Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy

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Items 301–400 of 1,006

1. Spatiotemporal Adaptations of Macrophage and Dendritic Cell Development and Function
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2. Lipopolysaccharide-Induced CD300b Receptor Binding to Toll-like Receptor 4 Alters Signaling to Drive Cytokine Responses that Enhance Septic Shock
   Oliver H. Voss, Yousuke Murakami, Mirna Peña, Hana Lee, Linjie Tian, David H. Margulies, Jonathan M. Street, Peter S.T. Yuen, Chen‐Feng Qi, Konrad Krzewski et al. · 2016 · Immunity
3. Sepsis and Risk of Cancer Among Elderly Adults in the United States
   Zhiwei Liu, Parag S. Mahale, Eric A. Engels · 2018 · Clinical Infectious Diseases
4. Pharmacokinetics, Pharmacodynamics, and Safety of Nivolumab in Patients With Sepsis-Induced Immunosuppression: A Multicenter, Open-Label Phase 1/2 Study
   Eizo Watanabe, Osamu Nishida, Yasuyuki Kakihana, Motoi Odani, Tatsuaki Okamura, Tomohiro Harada, Shigeto Oda · 2019 · Shock
5. The role of mitophagy in pulmonary sepsis
   Mohd Mohsin, Gulnaz Tabassum, Shaniya Ahmad, Shakir Ali, Mansoor Ali Syed · 2021 · Mitochondrion
6. Development of Exhausted Memory Monocytes and Underlying Mechanisms
   Kisha Pradhan, Ziyue Yi, Shuo Geng, Liwu Li · 2021 · Frontiers in Immunology
7. HSV-1 reactivation is associated with an increased risk of mortality and pneumonia in critically ill COVID-19 patients
   Antoine Meyer, Niccolò Buetti, Nadhira Houhou‐Fidouh, Juliette Patrier, Moustafa Abdel-Nabey, Pierre Jaquet, Simona Presente, Tiphaine Girard, Faiza Sayagh, Stéphane Ruckly et al. · 2021 · Critical Care
8. NLRC3 expression in macrophage impairs glycolysis and host immune defense by modulating the NF-κB-NFAT5 complex during septic immunosuppression
   Jiqian Xu, Chenggang Gao, Yajun He, Xiangzhi Fang, Deyi Sun, Zhe-Kang Peng, Hairong Xiao, Miaomiao Sun, Pei Zhang, Ting Zhou et al. · 2022 · Molecular Therapy
9. Lactate and Lactylation in Sepsis: A Comprehensive Review
   Sijia Liu, Ting Yang, Qingsong Jiang, Liang Zhang, Xinhui Shi, Xin Liu, Xiaoli Li · 2024 · Journal of Inflammation Research
10. Sepsis Induces Prolonged Epigenetic Modifications in Bone Marrow and Peripheral Macrophages Impairing Inflammation and Wound Healing
    Frank M. Davis, Matthew A Schaller, Aaron D. denDekker, Amrita Joshi, Andrew Kimball, Holly L. Evanoff, Carol A. Wilke, Andrea T. Obi, William James Melvin, Karen Angelica Cavassani et al. · 2019 · Arteriosclerosis Thrombosis and Vascular Biology
11. Late immune consequences of combat trauma: a review of trauma-related immune dysfunction and potential therapies
    Kelly B. Thompson, Luke T. Krispinsky, Ryan J. Stark · 2019 · Military Medical Research
12. Differential Lung Protective Capacity of Exosomes Derived from Human Adipose Tissue, Bone Marrow, and Umbilical Cord Mesenchymal Stem Cells in Sepsis‐Induced Acute Lung Injury
    Huimin Deng, Lina Zhu, Yiguo Zhang, Zheng Li, Song Hu, Wenyu Zhou, Tong Zhang, Wenting Xu, Yuanli Chen, Huanping Zhou et al. · 2022 · Oxidative Medicine and Cellular Longevity
13. From immune dysregulation to organ dysfunction: understanding the enigma of Sepsis
    Zhi Liu, Yuan Ting, Miao Li, Yukun Li, Yingzheng Tan, Yunzhu Long · 2024 · Frontiers in Microbiology
14. Identification of CD177 as the most dysregulated parameter in a microarray study of purified neutrophils from septic shock patients
