Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy

PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer

Hartkopf, A. D., Taran, F., Wallwiener, M., Walter, C. B., Krämer, B., Grischke, E., & Brucker, S. Y. (2016) · Breast Care · doi:10.1159/000453569 · Cited by 30,989

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

Hodi, F. S., O'Day, S. J., McDermott, D. F., Weber, R. W., Sosman, J. A., Haanen, J. B., Gonzalez, R., Robert, C., Schadendorf, D., Hassel, J. C., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1003466 · Cited by 15,155

Safety, activity, and immune correlates of anti–PD-1 antibody in cancer

Topalian, S. L., Hodi, F. S., Brahmer, J. R., Gettinger, S. N., Smith, D. C., McDermott, D. F., Powderly, J. D., Carvajal, R. D., Sosman, J. A., Atkins, M. B., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1200690 · Cited by 12,628

The Pathophysiology and Treatment of Sepsis

Hotchkiss, R. S., & Karl, I. E. (2003) · New England Journal of Medicine · doi:10.1056/nejmra021333 · Cited by 4,134

T cell exhaustion

Wherry, E. J. (2011) · Nature Immunology · doi:10.1038/ni.2035 · Cited by 4,062

Of Mice and Not Men: Differences between Mouse and Human Immunology

Mestas, J., & Hughes, C. C. W. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.5.2731 · Cited by 3,822

Genomic responses in mouse models poorly mimic human inflammatory diseases

Seok, J., Warren, H. S., Cuenca, A. G., Mindrinos, M. N., Baker, H. V., Xu, W., Richards, D. R., McDonald-Smith, G. P., Gao, H., Hennessy, L., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1222878110 · Cited by 3,005

Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function

Zajac, A. J., Blattman, J. N., Murali-Krishna, K., Sourdive, D. J. D., Suresh, M., Altman, J. D., & Ahmed, R. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.12.2205 · Cited by 1,978

Immunosuppression in Patients Who Die of Sepsis and Multiple Organ Failure

Boomer, J. S., To, K. B., Chang, K. C., Takasu, O., Osborne, D. F., Walton, A. H., Bricker, T. L., Jarman, S. D., Kreisel, D., Krupnick, A. S., et al. (2011) · JAMA · doi:10.1001/jama.2011.1829 · Cited by 1,839

Modulation of Inflammatory Cytokine Production in Human Monocytes by cGMP and IRAK3

Nguyen, T. H., Axell, A., Turek, I., Wright, B. A., Meehan-Andrews, T., & Irving, H. R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052552 · Cited by 28

Candida Worsens Klebsiella pneumoniae Induced-Sepsis in a Mouse Model with Low Dose Dextran Sulfate Solution through Gut Dysbiosis and Enhanced Inflammation

Panpetch, W., Phuengmaung, P., Hiengrach, P., Issara-Amphorn, J., Cheibchalard, T., Somboonna, N., Tumwasorn, S., & Leelahavanichkul, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137050 · Cited by 30

Ex vivo and in vitro Monocyte Responses Do Not Reflect in vivo Immune Responses and Tolerance

Jansen, A., Bruse, N., Waalders, N. J. B., Gerretsen, J., Rijbroek, D., Pickkers, P., & Kox, M. (2022) · Journal of Innate Immunity · doi:10.1159/000525572 · Cited by 28

Immune checkpoint inhibitors for the treatment of sepsis:insights from preclinical and clinical development

Rienzo, M., Skirecki, T., Monneret, G., & Timsit, J. (2022) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2022.2102477 · Cited by 28

Immunopathology of chronic critical illness in sepsis survivors: Role of abnormal myelopoiesis

Rincon, J. C., Efron, P. A., & Moldawer, L. L. (2022) · Journal of Leukocyte Biology · doi:10.1002/jlb.4mr0922-690rr · Cited by 29

Hippocampus‐prefrontal cortex inputs modulate spatial learning and memory in a mouse model of sepsis induced by cecal ligation puncture

Ge, C., Chen, W., Zhang, L., Ai, Y., Zou, Y., & Peng, Q. (2022) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14013 · Cited by 28

