Cited by 290T-cell and B-cell ImmunologyGenomics and Chromatin DynamicsEpigenetics and DNA Methylation

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The molecular basis of the memory T cell response: differential gene expression and its epigenetic regulation

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Weng, Nan-ping, Araki, Yasuto, Subedi, Kalpana·2012·Nature Reviews Immunology

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Abstract

How the immune system remembers a previous encounter with a pathogen and responds more efficiently to a subsequent encounter has been one of the central enigmas for immunologists for over a century. The identification of pathogen-specific memory lymphocytes that arise after an infection provided a cellular basis for immunological memory. But the molecular mechanisms of immunological memory remain only partially understood. The emerging evidence suggests that epigenetic changes have a key role in controlling the distinct transcriptional profiles of memory lymphocytes and thus in shaping their function. In this Review, we summarize the recent progress that has been made in assessing the differential gene expression and chromatin modifications in memory CD4(+) and CD8(+) T cells, and we present our current understanding of the molecular basis of memory T cell function.

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High-Resolution Profiling of Histone Methylations in the Human Genome
Barski, A., Cuddapah, S., Cui, K., Roh, T.-Y., Schones, D. E., Wang, Z., Wei, G., Chepelev, I., & Zhao, K. (2007) · Cell · doi:10.1016/j.cell.2007.05.009 · Cited by 6,845
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846 · cited 1×
“Memory T cell populations are heterogeneous and can be divided into two main subsets: central memory T cells (T CM cells) and effector memory T cells (T EM cells”
Background
A bivalent chromatin structure marks key developmental genes in embryonic stem cells
Bernstein, B. E., Mikkelsen, T. S., Xie, X., Kamal, M., Huebert, D. J., Cuff, J., Fry, B., Meissner, A., Wernig, M., Plath, K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.02.041 · Cited by 5,361
CpG islands and the regulation of transcription
Deaton, A. M., & Bird, A. (2011) · Genes & Development · doi:10.1101/gad.2037511 · Cited by 3,187
The complex language of chromatin regulation during transcription
Berger, S. L. (2007) · Nature · doi:10.1038/nature05915 · Cited by 2,768
Combinatorial patterns of histone acetylations and methylations in the human genome
Wang, Z., Zang, C., Rosenfeld, J. A., Schones, D. E., Barski, A., Cuddapah, S., Cui, K., Roh, T.-Y., Peng, W., Zhang, M. Q., et al. (2008) · Nature Genetics · doi:10.1038/ng.154 · Cited by 2,331
A Chromatin Landmark and Transcription Initiation at Most Promoters in Human Cells
Guenther, M. G., Levine, S. S., Boyer, L. A., Jaenisch, R., & Young, R. A. (2007) · Cell · doi:10.1016/j.cell.2007.05.042 · Cited by 2,002
An operational definition of epigenetics: Figure 1.Preprint
Berger, S. L., Kouzarides, T., Shiekhattar, R., & Shilatifard, A. (2009) · Genes & Development · doi:10.1101/gad.1787609 · Cited by 1,889
Conserved role of intragenic DNA methylation in regulating alternative promoters
Maunakea, A. K., Nagarajan, R. P., Bilenky, M., Ballinger, T. J., D’Souza, C., Fouse, S. D., Johnson, B. E., Hong, C., Nielsen, C., Zhao, Y., et al. (2010) · Nature · doi:10.1038/nature09165 · Cited by 1,743
A genome-wide analysis of CpG dinucleotides in the human genome distinguishes two distinct classes of promoters
Saxonov, S., Berg, P., & Brutlag, D. L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510310103 · Cited by 1,401

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Additional file 3 of Per-cell histone acetylation is associated with terminal differentiation in human T cells
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Additional file 1 of Per-cell histone acetylation is associated with terminal differentiation in human T cells
Yang, C., Li, Y., Hu, Y., Li, Q., Lan, Y., & Li, Y. (2024) · Figshare · doi:10.6084/m9.figshare.25157322
Additional file 4 of Per-cell histone acetylation is associated with terminal differentiation in human T cells
Yang, C., Li, Y., Hu, Y., Li, Q., Lan, Y., & Li, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26677652
Additional file 5 of Per-cell histone acetylation is associated with terminal differentiation in human T cells
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Authors: Weng, N.-P., Araki, Y., & Subedi, K.
Affiliations: National Institutes of Health (US)
Corresponding author: Weng, Nan-ping
ORCID: Weng, Nan-ping
Araki, Yasuto
Subedi, Kalpana
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2012-03-16
Volume: 12
Issue: 4
Pages: 306-315
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri3173
PMC: PMC4686144
OpenAlex: W2084317828
Cited by: 290
References: 68
Citations by year: 2026: 11 · 2025: 13 · 2024: 22 · 2023: 20 · 2022: 25 · 2021: 20 · 2020: 11 · 2019: 26 · 2018: 22 · 2017: 27 · 2016: 18 · 2015: 24 · 2014: 21 · 2013: 20 · 2012: 10
FWCI: 2.21
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
Japan Society for the Promotion of Science (23790544)
National Institute on Aging (ZIAAG000112)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords: memory T cells, immunological memory, epigenetic regulation, chromatin modification, differential gene expression, naive T cells, CD4+ T cells, CD8+ T cells, gene expression profiling
MeSH terms: Animals, Gene Expression Regulation, Humans, Immunologic Memory, T-Lymphocyte Subsets, Epigenesis, Genetic

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The molecular basis of the memory T cell response: differential gene expression and its epigenetic regulation

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