Nutrient-sensing pathways and metabolic regulation in stem cells

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197 · see citing works

Embryonic Stem Cell Lines Derived from Human Blastocysts

Thomson, J. A., Itskovitz‐Eldor, J., Shapiro, S. S., Waknitz, M. A., Swiergiel, J. J., Marshall, V. S., & Jones, J. M. (1998) · Science · doi:10.1126/science.282.5391.1145 · Cited by 15,947 · see citing works

HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia

Kim, J.-W., Tchernyshyov, I., Semenza, G. L., & Dang, C. V. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.02.002 · Cited by 3,905 · see citing works

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Inoki, K., Li, Y., Zhu, T., Wu, J., & Guan, K.-L. (2002) · Nature Cell Biology · doi:10.1038/ncb839 · Cited by 3,083 · see citing works

Association of reactive oxygen species levels and radioresistance in cancer stem cells

Diehn, M., Cho, R. W., Lobo, N. A., Kalisky, T., Dorie, M. J., Kulp, A. N., Qian, D., Lam, J. S., Ailles, L. E., Wong, M., et al. (2009) · Nature · doi:10.1038/nature07733 · Cited by 2,555 · see citing works

Mammalian Sirtuins: Biological Insights and Disease Relevance

Haigis, M. C., & Sinclair, D. A. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092250 · Cited by 2,085 · see citing works

The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate

Ward, P. S., Patel, J., Wise, D. R., Abdel-Wahab, O., Bennett, B. D., Coller, H. A., Cross, J. R., Fantin, V. R., Hedvat, C. V., Perl, A. E., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.01.020 · Cited by 2,020 · see citing works

IDH mutation impairs histone demethylation and results in a block to cell differentiation

Lu, C., Ward, P. S., Kapoor, G. S., Rohle, D., Turcan, S., Abdel-Wahab, O., Edwards, C. R., Khanin, R., Figueroa, M. E., Melnick, A., et al. (2012) · Nature · doi:10.1038/nature10860 · Cited by 1,985 · see citing works

AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice

Li, Y., Xu, S., Mihaylova, M. M., Zheng, B., Hou, X., Jiang, B., Park, O., Luo, Z., Lefai, É., Shyy, J. Y.-J., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.009 · Cited by 1,788 · see citing works

A serine/threonine kinase gene defective in Peutz–Jeghers syndrome

Hemminki, A., Markie, D., Tomlinson, I. P. M., Avizienyte, E., Roth, S., Loukola, A., Bignell, G. R., Warren, W., Aminoff, M., Höglund, P., et al. (1998) · Nature · doi:10.1038/34432 · Cited by 1,652 · see citing works

Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

Kops, G. J. P. L., Dansen, T. B., Polderman, P. E., Saarloos, I., Wirtz, K. W. A., Coffer, P. J., Huang, T.-T., Bos, J. L., Medema, R. H., & Burgering, B. M. T. (2002) · Nature · doi:10.1038/nature01036 · Cited by 1,580 · see citing works

FoxOs Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress

Tothova, Z., Kollipara, R., Huntly, B. J., Lee, B. H., Castrillon, D. H., Cullen, D. E., McDowell, E. P., Lazo-Kallanian, S., Williams, I. R., Sears, C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.01.003 · Cited by 1,562 · see citing works

Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells

Ito, K., Hirao, A., Arai, F., Takubo, K., Matsuoka, S., Miyamoto, K., Ohmura, M., Naka, K., Hosokawa, K., Ikeda, Y., et al. (2006) · Nature Medicine · doi:10.1038/nm1388 · Cited by 1,362 · see citing works

Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells

Yilmaz, Ö. H., Valdez, R., Theisen, B. K., Guo, W., Ferguson, D. O., Wu, H., & Morrison, S. J. (2006) · Nature · doi:10.1038/nature04703 · Cited by 1,272 · see citing works

Peutz-Jeghers syndrome is caused by mutations in a novel serine threoninekinase

Jenne, D. E., Reomann, H., Nezu, J., Friedel, W., Loff, S., Jeschke, R., Müller, O., Back, W. E., & Zimmer, M. (1998) · Nature Genetics · doi:10.1038/ng0198-38 · Cited by 1,201 · see citing works

Dnmt3a is essential for hematopoietic stem cell differentiation

Challen, G. A., Sun, D., Jeong, M., Luo, M., Jelinek, J., Berg, J. S., Bock, C., Vasanthakumar, A., Gu, H., Xi, Y., et al. (2012) · Nature Genetics · doi:10.1038/ng.1009 · Cited by 1,122 · see citing works

The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche

Simsek, T., Kocabas, F., Zheng, J., DeBerardinis, R. J., Mahmoud, A. I., Olson, E. N., Schneider, J. W., Zhang, C. C., & Sadek, H. A. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.07.011 · Cited by 1,101 · see citing works

AMP-activated protein kinase, a metabolic master switch: possible roles in Type 2 diabetes

Winder, W. W., & Hardie, D. G. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.1.e1 · Cited by 1,000 · see citing works

Somatic Oxidative Bioenergetics Transitions into Pluripotency-Dependent Glycolysis to Facilitate Nuclear Reprogramming

Folmes, C. D. L., Nelson, T. J., Martinez‐Fernandez, A., Arrell, D. K., Lindor, J. Z., Dzeja, P. P., Ikeda, Y., Pérez-Terzic, C. M., & Terzic, A. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.011 · Cited by 980 · see citing works

A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche

Jang, Y.-Y., & Sharkis, S. J. (2007) · Blood · doi:10.1182/blood-2007-05-087759 · Cited by 894 · see citing works

Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells

Takubo, K., Goda, N., Yamada, W., Iriuchishima, H., Ikeda, E., Kubota, Y., Shima, H., Johnson, R. S., Hirao, A., Suematsu, M., et al. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.06.020 · Cited by 891 · see citing works

Foxo3a is essential for maintenance of the hematopoietic stem cell pool

Miyamoto, K., Kazuhito, N., & Atsushi, H. (2009) · Kanazawa University Repository for Academic Resources (DSpace) (Kanazawa University) · Cited by 858 · see citing works

HIF-2α regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growthPreprint

Covello, K. L., Kehler, J., Yu, H., Gordan, J. D., Arsham, A. M., Hu, C., Labosky, P. A., Simon, M. C., & Keith, B. (2006) · Genes & Development · doi:10.1101/gad.1399906 · Cited by 818 · see citing works

PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention

Zhang, J., Grindley, J. C., Yin, T., Jayasinghe, S., He, X. C., Ross, J. T., Haug, J. S., Rupp, D., Porter-Westpfahl, K. S., Wiedemann, L. M., et al. (2006) · Nature · doi:10.1038/nature04747 · Cited by 817 · see citing works

Regulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells

Takubo, K., Nagamatsu, G., Kobayashi, C. I., Nakamura‐Ishizu, A., Kobayashi, H., Ikeda, E., Goda, N., Rahimi, Y., Johnson, R. S., Soga, T., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2012.10.011 · Cited by 810 · see citing works

HIF and c-Myc: Sibling Rivals for Control of Cancer Cell Metabolism and Proliferation

Gordan, J. D., Thompson, C. B., & Simon, M. C. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.07.006 · Cited by 806 · see citing works

Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation

Wang, F., Travins, J., DeLaBarre, B., Penard-Lacronique, V., Schalm, S., Hansen, E., Straley, K., Kernytsky, A., Liu, W., Gliser, C., et al. (2013) · Science · doi:10.1126/science.1234769 · Cited by 804 · see citing works

mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake

Yilmaz, Ö. H., Katajisto, P., Lamming, D. W., Gültekin, Y., Bauer-Rowe, K. E., Sengupta, S., Birsoy, K., Dursun, A., Yilmaz, V. O., Selig, M., et al. (2012) · Nature · doi:10.1038/nature11163 · Cited by 753 · see citing works

