Cited by 2,256Gut microbiota and healthInflammatory Bowel DiseaseOral microbiology and periodontitis research

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Role of the gut microbiota in immunity and inflammatory disease

Kamada, Nobuhiko, Seo, Sang-Uk, Chen, Grace Y., Núñez, Gabriel·2013·Nature reviews. Immunology

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Abstract

The mammalian intestine is colonized by trillions of microorganisms, most of which are bacteria that have co-evolved with the host in a symbiotic relationship. The collection of microbial populations that reside on and in the host is commonly referred to as the microbiota. A principal function of the microbiota is to protect the intestine against colonization by exogenous pathogens and potentially harmful indigenous microorganisms via several mechanisms, which include direct competition for limited nutrients and the modulation of host immune responses. Conversely, pathogens have developed strategies to promote their replication in the presence of competing microbiota. Breakdown of the normal microbial community increases the risk of pathogen infection, the overgrowth of harmful pathobionts and inflammatory disease. Understanding the interaction of the microbiota with pathogens and the host might provide new insights into the pathogenesis of disease, as well as novel avenues for preventing and treating intestinal and systemic disorders.

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Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
Hugot, J.-P., Chamaillard, M., Zouali, H., Lesage, S., Cézard, J.-P., Belaiche, J., Almer, S., Tysk, C., O'Morain, C. A., Gassull, M., et al. (2001) · Nature · doi:10.1038/35079107 · Cited by 5,591
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
Ogura, Y., Bonen, D. K., Inohara, N., Nicolae, D. L., Chen, F. F., Ramos, R., Britton, H., Moran, T., Karaliuskas, R., Duerr, R. H., et al. (2001) · Nature · doi:10.1038/35079114 · Cited by 5,030
Self-citation
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.033 · Cited by 4,554
Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients
Sokol, H., Pigneur, B., Watterlot, L., Lakhdari, O., Bermúdez-Humarán, L. G., Gratadoux, J.-J., Blugeon, S., Bridonneau, C., Furet, J.-P., Corthier, G., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804812105 · Cited by 4,413
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251
Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species
Atarashi, K., Tanoue, T., Shima, T., Imaoka, A., Kuwahara, T., Momose, Y., Cheng, G., Yamasaki, S., Saito, T., Ohba, Y., et al. (2011) · Science · doi:10.1126/science.1198469 · Cited by 3,752
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
Maslowski, K. M., Vieira, A. T., Ng, A., Kranich, J., Sierro, F., Yu, D., Schilter, H. C., Rolph, M. S., Mackay, F., Artis, D., et al. (2009) · Nature · doi:10.1038/nature08530 · Cited by 3,241
An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System
Mazmanian, S. K., Liu, C. H., Tzianabos, A. O., & Kasper, D. L. (2005) · Cell · doi:10.1016/j.cell.2005.05.007 · Cited by 2,910
Bifidobacteria can protect from enteropathogenic infection through production of acetate
Fukuda, S., Toh, H., Hase, K., Oshima, K., Nakanishi, Y., Yoshimura, K., Tobe, T., Clarke, J. M., Topping, D. L., Suzuki, T., et al. (2011) · Nature · doi:10.1038/nature09646 · Cited by 2,387
A microbial symbiosis factor prevents intestinal inflammatory disease
Mazmanian, S. K., Round, J. L., & Kasper, D. L. (2008) · Nature · doi:10.1038/nature07008 · Cited by 2,340