Novel plasma protein biomarkers from critically ill sepsis patients

Nynatten, L. R. V., Slessarev, M., Martin, C. M., Leligdowicz, A., Miller, M. R., Patel, M. A., Daley, M., Patterson, E. K., Cepinskas, G., & Fraser, D. D. (2022) · Clinical Proteomics · doi:10.1186/s12014-022-09389-3 · Cited by 29

Diagnostic and therapeutic value of biomarkers in urosepsis

Wu, Y., Wang, G., Huang, Z., Yang, B., Yang, T., Liu, J., Li, P., & Li, J. (2023) · Therapeutic Advances in Urology · doi:10.1177/17562872231151852 · Cited by 29

Therapeutic potential of the sphingosine kinase 1 inhibitor, PF-543

Yi, X., Tang, X., Li, T., Chen, L., He, H., Wu, X., Xiang, C., Cao, M., Wang, Z., Wang, Y., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114401 · Cited by 28

Shikonin inhibits immune checkpoint PD-L1 expression on macrophage in sepsis by modulating PKM2

Yuan, L., Wang, Y., Chen, Y., Chen, X., Li, S., & Liu, X. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110401 · Cited by 28

Deciphering the molecular and cellular atlas of immune cells in septic patients with different bacterial infections

Sun, P., Cui, M., Jing, J., Kong, F., Wang, S., Tang, L., Leng, J., & Chen, K. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04631-4 · Cited by 28

Altered T Lymphocyte Proliferation upon Lipopolysaccharide Challenge Ex Vivo

Poujol, F., Monneret, G., Pachot, A., Textoris, J., & Venet, F. (2015) · PLoS ONE · doi:10.1371/journal.pone.0144375 · Cited by 28

The fifth epidermal growth factor like region of thrombomodulin alleviates LPS-induced sepsis through interacting with GPR15

Pan, B., Wang, X., Kojima, S., Nishioka, C., Yokoyama, A., Honda, G., Xu, K., & Ikezoe, T. (2017) · Thrombosis and Haemostasis · doi:10.1160/th16-10-0762 · Cited by 28

Ethyl pyruvate reverses development of Pseudomonas aeruginosa pneumonia during sepsis-induced immunosuppression

Chen, W., Lian, J., Ye, J., Mo, Q., Qin, J., Hong, G., Chen, L., Zhi, S., Zhao, G., & Lu, Z. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.08.024 · Cited by 28

Mitofusin 2 Promotes Apoptosis of CD4 + T Cells by Inhibiting Autophagy in Sepsis

Lan, Y., Zhao, G., Wu, Y., Ke, H.-L., Hong, G., Zhang, H., Dong, N., Wu, Y., Yao, Y.-M., & Lu, Z. (2017) · Mediators of Inflammation · doi:10.1155/2017/4926205 · Cited by 28

HLA-DR Expression on Monocyte Subsets in Critically Ill Children

Boeddha, N. P., Kerklaan, D., Dunbar, A., van Puffelen, E., Nagtzaam, N. M. A., Vanhorebeek, I., den Berghe, G. V., Hazelzet, J. A., Joosten, K. F. M., Verbruggen, S. C. A. T., et al. (2018) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000001990 · Cited by 28

Mitochondria-Derived Damage-Associated Molecular Patterns in Sepsis: From Bench to Bedside

Li, S., Hu, Q., Huang, J., Wu, X., & Ren, J. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/6914849 · Cited by 29

Immune Profiling Panel: A Proof-of-Concept Study of a New Multiplex Molecular Tool to Assess the Immune Status of Critically Ill Patients

Tawfik, D. M., Vachot, L., Bocquet, A., Venet, F., Rimmelé, T., Monneret, G., Blein, S., Montgomery, J., Hemmert, A., Pachot, A., et al. (2020) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiaa248 · Cited by 28

Mesenchymal stromal cells for sepsis and septic shock: Lessons for treatment of COVID-19

Laroye, C., Gibot, S., Huselstein, C., & Bensoussan, D. (2020) · Stem Cells Translational Medicine · doi:10.1002/sctm.20-0239 · Cited by 28

Glutamine, fish oil and antioxidants in critical illness: MetaPlus trial post hoc safety analysis