A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance

Ito, K., Carracedo, A., Weiss, D., Arai, F., Ala, U., Avigan, D., Schafer, Z. T., Evans, R. M., Suda, T., Lee, C., et al. (2012) · Nature Medicine · doi:10.1038/nm.2882 · Cited by 731 · see citing works

Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia

Jan, M., Snyder, T. M., Corces-Zimmerman, M. R., Vyas, P., Weissman, I. L., Quake, S. R., & Majeti, R. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004315 · Cited by 721 · see citing works

( <i>R</i> )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible

Losman, J.-A., Looper, R. E., Koivunen, P., Lee, S., Schneider, R. K., McMahon, C., Cowley, G. S., Root, D. E., Ebert, B. L., & Kaelin, W. G. (2013) · Science · doi:10.1126/science.1231677 · Cited by 703 · see citing works

TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species

Chen, C., Liu, Y., Liu, R., Ikenoue, T., Guan, K.-L., Liu, Y., & Zheng, P. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20081297 · Cited by 682 · see citing works

mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells

Chen, C., Liu, Y., Liu, Y., & Zheng, P. (2009) · Science Signaling · doi:10.1126/scisignal.2000559 · Cited by 680 · see citing works

Energy Metabolism in Human Pluripotent Stem Cells and Their Differentiated Counterparts

Varum, S., Rodrigues, A. S., Moura, M. B., Momcilovic, O., Easley, C. A., Ramalho-Santos, J., Van Houten, B., & Schatten, G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020914 · Cited by 671 · see citing works

The Placenta Is a Niche for Hematopoietic Stem Cells

Gekas, C., Dieterlen‐Lièvre, F., Orkin, S. H., & Mikkola, H. K. A. (2005) · Developmental Cell · doi:10.1016/j.devcel.2004.12.016 · Cited by 664 · see citing works

Influence of Threonine Metabolism on <i>S</i> -Adenosylmethionine and Histone Methylation

Shyh-Chang, N., Locasale, J. W., Lyssiotis, C. A., Zheng, Y., Teo, R. Y., Ratanasirintrawoot, S., Zhang, J., Onder, T., Unternaehrer, J. J., Zhu, H., et al. (2013) · Science · doi:10.1126/science.1226603 · Cited by 638 · see citing works

Comprehensive methylome map of lineage commitment from haematopoietic progenitors

Ji, H., Ehrlich, L. I. R., Seita, J., Murakami, P. N., Doi, A., Lindau, P., Lee, H.-J., Aryee, M. J., Irizarry, R. A., Kim, K., et al. (2010) · Nature · doi:10.1038/nature09367 · Cited by 636 · see citing works

FOXO3A directs a protective autophagy program in haematopoietic stem cells

Warr, M. R., Binnewies, M., Flach, J., Reynaud, D., Garg, T., Malhotra, R., Debnath, J., & Passegué, E. (2013) · Nature · doi:10.1038/nature11895 · Cited by 625 · see citing works

mTOR Is Essential for Growth and Proliferation in Early Mouse Embryos and Embryonic Stem Cells

Murakami, M., Ichisaka, T., Maeda, M., Oshiro, N., Hara, K., Edenhofer, F., Kiyama, H., Yonezawa, K., & Yamanaka, S. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.15.6710-6718.2004 · Cited by 620 · see citing works

The Senescence‐Related Mitochondrial/Oxidative Stress Pathway is Repressed in Human Induced Pluripotent Stem Cells

Prigione, A., Fauler, B., Lurz, R., Lehrach, H., & Adjaye, J. (2010) · Stem Cells · doi:10.1002/stem.404 · Cited by 617 · see citing works

Hypoxic Regulation of Lactate Dehydrogenase A

Firth, J. D., Ebert, B. L., & Ratcliffe, P. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.36.21021 · Cited by 576 · see citing works

Hypoxia and Mitochondrial Inhibitors Regulate Expression of Glucose Transporter-1 via Distinct Cis-acting Sequences

Ebert, B. L., Firth, J. D., & Ratcliffe, P. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.49.29083 · Cited by 569 · see citing works

mTOR complex 2 signaling and functions

Oh, W. J., & Jacinto, E. (2011) · Cell Cycle · doi:10.4161/cc.10.14.16586 · Cited by 561 · see citing works

The role of FoxO in the regulation of metabolism

Gross, D. N., van den Heuvel, A. P. J., & Birnbaum, M. J. (2008) · Oncogene · doi:10.1038/onc.2008.25 · Cited by 555 · see citing works

Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells

Nakada, D., Saunders, T. L., & Morrison, S. J. (2010) · Nature · doi:10.1038/nature09571 · Cited by 524 · see citing works

IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

Sasaki, M., Knobbe, C. B., Munger, J. C., Lind, E. F., Brenner, D., Brüstle, A., Harris, I. S., Holmes, R., Wakeham, A., Haight, J., et al. (2012) · Nature · doi:10.1038/nature11323 · Cited by 513 · see citing works

Metabolic oxidation regulates embryonic stem cell differentiation

Yanes, Ó., Clark, J., Wong, D. M., Patti, G. J., Sánchez‐Ruiz, A., Benton, H. P., Trauger, S. A., Desponts, C., Ding, S., & Siuzdak, G. E. (2010) · Nature Chemical Biology · doi:10.1038/nchembio.364 · Cited by 506 · see citing works

Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis

Knobloch, M., Braun, S., Zurkirchen, L., Schoultz, C., Zamboni, N., Araúzo-Bravo, M., Kovacs, W. J., Karalay, Ö., Suter, U., Machado, R. A. C., et al. (2012) · Nature · doi:10.1038/nature11689 · Cited by 503 · see citing works

UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells

Zhang, J., Khvorostov, I., Hong, J. S., Oktay, Y., Vergnes, L., Nuebel, E., Wahjudi, P. N., Setoguchi, K., Wang, G., Do, A., et al. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.401 · Cited by 499 · see citing works

The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming

Panopoulos, A. D., Yanes, Ó., Ruiz, S., Kida, Y. S., Diep, D. H., Tautenhahn, R., Herrerias, A., Batchelder, E. M., Plongthongkum, N., Lutz, M. K., et al. (2011) · Cell Research · doi:10.1038/cr.2011.177 · Cited by 493 · see citing works

Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease

Lin, S.-J., & Guarente, L. (2003) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(03)00006-1 · Cited by 477 · see citing works

Dynamic changes in mitochondrial biogenesis and antioxidant enzymes during the spontaneous differentiation of human embryonic stem cells

Cho, Y. M., Kwon, S., Pak, Y. K., Seol, H. W., Choi, Y. M., Park, D. J., Park, K. S., & Lee, H. K. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.08.020 · Cited by 465 · see citing works

Self‐renewal of human embryonic stem cells is supported by a shortened G1 cell cycle phase

Becker, K. A., Ghule, P. N., Therrien, J. A., Lian, J. B., Stein, J. L., van Wijnen, A. J., & Stein, G. S. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20776 · Cited by 460 · see citing works

O2 regulates stem cells through Wnt/β-catenin signalling

Mazumdar, J., O'Brien, W. T., Johnson, R. S., LaManna, J. C., Chavez, J. C., Klein, P. S., & Simon, M. C. (2010) · Nature Cell Biology · doi:10.1038/ncb2102 · Cited by 456 · see citing works

