The DOI matches its Crossref record; 168 of the 168 references it cites were found in a registry or an index.
Role of the gut microbiota in immunity and inflammatory disease
Abstract
The mammalian intestine is colonized by trillions of microorganisms, most of which are bacteria that have co-evolved with the host in a symbiotic relationship. The collection of microbial populations that reside on and in the host is commonly referred to as the microbiota. A principal function of the microbiota is to protect the intestine against colonization by exogenous pathogens and potentially harmful indigenous microorganisms via several mechanisms, which include direct competition for limited nutrients and the modulation of host immune responses. Conversely, pathogens have developed strategies to promote their replication in the presence of competing microbiota. Breakdown of the normal microbial community increases the risk of pathogen infection, the overgrowth of harmful pathobionts and inflammatory disease. Understanding the interaction of the microbiota with pathogens and the host might provide new insights into the pathogenesis of disease, as well as novel avenues for preventing and treating intestinal and systemic disorders.
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“In addition, intestinal microorganisms are closely associated with a variety of immune cells, typically T helper 17 (TH17) cells, regulatory T (TReg) cells, and gut-specific B cells [45].”
From Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity (2021) · cites this paper as [45]
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Cites
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Metadata
- Authors
- Kamada, N., Seo, S.-U., Chen, G. Y., & Núñez, G.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Núñez, Gabriel
- Venue
- Nature reviews. Immunology
- Published
- 2013-04-25
- Volume
- 13
- Issue
- 5
- Pages
- 321-335
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2052554412
- Cited by
- 2,256
- References
- 168
- Citations by year
- 2026: 117 · 2025: 190 · 2024: 174 · 2023: 206 · 2022: 229 · 2021: 235 · 2020: 193 · 2019: 181 · 2018: 163 · 2017: 170 · 2016: 132 · 2015: 128 · 2014: 109 · 2013: 25
- FWCI
- 12.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Crohn's and Colitis Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- gut microbiota, host-microbe symbiosis, intestinal immunity, inflammatory diseases, intestinal homeostasis, pathobionts, dysbiosis, intestinal disorders, systemic disease
- MeSH terms
- Animals, Humans, Inflammation, Intestinal Mucosa, Symbiosis, Gastrointestinal Tract, Host-Pathogen Interactions, Metagenome
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