Hofman, Z., Swinkels, S., & van Zanten, A. R. H. (2016) · Annals of Intensive Care · doi:10.1186/s13613-016-0220-y · Cited by 27

PD-L1 Blockade Improves Survival in Sepsis by Reversing Monocyte Dysfunction and Immune Disorder

Li, Y., Gao, Q., Li, Q., & Guo, S. (2023) · Inflammation · doi:10.1007/s10753-023-01897-0 · Cited by 27

Sepsis in elderly patients: the role of neutrophils in pathophysiology and therapy

Ramoni, D., Tirandi, A., Montecucco, F., & Liberale, L. (2024) · Internal and Emergency Medicine · doi:10.1007/s11739-023-03515-1 · Cited by 27

A citrullinated histone H3 monoclonal antibody for immune modulation in sepsis

Ouyang, W., Chen, Y., Tan, T., Song, Y., Dong, T., Yu, X., Lee, K. E., Zhou, X., Tetz, Z., Go, S., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-62788-6 · Cited by 27

Tanshinone IIA attenuates sepsis-induced immunosuppression and improves survival rate in a mice peritonitis model

Gao, M., Ou, H., Jiang, Y., Wang, K., Peng, Y., Zhang, H., Yang, M., & Xiao, X. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.108609 · Cited by 27

MicroRNA-140 inhibits skeletal muscle glycolysis and atrophy in endotoxin-induced sepsis in mice via the WNT signaling pathway

Liu, L., Li, T.-M., Liu, X., Bai, Y., Li, J., Tang, N., & Wang, X. (2019) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00419.2018 · Cited by 27

Efficacy and safety of corticosteroids for septic shock in immunocompromised patients: A cohort study from MIMIC

Lu, X., Wang, X., Gao, Y., Yu, S., Zhao, L., Zhang, Z., Zhu, H., & Li, Y. (2020) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2020.02.002 · Cited by 28

Lessons Learned Comparing Immune System Alterations of Bacterial Sepsis and SARS-CoV-2 Sepsis

Dong, X., Wang, C., Liu, X., Gao, W., Bai, X., & Li, Z. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.598404 · Cited by 27

Analysis of interleukin-1 receptor associated kinase-3 (IRAK3) function in modulating expression of inflammatory markers in cell culture models: A systematic review and meta-analysis

Nguyen, T. H., Turek, I., Meehan-Andrews, T., Zacharias, A., & Irving, H. R. (2020) · PLoS ONE · doi:10.1371/journal.pone.0244570 · Cited by 27

Transglutaminase 2 as a Marker for Inflammation and Therapeutic Target in Sepsis

Su, T., Qin, X., & Furutani, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041897 · Cited by 27

Covid Assossiated Invasive Fungal Sinusitis

Sebastian, S. K., Kumar, V. B., Gupta, M., & Sharma, Y. (2021) · Indian Journal of Otolaryngology and Head & Neck Surgery · doi:10.1007/s12070-021-02471-6 · Cited by 27

Metabolic responses in neonatal sepsis—A systematic review of human metabolomic studies

Bjerkhaug, A. U., Granslo, H. N., & Klingenberg, C. (2021) · Acta Paediatrica · doi:10.1111/apa.15874 · Cited by 27

Intravenous calcitriol administration regulates the renin-angiotensin system and attenuates acute lung injury in obese mice complicated with polymicrobial sepsis

Yeh, C., Wu, J., Su, L.-H., Yang, P., Lee, P., Chen, K.-Y., Yeh, S., & Lin, M. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111856 · Cited by 27

Characterization of the blood and neutrophil‐specific microbiomes and exploration of potential bacterial biomarkers for sepsis in surgical patients

Wang, C., Li, Q., Tang, C. X., Zhao, X., He, Q., Tang, X., & Ren, J. (2021) · Immunity Inflammation and Disease · doi:10.1002/iid3.483 · Cited by 27

Concomitant Assessment of Monocyte HLA-DR Expression and Ex Vivo TNF-α Release as Markers of Adverse Outcome after Various Injuries—Insights from the REALISM Study

Bidar, F., Bodinier, M., Venet, F., Lukaszewicz, A., Brengel‐Pesce, K., Conti, F., Quéméneur, L., Leissner, P., Tan, L., Textoris, J., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm11010096 · Cited by 27