Regulation of oxidative phosphorylation in the mammalian cell

Balaban, R. S. (1990) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1990.258.3.c377 · Cited by 446 · see citing works

Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells

Gan, B., HU, J. L., Jiang, S., Liu, Y., Sahin, E., Li, Z., Fletcher-Sananikone, E., Colla, S., Wang, Y., Chin, L., et al. (2010) · Nature · doi:10.1038/nature09595 · Cited by 437 · see citing works

Hypoxia. 2. Hypoxia regulates cellular metabolism

Wheaton, W. W., & Chandel, N. S. (2011) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00485.2010 · Cited by 426 · see citing works

Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value

Abbas, S., Lugthart, S., Kavelaars, F. G., Schelen, A. M., Koenders, J. E., Zeilemaker, A., van Putten, W. J. L., Rijneveld, A. W., Löwenberg, B., & Valk, P. J. M. (2010) · Blood · doi:10.1182/blood-2009-11-250878 · Cited by 394 · see citing works

The Lkb1 metabolic sensor maintains haematopoietic stem cell survival

Gurumurthy, S., Xie, S. Z.-J., Alagesan, B., Kim, J., Yusuf, R. Z., Sáez, B., Tzatsos, A., Ozsolak, F., Milos, P. M., Ferrari, F., et al. (2010) · Nature · doi:10.1038/nature09572 · Cited by 391 · see citing works

Dependence of Mouse Embryonic Stem Cells on Threonine Catabolism

Wang, J., Alexander, P. B., Wu, L. C., Hammer, R. E., Cleaver, O. B., & McKnight, S. L. (2009) · Science · doi:10.1126/science.1173288 · Cited by 365 · see citing works

FOXO transcription factors throughout T cell biology

Hedrick, S. M., Michelini, R. H., Doedens, A. L., Goldrath, A. W., & Stone, E. L. (2012) · Nature Reviews Immunology · doi:10.1038/nri3278 · Cited by 347 · see citing works

Metabolic Regulation by the Mitochondrial Phosphatase PTPMT1 Is Required for Hematopoietic Stem Cell Differentiation

Yu, W., Liu, X., Shen, J., Jovanović, O., Pohl, E. E., Gerson, S. L., Finkel, T., Broxmeyer, H. E., & Qu, C. (2013) · Cell stem cell · doi:10.1016/j.stem.2012.11.022 · Cited by 341 · see citing works

A family business: stem cell progeny join the niche to regulate homeostasis

Hsu, Y., & Fuchs, E. V. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3272 · Cited by 307 · see citing works

Bioenergetics at low oxygen: dependence of respiration and phosphorylation on oxygen and adenosine diphosphate supply

Gnaiger, E. (2001) · Respiration Physiology · doi:10.1016/s0034-5687(01)00307-3 · Cited by 280 · see citing works

Cardiospheres Recapitulate a Niche-Like Microenvironment Rich in Stemness and Cell-Matrix Interactions, Rationalizing Their Enhanced Functional Potency for Myocardial Repair

Li, T., Cheng, K., Lee, S.-T., Matsushita, S., Davis, D. R., Malliaras, K. G., Zhang, Y., Matsushita, N., Smith, R. R., & Marbán, E. (2010) · Stem Cells · doi:10.1002/stem.532 · Cited by 262 · see citing works

Foxo3 Is Essential for the Regulation of Ataxia Telangiectasia Mutated and Oxidative Stress-mediated Homeostasis of Hematopoietic Stem Cells

Yalcin, S., Zhang, X., Luciano, J. P., Mungamuri, S. K., Marinkovic, D., Vercherat, C., Sarkar, A., Grisotto, M., Taneja, R., & Ghaffari, S. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800517200 · Cited by 247 · see citing works

The Relationship Between Pluripotency and Mitochondrial DNA Proliferation During Early Embryo Development and Embryonic Stem Cell Differentiation

Facucho-Oliveira, J., & John, J. C. S. (2009) · Stem Cell Reviews and Reports · doi:10.1007/s12015-009-9058-0 · Cited by 235 · see citing works

Amino Acid Signaling in TOR Activation

Kim, J., & Guan, K. (2011) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-062209-094414 · Cited by 235 · see citing works

An Autogeneic Feeder Cell System That Efficiently Supports Growth of Undifferentiated Human Embryonic Stem Cells

Stojković, P., Lako, M., Stewart, R., Przyborski, S. A., Armstrong, L., Evans, J., Murdoch, A. P., Strachan, T., & Stojković, M. (2005) · Stem Cells · doi:10.1634/stemcells.2004-0137 · Cited by 232 · see citing works

Regulation of FOXO protein stability via ubiquitination and proteasome degradation

Huang, H., & Tindall, D. J. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.01.007 · Cited by 227 · see citing works

Human embryonic stem cells: Derivation, culture, and differentiation: A review

Vazin, T., & Freed, W. J. (2010) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-2010-0543 · Cited by 225 · see citing works

Noggin and bFGF cooperate to maintain the pluripotency of human embryonic stem cells in the absence of feeder layers

Wang, G., Zhang, H., Zhao, Y., Li, J., Cai, J., Wang, P., Meng, S., Feng, J., Miao, C., Ding, M., et al. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.03.058 · Cited by 225 · see citing works

The role of the Crabtree effect and an endogenous fuel in the energy metabolism of resting and proliferating thymocytes

Guppy, M., Greiner, E. F., & Brand, K. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb17637.x · Cited by 209 · see citing works

mTOR supports long-term self-renewal and suppresses mesoderm and endoderm activities of human embryonic stem cells

Zhou, J., Su, P., Wang, L., Chen, J., Zimmermann, M., Genbačev, O., Afonja, O., Horne, M. C., Tanaka, T. S., Duan, E., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901854106 · Cited by 205 · see citing works

Activation of AMPK by the putative dietary restriction mimetic metformin is insufficient to extend lifespan in Drosophila

Slack, C., Foley, A., & Partridge, L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047699 · Cited by 199 · see citing works

mTOR Complex 1 Plays Critical Roles in Hematopoiesis and Pten-Loss-Evoked Leukemogenesis

Kalaitzidis, D., Sykes, S. M., Wang, Z., Punt, N., Tang, Y., Ragu, C., Sinha, A. U., Lane, S., Souza, A. L., Clish, C. B., et al. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.06.009 · Cited by 197 · see citing works

Adenosine Nucleotide Biosynthesis and AMPK Regulate Adult Life Span and Mediate the Longevity Benefit of Caloric Restriction in Flies

Stenesen, D., Suh, J. M., Seo, J. H., Yu, K., Lee, K., Kim, J.-S., Min, K., & Graff, J. M. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.006 · Cited by 192 · see citing works

Identification of additional IDH mutations associated with oncometabolite R(−)-2-hydroxyglutarate production

Ward, P. S., Cross, J. R., Lü, C., Weigert, O., Abdel-Wahab, O. I., Levine, R. L., Weinstock, D. M., Sharp, K. A., & Thompson, C. B. (2011) · Oncogene · doi:10.1038/onc.2011.416 · Cited by 191 · see citing works

mTOR Activation Induces Tumor Suppressors that Inhibit Leukemogenesis and Deplete Hematopoietic Stem Cells after Pten Deletion

Lee, J., Nakada, D., Yilmaz, Ö. H., Tóthová, Z., Joseph, N. M., Lim, M. S., Gilliland, D. G., & Morrison, S. J. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.09.015 · Cited by 186 · see citing works

Temporal changes in PTEN and mTORC2 regulation of hematopoietic stem cell self-renewal and leukemia suppression

