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Cited by 363

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

Cytokine-mediated regulation of antimicrobial proteins

Open access
Kolls, Jay K., McCray, Paul B., Chan, Yvonne R.·2008·Nature Reviews Immunology

Abstract

Antimicrobial proteins constitute a phylogenetically ancient form of innate immunity that provides host defence at skin and mucosal surfaces. Although some components of this system are constitutively expressed, new evidence reviewed in this Progress article shows that the production of certain antimicrobial proteins by epithelial cells can also be regulated by cytokines of the innate and adaptive immune systems. In particular, the effector cytokines interleukin-17 and interleukin-22, which are produced by the T-helper-17-cell subset, are emerging as crucial regulators of antimicrobial-peptide production in the gut and the lungs. This suggests that this T-cell lineage and its cytokines have important roles in skin and mucosal immunity.

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Crossref · 10.1038/nri2433

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Metadata

Authors
Kolls, J. K., McCray, P. B., & Chan, Y. R.
Venue
Nature Reviews Immunology
Published
2008-11
Volume
8
Issue
11
Pages
829-835
ISSN
  • 1474-1733 (ISSN-L)
  • 1474-1741
OpenAlex
W2055403920
Cited by
363
References
13
FWCI
3.64
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Cytokine-mediated regulation of antimicrobial proteins. https://app.cochat.ai/papers/10.1038/nri2433
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Kolls, J. K., McCray, P. B., & Chan, Y. R. (2008). Cytokine-mediated regulation of antimicrobial proteins. Nature Reviews Immunology. https://doi.org/10.1038/nri2433

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.