Long Noncoding RNA HOTAIRM1 Promotes Immunosuppression in Sepsis by Inducing T Cell Exhaustion

Chen, W., Liu, J., Ge, F., Chen, Z., Qu, M., Nan, K., Gu, J., Jiang, Y., Gao, S., Liao, Y., et al. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2100709 · Cited by 27

A systematic review and meta-analyses of interleukin-1 receptor associated kinase 3 (IRAK3) action on inflammation in in vivo models for the study of sepsis

Nguyen, T. H., Turek, I., Meehan-Andrews, T., Zacharias, A., & Irving, H. R. (2022) · PLoS ONE · doi:10.1371/journal.pone.0263968 · Cited by 27

TLR2, TLR4, and NLRP3 mediated the balance between host immune-driven resistance and tolerance in Staphylococcus aureus-infected mice

Gong, Z., Zhang, J., Zhang, S., Cao, J., Fu, Y., Hu, X., Zhao, J., Gu, B., Li, Q., Zhang, K., et al. (2022) · Microbial Pathogenesis · doi:10.1016/j.micpath.2022.105671 · Cited by 27

Sustained Inflammation Induced by LPS Leads to Tolerable Anorexia and Fat Loss via Tlr4 in Mice

Yang, Y., Zhong, W., Zhang, Y., Cheng, Y., Lai, H., Yu, H., Feng, N., Han, Y., Huang, R., & Zhai, Q. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s358518 · Cited by 27

Monocytic HLA-DR Expression in Immune Responses of Acute Pancreatitis and COVID-19

Liu, S., Luo, W., Szatmary, P., Zhang, X., Lin, J., Chen, L., Liu, D., Sutton, R., Xia, Q., Jin, T., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043246 · Cited by 29

Immunosuppressive effects of circulating bile acids in human endotoxemia and septic shock: patients with liver failure are at risk

Leonhardt, J., Dorresteijn, M. J., Neugebauer, S., Mihaylov, D., Kunze, J., Rubio, I., Hohberger, F.-S., Leonhardt, S., Kiehntopf, M., Stahl, K., et al. (2023) · Critical Care · doi:10.1186/s13054-023-04620-5 · Cited by 28

The Human Host Defense Ribonucleases 1, 3 and 7 Are Elevated in Patients with Sepsis after Major Surgery—A Pilot Study

Märtin, L., Koczera, P., Simons, N., Zechendorf, E., Hoeger, J., Marx, G., & Schuerholz, T. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17030294 · Cited by 27

Attrition of memory CD8 T cells during sepsis requires LFA-1

Serbanescu, M. A., Ramonell, K. M., Hadley, A., Margoles, L. M., Mittal, R., Lyons, J. D., Liang, Z., Coopersmith, C. M., Ford, M. L., & McConnell, K. W. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.4a1215-563rr · Cited by 27

Phenotypic Changes and Impaired Function of Peripheral γδ T Cells in Patients With Sepsis

Liao, X.-L., Feng, T., Zhang, J.-Q., Cao, X., Wu, Q., Xie, Z., Kang, Y., & Li, H. (2017) · Shock · doi:10.1097/shk.0000000000000857 · Cited by 27

Immunomodulatory treatment with systemic GM-CSF augments pulmonary immune responses and improves neurological outcome after experimental stroke

Dames, C., Winek, K., Beckers, Y., Engel, O., Meisel, A., & Meisel, C. (2018) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2018.03.005 · Cited by 27

Plasma Proteome Signature of Sepsis: a Functionally Connected Protein Network

Pimienta, G., Heithoff, D. M., Campos, A. R., Tran, M., Esko, J. D., Mahan, M. J., Marth, J. D., & Smith, J. W. (2019) · PROTEOMICS · doi:10.1002/pmic.201800389 · Cited by 27

Septic patients presenting with apparently normal C-reactive protein

Wasserman, A., Karov, R., Shenhar‐Tsarfaty, S., Paran, Y., Zeltzer, D., Shapira, I., Trotzky, D., Halpern, P., Meilik, A., Raykhshtat, E., et al. (2019) · Medicine · doi:10.1097/md.0000000000013989 · Cited by 27