Magee, J. A., Ikenoue, T., Nakada, D., Lee, J. Y., Guan, K., & Morrison, S. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2012.05.026 · Cited by 185 · see citing works

Hypoxia mediates low cell-cycle activity and increases the proportion of long-term–reconstituting hematopoietic stem cells during in vitro culture

Eliasson, P., Rehn, M., Hammar, P., Larsson, P., Sirenko, O., Flippin, L. A., Cammenga, J., & Jönsson, J. (2010) · Experimental Hematology · doi:10.1016/j.exphem.2010.01.005 · Cited by 177 · see citing works

Physiological Levels of Reactive Oxygen Species Are Required to Maintain Genomic Stability in Stem Cells

Li, T., & Marbán, E. (2010) · Stem Cells · doi:10.1002/stem.438 · Cited by 171 · see citing works

Transcriptional Control of Cellular Metabolism by mTOR Signaling

Yecies, J. L., & Manning, B. D. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-4158 · Cited by 160 · see citing works

Roles of Reactive Oxygen Species in the Fate of Stem Cells

Chaudhari, P., Ye, Z., & Jang, Y.-Y. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4963 · Cited by 146 · see citing works

Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model

Bernhardt, W. M., Göttmann, U., Doyon, F., Buchholz, B., Câmpean, V., Schödel, J., Reisenbuechler, A., Klaus, S. J., Arend, M., Flippin, L. A., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903978106 · Cited by 145 · see citing works

ROS‐mediated amplification of AKT/mTOR signalling pathway leads to myeloproliferative syndrome in Foxo3−/− mice

Yalcin, S., Marinković, D., Mungamuri, S. K., Zhang, X., Tong, W., Sellers, R. S., & Ghaffari, S. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.292 · Cited by 144 · see citing works

Homeostasis and the Importance for a Balance Between AKT/mTOR Activity and Intracellular Signaling

Altomare, D. A., & Khaled, A. R. (2012) · Current Medicinal Chemistry · doi:10.2174/092986712801661130 · Cited by 132 · see citing works

Hypoxia‐inducible factors in stem cells and cancer

Mazumdar, J., Dondeti, V. R., & Simon, M. C. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00963.x · Cited by 127 · see citing works

mTOR-Mediated Activation of p70 S6K Induces Differentiation of Pluripotent Human Embryonic Stem Cells

Easley, C. A., Ben‐Yehudah, A., Redinger, C. J., Oliver, S. L., Varum, S., Eisinger, V. M., Carlisle, D. L., Donovan, P. J., & Schatten, G. P. (2010) · Cellular Reprogramming · doi:10.1089/cell.2010.0011 · Cited by 120 · see citing works

Loss of Lkb1 Provokes Highly Invasive Endometrial Adenocarcinomas

Contreras, C. M., Gurumurthy, S., Haynie, J. M., Shirley, L. J., Akbay, E. A., Wingo, S. N., Schorge, J. O., Broaddus, R. R., Wong, K., Bardeesy, N. M., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5014 · Cited by 108 · see citing works

A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels

Peserico, A., Chiacchiera, F., Grossi, V., Matrone, A., Latorre, D., Simonatto, M., Fusella, A., Ryall, J. G., Finley, L. W. S., Haigis, M. C., et al. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1244-6 · Cited by 103 · see citing works

Mammalian target of rapamycin activation underlies HSC defects in autoimmune disease and inflammation in mice

Chen, C., Liu, Y., Liu, Y., & Zheng, P. (2010) · Journal of Clinical Investigation · doi:10.1172/jci43873 · Cited by 103 · see citing works

The human L-threonine 3-dehydrogenase gene is an expressed pseudogene

Edgar, A. J. (2002) · BMC Genetics · doi:10.1186/1471-2156-3-18 · Cited by 92 · see citing works

l-Threonine Regulates G1/S Phase Transition of Mouse Embryonic Stem Cells via PI3K/Akt, MAPKs, and mTORC Pathways

Ryu, J. M., & Han, H. J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.216283 · Cited by 78 · see citing works

Lkb1 Deficiency Causes Prostate Neoplasia in the Mouse

Pearson, H. B., McCarthy, A., Collins, C. M. P., Ashworth, A., & Clarke, A. R. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5169 · Cited by 76 · see citing works

O 2 Regulates Skeletal Muscle Progenitor Differentiation through Phosphatidylinositol 3-Kinase/AKT Signaling

Majmundar, A. J., Skuli, N., Mesquita, R. C., Kim, M. N., Yodh, A. G., Nguyen-McCarty, M., & Simon, M. C. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05857-11 · Cited by 75 · see citing works

Environmental Oxygen Tension Regulates the Energy Metabolism and Self-Renewal of Human Embryonic Stem Cells

Forristal, C. E., Christensen, D. R., Chinnery, F. E., Petruzzelli, R., Parry, K. L., Sánchez-Elsner, T., & Houghton, F. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062507 · Cited by 74 · see citing works

Hematopoietic stem cell development in the placenta

Gekas, C., Rhodes, K. E., Handel, B. V., Chhabra, A., Ueno, M., & Mikkola, H. K. A. (2010) · The International Journal of Developmental Biology · doi:10.1387/ijdb.103070cg · Cited by 74 · see citing works

Targeted killing of a mammalian cell based upon its specialized metabolic state

Alexander, P. B., Wang, J., & McKnight, S. L. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1111312108 · Cited by 64 · see citing works

NAD-dependent histone deacetylase, SIRT1, plays essential roles in the maintenance of hematopoietic stem cells

Matsui, K., Ezoe, S., Oritani, K., Shibata, M., Tokunaga, M., Fujita, N., Tanimura, A., Sudo, T., Tanaka, H., McBurney, M. W., et al. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.01.109 · Cited by 61 · see citing works

From stem cells to cancer stem cells: HIF takes the stage

Lee, K. E., & Simon, M. C. (2012) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2012.01.005 · Cited by 57 · see citing works

Inositol polyphosphate multikinase signaling in the regulation of metabolism

Lee, J., Kim, Y., Park, J., & Kim, S. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06725.x · Cited by 55 · see citing works

H 2 O 2 Accumulation Mediates Differentiation Capacity Alteration, But Not Proliferative Decline, in Senescent Human Fetal Mesenchymal Stem Cells

Ho, P.-J., Yen, M., Tang, B.-C., Chen, C., & Yen, B. L. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4692 · Cited by 54 · see citing works

Exploring metabolic pathways that contribute to the stem cell phenotype

Vacanti, N. M., & Metallo, C. M. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.08.007 · Cited by 50 · see citing works

Metabolic Rate Regulates L1 Longevity in C. elegans

Lee, I., Hendrix, A., Kim, J., Yoshimoto, J., & You, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044720 · Cited by 43 · see citing works

Foxo3a is essential for maintenance of the hematopoietic stem cell pool.