Show all 168 references

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Causality of small and large intestinal microbiota in weight regulation and insulin resistance
Scheithauer, T. P. M., Dallinga-Thie, G. M., de Vos, W. M., Nieuwdorp, M., & van Raalte, D. H. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.06.002 · Cited by 188
“com growth via bacteriocins and SCFAs [58,59], 2) suppression of virulent factors [60], 3) facilitation of host barrier function through upregulation of the mucus layer and induction of antimicrobial molecules and (fecal) IgA [61], as well as 4) priming of intestinal immune cells [62,63].”
Background
Dysbiosis in intestinal inflammation: Cause or consequence
Buttó, L. F., & Haller, D. (2016) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2016.02.010 · Cited by 202
Could the gut microbiota reconcile the oral bioavailability conundrum of traditional herbs?
Chen, F., Wen, Q., Jiang, J., Li, H.-L., Tan, Y.-F., Li, Y.-H., & Zeng, N.-K. (2015) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2015.12.031 · Cited by 186
5-Aminosalicylic Acid Alters the Gut Bacterial Microbiota in Patients With Ulcerative Colitis
Xu, J., Chen, N., Wu, Z., Song, Y., Zhang, Y., Wu, N., Zhang, F., Ren, X., & Liu, Y. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01274 · Cited by 187
Gut-innervating nociceptors regulate the intestinal microbiota to promote tissue protection
Zhang, W., Lyu, M., Bessman, N. J., Xie, Z., Arifuzzaman, M., Yano, H., Parkhurst, C. N., Chu, C., Zhou, L., Putzel, G., et al. (2022) · Cell · doi:10.1016/j.cell.2022.09.008 · Cited by 185
Detection of Increased Plasma Interleukin-6 Levels and Prevalence of Prevotella copri and Bacteroides vulgatus in the Feces of Type 2 Diabetes Patients
Leite, A. Z., Rodrigues, N. D. C., Gonzaga, M. I., Paiolo, J. C. C., de Souza, C. A., Stefanutto, N. A. V., Omori, W. P., Pinheiro, D. G., Brisotti, J. L., Matheucci, E., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01107 · Cited by 192
Immunomodulatory effects of polysaccharides from edible fungus: a review
Yin, Z., Liang, Z., Li, C., Wang, J., Ma, C., & Kang, W. (2021) · Food Science and Human Wellness · doi:10.1016/j.fshw.2021.04.001 · Cited by 185
Altered Distribution and Increased IL-17 Production by Mucosal-Associated Invariant T Cells in Adult and Childhood Obesity
Carolan, E., Tobin, L. M., Mangan, B. A., Corrigan, M. A., Gaoatswe, G., Byrne, G., Geoghegan, J., Cody, D., O’Connell, J., Winter, D. C., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402945 · Cited by 190
Rapidly expanding knowledge on the role of the gut microbiome in health and disease
Cénit, M. C., Matzaraki, V., Tigchelaar, E. F., & Zhernakova, A. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.05.023 · Cited by 197
The microbiome-gut-brain axis in acute and chronic brain diseases
Benakis, C., Martin‐Gallausiaux, C., Trezzi, J., Melton, P., Liesz, A., & Wilmes, P. (2019) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2019.11.009 · Cited by 189
Blockade of interleukin-6 receptor in the periphery promotes rapid and sustained antidepressant actions: a possible role of gut–microbiota–brain axis
Zhang, J.-C., Yao, W., Dong, C., Yang, C., Ren, Q., Ma, M., & Hashimoto, K. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.112 · Cited by 182
Gut microbiome modulates efficacy of immune checkpoint inhibitors
Yi, M., Yu, S., Qin, S., Liu, Q., Xu, H., Zhao, W., Chu, Q., & Wu, K. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-018-0592-6 · Cited by 179
An appraisal of the role of specific bacteria in the initial pathogenesis of periodontitis
Bartold, P. M., & Van Dyke, T. E. (2019) · Journal of Clinical Periodontology · doi:10.1111/jcpe.13046 · Cited by 181
Orally administered CLA ameliorates DSS-induced colitis in mice via intestinal barrier improvement, oxidative stress reduction, and inflammatory cytokine and gut microbiota modulation
Chen, Y., Yang, B., Ross, R. P., Jin, Y., Stanton, C., Zhao, J., Zhang, H., & Chen, W. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b05744 · Cited by 185
Colorectal carcinogenesis-update and perspectives
Raskov, H. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i48.18151 · Cited by 193
Host-microbial Cross-talk in Inflammatory Bowel Disease
Nagao‐Kitamoto, H., & Kamada, N. (2017) · Immune Network · doi:10.4110/in.2017.17.1.1 · Cited by 185
Self-citation
Hospitalization type and subsequent severe sepsis
Prescott, H. C., Dickson, R. P., Rogers, M. A. M., Langa, K. M., & Iwashyna, T. J. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201503-0483oc · Cited by 181
The interplay between host immune cells and gut microbiota in chronic inflammatory diseases
Kim, D.-H., Zeng, M. Y., & Núñez, G. (2017) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.24 · Cited by 191
Self-citation
Enterotoxigenic Escherichia coli : intestinal pathogenesis mechanisms and colonization resistance by gut microbiota
Zhang, Y., Tan, P., Zhao, Y., & Ma, X. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2055943 · Cited by 206
Aryl hydrocarbon receptor ligand production by the gut microbiota is decreased in celiac disease leading to intestinal inflammation
Lamas, B., Hernandez-Galan, L., Galipeau, H. J., Constante, M., Clarizio, A., Jury, J., Breyner, N. M., Caminero, A., Rueda, G., Hayes, C. L., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aba0624 · Cited by 179
The involvement of gut microbiota in inflammatory bowel disease pathogenesis: Potential for therapy
Cammarota, G., Ianiro, G., Cianci, R., Bibbò, S., Gasbarrini, A., & Currò, D. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.12.006 · Cited by 184
An Interleukin-23-Interleukin-22 Axis Regulates Intestinal Microbial Homeostasis to Protect from Diet-Induced Atherosclerosis
Fatkhullina, A. R., Peshkova, I. O., Dzutsev, A., Aghayev, T., McCulloch, J. A., Thovarai, V., Badger, J. H., Vats, R., Sundd, P., Tang, H., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.09.011 · Cited by 186
Dysbiosis Disrupts Gut Immune Homeostasis and Promotes Gastric Diseases
Toor, D., Wasson, M. K., Goel, C., Kaushik, N. K., Kaushik, N. K., Singh, S., Karthikeyan, G., Kumar, A., & Prakash, H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20102432 · Cited by 188
Regulation of T Cell Immunity in Atopic Dermatitis by Microbes: The Yin and Yang of Cutaneous Inflammation
Biedermann, T., Skabytska, Y., Kaesler, S., & Volz, T. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00353 · Cited by 184
Carrageenan-induced colitis is associated with decreased population of anti-inflammatory bacterium, Akkermansia muciniphila , in the gut microbiota of C57BL/6J mice
Shang, Q., Sun, W., Shan, X., Jiang, H., Cai, C., Hao, J., Li, G., & Yu, G. (2017) · Toxicology Letters · doi:10.1016/j.toxlet.2017.07.904 · Cited by 182

