The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Tissue-based class control: the other side of tolerance
Abstract
In this Essay, we offer a new perspective on how immune responses are regulated. We do not cover how they are turned on and off, but focus instead on the second major aspect of an immune response: the control of effector class. Although it is generally thought that the class of an immune response is tailored to fit the invading pathogen, we suggest here that it is primarily tailored to fit the tissue in which the response occurs. To this end, we cover such topics as the nature of T helper (TH) cell subsets (current and yet to be discovered), the nature of privileged sites, the difference between oral tolerance and oral vaccination, why the route of immunization matters, whether the TH1-type response is really the immune system's primary defense, and whether there might be a different role for some regulatory T cells.
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Cites
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Medzhitov, R., Schneider, D. S., & Soares, M. P. (2012) · Science · doi:10.1126/science.1214935 · Cited by 1,718
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Mauri, C., & Bosma, A. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074934 · Cited by 1,249
Aryl hydrocarbon receptor control of a disease tolerance defence pathway
Bessede, A., Gargaro, M., Pallotta, M. T., Matino, D., Servillo, G., Brunacci, C., Bicciato, S., Mazza, E. M. C., Macchiarulo, A., Vacca, C., et al. (2014) · Nature · doi:10.1038/nature13323 · Cited by 674
Metadata
- Authors
- Matzinger, P., & Kamala, T.
- Venue
- Nature Reviews Immunology
- Published
- 2011-02-25
- Volume
- 11
- Issue
- 3
- Pages
- 221-230
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2094601991
- Cited by
- 343
- References
- 11
- FWCI
- 2.83
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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