Cited by 2,772Sepsis Diagnosis and TreatmentInflammation biomarkers and pathwaysImmune Response and Inflammation

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Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy

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Hotchkiss, Richard S., Monneret, Guillaume, Payen, Didier·2013·Nature Reviews Immunology

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Abstract

Sepsis - which is a severe life-threatening infection with organ dysfunction - initiates a complex interplay of host pro-inflammatory and anti-inflammatory processes. Sepsis can be considered a race to the death between the pathogens and the host immune system, and it is the proper balance between the often competing pro- and anti-inflammatory pathways that determines the fate of the individual. Although the field of sepsis research has witnessed the failure of many highly touted clinical trials, a better understanding of the pathophysiological basis of the disorder and the mechanisms responsible for the associated pro- and anti-inflammatory responses provides a novel approach for treating this highly lethal condition. Biomarker-guided immunotherapy that is administered to patients at the proper immune phase of sepsis is potentially a major advance in the treatment of sepsis and in the field of infectious disease.

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Authors: Hotchkiss, R. S., Monneret, G., & Payen, D.
Affiliations: Washington University in St. Louis (US)
Hospices Civils de Lyon (FR)
Assistance Publique – Hôpitaux de Paris (FR)
Corresponding author: Hotchkiss, Richard S.
ORCID: Hotchkiss, Richard S.
Monneret, Guillaume
Payen, Didier
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2013-11-15
Volume: 13
Issue: 12
Pages: 862-874
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri3552
PMC: PMC4077177
OpenAlex: W2083513831
Cited by: 2,772
References: 174
Citations by year: 2026: 364 · 2025: 277 · 2024: 241 · 2023: 227 · 2022: 239 · 2021: 286 · 2020: 227 · 2019: 220 · 2018: 178 · 2017: 199 · 2016: 147 · 2015: 101 · 2014: 62 · 2013: 1
FWCI: 12.16
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: University of Washington
Hospices Civils de Lyon
National Institutes of Health (GM44118)
National Cancer Institute (P30CA091842)
National Institute of General Medical Sciences (GM55194, R01GM055194, R37GM044118, R01GM098391, R01GM044118, GM 44118)
Topics: Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: sepsis, sepsis-induced immunosuppression, immunotherapy, cellular dysfunction, hyperinflammation, biomarker-guided therapy, host immune response, organ dysfunction, intensive care
MeSH terms: Animals, Humans, Immune Tolerance, Immunity, Cellular, Immunity, Innate, Immunotherapy, Inflammation, Sepsis, Models, Animal, Mice

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Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy

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