    Julie Demaret, Fabienne Venet, Jonathan Plassais, Marie-Angélique Cazalis, Hélène Vallin, Arnaud Friggeri, Alain Lepape, Thomas R. Rimmele, Julien Textoris, Guillaume Monneret · 2016 · Immunology Letters
15. MicroRNA-21 Is Required for Local and Remote Ischemic Preconditioning in Multiple Organ Protection Against Sepsis*
    Ping Jia, Xiaoli Wu, Yan Dai, Jie Teng, Yi Fang, Jiachang Hu, Jianzhou Zou, Mingyu Liang, Xiaoqiang Ding · 2017 · Critical Care Medicine
16. Early PREdiction of sepsis using leukocyte surface biomarkers: the ExPRES-sepsis cohort study
    Shankar-Hari, Manu, Datta, Deepankar, Wilson, Julie, Assi, Valentina, Stephen, Jacqueline, Weir, Christopher J., Rennie, Jillian, Antonelli, Jean, Bateman, Anthony, Felton, Jennifer M. et al. · 2018 · Intensive Care Medicine
17. Role of miRNA dysregulation in sepsis
    Amanda Formosa, Paul J. Turgeon, Claúdia C. dos Santos · 2022 · Molecular Medicine
18. Lactate’s impact on immune cells in sepsis: unraveling the complex interplay
    Tao Zhang, Linjian Chen, Gatkek Kueth, Emily Shao, Xiaohui Wang, Tuanzhu Ha, David L. Williams, Chuanfu Li, Min Fan, Kun Yang · 2024 · Frontiers in Immunology
19. Mechanisms of sepsis-induced acute liver injury: a comprehensive review
    Yongjing Guo, Wanxu Guo, Huimin Chen, Jian Sun, Yongjie Yin · 2025 · Frontiers in Cellular and Infection Microbiology
20. Synthetic high-density lipoprotein-like nanoparticles potently inhibit cell signaling and production of inflammatory mediators induced by lipopolysaccharide binding Toll-like receptor 4
    Linda Foit, Colby Shad Thaxton · 2016 · Biomaterials
21. Incidence, risk factors and impact on outcomes of secondary infection in patients with septic shock: an 8-year retrospective study
    Guangju Zhao, Li Dong, Qian Zhao, Jiaxing Song, Xiaorong Chen, Guangliang Hong, Mengfang Li, Bing Wu, Zhongqiu Lu · 2016 · Scientific Reports
22. Circulating IL-6 upregulates IL-10 production in splenic CD4+ T cells and limits acute kidney injury–induced lung inflammation
    Ana Andrés-Hernando, Kayo Okamura, Rhea Bhargava, Carol M. Kiekhaefer, Danielle Elise Soranno, Lara A. Kirkbride-Romeo, Hyo‐Wook Gil, Chris Altmann, Sarah G. Faubel · 2017 · Kidney International
23. Bacterial capture efficiency in fluid bloodstream improved by bendable nanowires
    Lizhi Liu, Sheng Chen, Zhenjie Xue, Zhen Zhang, Xuezhi Qiao, Zongxiu Nie, Dong Chul Han, Jianlong Wang, Tie Wang · 2018 · Nature Communications
24. Pathophysiology of Disseminated Intravascular Coagulation in Sepsis: A Clinically Focused Overview
    Ahsanullah Unar, Lorenzo Bertolino, Fabian Patauner, Raffaella Gallo, Emanuele Durante‐Mangoni · 2023 · Cells
25. Management of Sepsis-Induced Immunosuppression
    Fabienne Venet, Thomas R. Rimmele, Guillaume Monneret · 2017 · Critical Care Clinics
26. Modulation of LILRB2 protein and mRNA expressions in septic shock patients and after ex vivo lipopolysaccharide stimulation
    Fabienne Venet, Jeremy Schilling, Marie-Angélique Cazalis, Julie Demaret, Fanny Poujol, Thibaut Girardot, Christelle Rouget, Alexandre Pachot, Alain Lepape, Arnaud Friggeri et al. · 2017 · Human Immunology
27. TREML4 receptor regulates inflammation and innate immune cell death during polymicrobial sepsis
    Christina Nedeva, Joseph Menassa, Mubing Duan, Chuanxin Liu, Marcel Doerflinger, Andrew J. Kueh, Marco J. Herold, Pamali Fonseka, Thanh Kha Phan, Pierre Faou et al. · 2020 · Nature Immunology