Fish oils protects against cecal ligation and puncture‑induced septic acute kidney injury via the regulation of inflammation, oxidative stress and apoptosis

Lin, Z., Jin, J., & Shan, X. (2019) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2019.4337 · Cited by 27

Experimental pancreatitis is characterized by rapid T cell activation, Th2 differentiation that parallels disease severity, and improvement after CD4+ T cell depletion

Glaubitz, J., Wilden, A., van den Brandt, C., Weiß, F. U., Bröker, B. M., Mayerle, J. V., Lerch, M. M., & Sendler, M. (2020) · Pancreatology · doi:10.1016/j.pan.2020.10.044 · Cited by 27

Biological basis of critical illness subclasses: from the bedside to the bench and back again

Stevens, J., Tezel, O., Bonnefil, V., Hapstack, M. A., & Atreya, M. R. (2024) · Critical Care · doi:10.1186/s13054-024-04959-3 · Cited by 28

What do we know about micronutrients in critically ill patients? A narrative review

de Man, A., Stoppe, C., Koekkoek, K. W. A. C., Briassoulis, G. C., Subasinghe, L., Cobilinschi, C., Deane, A. M., Manzanares, W., Grințescu, I. M., Mirea, L. E., et al. (2024) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.2700 · Cited by 27

Time-dependent variation in immunoparalysis biomarkers among patients with sepsis and critical illness

Samuelsen, A. M., Lehman, E. B., Burrows, P., & Bonavia, A. S. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1498974 · Cited by 26

Interaction between endothelial injury and immune response in septic shock: from basic research to clinical applications

Wang, Y., Guan, Q.-N., Zhang, Z.-J., & Zhang, Y. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1627008 · Cited by 26

Modulation of dendritic cell antigen presentation by pathogens, tissue damage and secondary inflammatory signals

Vega‐Ramos, J., Roquilly, A., Asehnoune, K., & Villadangos, J. A. (2014) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2014.07.013 · Cited by 26

STAT5 phosphorylation in T cell subsets from septic patients in response to recombinant human interleukin-7: a pilot study

Demaret, J., Dupont, G., Venet, F., Friggeri, A., Lepape, A., Rimmelé, T., Morel, J. ́., & Monneret, G. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.5ab1114-545r · Cited by 26

Pellino-3 promotes endotoxin tolerance and acts as a negative regulator of TLR2 and TLR4 signaling

Murphy, M. B., Xiong, Y., Pattabiraman, G., Manavalan, T. T., Qiu, F., & Medvedev, A. E. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.2vma0515-229rr · Cited by 26

Systematic investigation on the turning point of over-inflammation to immunosuppression in CLP mice model and their characteristics

Deng, D., Li, X., Liu, C., Zhai, Z., Li, B., Kuang, M., Li, P., Shang, S., Song, Y., Cen, Y., et al. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.11.011 · Cited by 26

Ventilator-associated pneumonia in extracorporeal membrane oxygenation-assisted patients

Franchineau, G., Luyt, C. E., Combes, A., & Schmidt, M. (2018) · Annals of Translational Medicine · doi:10.21037/atm.2018.10.18 · Cited by 26

Qiang-Xin 1 Formula Prevents Sepsis-Induced Apoptosis in Murine Cardiomyocytes by Suppressing Endoplasmic Reticulum- and Mitochondria-Associated Pathways

Xu, X., Liu, Q., He, S., Zhao, J., Wang, N., Han, X., & Guo, Y. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00818 · Cited by 26

Decreased Protein Kinase C-β Type II Associated with the Prominent Endotoxin Exhaustion in the Macrophage of FcGRIIb−/− Lupus Prone Mice is Revealed by Phosphoproteomic Analysis

Ondee, T., Jaroonwitchawan, T., Pisitkun, T., Gillen, J., Nita‐Lazar, A., Leelahavanichkul, A., & Somparn, P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20061354 · Cited by 26

Identification of suitable controls for miRNA quantification in T-cells and whole blood cells in sepsis

