammarota, G., Ianiro, G., Cianci, R., Bibbò, S., Gasbarrini, A., & Currò, D. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.12.006 · Cited by 184
Chitosan oligosaccharide as potential therapy of inflammatory bowel disease: Therapeutic efficacy and possible mechanisms of action
Yousef, M., Pichyangkura, R., Soodvilai, S., Chatsudthipong, V., & Muanprasat, C. (2012) · Pharmacological Research · doi:10.1016/j.phrs.2012.03.013 · Cited by 182
Genetics of inflammatory bowel disease in Asia: Systematic review and meta-analysis
Ng, S. C., Tsoi, K. K. F., Kamm, M. A., Xia, B., Wu, J. C., Chan, F. K. L., & Sung, J. J. �. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21845 · Cited by 179
The Immunological Basis of Inflammatory Bowel Disease
Silva, F. A. R., Rodrigues, B. L., Ayrizono, M. D. L. S., & Leal, R. F. (2016) · Gastroenterology Research and Practice · doi:10.1155/2016/2097274 · Cited by 188

Authors: Cho, J. H.
Affiliations: Yale University (US)
Corresponding author: Cho, Judy H.
ORCID: Cho, Judy H.
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2008-06
Volume: 8
Issue: 6
Pages: 458-466
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri2340
OpenAlex: W2066203385
Cited by: 940
References: 99
Citations by year: 2026: 16 · 2025: 14 · 2024: 28 · 2023: 30 · 2022: 30 · 2021: 32 · 2020: 47 · 2019: 39 · 2018: 45 · 2017: 37 · 2016: 53 · 2015: 50 · 2014: 61 · 2013: 71 · 2012: 80
FWCI: 9.45
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: Georgia Clinical and Translational Science Alliance
National Institute of Diabetes and Digestive and Kidney Diseases (U01-DK62429, U01DK62422, R01DK072373, U01DK062429, U01DK062422)
Topics: Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Keywords: inflammatory bowel disease, Crohn's disease, ulcerative colitis, genetic susceptibility, immunopathogenesis, NOD2, ATG16L1, autophagy, IL23R, IL12B, STAT3, NKX2-3, bacterial sensing, cytokine signaling, innate immunity, adaptive immunity, genome-wide association study
MeSH terms: Animals, Colitis, Ulcerative, Crohn Disease, Humans, Inflammatory Bowel Diseases, Genetic Predisposition to Disease

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The genetics and immunopathogenesis of inflammatory bowel disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks