Cited by 1,306Mitochondrial Function and PathologyAutophagy in Disease and TherapyCell death mechanisms and regulation

Mitochondrial dynamics in health and disease: mechanisms and potential targets

Open access
Chen, Wen, Zhao, Huakan, Li, Yongsheng·2023·Signal Transduction and Targeted Therapy

Abstract

Mitochondria are organelles that are able to adjust and respond to different stressors and metabolic needs within a cell, showcasing their plasticity and dynamic nature. These abilities allow them to effectively coordinate various cellular functions. Mitochondrial dynamics refers to the changing process of fission, fusion, mitophagy and transport, which is crucial for optimal function in signal transduction and metabolism. An imbalance in mitochondrial dynamics can disrupt mitochondrial function, leading to abnormal cellular fate, and a range of diseases, including neurodegenerative disorders, metabolic diseases, cardiovascular diseases and cancers. Herein, we review the mechanism of mitochondrial dynamics, and its impacts on cellular function. We also delve into the changes that occur in mitochondrial dynamics during health and disease, and offer novel perspectives on how to target the modulation of mitochondrial dynamics.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/s41392-023-01547-9

Cites

323 of 323 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

2 retracted

Flagged first, then by citations

Research works printed but not linked: 1

  1. [72]Morin M Moindjie H Nahmias C [Mitochondrial transport: How does it impact cancer?] Med. Sci. (Paris) 2022 38 585 593 35766857

Cited by

Sorted by citations

Authors
Chen, W., Zhao, H., & Li, Y.
Affiliations
Chongqing University (CN)
Corresponding author
  • Zhao, Huakan
  • Li, Yongsheng
Venue
Signal Transduction and Targeted Therapy
Published
2023-09-06
Volume
8
Issue
1
Pages
333-333
ISSN
2059-3635 (ISSN-L)
OpenAlex
W4386448978
Cited by
1,306
References
323
Citations by year
2026: 481 · 2025: 560 · 2024: 259 · 2023: 5 · 2016: 1
FWCI
34.28
Type
journal article
Language
en
Open access
Locations
  • Signal Transduction and Targeted Therapy (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Science Foundation of China | Major International Joint Research Programme (81920108027)
  • National Natural Science Foundation of China (82273212)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords
mitochondrial dynamics, mitochondrial fission, mitochondrial fusion, mitophagy, mitochondrial transport, mitochondrial plasticity, mitochondrial metabolism, neurodegenerative diseases, metabolic disorders, cardiovascular disease, cancer, therapeutic target
MeSH terms
Cardiovascular Diseases, Cell Differentiation, Humans, Mitochondria, Mitochondrial Dynamics, Mitophagy

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review