Hirschberger, S., Hübner, M., Strauß, G., Effinger, D., Bauer, M. W., Weis, S., Giamarellos‐Bourboulis, E. J., & Kreth, S. (2019) · Scientific Reports · doi:10.1038/s41598-019-51782-w · Cited by 27

Slow-Release and Nontoxic Pickering Emulsion Platform for Antimicrobial Peptide

Cai, L., Cao, M., & Regenstein, J. M. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c00874 · Cited by 26

Polymicrobial Sepsis Impairs Antigen-Specific Memory CD4 T Cell-Mediated Immunity

Sjaastad, F. V., Kucaba, T. A., Dileepan, T., Swanson, W. L., Dail, C., Cabrera-Pérez, J., Murphy, K. A., Badovinac, V. P., & Griffith, T. S. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01786 · Cited by 26

Immune gene expression networks in sepsis: A network biology approach

Kim, K. S., Jekarl, D. W., Yoo, J., Lee, S., Kim, M., & Kim, Y. (2021) · PLoS ONE · doi:10.1371/journal.pone.0247669 · Cited by 26

Serum‐soluble PD‐L1 may be a potential diagnostic biomarker in sepsis

Sun, S., Yang, C., Liu, Z., Tian, R., Liu, J., Chen, E., Mao, E., Pan, T., & Qu, H. (2021) · Scandinavian Journal of Immunology · doi:10.1111/sji.13049 · Cited by 26

Sepsis Inflammation Impairs the Generation of Functional Dendritic Cells by Targeting Their Progenitors

Lu, J., Sun, K., Yang, H., Fan, D., Huang, H., Hong, Y., Wu, S., Zhou, H., Fang, F., Li, Y., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.732612 · Cited by 26

The Transcription Factor FRA-1/AP-1 Controls Lipocalin-2 Expression and Inflammation in Sepsis Model

Cao, S., Schnelzer, A., Hannemann, N., Schett, G. A., Soulat, D., & Bözec, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.701675 · Cited by 28

miR-126 ameliorates multiple organ dysfunction in septic rats by regulating the differentiation of Th17/Treg

Zou, Q., Liu, C., Hu, N., Wang, W., & Wang, H. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-07121-w · Cited by 26

Chemokines, soluble PD-L1, and immune cell hyporesponsiveness are distinct features of SARS-CoV-2 critical illness

Morrell, E. D., Bhatraju, P. K., Sathe, N. A., Lawson, J. J., Mabrey, L., Holton, S. E., Presnell, S., WIEDEMAN, A. E., Acosta‐Vega, C., Mitchem, M. A., et al. (2022) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00049.2022 · Cited by 26

Effects of fish oil-containing nutrition supplementation in adult sepsis patients: a systematic review and meta-analysis

Wang, H., Su, S., Wang, C., Hu, J., Dan, W., & Peng, X. (2022) · Burns & Trauma · doi:10.1093/burnst/tkac012 · Cited by 26

During Sepsis and COVID-19, the Pro-Inflammatory and Anti-Inflammatory Responses Are Concomitant

Cavaillon, J. (2023) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-023-08965-1 · Cited by 26

MicroRNA-29a promotes apoptosis of monocytes by targeting STAT3 during sepsis

Song, X., Wang, C. T., & Geng, X. (2015) · Genetics and Molecular Research · doi:10.4238/2015.october.28.37 · Cited by 26

Myeloid Cell-Specific Knockout of NFI-A Improves Sepsis Survival

McPeak, M. B., Youssef, D. A., Williams, D. A., Pritchett, C. L., Yao, Z. Q., McCall, C. E., & Gazzar, M. E. (2017) · Infection and Immunity · doi:10.1128/iai.00066-17 · Cited by 26

Cannabinoid Receptor 2 Modulates Neutrophil Recruitment in a Murine Model of Endotoxemia

Kapellos, T. S., Recio, C., Greaves, D. R., & Iqbal, A. J. (2017) · Mediators of Inflammation · doi:10.1155/2017/4315412 · Cited by 26

IL-7 treatment augments and prolongs sepsis-induced expansion of IL-10-producing B lymphocytes and myeloid-derived suppressor cells

Kulkarni, U., Ammer‐Herrmenau, C., Win, S. J., Bauer, M. W., & Kamradt, T. (2018) · PLoS ONE · doi:10.1371/journal.pone.0192304 · Cited by 26