Authors: Kamada, N., Seo, S.-U., Chen, G. Y., & Núñez, G.
Affiliations: University of Michigan (US)
Corresponding author: Núñez, Gabriel
ORCID: Kamada, Nobuhiko
Seo, Sang-Uk
Chen, Grace Y.
Núñez, Gabriel
Venue: Nature reviews. Immunology
Publisher: Springer Science and Business Media LLC
Published: 2013-04-25
Volume: 13
Issue: 5
Pages: 321-335
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri3430
OpenAlex: W2052554412
Cited by: 2,256
References: 168
Citations by year: 2026: 117 · 2025: 190 · 2024: 174 · 2023: 206 · 2022: 229 · 2021: 235 · 2020: 193 · 2019: 181 · 2018: 163 · 2017: 170 · 2016: 132 · 2015: 128 · 2014: 109 · 2013: 25
FWCI: 12.09
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: Crohn's and Colitis Foundation
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Keywords: gut microbiota, host-microbe symbiosis, intestinal immunity, inflammatory diseases, intestinal homeostasis, pathobionts, dysbiosis, intestinal disorders, systemic disease
MeSH terms: Animals, Humans, Inflammation, Intestinal Mucosa, Symbiosis, Gastrointestinal Tract, Host-Pathogen Interactions, Metagenome

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Role of the gut microbiota in immunity and inflammatory disease

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