The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see)
Open accessAbstract
The fate of developing T cells is specified by the interaction of their antigen receptors with self-peptide–MHC complexes that are displayed by thymic antigen-presenting cells (APCs). Various subsets of thymic APCs are strategically positioned in particular thymic microenvironments and they coordinate the selection of a functional and self-tolerant T cell repertoire. In this Review, we discuss the different strategies that these APCs use to sample and process self antigens and to thereby generate partly unique, 'idiosyncratic' peptide–MHC ligandomes. We discuss how the particular composition of the peptide–MHC ligandomes that are presented by specific APC subsets not only shapes the T cell repertoire in the thymus but may also indelibly imprint the behaviour of mature T cells in the periphery.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Pugliese, A., Zeller, M., Fernandez, A., Zalcberg, L. J., Bartlett, R. J., Ricordi, C., Pietropaolo, M., Eisenbarth, G. S., Bennett, S. T., & Patel, D. D. (1997) · Nature Genetics · doi:10.1038/ng0397-293 · Cited by 945
Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus
Vafiadis, P., Bennett, S. T., Todd, J. A., Nadeau, J., Grabs, R., Goodyer, C. G., Wickramasinghe, S., Colle, E., & Polychronakos, C. (1997) · Nature Genetics · doi:10.1038/ng0397-289 · Cited by 809
Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes
Stefanová, I., Dorfman, J. R., & Germain, R. N. (2002) · Nature · doi:10.1038/nature01146 · Cited by 389
Ebert, P. J. R., Jiang, S., Xie, J., Li, Q.-J., & Davis, M. M. (2009) · Nature Immunology · doi:10.1038/ni.1797 · Cited by 251
Impaired thymic tolerance to α-myosin directs autoimmunity to the heart in mice and humans
Lv, H., Havari, E., Pinto, S., Gottumukkala, R. V. S. R. K., Cornivelli, L., Raddassi, K., Matsui, T., Rosenzweig, A., Bronson, R. T., Smith, R., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44583 · Cited by 228
Self-citationLo, W.-L., Felix, N. J., Walters, J. J., Rohrs, H., Gross, M. L., & Allen, P. M. (2009) · Nature Immunology · doi:10.1038/ni.1796 · Cited by 105
Self-citationMyocardial Infarction Triggers Chronic Cardiac Autoimmunity in Type 1 Diabetes
Gottumukkala, R. V. S. R. K., Lv, H., Cornivelli, L., Wagers, A. J., Kwong, R. Y., Bronson, R., Stewart, G. C., Schulze, P. C., Chutkow, W., Wolpert, H. A., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003551 · Cited by 76
Cited by
Immunogenic cell stress and death
Kroemer, G., Galassi, C., Zitvogel, L., & Galluzzi, L. (2022) · Nature Immunology · doi:10.1038/s41590-022-01132-2 · Cited by 1,353
Human T cell development, localization, and function throughout life
Kumar, B. V., Connors, T. J., & Farber, D. L. (2018) · Immunity · doi:10.1016/j.immuni.2018.01.007 · Cited by 1,257
Mitochondrial dynamics in health and disease: mechanisms and potential targets
Chen, W., Zhao, H., & Li, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01547-9 · Cited by 1,306
Multiple Sclerosis: Mechanisms and Immunotherapy
Baecher-Allan, C., Kaskow, B. J., & Weiner, H. L. (2018) · Neuron · doi:10.1016/j.neuron.2018.01.021 · Cited by 938
Tumor-infiltrating regulatory T cells as targets of cancer immunotherapy
Tay, C., Tanaka, A., & Sakaguchi, S. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.02.014 · Cited by 580
Metadata
- Authors
- Klein, L., Kyewski, B., Allen, P. M., & Hogquist, K. A.
- Venue
- Nature Reviews Immunology
- Published
- 2014-05-16
- Volume
- 14
- Issue
- 6
- Pages
- 377-391
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2024748688
- Cited by
- 1,383
- References
- 7
- FWCI
- 7.71
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see). https://app.cochat.ai/papers/10.1038/nri3667
- The paper
- Klein, L., Kyewski, B., Allen, P. M., & Hogquist, K. A. (2014). Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see). Nature Reviews Immunology. https://doi.org/10.1038/nri3667
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