Miyamoto, K., Araki, K. Y., Naka, K., Arai, F., Takubo, K., Yamazaki, S., Matsuoka, S., Miyamoto, T., Ito, K., Ohmura, M., et al. (2007) · Cell stem cell · doi:10.1016/j.stem.2007.02.001 · Cited by 41 · see citing works

Gene Expression of the Tumour Suppressor LKB1 Is Mediated by Sp1, NF-Y and FOXO Transcription Factors

Lützner, N., Arce, J. D.-C., & Rösl, F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032590 · Cited by 37 · see citing works

Effects of 3-phosphoglycerate and other metabolites on the activation of AMP-activated protein kinase by LKB1-STRAD-MO25

Ellingson, W. J., Chesser, D. G., & Winder, W. W. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00322.2006 · Cited by 21 · see citing works

The Tumor Suppressor LKB1 Emerges as a Critical Factor in Hematopoietic Stem Cell Biology

Krock, B. L., Skuli, N., & Simon, M. C. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2010.12.015 · Cited by 20 · see citing works

Assessing the Function of mTOR in Human Embryonic Stem Cells

Zhou, J., Li, D., & Wang, F. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-430-8_23 · Cited by 11 · see citing works

Placental Origins of Chronic Disease

Burton, G. J., Fowden, A. L., & Thornburg, K. L. (2016) · Physiological Reviews · doi:10.1152/physrev.00029.2015 · Cited by 717 · see citing works

Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation

Zheng, X., Boyer, L., Jin, M., Mertens, J., Kim, Y., Ma, L., Ma, L., Hamm, M., Gage, F. H., & Hunter, T. (2016) · eLife · doi:10.7554/elife.13374 · Cited by 671 · see citing works

Mitochondrial control by DRP1 in brain tumor initiating cells

Xie, Q., Wu, Q., Horbinski, C., Flavahan, W. A., Yang, K., Zhou, W., Dombrowski, S. M., Huang, Z., Fang, X., Shi, Y., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.3960 · Cited by 415 · see citing works

Aerobic glycolysis tunes YAP/TAZ transcriptional activity

Enzo, E., Santinon, G., Pocaterra, A., Aragona, M., Bresolin, S., Forcato, M., Grifoni, D., Pession, A., Zanconato, F., Guzzo, G., et al. (2015) · The EMBO Journal · doi:10.15252/embj.201490379 · Cited by 414 · see citing works

Current treatment strategies for inhibiting mTOR in cancer.

Chiarini, F., Evangelisti, C., McCubrey, J., & Martelli, A. (2015) · TIPS - Trends in Pharmacological Sciences · doi:10.1016/j.tips.2014.11.004 · Cited by 262 · see citing works

Analytic Models of Oxygen and Nutrient Diffusion, Metabolism Dynamics, and Architecture Optimization in Three-Dimensional Tissue Constructs with Applications and Insights in Cerebral Organoids

McMurtrey, R. J. (2015) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2015.0375 · Cited by 248 · see citing works

Physiological Functions of Threonine in Animals: Beyond Nutrition Metabolism

Tang, Q., Tan, P., Ma, N., & Ma, X. (2021) · Nutrients · doi:10.3390/nu13082592 · Cited by 212 · see citing works

Control of YAP/TAZ Activity by Metabolic and Nutrient-Sensing Pathways

Santinon, G., Pocaterra, A., & Dupont, S. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.11.004 · Cited by 164 · see citing works

Dietary and Metabolic Control of Stem Cell Function in Physiology and Cancer

Mihaylova, M. M., Sabatini, D. M., & Yilmaz, Ö. H. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.02.008 · Cited by 153 · see citing works

Proteostatic and Metabolic Control of Stemness

García‐Prat, L., Sousa‐Victor, P., & Muñoz‐Cánoves, P. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.04.011 · Cited by 123 · see citing works

AMP-activated Protein Kinase Stimulates Warburg-like Glycolysis and Activation of Satellite Cells during Muscle Regeneration

Fu, X., Zhu, M. J., Dodson, M. V., & Du, ‬. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.665232 · Cited by 96 · see citing works

Regulation of glycolytic flux and overflow metabolism depending on the source of energy generation for energy demand

Shimizu, K., & Matsuoka, Y. (2018) · Biotechnology Advances · doi:10.1016/j.biotechadv.2018.12.007 · Cited by 88 · see citing works

Quiescence Entry, Maintenance, and Exit in Adult Stem Cells

Mohammad, K., Dakik, P., Medkour, Y., Mitrofanova, D., & Titorenko, V. I. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092158 · Cited by 90 · see citing works

Hybrid Cellular Metabolism Coordinated by Zic3 and Esrrb Synergistically Enhances Induction of Naive Pluripotency

Sone, M., Morone, N., Nakamura, T., Tanaka, A., Okita, K., Woltjen, K., Nakagawa, M., Heuser, J. E., Yamada, Y., Yamanaka, S., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.04.017 · Cited by 77 · see citing works

Transcriptome analysis of grass carp (Ctenopharyngodon idella) between fast- and slow-growing fish

Lu, X. M., Chen, H.-M., Qian, X., & Gui, J. (2020) · Comparative Biochemistry and Physiology Part D Genomics and Proteomics · doi:10.1016/j.cbd.2020.100688 · Cited by 78 · see citing works

Stem Cells of the Aging Brain

Nicaise, A. M., Willis, C. M., Crocker, S. J., & Pluchino, S. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00247 · Cited by 73 · see citing works

Mitochondrial dependency in progression of acute myeloid leukemia.

Basak, N., & Banerjee, S. (2015) · Mitochondrion (Amsterdam. Print) · doi:10.1016/j.mito.2015.01.006 · Cited by 61 · see citing works

Notch stimulates growth by direct regulation of genes involved in the control of glycolysis and the tricarboxylic acid cycle

Slaninová, V., Krafčíková, M., Pérez-Gómez, R., Steffal, P., Trantı́rek, L., Bray, S. J., & Krejčı́, A. (2016) · Open Biology · doi:10.1098/rsob.150155 · Cited by 71 · see citing works

Neural Stem Cells and Nutrients: Poised Between Quiescence and Exhaustion

Cavallucci, V., Fidaleo, M., & Pani, G. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.06.007 · Cited by 72 · see citing works

Quiescence Preconditioned Human Multipotent Stromal Cells Adopt a Metabolic Profile Favorable for Enhanced Survival under Ischemia

Moya, A., Larochette, N., Paquet, J., Deschepper, M., Bensidhoum, M., Izzo, V., Kroemer, G., Petite, H., & Logeart‐Avramoglou, D. (2016) · Stem Cells · doi:10.1002/stem.2493 · Cited by 71 · see citing works

Transcriptional control of stem cell fate by E2Fs and pocket proteins

Julian, L., & Blais, A. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00161 · Cited by 68 · see citing works

The nutritional phenome of EMT-induced cancer stem-like cells

Cuyàs, E., Corominas-Faja, B., & Menéndez, J. A. (2014) · Oncotarget · doi:10.18632/oncotarget.2147 · Cited by 69 · see citing works

Blood Vessels as Regulators of Neural Stem Cell Properties

Karakatsani, A., Shah, B., & de Almodóvar, C. R. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00085 · Cited by 72 · see citing works

Hallmarks of intestinal stem cells

Baulies, A., Angelis, N., & Li, V. S. W. (2020) · Development · doi:10.1242/dev.182675 · Cited by 66 · see citing works

OGT Regulates Hematopoietic Stem Cell Maintenance via PINK1-Dependent Mitophagy

Murakami, K., Kurotaki, D., Kawase, W., Soma, S., Fukuchi, Y., Kunimoto, H., Yoshimi, R., Koide, S., Oshima, M., Hishiki, T., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2020.108579 · Cited by 61 · see citing works

Maternal Inactivity Programs Skeletal Muscle Dysfunction in Offspring Mice by Attenuating Apelin Signaling and Mitochondrial Biogenesis

Son, J. S., Chae, S. A., Wang, H., Chen, Y., Iniguez, A. B., de Avila, J. M., Jiang, Z., Zhu, M.-J., & Du, ‬. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108461 · Cited by 56 · see citing works

Metabolic circuits in neural stem cells

Kim, D., Rhee, I., & Paik, J. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1686-0 · Cited by 56 · see citing works