28. Lymphopenia in sepsis—an acquired immunodeficiency?
    Simon R. Finfer, Balasubramanian Venkatesh, Richard S. Hotchkiss, Sarah Christina Sasson · 2022 · Immunology and Cell Biology
29. The potential immunological mechanisms of sepsis
    Xinyu Zhang, Yujing Zhang, Shiying Yuan, Jiancheng Zhang · 2024 · Frontiers in Immunology
30. Therapeutic interventions in sepsis: current and anticipated pharmacological agents
    Prashant Shukla, G Madhava Rao, Gitu Pandey, Shweta Sharma, Naresh Mittapelly, Ranjita Shegokar, Prabhat Ranjan Mishra · 2014 · British Journal of Pharmacology
31. Endotoxin-Induced Tryptophan Degradation along the Kynurenine Pathway: The Role of Indolamine 2,3-Dioxygenase and Aryl Hydrocarbon Receptor-Mediated Immunosuppressive Effects in Endotoxin Tolerance and Cancer and Its Implications for Immunoparalysis
    Elisa Wirthgen, Andreas Hoeflich · 2015 · Journal of Amino Acids
32. Acute-on-Chronic Liver Failure
    Sumeet K. Asrani, Douglas Alano Simonetto, Patrick S. Kamath · 2015 · Clinical Gastroenterology and Hepatology
33. Glucose homeostasis, nutrition and infections during critical illness
    Catherine Ingels, Ilse Vanhorebeek, Greet Van den Berghe · 2017 · Clinical Microbiology and Infection
34. Validation of two multiplex platforms to quantify circulating markers of inflammation and endothelial injury in severe infection
    Aleksandra Leligdowicz, Andrea L. Conroy, Michael Hawkes, Kathleen Zhong, Gerald Lebovic, Michael A. Matthay, Kevin C. Kain · 2017 · PLoS ONE
35. Readmissions for Recurrent Sepsis: New or Relapsed Infection?*
    Kimberley M. DeMerle, Stephanie Royer, Mark E. Mikkelsen, Hallie C. Prescott · 2017 · Critical Care Medicine
36. Sepsis Induces a Long-Lasting State of Trained Immunity in Bone Marrow Monocytes
    Katharina Bomans, Judith Schenz, Isabella Sztwiertnia, Dominik Schaack, Markus Alexander Weigand, Florian Uhle · 2018 · Frontiers in Immunology
37. Current Understanding of Cytomegalovirus Reactivation in Critical Illness
    Hannah N. Imlay, Ajit P. Limaye · 2019 · The Journal of Infectious Diseases
38. Monocyte HLA‐DR Measurement by Flow Cytometry in COVID ‐19 Patients: An Interim Review
    Ihsane Benlyamani, Fabienne Venet, Rémy Coudereau, Morgane Gossez, Guillaume Monneret · 2020 · Cytometry Part A
39. Mitochondrial DNA
    Simon Thomas Schäfer, Lars Franken, Michael Adamzik, Beatrix Schumak, André Scherag, Andrea Engler, Niels Schönborn, Jennifer Walden, Susanne Koch, Hideo Andreas Baba et al. · 2016 · Anesthesiology
40. Oral administration of live- or heat-killed Candida albicans worsened cecal ligation and puncture sepsis in a murine model possibly due to an increased serum (1→3)-β-D-glucan
    Wimonrat Panpetch, Naraporn Somboonna, Dewi Embong Bulan, Jiraphorn Issara-Amphorn, Malcolm Finkelman, Navaporn Worasilchai, Ariya Chindamporn, Tanapat Palaga, Somying Tumwasorn, Asada Leelahavanichkul · 2017 · PLoS ONE
41. Stem Cell–based Therapies for Sepsis
    Colm Keane, Mirjana Jerkić, John Gerard Laffey · 2017 · Anesthesiology
42. Immune checkpoint receptors: homeostatic regulators of immunity
    Antonio Riva, Shilpa Chokshi · 2018 · Hepatology International
43. Understanding Immunosuppression after Sepsis
    Fatemeh Fattahi, Peter A. Ward · 2017 · Immunity
44. Sepsis in the era of data-driven medicine: personalizing risks, diagnoses, treatments and prognoses
    Andrew C. Liu, Krishna Patel, Ramya Vunikili, Kipp W. Johnson, Fahad Abdu, Shivani Kamath Belman, Benjamin Scott Glicksberg, Pratyush P. Tandale, Roberto Fontanez, Oommen K. Mathew et al. · 2019 · Briefings in Bioinformatics
45. S100A8/A9: An emerging player in sepsis and sepsis-induced organ injury
    Qian Wang, Gangyu Long, Hong Jie Luo, Xiqun Zhu, Yang Han, You Shang, Dingyu Zhang, Rui Gong · 2023 · Biomedicine & Pharmacotherapy
46. Pterostilbene alleviates polymicrobial sepsis-induced liver injury: Possible role of SIRT1 signaling
