The DOI matches its Crossref record; 104 of the 104 references it cites were found in a registry or an index.
Immune Regulatory Function of B Cells
Abstract
B cells are regarded for their capacity to produce antibody. However, recent advances in B cell biology have capitalized on old findings and demonstrated that B cells also release a broad variety of cytokines. As with T helper cells, B cells can be classified into subsets according to the cytokine milieu that they produce. One functional B cell subset, regulatory B cells (Bregs), has recently been shown to contribute to the maintenance of the fine equilibrium required for tolerance. Bregs restrain the excessive inflammatory responses that occur during autoimmune diseases or that can be caused by unresolved infections. Pivotal to Breg function is interleukin-10 (IL-10), which inhibits proinflammatory cytokines and supports regulatory T cell differentiation. This review reports and discusses the factors that are important for Breg differentiation and for their effector function in both mouse and human.
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Cites
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Self-citationThe CD40 Antigen and Its Ligand
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Regulatory B Cells: Origin, Phenotype, and Function
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Metadata
- Authors
- Mauri, C., & Bosma, A.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2012-04-23
- Volume
- 30
- Issue
- 1
- Pages
- 221-241
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2140821709
- Cited by
- 1,249
- References
- 104
- FWCI
- 6.80
- Type
- journal article
- Language
- en
- Open access
- closed
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