The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Harnessing the biology of IL-7 for therapeutic application
Open accessAbstract
Interleukin-7 (IL-7) is required for T cell development and for maintaining and restoring homeostasis of mature T cells. IL-7 is a limiting resource under normal conditions, but it accumulates during lymphopaenia, leading to increased T cell proliferation. The administration of recombinant human IL-7 to normal or lymphopenic mice, non-human primates and humans results in widespread T cell proliferation, increased T cell numbers, modulation of peripheral T cell subsets and increased T cell receptor repertoire diversity. These effects raise the prospect that IL-7 could mediate therapeutic benefits in several clinical settings. This Review summarizes the biology of IL-7 and the results of its clinical use that are available so far to provide a perspective on the opportunities for clinical application of this cytokine.
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“An exception to this rule occurs during primary immune responses, when IL-7Rα is selectively expressed on a small minority of effector T cells that are destined to enter the central memory T cell pool, thus implicating IL-7 as a modulator of the effector to memory cell transitio”
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“IL-7Rα expression is notably low on FOXP3 + T Reg cells compared with non-regulatory T cell subsets, such that cells with a CD4 + CD25 hi IL-7Rα low phenotype are highly enriched for T Reg cell”
BackgroundLymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis
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Variation in interleukin 7 receptor α chain (IL7R) influences risk of multiple sclerosis
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Self-citation
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Hotchkiss, R. S., Monneret, G., & Payen, D. (2013) · Nature Reviews Immunology · doi:10.1038/nri3552 · Cited by 2,772
The immunopathology of sepsis and potential therapeutic targets
van der Poll, T., van de Veerdonk, F. L., Scicluna, B. P., & Netea, M. G. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.36 · Cited by 1,957
Adoptive immunotherapy for cancer: harnessing the T cell response
Restifo, N. P., Dudley, M. E., & Rosenberg, S. A. (2012) · Nature Reviews Immunology · doi:10.1038/nri3191 · Cited by 1,688
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Delano, M. J., & Ward, P. A. (2016) · Immunological Reviews · doi:10.1111/imr.12499 · Cited by 880
Contributions of Age-Related Thymic Involution to Immunosenescence and Inflammaging
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Metadata
- Authors
- Mackall, C. L., Fry, T. J., & Gress, R. E.
- Venue
- Nature Reviews Immunology
- Published
- 2011-04-21
- Volume
- 11
- Issue
- 5
- Pages
- 330-342
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W1994844769
- Cited by
- 571
- References
- 7
- FWCI
- 2.69
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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