Cited by 2,256Gut microbiota and healthInflammatory Bowel DiseaseOral microbiology and periodontitis research

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Role of the gut microbiota in immunity and inflammatory disease

Kamada, Nobuhiko, Seo, Sang-Uk, Chen, Grace Y., Núñez, Gabriel·2013·Nature reviews. Immunology

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Abstract

The mammalian intestine is colonized by trillions of microorganisms, most of which are bacteria that have co-evolved with the host in a symbiotic relationship. The collection of microbial populations that reside on and in the host is commonly referred to as the microbiota. A principal function of the microbiota is to protect the intestine against colonization by exogenous pathogens and potentially harmful indigenous microorganisms via several mechanisms, which include direct competition for limited nutrients and the modulation of host immune responses. Conversely, pathogens have developed strategies to promote their replication in the presence of competing microbiota. Breakdown of the normal microbial community increases the risk of pathogen infection, the overgrowth of harmful pathobionts and inflammatory disease. Understanding the interaction of the microbiota with pathogens and the host might provide new insights into the pathogenesis of disease, as well as novel avenues for preventing and treating intestinal and systemic disorders.

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Authors: Kamada, N., Seo, S.-U., Chen, G. Y., & Núñez, G.
Affiliations: University of Michigan (US)
Corresponding author: Núñez, Gabriel
ORCID: Kamada, Nobuhiko
Seo, Sang-Uk
Chen, Grace Y.
Núñez, Gabriel
Venue: Nature reviews. Immunology
Publisher: Springer Science and Business Media LLC
Published: 2013-04-25
Volume: 13
Issue: 5
Pages: 321-335
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri3430
OpenAlex: W2052554412
Cited by: 2,256
References: 168
Citations by year: 2026: 117 · 2025: 190 · 2024: 174 · 2023: 206 · 2022: 229 · 2021: 235 · 2020: 193 · 2019: 181 · 2018: 163 · 2017: 170 · 2016: 132 · 2015: 128 · 2014: 109 · 2013: 25
FWCI: 12.09
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: Crohn's and Colitis Foundation
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Keywords: gut microbiota, host-microbe symbiosis, intestinal immunity, inflammatory diseases, intestinal homeostasis, pathobionts, dysbiosis, intestinal disorders, systemic disease
MeSH terms: Animals, Humans, Inflammation, Intestinal Mucosa, Symbiosis, Gastrointestinal Tract, Host-Pathogen Interactions, Metagenome

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Role of the gut microbiota in immunity and inflammatory disease

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