Metabolic regulation of mesenchymal stem cell in expansion and therapeutic application

Liu, Y., & Ma, T. (2014) · Biotechnology Progress · doi:10.1002/btpr.2034 · Cited by 54 · see citing works

Co-expression network of neural-differentiation genes shows specific pattern in schizophrenia

Maschietto, M. C., Tahira, A. C., Puga, R., Lima, L. D. A., Mariani, D., Paulsen, B. D. S., Belmonte-de-Abreu, P. S., Vieira, H. C., Krepischi, A. C. V., Carraro, D. M., et al. (2015) · BMC Medical Genomics · doi:10.1186/s12920-015-0098-9 · Cited by 52 · see citing works

Profiling the ToxCast Library With a Pluripotent Human (H9) Stem Cell Line-Based Biomarker Assay for Developmental Toxicity

Zurlinden, T. J., Saili, K. S., Rush, N., Kothiya, P., Judson, R., Houck, K. A., Hunter, E. S., Baker, N., Palmer, J. A., Thomas, R. S., et al. (2020) · Toxicological Sciences · doi:10.1093/toxsci/kfaa014 · Cited by 52 · see citing works

Sirtuins in kidney health and disease

Perico, L., Remuzzi, G., & Benigni, A. (2024) · Nature Reviews Nephrology · doi:10.1038/s41581-024-00806-4 · Cited by 52 · see citing works

Dclk1+ small intestinal epithelial tuft cells display the hallmarks of quiescence and self-renewal

Chandrakesan, P., May, R. J., Qu, D., Weygant, N., Taylor, V. E., Li, J. D., Ali, N., Sureban, S. M., Qante, M., Wang, T. C., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.5129 · Cited by 50 · see citing works

Nutrients, neurogenesis and brain ageing: From disease mechanisms to therapeutic opportunities

Fidaleo, M., Cavallucci, V., & Pani, G. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.05.016 · Cited by 50 · see citing works

PFKFB4 controls embryonic patterning via Akt signalling independently of glycolysis

Pegoraro, C., Figueiredo, A. L., Maczkowiak, F., Pouponnot, C., Eychène, A., & Monsoro-Burq, A. H. (2015) · Nature Communications · doi:10.1038/ncomms6953 · Cited by 48 · see citing works

mTOR signalling, embryogenesis and the control of lung development

Land, S. C., Scott, C. L., & Walker, D. J. (2014) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2014.09.023 · Cited by 48 · see citing works

Dietary Factors in the Control of Gut Homeostasis, Intestinal Stem Cells, and Colorectal Cancer

Francescangeli, F., Angelis, M. L. D., & Zeuner, A. (2019) · Nutrients · doi:10.3390/nu11122936 · Cited by 49 · see citing works

SOD2 and the Mitochondrial UPR: Partners Regulating Cellular Phenotypic Transitions

He, C., Hart, P. C., Germain, D., & Bonini, M. G. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.04.004 · Cited by 47 · see citing works

Intestinal tuft cells regulate the ATM mediated DNA Damage response via Dclk1 dependent mechanism for crypt restitution following radiation injury

Chandrakesan, P., May, R. J., Weygant, N., Qu, D., Berry, W. L., Sureban, S. M., Ali, N., Rao, C. V., Huycke, M. M., Bronze, M. S., et al. (2016) · Scientific Reports · doi:10.1038/srep37667 · Cited by 47 · see citing works

Novel therapeutic strategies to target leukemic cells that hijack compartmentalized continuous hematopoietic stem cell niches

Hira, V. V. V., Noorden, C. J. F. V., Carraway, H. E., Maciejewski, J. P., & Molenaar, R. J. (2017) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2017.03.010 · Cited by 46 · see citing works

Rapamycin, the only drug that has been consistently demonstrated to increase mammalian longevity. An update

Sharp, Z. D., & Strong, R. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112166 · Cited by 40 · see citing works

Targeted and untargeted metabolomics reveals meat quality in grazing yak during different phenology periods on the Qinghai-Tibetan Plateau

Guo, T., Zhang, Q., Wang, X., Xu, X., Wang, Y., Wei, L. S., Li, N., Liu, H., Hu, L., Zhao, N., et al. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.138855 · Cited by 41 · see citing works

Similarities Between Stem Cell Niches in Glioblastoma and Bone Marrow: Rays of Hope for Novel Treatment Strategies

Hira, V. V. V., Breznik, B., Vittori, M., de Jong, A. L., Mlakar, J., Oostra, R., Khurshed, M., Molenaar, R. J., Lah, T. T., & Noorden, C. J. F. V. (2019) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155419878416 · Cited by 41 · see citing works

Renal Cancer Stem Cells: Characterization and Targeted Therapies

Peired, A. J., Sisti, A., & Romagnani, P. (2016) · Stem Cells International · doi:10.1155/2016/8342625 · Cited by 40 · see citing works

Periarteriolar Glioblastoma Stem Cell Niches Express Bone Marrow Hematopoietic Stem Cell Niche Proteins

Hira, V. V. V., Wormer, J. R., Kakar, H., Breznik, B., van der Swaan, B., Hulsbos, R., Tigchelaar, W., Tonar, Z., Khurshed, M., Molenaar, R. J., et al. (2018) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155417749174 · Cited by 40 · see citing works

PPARs and Energy Metabolism Adaptation during Neurogenesis and Neuronal Maturation

d’Angelo, M., Antonosante, A., Castelli, V., Catanesi, M., Moorthy, N. K., Iannotta, D., Cimini, A., & Benedetti, E. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19071869 · Cited by 38 · see citing works

The TZD insulin sensitizer clue provides a new route into diabetes drug discovery

Colca, J. R. (2015) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2015.1100164 · Cited by 36 · see citing works

Succinate Supplement Elicited “Pseudohypoxia” Condition to Promote Proliferation, Migration, and Osteogenesis of Periodontal Ligament Cells

Mao, H., Yang, A., Zhao, Y., Lei, L., & Li, H. (2020) · Stem Cells International · doi:10.1155/2020/2016809 · Cited by 35 · see citing works

Metformin alleviates muscle wasting post-thermal injury by increasing Pax7-positive muscle progenitor cells

Yousuf, Y., Datu, A., Barnes, B., Amini‐Nik, S., & Jeschke, M. G. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1480-x · Cited by 34 · see citing works

Effects of Poor Maternal Nutrition during Gestation on Bone Development and Mesenchymal Stem Cell Activity in Offspring

Pillai, S. M., Sereda, N. H., Hoffman, M. L., Valley, E. V., Crenshaw, T. D., Park, Y., Lee, J., Zinn, S. A., & Govoni, K. E. (2016) · PLoS ONE · doi:10.1371/journal.pone.0168382 · Cited by 34 · see citing works

Stem cell fate determination through protein O-GlcNAcylation

Sheikh, M. A., Emerald, B. S., & Ansari, S. A. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev120.014915 · Cited by 33 · see citing works

Signaling Pathways Involved in Nutrient Sensing Control in Cancer Stem Cells: An Overview

Robles‐Flores, M., Moreno-Londoño, Á. P., & Castañeda‐Patlán, M. C. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.627745 · Cited by 33 · see citing works

The systemic milieu as a mediator of dietary influence on stem cell function during ageing

Murphy, T., & Thuret, S. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.11.004 · Cited by 33 · see citing works

Prolonged Absence of Mechanoluminal Stimulation in Human Intestine Alters the Transcriptome and Intestinal Stem Cell Niche