Preoperative Therapy for Gastric Adenocarcinoma is Protective for Poor Oncologic Outcomes in Patients with Complications After Gastrectomy

Vicente, D. A., Ikoma, N., Chiang, Y., Fournier, K. F., Tzeng, C.-W. D., Song, S., Mansfield, P. F., Ajani, J. A., & Badgwell, B. D. (2018) · Annals of Surgical Oncology · doi:10.1245/s10434-018-6638-8 · Cited by 27

Impact of Blood Product Transfusions on the Risk of ICU-Acquired Infections in Septic Shock*

Péju, E., Llitjos, J., Charpentier, J., François, A., Marin, N., Cariou, A., Chiche, J., Mira, J. P., Lambert, J., Jamme, M., et al. (2021) · Critical Care Medicine · doi:10.1097/ccm.0000000000004887 · Cited by 27

Endotoxemia in Acute Heart Failure and Cardiogenic Shock: Evidence, Mechanisms and Therapeutic Options

Nguyen, M., Gautier, T., Masson, D., Bouhemad, B., & Guinot, P.-G. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12072579 · Cited by 25

Sepsis in cirrhosis: emerging concepts in pathogenesis, diagnosis and management

Philips, C. A., & Sarin, S. K. (2016) · Hepatology International · doi:10.1007/s12072-016-9753-2 · Cited by 25

Lymphopaenia in cardiac arrest patients

Villois, P., Grimaldi, D., Spadaro, S., Shinotsuka, C. R., Fontana, V., Scolletta, S., Franchi, F., Vincent, J., Créteur, J., & Taccone, F. S. (2017) · Annals of Intensive Care · doi:10.1186/s13613-017-0308-z · Cited by 25

Respective impact of implementation of prevention strategies, colonization with multiresistant bacteria and antimicrobial use on the risk of early- and late-onset VAP: An analysis of the OUTCOMEREA network

Saied, W. I., Souweine, B., Garrouste-Orgeas, M., Ruckly, S., Darmon, M., Bailly, S., Cohen, Y., Azoulay, É., Schwebel, C., Radjou, A., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0187791 · Cited by 25

Mdivi-1 Protects CD4+ T Cells against Apoptosis via Balancing Mitochondrial Fusion-Fission and Preventing the Induction of Endoplasmic Reticulum Stress in Sepsis

Wu, Y., Yao, Y.-M., Ke, H.-L., Lan, Y., Wu, Y., Zhao, G., & Lu, Z. (2019) · Mediators of Inflammation · doi:10.1155/2019/7329131 · Cited by 27

Association of Lymphopenia with Short Term Outcomes of Sepsis Patients; a Brief Report.

Vahedi, H. S. M., Bagheri, A., Jahanshir, A., Seyedhosseini, J., & Vahidi, E. (2019) · Archives of Academic Emergency Medicine · doi:10.22037/aaem.v7i1.117 · Cited by 25

Immune Response Resetting in Ongoing Sepsis

Nowill, A. E., Fornazin, M. C., Spago, M. C., Neto, V. D., Pinheiro, V. R. P., Alexandre, S. S. S., Moraes, E. O., Souza, G. H. M. F., Eberlin, M. N., Marques, L. A., et al. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1900104 · Cited by 25

Downregulation of miR-574-5p inhibits HK-2 cell viability and predicts the onset of acute kidney injury in sepsis patients

Liu, S., Zhao, L., Zhang, L., Qiao, L., & Gao, S. (2021) · Renal Failure · doi:10.1080/0886022x.2021.1939051 · Cited by 25

Long noncoding RNAs: A potential target in sepsis-induced cellular disorder

Lu, F., Hong, Y., Liu, L., Wei, N., Lin, Y., He, J., & Shao, Y. (2021) · Experimental Cell Research · doi:10.1016/j.yexcr.2021.112756 · Cited by 25

Impairment of antigen-presenting function of peripheral γδ T cells in patients with sepsis

Yang, X., Li, H., Feng, T., Zhang, W., Song, X., Ma, C., Nie, M., Wang, L., Tan, X., Kang, Y., et al. (2021) · Clinical & Experimental Immunology · doi:10.1093/cei/uxab029 · Cited by 25

