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Cited by 69Gut microbiota and healthSepsis Diagnosis and TreatmentClostridium difficile and Clostridium perfringens research

Crosstalk between gut microbiota and sepsis

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Niu, Mengwei, Chen, Peng·2021·Burns & Trauma
DOI 10.1093/burnst/tkab036PMC PMC8547143
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Abstract

Sepsis is an overwhelming inflammatory response to microbial infection. Sepsis management remains a clinical challenge. The role of the gut microbiome in sepsis has gained some attention. Recent evidence has demonstrated that gut microbiota regulate host physiological homeostasis mediators, including the immune system, gut barrier function and disease susceptibility pathways. Therefore, maintenance or restoration of microbiota and metabolite composition might be a therapeutic or prophylactic target against critical illness. Fecal microbiota transplantation and supplementation of probiotics are microbiota-based treatment methods that are somewhat limited in terms of evidence-based efficacy. This review focuses on the importance of the crosstalk between the gastrointestinal ecosystem and sepsis to highlight novel microbiota-targeted therapies to improve the outcomes of sepsis treatment.

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  • Gut dysbiosis is an active driver of sepsis aggravation through barrier dysfunction, immune-metabolic disturbances, and amplified systemic inflammation.

    “Gut dysbiosis is not a passive consequence but an active driver of sepsis aggravation, primarily through barrier dysfunction, immune-metabolic disturbances, and amplified systemic inflammation”

    From Progress on the correlation between sepsis and gut microbiota: a narrative review (2026) · cites this paper as Niu and Chen, 2021

    The Review section 'Sepsis may aggravate gut microbiome dysbiosis' says disrupted gut ecosystems could promote septic organ damage and that reduced short-chain fatty acids could worsen barrier function and affect systemic immunity. 'Gut microbiota modulate sepsis progression' also links microbial metabolites to immune regulation and inflammation. The paper treats dysbiosis as a possible contributor, however; it does not establish it as an active driver acting primarily through the three stated pathways. (LLM, conf=0.84)

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Cited by

Sorted by citations

Authors
Niu, M., & Chen, P.
Affiliations
Southern Medical University (CN)
Corresponding author
Chen, Peng
ORCID
Venue
Burns & Trauma
Publisher
Oxford University Press (OUP)
Published
2021-01-01
Volume
9
Pages
tkab036-tkab036
ISSN
  • 2321-3868 (ISSN-L)
  • 2321-3876
DOI
10.1093/burnst/tkab036
PMC
PMC8547143
OpenAlex
W3210546158
Cited by
69
References
18
Citations by year
2026: 19 · 2025: 13 · 2024: 13 · 2023: 19 · 2022: 5
FWCI
0.97
Type
journal article
Language
en
Open access
Licence
Locations
  • Burns & Trauma (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (81 873 926)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
  • Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
Keywords
sepsis, gut microbiota, microbiota-targeted therapy, fecal microbiota transplantation, probiotics, intestinal barrier, host immune modulation, microbial metabolites, critical illness

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