Foxo transcription factors in T cell biology and tumor immunity
Open accessAbstract
The evolutionally conserved forkhead box O (Foxo) family of transcription factors is pivotal in the control of nutrient sensing and stress responses. Recent studies have revealed that the Foxo proteins have been rewired to regulate highly specialized T cell activities. Here, we review the latest advances in the understanding of how Foxo transcription factors control T cell biology, including T cell trafficking, naive T cell homeostasis, effector and memory responses, as well as the differentiation and function of regulatory T cells. We also discuss the emerging evidence on Foxo-mediated regulation in antitumor immunity. Future work will further explore how the Foxo-dependent programs in T cells can be exploited for cancer immunotherapy.
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In T cells, AKT/FOXO signalling controls cell differentiation and adaptation to nutrients and stress.
“in T cells, the AKT/FOXO signalling controls cell differentiation and adaptation to nutrients and stress [85,86].”
From Phosphatidylinositol(4,5)bisphosphate: diverse functions at the plasma membrane (2020) · cites this paper as [86]
The Abstract and the section on regulatory T cell development support a role for Foxo and Akt–Foxo signalling in T-cell differentiation. The Abstract and Introduction describe Foxo’s role in nutrient sensing and stress responses as a general cellular function, but do not establish that Akt–Foxo signalling controls T-cell adaptation to nutrients and stress. Page numbers are not available in our copy. (LLM, conf=0.83)
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Lipid Signaling in T-Cell Development and FunctionPreprint
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Urolithin-A Promotes CD8+ T Cell–mediated Cancer Immunosurveillance via FOXO1 Activation
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Self-citationSystems-level identification of key transcription factors in immune cell specification
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- Authors
- Luo, C. T., & Li, M. O.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Li, Ming O.
- Venue
- Seminars in Cancer Biology
- Publisher
- Elsevier BV
- Published
- 2018-06
- Volume
- 50
- Pages
- 13-20
- ISSN
- 1044-579X (ISSN-L)
- PMC
- PMC5986613
- OpenAlex
- W2800638909
- Cited by
- 46
- References
- 105
- Citations by year
- 2026: 8 · 2025: 2 · 2024: 4 · 2023: 6 · 2022: 8 · 2021: 5 · 2020: 6 · 2019: 5 · 2018: 2
- FWCI
- 0.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Seminars in Cancer Biology (acceptedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R01 AI102888-01A1)
- Howard Hughes Medical Institute (P30 CA008748)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › FOXO transcription factor regulation
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Keywords
- FOXO transcription factors, forkhead box O, T cell biology, T cell migration, effector T cells, memory T cells, regulatory T cells, antitumor immunity, cancer immunotherapy, nutrient sensing, stress response
- MeSH terms
- Cell Differentiation, Humans, Immunotherapy, Neoplasms, Signal Transduction, T-Lymphocytes, Regulatory, Forkhead Transcription Factors
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