More Prominent Inflammatory Response to Pachyman than to Whole-Glucan Particle and Oat-β-Glucans in Dextran Sulfate-Induced Mucositis Mice and Mouse Injection through Proinflammatory Macrophages

Hiengrach, P., Visitchanakun, P., Finkelman, M., Chancharoenthana, W., & Leelahavanichkul, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23074026 · Cited by 26

mTOR pathway mediates endoplasmic reticulum stress-induced CD4+ T cell apoptosis in septic mice

Bai, G., Wang, H., & Cui, N. (2022) · APOPTOSIS · doi:10.1007/s10495-022-01740-1 · Cited by 25

Immune dysregulation and RNA N6 ‐methyladenosine modification in sepsis

Chen, H., Zhang, X., Su, H., Zeng, J., Chan, H., Li, Q., Liu, X., Zhang, L., Wu, W. K. K., Chan, M. T. V., et al. (2022) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1764 · Cited by 25

PINK1 protects against dendritic cell dysfunction during sepsis through the regulation of mitochondrial quality control

Wu, Y., Chen, L., Qiu, Z., Zhang, X., Zhao, G., & Lu, Z. (2023) · Molecular Medicine · doi:10.1186/s10020-023-00618-5 · Cited by 25

Single-cell transcriptomics reveals immune infiltrate in sepsis

Tu, X., Huang, H., Xu, S., Li, C., & Luo, S. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1133145 · Cited by 25

A Leukocyte Score to Improve Clinical Outcome Predictions in Bacteremic Pneumococcal Pneumonia in Adults

Blot, M., Croisier, D., Péchinot, A., Vagner, A., Putot, A., Fillion, A., Baudouin, N., Quenot, J., Charles, P., Bonniaud, P., et al. (2014) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofu075 · Cited by 25

Sepsis After Cardiac Surgery: From Pathophysiology to Management

Paternoster, G., & Guarracino, F. (2015) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2015.11.009 · Cited by 25

Dose-Dependent Effect of Granulocyte Transfusions in Hematological Patients with Febrile Neutropenia

Teofili, L., Valentini, C. G., Blasi, R. D., Orlando, N., Fianchi, L., Zini, G., Sica, S., Stefano, V. D., & Pagano, L. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159569 · Cited by 25

Can Concurrent Abnormalities in Free Light Chains and Immunoglobulin Concentrations Identify a Target Population for Immunoglobulin Trials in Sepsis?*

Shankar‐Hari, M., Singer, M., & Spencer, J. (2017) · Critical Care Medicine · doi:10.1097/ccm.0000000000002627 · Cited by 25

Automated bedside flow cytometer for mHLA-DR expression measurement: a comparison study with reference protocol

Zouiouich, M., Gossez, M., Venet, F., Rimmele, T. R., & Monneret, G. (2017) · Intensive Care Medicine Experimental · doi:10.1186/s40635-017-0156-z · Cited by 25

Vasopressor Cumulative Dose Requirement and Risk of Early Death During Septic Shock: An Analysis From The EPISS Cohort

Dargent, A., Nguyen, M., Fournel, I., Bourredjem, A., Charles, P., & Quenot, J. (2017) · Shock · doi:10.1097/shk.0000000000001022 · Cited by 25

Immunotherapy: A promising approach to reverse sepsis-induced immunosuppression

Patil, N. K., Bohannon, J. K., & Sherwood, E. R. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.07.019 · Cited by 173

Advances in the understanding and treatment of sepsis-induced immunosuppression

Venet, F., & Monneret, G. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.165 · Cited by 1,029

Sepsis-associated immunosuppression: mechanistic Insights, Biomarkers, and therapeutic perspectives

Ovalı, M. A., & Percin, S. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-11312-6 · Cited by 11

The changing immune system in sepsis

Boomer, J. S., Green, J. M., & Hotchkiss, R. S. (2013) · Virulence · doi:10.4161/viru.26516 · Cited by 340

Potential Immunotherapeutics for Immunosuppression in Sepsis

Shin, J., & Jin, M. (2017) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2017.193 · Cited by 22