The DOI matches its Crossref record; 119 of the 119 references it cites were found in a registry or an index.
How are TH2-type immune responses initiated and amplified?
Open accessAbstract
CD4+ T helper (TH) cells have crucial roles in orchestrating adaptive immune responses. TH2 cells control immunity to extracellular parasites and all forms of allergic inflammatory responses. Although we understand the initiation of the TH2-type response in tissue culture in great detail, much less is known about TH2 cell induction in vivo. Here we discuss the involvement of allergen- and parasite product-mediated activation of epithelial cells, basophils and dendritic cells and the functions of the cytokines interleukin-4 (IL-4), IL-25, IL-33 and thymic stromal lymphopoietin in the initiation and amplification of TH2-type immune responses in vivo.
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Self-citation
Cited by
Romani, L. (2011) · Nature Reviews Immunology · doi:10.1038/nri2939 · Cited by 1,793
SARS-CoV-2 infection: The role of cytokines in COVID-19 disease
Costela-Ruiz, V. J., Illescas-Montes, R., Puerta-Puerta, J. M., Ruiz, C., & Melguizo-Rodríguez, L. (2020) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2020.06.001 · Cited by 1,121
Diversity and dialogue in immunity to helminths
Allen, J. E., & Maizels, R. M. (2011) · Nature reviews. Immunology · doi:10.1038/nri2992 · Cited by 831
Type 2 cytokines: mechanisms and therapeutic strategies
Wynn, T. A. (2015) · Nature Reviews Immunology · doi:10.1038/nri3831 · Cited by 678
Food allergy: immune mechanisms, diagnosis and immunotherapy
Yu, W., Freeland, D. M. H., & Nadeau, K. C. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.111 · Cited by 659
Metadata
- Authors
- Paul, W. E., & Zhu, J.
- Venue
- Nature Reviews Immunology
- Published
- 2010-04
- Volume
- 10
- Issue
- 4
- Pages
- 225-235
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2026028987
- Cited by
- 963
- References
- 119
- FWCI
- 4.60
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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