Wieck, M. M., Schlieve, C. R., Thornton, M. E., Fowler, K. L., Isani, M. A., Grant, C. N., Hilton, A. E., Hou, X., Grubbs, B. H., Frey, M. R., et al. (2017) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2016.12.008 · Cited by 31 · see citing works

Energy metabolic capacities of human adipose-derived mesenchymal stromal cells in vitro and their adaptations in osteogenic and adipogenic differentiation

Meyer, J., Salamon, A., Mispagel, S., Kamp, G., & Peters, K. (2018) · Experimental Cell Research · doi:10.1016/j.yexcr.2018.07.028 · Cited by 29 · see citing works

Regulation of Glucose-Dependent Gene Expression by the RNA Helicase Dbp2 in Saccharomyces cerevisiae

Beck, Z. T., Cloutier, S. C., Schipma, M. J., Petell, C. J., Ma, W. K., Ma, & Tran, E. J. (2014) · Genetics · doi:10.1534/genetics.114.170019 · Cited by 29 · see citing works

Mammalian Target of Rapamycin Inhibitors Resistance Mechanisms in Clear Cell Renal Cell Carcinoma

Kornakiewicz, A., Solarek, W., Bielecka, Z. F., Lian, F., Szczylik, C. A., & Czarnecka, A. M. (2014) · Current Signal Transduction Therapy · doi:10.2174/1574362409666140206222746 · Cited by 28 · see citing works

Nutrient-sensing alteration leads to age-associated distortion of intestinal stem cell differentiating direction

Yu, Z., Zhu, Y., Chen, Y., Feng, C., Zhang, Z., Guo, X., Chen, H., Liu, X., Yu, Y., & Chen, H. (2024) · Nature Communications · doi:10.1038/s41467-024-53675-7 · Cited by 27 · see citing works

Differential gene expression in small and large rainbow trout derived from two seasonal spawning groups

Kocmarek, A. L., Ferguson, M. M., & Danzmann, R. G. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-57 · Cited by 27 · see citing works

Energy Metabolism and Metabolic Sensors in Stem Cells: The Metabostem Crossroads of Aging and Cancer

Menéndez, J. A., & Joven, J. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-07320-0_10 · Cited by 27 · see citing works

Nutrient-Mediated Perception and Signalling in Human Metabolism: A Perspective of Nutrigenomics

Lal, M. K., Sharma, E., Tiwari, R. K., Devi, R., Mishra, U. N., Thakur, R., Gupta, R., Dey, A., Lal, P., Kumar, A., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911305 · Cited by 26 · see citing works

Metabolism of Stem and Progenitor Cells: Proper Methods to Answer Specific Questions

Martano, G., Borroni, E. M., Lopci, E., Cattaneo, M. G., Mattioli, M., Bachi, A., Decimo, I., & Bifari, F. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00151 · Cited by 24 · see citing works

Fetal Hematopoietic Stem Cells Are the Canaries in the Coal Mine That Portend Later Life Immune Deficiency

Laiosa, M. D., & Tate, E. R. (2015) · Endocrinology · doi:10.1210/en.2015-1347 · Cited by 22 · see citing works

Modulation of miRNAs by Vitamin C in Human Bone Marrow Stromal Cells

Kolhe, R. B., Mondal, A. K., Pundkar, C. Y., Periyasamy‐Thandavan, S., Mendhe, B., Hunter, M., Isales, C. M., Hill, W., Hamrick, M. W., & Fulzele, S. (2018) · Nutrients · doi:10.3390/nu10020186 · Cited by 24 · see citing works

Tryptophan and Kynurenine Enhances the Stemness and Osteogenic Differentiation of Bone Marrow-Derived Mesenchymal Stromal Cells In Vitro and In Vivo

Pham, H. T., Ono, M., Hara, E. S., Nguyen, H., Dang, A., Do, H., Komori, T., Tosa, I., Hazehara, Y., Yoshioka, Y., et al. (2021) · Materials · doi:10.3390/ma14010208 · Cited by 24 · see citing works

Mitochondrial fatty acid oxidation regulates adult muscle stem cell function through modulating metabolic flux and protein acetylation

Yue, F., Gu, L., Qiu, J., Oprescu, S. N., Beckett, L. M., Ellis, J. M., Donkin, S. S., & Kuang, S. (2025) · The EMBO Journal · doi:10.1038/s44318-025-00397-1 · Cited by 23 · see citing works

Strategies for the induction of anti-inflammatory mesenchymal stem cells and their application in the treatment of immune-related nephropathy

Zhou, C., & Bai, X. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.891065 · Cited by 23 · see citing works

Glutamine contributes to maintenance of mouse embryonic stem cell self-renewal through PKC-dependent downregulation of HDAC1 and DNMT1/3a

Ryu, J. M., Lee, S. H., Seong, J. K., & Han, H. J. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1087620 · Cited by 23 · see citing works

Metabolism and adult neurogenesis: Towards an understanding of the role of lipocalin-2 and iron-related oxidative stress

Ferreira, A. C., Sousa, N., Bessa, J. M., Sousa, J. C., & Marques, F. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.014 · Cited by 23 · see citing works

LKB1 specifies neural crest cell fates through pyruvate-alanine cycling

Radu, A. G., Torch, S., Fauvelle, F., Pernet‐Gallay, K., Lucas, A., Blervaque, R., Delmas, V., Schlattner, U., Lafanéchère, L., Hainaut, P. L., et al. (2019) · Science Advances · doi:10.1126/sciadv.aau5106 · Cited by 22 · see citing works

LKB1-AMPK modulates nutrient-induced changes in the mode of division of intestinal epithelial crypt cells in mice

Blackmore, K. A., Zhou, W., & Dailey, M. J. (2017) · Experimental Biology and Medicine · doi:10.1177/1535370217724427 · Cited by 21 · see citing works

Balancing glycolysis and mitochondrial OXPHOS: Lessons from the hematopoietic system and exercising muscles

Haran, M. Z., & Gross, A. (2014) · Mitochondrion · doi:10.1016/j.mito.2014.09.007 · Cited by 21 · see citing works

Comprehensive Metabolic Profiling of MYC-Amplified Medulloblastoma Tumors Reveals Key Dependencies on Amino Acid, Tricarboxylic Acid and Hexosamine Pathways

Pham, K., Hanaford, A. R., Poore, B., Maxwell, M. J., Sweeney, H., Parthasarathy, A., Alt, J., Rais, R., Slusher, B. S., Eberhart, C. G., et al. (2022) · Cancers · doi:10.3390/cancers14051311 · Cited by 21 · see citing works

Intercellular communication is crucial in the regulation of healthy aging via exosomes

Sun, H., Xia, T., Ma, S., Lv, T., & Li, Y. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107591 · Cited by 23 · see citing works

Glycolytic adaptation and progression of kidney disease

Rabelink, T. J., & Carmeliet, P. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.173 · Cited by 20 · see citing works

Inflammatory signals in HSPC development and homeostasis: Too much of a good thing?