    Xiaojing Liu, Xueliang Yang, Ling‐Na Han, Feng Ye, Min Liu, Wanhu Fan, Kai Zhang, Ying Kong, Jian Zhang, Lei Shi et al. · 2017 · International Immunopharmacology
47. Crosstalk between gut microbiota and sepsis
    Niu, Mengwei, Chen, Peng · 2021 · Burns & Trauma
48. IL-7 Restores T Lymphocyte Immunometabolic Failure in Septic Shock Patients through mTOR Activation
    Fabienne Venet, Julie Demaret, Benjamin J. Blaise, Christelle Rouget, Thibaut Girardot, Estellie Idealisoa, Thomas R. Rimmele, François Mallet, Alain Lepape, Julien Textoris et al. · 2017 · The Journal of Immunology
49. Sepsis-Induced Immunosuppression in Neonates
    Julie Hibbert, Andrew J Currie, Tobias Strunk · 2018 · Frontiers in Pediatrics
50. Single-Cell RNA-seq of Human Myeloid-Derived Suppressor Cells in Late Sepsis Reveals Multiple Subsets With Unique Transcriptional Responses: A Pilot Study
    Dijoia B. Darden, Rhonda L. Bacher, Maigan Brusko, Parker Knight, Russell B. Hawkins, Michael C. Cox, Marvin L. S. Dirain, Ricardo F. Ungaro, Dina C. Nacionales, Jaimar C. Rincon et al. · 2020 · Shock
51. Mechanism of Mitophagy and Its Role in Sepsis Induced Organ Dysfunction: A Review
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52. Blood Purification for Adult Patients With Severe Infection or Sepsis/Septic Shock: A Network Meta-Analysis of Randomized Controlled Trials
    Jia‐Jin Chen, Pei-Chun Lai, Tao Han Lee, Yen‐Ta Huang · 2023 · Critical Care Medicine
53. A Personalized Signature and Chronotherapy-Based Platform for Improving the Efficacy of Sepsis Treatment
    Ariel Kenig, Yaron Ilan · 2019 · Frontiers in Physiology
54. PPAR αcontributes to protection against metabolic and inflammatory derangements associated with acute kidney injury in experimental sepsis
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55. BMP-2 delivery strategy modulates local bone regeneration and systemic immune responses to complex extremity trauma
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56. SLAMF7 regulates the inflammatory response in macrophages during polymicrobial sepsis
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57. Immune and metabolic effects of African heritage diets versus Western diets in men: a randomized controlled trial
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58. Proteomic study revealed cellular assembly and lipid metabolism dysregulation in sepsis secondary to community-acquired pneumonia
    Narendra Kumar Sharma, Alexandre K. Tashima, Milena Karina Coló Brunialti, Éden Ramalho Ferreira, Ricardo J.S. Torquato, Renato A. Mortara, Flávia Ribeiro Machado, Murillo Santucci César de Assunção, Otelo Rigato, Reinaldo Salomão · 2017 · Scientific Reports
59. Polymicrobial sepsis influences NK-cell-mediated immunity by diminishing NK-cell-intrinsic receptor-mediated effector responses to viral ligands or infections
    Isaac J. Jensen, Christina S. Winborn, Micaela G. Fosdick, Peng Shao, Mikaela M. Tremblay, Qiang Shan, Sandeep K. Tripathy, Christopher M. Snyder, Hai‐Hui Xue, Thomas S. Griffith et al. · 2018 · PLoS Pathogens
60. Polymicrobial Sepsis Increases Susceptibility to Chronic Viral Infection and Exacerbates CD8+ T Cell Exhaustion
    Stephanie A. Condotta, Shaniya H. Khan, Deepa Rai, Thomas S. Griffith, Vladimir P. Badovinac · 2015 · The Journal of Immunology
61. Polymicrobial Sepsis Alters Antigen-Dependent and -Independent Memory CD8 T Cell Functions
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62. Silence of long noncoding RNA NEAT1 exerts suppressive effects on immunity during sepsis by promoting microRNA‐125‐dependent MCEMP1 downregulation
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63. Improvement of Sepsis Prognosis by Ulinastatin: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
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64. Multidrug-resistant Candida auris : an epidemiological review
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65. Immune therapy in sepsis: Are we ready to try again?