Luis, T., Tremblay, C., Manz, M., North, T., King, K., & Challen, G. A. (2016) · Experimental Hematology · doi:10.1016/j.exphem.2016.06.254 · Cited by 15 · see citing works

Nutrient sensitive protein O -GlcNAcylation modulates the transcriptome through epigenetic mechanisms during embryonic neurogenesis

Parween, S., Alawathugoda, T. T., Prabakaran, A. D., Dheen, S. T., Morse, R. H., Emerald, B. S., & Ansari, S. A. (2022) · Life Science Alliance · doi:10.26508/lsa.202201385 · Cited by 19 · see citing works

Comparative transcriptome and metabolome analysis suggests bottlenecks that limit seed and oil yields in transgenic Camelina sativa expressing diacylglycerol acyltransferase 1 and glycerol-3-phosphate dehydrogenase

Abdullah, H., Chhikara, S., Akbari, P., Schnell, D. J., Pareek, A., & Dhankher, O. P. (2018) · Biotechnology for Biofuels · doi:10.1186/s13068-018-1326-2 · Cited by 18 · see citing works

Nutrient restriction causes reversible G2 arrest in Xenopus neural progenitors

McKeown, C. R., & Cline, H. T. (2019) · Development · doi:10.1242/dev.178871 · Cited by 18 · see citing works

Cross-talk between signaling and metabolism in the vasculature

Uebelhoer, M., & Iruela‐Arispe, M. L. (2016) · Vascular Pharmacology · doi:10.1016/j.vph.2016.06.002 · Cited by 18 · see citing works

Metabolic Teamwork in the Stem Cell Niche

Roper, J., & Yilmaz, Ö. H. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.04.019 · Cited by 18 · see citing works

Regulation of energy metabolism in human pluripotent stem cells

Liu, W., & Chen, G. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-04016-0 · Cited by 16 · see citing works

DNA Methylation Changes in Regional Lung Macrophages Are Associated with Metabolic Differences

Armstrong, D. A., Chen, Y., Dessaint, J. A., Aridgides, D. S., Channon, J. Y., Mellinger, D., Christensen, B. C., & Ashare, A. (2019) · ImmunoHorizons · doi:10.4049/immunohorizons.1900042 · Cited by 16 · see citing works

Mitochondrial Control of Stem Cell State and Fate: Lessons From Drosophila

Tiwari, S. K., & Mandal, S. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.606639 · Cited by 15 · see citing works

Emerging Molecular Pathways Governing Dietary Regulation of Neural Stem Cells during Aging

de Lucia, C., Murphy, T., & Thuret, S. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00017 · Cited by 15 · see citing works

Glucose Metabolism: Optimizing Regenerative Functionalities of Mesenchymal Stromal Cells Postimplantation

Luo, G., Wosinski, P., Salazar-Noratto, G. E., Bensidhoum, M., Bizios, R., Marashi, S., Potier, E., Sheng, P., & Petite, H. (2022) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2022.0063 · Cited by 14 · see citing works

Epigenetic metabolites license stem cell states

Somasundaram, L., Levy, S., Hussein, A. M., Ehnes, D. D., Mathieu, J., & Ruohola‐Baker, H. (2020) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2020.02.003 · Cited by 12 · see citing works

Nutritional interventions for spinal cord injury: preclinical efficacy and molecular mechanisms

Campos, J., Silva, N. A., & Salgado, A. J. (2021) · Nutrition Reviews · doi:10.1093/nutrit/nuab068 · Cited by 12 · see citing works

RhoA/ROCK inhibition improves the beneficial effects of glucocorticoid treatment in dystrophic muscle: implications for stem cell depletion

Mu, X., Tang, Y. M., Takayama, K., Chen, W., Lu, A., Wang, B., Weiss, K. R., & Huard, J. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx117 · Cited by 12 · see citing works

Lysine-arginine imbalance overcomes therapeutic tolerance governed by the transcription factor E3-lysosome axis in glioblastoma

Jing, Y., Kobayashi, M., Shoulkamy, M. I., Zhou, M., Vu, H. T., Arakawa, H., Sabit, H., Iwabuchi, S., Vu, C. Q., Kasahara, A., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-56946-z · Cited by 11 · see citing works

Evolving paradigms in clinical pharmacology and therapeutics for the treatment of Duchenne muscular dystrophy

Huard, J., Mu, X., & Lu, A. (2016) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.379 · Cited by 11 · see citing works

Stem cell autotomy and niche interaction in different systems

Dorn, D. C. (2015) · World Journal of Stem Cells · doi:10.4252/wjsc.v7.i6.922 · Cited by 11 · see citing works

The E3 ubiquitin ligase Pib1 regulates effective gluconeogenic shutdown upon glucose availability

Vengayil, V., Rashida, Z., & Laxman, S. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.009822 · Cited by 10 · see citing works

Preparation of Spheroids from Primary Pig Cells in a Mid-Scale Bioreactor Retaining Their Myogenic Potential

Stange, K., Keric, A., Friese, A., & Röntgen, M. (2022) · Cells · doi:10.3390/cells11091453 · Cited by 10 · see citing works

PPARγ-sparing thiazolidinediones as insulin sensitizers. Design, synthesis and selection of compounds for clinical development

Tanis, S. P., Colca, J. R., Parker, T. T., Artman, G. D., Larsen, S. D., McDonald, W. G., Gadwood, R. C., Kletzien, R. F., Zeller, J. B., Lee, P. H., et al. (2018) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2018.10.033 · Cited by 11 · see citing works

TGF-ß1 Induces Changes in the Energy Metabolism of White Adipose Tissue-Derived Human Adult Mesenchymal Stem/Stromal Cells In Vitro

Hahn, O., Ingwersen, L.-C., Soliman, A., Hamed, M., Fuellen, G., Wolfien, M., Scheel, J., Olaf Wolkenhauer, A., Koczan, D., Kamp, G., et al. (2020) · Metabolites · doi:10.3390/metabo10020059 · Cited by 10 · see citing works

At Least Three Transporters Likely Mediate Threonine Uptake Needed for Mouse Embryonic Stem Cell Proliferation

Formisano, T. M., & Winkle, L. J. V. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00017 · Cited by 10 · see citing works

From mutation to mechanism: deciphering the molecular function of genetic variants linked to human ageing

Baghdadi, M., Hinterding, H. M., Partridge, L., & Deelen, J. (2021) · Briefings in Functional Genomics · doi:10.1093/bfgp/elab005 · Cited by 10 · see citing works

Wnt of the Two Horizons: Putting Stem Cell Self-Renewal and Cell Fate Determination into Context

Serio, R. N. (2014) · Stem Cells and Development · doi:10.1089/scd.2014.0055 · Cited by 9 · see citing works

Calorie restriction and rapamycin administration induce stem cell self-renewal and consequent development and production in the mammary gland

Kfir, S. H., & Barash, I. (2019) · Experimental Cell Research · doi:10.1016/j.yexcr.2019.06.022 · Cited by 9 · see citing works

Cbl and Cbl-b ubiquitin ligases are essential for intestinal epithelial stem cell maintenance

Zutshi, N., Mohapatra, B. C., Mondal, P., An, W., Goetz, B. T., Wang, S., Li, S., Storck, M. D., Mercer, D. F. F., Black, A. R., et al. (2024) · iScience · doi:10.1016/j.isci.2024.109912 · Cited by 13 · see citing works

Burn to cycle: Energetics of cell-cycle control and stem cell maintenance

Mans, L. A. (2014) · Frontiers in bioscience · doi:10.2741/4263 · Cited by 5 · see citing works

Metabolic requirements for the maintenance of self-renewing stem cells

Ito, K., & Suda, T. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3772 · Cited by 1,014 · see citing works

Metabolic Peculiarities of the Stem Cell Entity

Ivanović, Z., & Vlaski‐Lafarge, M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800540-8.00006-5

Energy Metabolism Plays a Critical Role in Stem Cell Maintenance and Differentiation

Hu, C., Fan, L., Cen, P., Chen, E., Jiang, Z., & Li, L. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17020253 · Cited by 138 · see citing works

Exploring metabolic pathways that contribute to the stem cell phenotype

Vacanti, N. M., & Metallo, C. M. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.08.007 · Cited by 50 · see citing works