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66. Blood Purification Techniques for Sepsis and Septic AKI
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67. Immune Cell Number, Phenotype, and Function in the Elderly with Sepsis
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68. Immune Intervention in Sepsis
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69. Treatment Advances in Sepsis and Septic Shock: Modulating Pro- and Anti-Inflammatory Mechanisms
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70. Shikonin induces apoptosis of lung cancer cells via activation of FOXO3a/EGR1/SIRT1 signaling antagonized by p300
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71. B-1a Cells Protect Mice from Sepsis: Critical Role of CREB
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72. Utility and Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Dogs with Septic Peritonitis
    Natasha Hodgson, Efa A. Llewellyn, David J. Schaeffer · 2018 · Journal of the American Animal Hospital Association
73. Circulating extracellular vesicle content reveals de novo DNA methyltransferase expression as a molecular method to predict septic shock
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74. Alveolar compartmentalization of inflammatory and immune cell biomarkers in pneumonia-related ARDS
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75. Immunosuppression after Sepsis: Systemic Inflammation and Sepsis Induce a Loss of Naïve T-Cells but No Enduring Cell-Autonomous Defects in T-Cell Function
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76. Sphingosine-1-Phosphate
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77. Autophagy: A Potential Therapeutic Target for Reversing Sepsis-Induced Immunosuppression
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78. The Central Role of the Inflammatory Response in Understanding the Heterogeneity of Sepsis-3
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79. Exploring the roles of MSCs in infections: focus on bacterial diseases
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80. T Cell– and Monocyte-Specific RNA-Sequencing Analysis in Septic and Nonseptic Critically Ill Patients and in Patients with Cancer
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81. CXCL5-mediated recruitment of neutrophils into the peritoneal cavity of Gdf15 -deficient mice protects against abdominal sepsis
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82. T-Cell Exhaustion in Mycobacterium tuberculosis and Nontuberculous Mycobacteria Infection: Pathophysiology and Therapeutic Perspectives
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83. Monitoring of circulating monocyte HLA-DR expression in a large cohort of intensive care patients: relation with secondary infections
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84. Barriers to the effective treatment of sepsis: antimicrobial agents, sepsis definitions, and host‐directed therapies
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85. AMP-Activated Protein Kinase and Glycogen Synthase Kinase 3β Modulate the Severity of Sepsis-induced Lung injury
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86. Post-Sepsis State Induces Tumor-Associated Macrophage Accumulation through CXCR4/CXCL12 and Favors Tumor Progression in Mice
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87. PPARα augments heart function and cardiac fatty acid oxidation in early experimental polymicrobial sepsis
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88. Blocking Liver Autophagy Accelerates Apoptosis and Mitochondrial Injury in Hepatocytes and Reduces Time to Mortality in a Murine Sepsis Model
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89. Inhibition of necroptosis attenuates lung injury and improves survival in neonatal sepsis
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90. Quantitative and simultaneous detection of two inflammation biomarkers via a fluorescent lateral flow immunoassay using dual-color SiO2@QD nanotags
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91. Energy Demands of Early Life Drive a Disease Tolerant Phenotype and Dictate Outcome in Neonatal Bacterial Sepsis
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92. HDL inflammatory index correlates with and predicts severity of organ failure in patients with sepsis and septic shock
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93. Vitamin C and the Immune System
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94. Best-practice IgM- and IgA-enriched immunoglobulin use in patients with sepsis
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95. Severe COVID-19 is characterized by the co-occurrence of moderate cytokine inflammation and severe monocyte dysregulation
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96. Lateral flow assays for detection of disease biomarkers
    Eda Gumus, Haluk Bingöl, Erhan Zor · 2022 · Journal of Pharmaceutical and Biomedical Analysis
97. Elevated miR-155 expression induces immunosuppression via CD39 + regulatory T-cells in sepsis patient
    Jingquan Liu, Kai Shi, Minhua Chen, Liang Zhong Xu, Jun Hong, Bangchuan Hu, Xianghong Yang, Ren-Hua Sun · 2015 · International Journal of Infectious Diseases
98. Different Expression Characteristics of LAG3 and PD-1 in Sepsis and Their Synergistic Effect on T Cell Exhaustion: A New Strategy for Immune Checkpoint Blockade
    Bailin Niu, Fachun Zhou, Yanxin Su, Long Wang, Yuanyuan Xu, Ziying Yi, Yushen Wu, Huimin Du, Guosheng Ren · 2019 · Frontiers in Immunology
99. Early or Late Bacterial Lung Infection Increases Mortality After Traumatic Brain Injury in Male Mice and Chronically Impairs Monocyte Innate Immune Function
    Sarah J. Doran, Rebecca J. Henry, Kari Ann Shirey, James P. Barrett, Rodney M. Ritzel, Wendy Lai, Jorge C. G. Blanco, Alan I. Faden, Stefanie N. Vogel, David J. Loane · 2020 · Critical Care Medicine
100. Novel Role of Endothelial Derived Exosomal HSPA12B in Regulating Macrophage Inflammatory Responses in Polymicrobial Sepsis
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